{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:26:52Z","timestamp":1793690812026,"version":"4.5.1"},"reference-count":158,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jacc.2025.10.074","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T20:28:55Z","timestamp":1763152135000},"page":"414-438","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Proactive Management and Treatment of Aortic Stenosis"],"prefix":"10.1016","volume":"87","author":[{"given":"Christopher M.","family":"Cook","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"G\u00e9n\u00e9reux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9841-2737","authenticated-orcid":false,"given":"Victoria","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1750-1982","authenticated-orcid":false,"given":"Kentaro","family":"Hayashida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-7315","authenticated-orcid":false,"given":"Radoslaw","family":"Parma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-7471","authenticated-orcid":false,"given":"Tsuyoshi","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8839-7476","authenticated-orcid":false,"given":"Tanja K.","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o L.","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen J.","family":"Bax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pilgrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9969-2649","authenticated-orcid":false,"given":"Francesco","family":"Saia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreekanth","family":"Vemulapalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Pellikka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9127-348X","authenticated-orcid":false,"given":"Bernard","family":"Iung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Guibone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Dweck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Eltchaninoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorav","family":"Ailawadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Cheung-Chi","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Poon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Unbehaun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Joner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Prendergast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1342-9191","authenticated-orcid":false,"given":"Rebecca T.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Lindman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2025.10.074_bib1","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1093\/eurheartj\/ehaf194","article-title":"2025 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"46","author":"Praz","year":"2025","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib2","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jacc.2020.11.035","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib3","article-title":"Detection of severe aortic stenosis by clinicians versus artificial intelligence: a retrospective clinical cohort study","volume":"48","author":"Strange","year":"2024","journal-title":"Am Heart J Plus"},{"key":"10.1016\/j.jacc.2025.10.074_bib4","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1093\/eurheartj\/ehab153","article-title":"Electrocardiogram screening for aortic valve stenosis using artificial intelligence","volume":"42","author":"Cohen-Shelly","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib5","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1161\/CIRCULATIONAHA.125.074470","article-title":"Electronic provider notification to facilitate the recognition and management of severe aortic stenosis: a randomized clinical trial","volume":"151","author":"Tanguturi","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.10.074_bib6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.athoracsur.2021.03.089","article-title":"The Society of Thoracic Surgeons 2021 Adult Cardiac Surgery Risk Models for Multiple Valve Operations","volume":"113","author":"Jacobs","year":"2022","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2025.10.074_bib7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1001\/jamacardio.2015.0326","article-title":"Development and validation of a risk prediction model for in-hospital mortality after transcatheter aortic valve replacement","volume":"1","author":"Edwards","year":"2016","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib8","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ejcts\/ezs043","article-title":"EuroSCORE II","volume":"41","author":"Nashef","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jacc.2025.10.074_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcmg.2018.12.003","article-title":"Computed tomography imaging in the context of transcatheter aortic valve implantation (TAVI)\/transcatheter aortic valve replacement (TAVR): an Expert Consensus Document of the Society of Cardiovascular Computed Tomography","volume":"12","author":"Blanke","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2025.10.074_bib10","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.athoracsur.2024.02.017","article-title":"Preprocedural computed tomography planning for surgical aortic valve replacement","volume":"117","author":"Okada","year":"2024","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2025.10.074_bib11","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","article-title":"Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery","volume":"363","author":"Leon","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.10.074_bib12","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or surgical aortic-valve replacement in intermediate-risk patients","volume":"374","author":"Leon","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.10.074_bib13","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients","volume":"380","author":"Mack","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.10.074_bib14","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients","volume":"380","author":"Popma","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.10.074_bib15","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1056\/NEJMoa1400590","article-title":"Transcatheter aortic-valve replacement with a self-expanding prosthesis","volume":"370","author":"Adams","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.10.074_bib16","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJMoa1700456","article-title":"Surgical or transcatheter aortic-valve replacement in intermediate-risk patients","volume":"376","author":"Reardon","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.10.074_bib17","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJMoa2400685","article-title":"Transcatheter or surgical treatment of aortic-valve stenosis","volume":"390","author":"Blankenberg","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.10.074_bib18","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.jacc.2015.03.014","article-title":"Transcatheter versus surgical aortic valve replacement in patients with severe aortic valve stenosis: 1-year results from the All-Comers NOTION Randomized Clinical Trial","volume":"65","author":"Thyregod","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib19","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1001\/jama.2022.5776","article-title":"Effect of transcatheter aortic valve implantation vs surgical aortic valve replacement on all-cause mortality in patients with aortic stenosis: a randomized clinical trial","volume":"327","author":"UK TAVI Trial Investigators","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2025.10.074_bib20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.athoracsur.2023.10.006","article-title":"Survival after surgical aortic valve replacement in low-risk patients: a contemporary trial benchmark","volume":"117","author":"Thourani","year":"2024","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2025.10.074_bib21","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.jtcvs.2021.04.064","article-title":"Outcomes of surgical aortic valve replacement over three decades","volume":"164","author":"\u00c7elik","year":"2022","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2025.10.074_bib22","article-title":"Trend and early outcomes in isolated surgical aortic valve replacement in the United Kingdom","volume":"9","author":"Chan","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jacc.2025.10.074_bib23","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the Management of Valvular Heart Disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1912846","article-title":"Early surgery or conservative care for asymptomatic aortic stenosis","volume":"382","author":"Kang","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.10.074_bib25","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1161\/CIRCULATIONAHA.121.057639","article-title":"Aortic valve replacement versus conservative treatment in asymptomatic severe aortic stenosis: the AVATAR Trial","volume":"145","author":"Banovic","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.10.074_bib26","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1093\/eurheartj\/ehae585","article-title":"Aortic valve replacement vs. conservative treatment in asymptomatic severe aortic stenosis: long-term follow-up of the AVATAR trial","volume":"45","author":"Banovic","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1056\/NEJMoa2405880","article-title":"Transcatheter aortic-valve replacement for asymptomatic severe aortic stenosis","volume":"392","author":"G\u00e9n\u00e9reux","year":"2025","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.10.074_bib28","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jacc.2024.11.006","article-title":"Aortic valve replacement vs clinical surveillance in asymptomatic severe aortic stenosis: a systematic review and meta-analysis","volume":"85","author":"G\u00e9n\u00e9reux","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib29","article-title":"Aortic valve replacement in asymptomatic severe aortic stenosis: a systematic review and meta-analysis","volume":"4","author":"G\u00e9n\u00e9reux","year":"2025","journal-title":"J Soc Cardiovasc Angiogr Interv"},{"key":"10.1016\/j.jacc.2025.10.074_bib30","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.jacc.2021.11.060","article-title":"Trends in utilization of aortic valve replacement for severe aortic stenosis","volume":"79","author":"Li","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib31","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1016\/j.jacc.2023.09.796","article-title":"The mortality burden of untreated aortic stenosis","volume":"82","author":"G\u00e9n\u00e9reux","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib32","first-page":"230","article-title":"Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology","volume":"28","author":"Vahanian","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib33","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2006.05.021","volume":"48","author":"Bonow","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/01.CIR.38.1S5.V-61","article-title":"Aortic stenosis","volume":"38","author":"Ross","year":"1968","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.10.074_bib35","first-page":"17","article-title":"Results of a 1 to 31 years follow-up after aortic valve replacement in 2327 patients","volume":"37","author":"Feyrer","year":"1996","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"10.1016\/j.jacc.2025.10.074_bib36","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.athoracsur.2025.03.011","article-title":"The Society of Thoracic Surgeons Adult Cardiac Surgery Database: 2024 Update on National Trends and Outcomes","volume":"119","author":"Iribarne","year":"2025","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2025.10.074_bib37","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/S0003-4975(00)01670-2","article-title":"Mortality after aortic valve replacement: results from a nationally representative database","volume":"70","author":"Astor","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2025.10.074_bib38","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jcmg.2019.02.034","article-title":"Multimodality imaging markers of adverse myocardial remodeling in aortic stenosis","volume":"12","author":"Treibel","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2025.10.074_bib39","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.jcmg.2016.10.007","article-title":"Myocardial fibrosis and cardiac decompensation in aortic stenosis","volume":"10","author":"Chin","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2025.10.074_bib40","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.jcin.2020.03.011","article-title":"Left ventricular hypertrophy and clinical outcomes over 5 years after TAVR: an analysis of the PARTNER Trials and Registries","volume":"13","author":"Gonzales","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.10.074_bib41","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.jcmg.2021.04.009","article-title":"Prognostic implications of associated cardiac abnormalities detected on echocardiography in patients with moderate aortic stenosis","volume":"14","author":"Amanullah","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2025.10.074_bib42","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/eurheartj\/ehx381","article-title":"Staging classification of aortic stenosis based on the extent of cardiac damage","volume":"38","author":"G\u00e9n\u00e9reux","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib43","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.119.009958","article-title":"Left ventricular global longitudinal strain is associated with long-term outcomes in moderate aortic stenosis","volume":"13","author":"Zhu","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2025.10.074_bib44","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1016\/j.jacc.2020.03.042","article-title":"Regression of left ventricular mass after transcatheter aortic valve replacement: the PARTNER Trials and Registries","volume":"75","author":"Chau","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib45","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jacc.2022.05.006","article-title":"Evolution and prognostic impact of cardiac damage after aortic valve replacement","volume":"80","author":"G\u00e9n\u00e9reux","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib46","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1001\/jamacardio.2021.2082","article-title":"Prevention and mitigation of heart failure in the treatment of calcific aortic stenosis: a unifying therapeutic principle","volume":"6","author":"Lindman","year":"2021","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib47","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/heartjnl-2019-315908","article-title":"Left ventricular filling pressure and survival following aortic valve replacement for severe aortic stenosis","volume":"106","author":"Thaden","year":"2020","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2025.10.074_bib48","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1001\/jamacardio.2024.3453","article-title":"Trends in transcatheter aortic valve replacement outcomes: insights from the STS\/ACC TVT Registry","volume":"9","author":"Arnold","year":"2024","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib49","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/ehjqcco\/qcab078","article-title":"Patient-reported vs. physician-estimated symptoms before and after transcatheter aortic valve replacement","volume":"8","author":"Arnold","year":"2022","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"10.1016\/j.jacc.2025.10.074_bib50","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1016\/j.jcin.2023.07.007","article-title":"Outcomes of transcatheter aortic valve replacement in asymptomatic or minimally symptomatic aortic stenosis","volume":"16","author":"Huded","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.10.074_bib51","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.115.002875","article-title":"Association of patient-reported health status with long-term mortality after transcatheter aortic valve replacement: report from the STS\/ACC TVT Registry","volume":"8","author":"Arnold","year":"2015","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.10.074_bib52","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1001\/jamacardio.2017.2952","article-title":"Association of guideline adherence for serial evaluations with survival and adverse clinical events in patients with asymptomatic severe aortic stenosis","volume":"2","author":"Ahmed","year":"2017","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib53","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2020-001547","article-title":"\u201cValve for Life\u201d: tackling the deficit in transcatheter treatment of heart valve disease in the UK","volume":"8","author":"Ali","year":"2021","journal-title":"Open Heart"},{"key":"10.1016\/j.jacc.2025.10.074_bib54","article-title":"The cost of waiting for a transcatheter aortic valve replacement in medicare beneficiaries with severe aortic stenosis","volume":"8","author":"Sethi","year":"2024","journal-title":"Struct Heart"},{"key":"10.1016\/j.jacc.2025.10.074_bib55","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2020-001485","article-title":"Management of patients with severe aortic stenosis in the TAVI-era: how recent recommendations are translated into clinical practice","volume":"8","author":"Lauten","year":"2021","journal-title":"Open Heart"},{"key":"10.1016\/j.jacc.2025.10.074_bib56","first-page":"704","article-title":"Medical management of symptomatic severe aortic stenosis in patients non-eligible for transcatheter aortic valve implantation","volume":"17","author":"Gheorghe","year":"2020","journal-title":"J Geriatr Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib57","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ahj.2024.04.006","article-title":"Examining lack of referrals to heart valve specialists as mechanisms of potential underutilization of aortic valve replacement","volume":"274","author":"Etiwy","year":"2024","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib58","article-title":"Acute valve syndrome in aortic stenosis","volume":"9","author":"G\u00e9n\u00e9reux","year":"2025","journal-title":"Struct Heart"},{"key":"10.1016\/j.jacc.2025.10.074_bib59","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1161\/CIRCULATIONAHA.125.074251","article-title":"New classification to describe clinical presentation in aortic stenosis: stable, progressive, and acute valve syndrome","volume":"151","author":"G\u00e9n\u00e9reux","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.10.074_bib60","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.amjcard.2024.02.034","article-title":"Asymptomatic aortic stenosis: from risk stratification to treatment","volume":"218","author":"Banovic","year":"2024","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib61","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.120.009297","article-title":"Increasing wait-time mortality for severe aortic stenosis: a population-level study of the transition in practice from surgical aortic valve replacement to transcatheter aortic valve replacement","volume":"13","author":"Albassam","year":"2020","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.10.074_bib62","first-page":"89","article-title":"Mortality whilst waiting for intervention in symptomatic severe aortic stenosis","volume":"6","author":"Bhattacharyya","year":"2020","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"10.1016\/j.jacc.2025.10.074_bib63","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.athoracsur.2014.06.040","article-title":"Mortality while waiting for aortic valve replacement","volume":"98","author":"Malaisrie","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2025.10.074_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2025.102178","article-title":"Early intervention vs conservative management in severe asymptomatic aortic stenosis: a critical review of randomized evidence","volume":"4","author":"Dayan","year":"2025","journal-title":"JACC Adv"},{"key":"10.1016\/j.jacc.2025.10.074_bib65","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1001\/jama.2024.22730","article-title":"Early intervention in patients with asymptomatic severe aortic stenosis and myocardial fibrosis: the EVOLVED Randomized Clinical Trial","volume":"333","author":"Loganath","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2025.10.074_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2025.133269","article-title":"Early aortic valve replacement versus conservative management in asymptomatic severe aortic stenosis: meta-analysis of time-to-event data of randomized controlled trials","volume":"432","author":"Jacquemyn","year":"2025","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib67","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031461","article-title":"Trends in complications among patients undergoing aortic valve replacement in the United States","volume":"13","author":"Harvey","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacc.2025.10.074_bib68","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1001\/jamacardio.2024.5648","article-title":"Aortic valve replacement for asymptomatic severe aortic stenosis-the time has come","volume":"10","author":"Lindman","year":"2025","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib69","author":"G\u00e9n\u00e9reux"},{"key":"10.1016\/j.jacc.2025.10.074_bib70","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ahj.2023.07.009","article-title":"Physician assessment of aortic stenosis severity, quantitative parameters, and long-term outcomes: results from the KP-VALVE project","volume":"266","author":"Solomon","year":"2023","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib71","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2020-001331","article-title":"Characterisation of aortic stenosis severity: a retrospective analysis of echocardiography reports in a clinical laboratory","volume":"7","author":"Raddatz","year":"2020","journal-title":"Open Heart"},{"key":"10.1016\/j.jacc.2025.10.074_bib72","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.021126","article-title":"Prevalence and outcomes of low-gradient severe aortic stenosis-from the National Echo Database of Australia","volume":"10","author":"Snir","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacc.2025.10.074_bib73","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1093\/eurheartj\/ehs443","article-title":"ESC Working Group on Valvular Heart Disease position paper--heart valve clinics: organization, structure, and experiences","volume":"34","author":"Lancellotti","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib74","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.025164","article-title":"Impact of managing provider type on severe aortic stenosis management and mortality","volume":"11","author":"Pellikka","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacc.2025.10.074_bib75","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.acvd.2025.02.003","article-title":"Death on waiting list for transcatheter aortic valve implantation: current incidence, clinical characteristics and predictive factors","volume":"118","author":"Poinsignon","year":"2025","journal-title":"Arch Cardiovasc Dis"},{"key":"10.1016\/j.jacc.2025.10.074_bib76","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.echo.2025.06.001","article-title":"Guidelines for the Standardization of Adult Echocardiography Reporting: Recommendations From the American Society of Echocardiography","volume":"38","author":"Taub","year":"2025","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2025.10.074_bib77","article-title":"Harnessing electronic health records and artificial intelligence for enhanced cardiovascular risk prediction: a comprehensive review","volume":"14","author":"Tsai","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacc.2025.10.074_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2024.101176","article-title":"An artificial intelligence algorithm for detection of severe aortic stenosis: a clinical cohort study","volume":"3","author":"Strom","year":"2024","journal-title":"JACC Adv"},{"key":"10.1016\/j.jacc.2025.10.074_bib79","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ijcard.2010.12.071","article-title":"Underestimation of aortic valve area in calcified aortic valve disease: effects of left ventricular outflow tract ellipticity","volume":"157","author":"Utsunomiya","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib80","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.echo.2020.03.020","article-title":"Estimation of stroke volume and aortic valve area in patients with aortic stenosis: a comparison of echocardiography versus cardiovascular magnetic resonance","volume":"33","author":"Guzzetti","year":"2020","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2025.10.074_bib81","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.amjcard.2014.01.429","article-title":"Impact of obesity and nonobesity on grading the severity of aortic valve stenosis","volume":"113","author":"Rogge","year":"2014","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib82","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/heartjnl-2018-313269","article-title":"Use of routinely captured echocardiographic data in the diagnosis of severe aortic stenosis","volume":"105","author":"Bradley","year":"2019","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2025.10.074_bib83","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.echo.2015.02.016","article-title":"Doppler imaging in aortic stenosis: the importance of the nonapical imaging windows to determine severity in a contemporary cohort","volume":"28","author":"Thaden","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2025.10.074_bib84","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jcmg.2018.11.027","article-title":"How do we reconcile echocardiography, computed tomography, and hybrid imaging in assessing discordant grading of aortic stenosis severity?","volume":"12","author":"Delgado","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2025.10.074_bib85","doi-asserted-by":"crossref","first-page":"e407","DOI":"10.4244\/EIJ-D-21-01091","article-title":"Lifetime management of patients with symptomatic severe aortic stenosis: a computed tomography simulation study","volume":"18","author":"Medranda","year":"2022","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jacc.2025.10.074_bib86","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s00330-011-2345-6","article-title":"Left and right ventricle assessment with cardiac CT: validation study vs. cardiac MR","volume":"22","author":"Maffei","year":"2012","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib87","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.jcmg.2020.05.029","article-title":"Identifying cardiac amyloid in aortic stenosis: ECV quantification by CT in TAVR patients","volume":"13","author":"Scully","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2025.10.074_bib88","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.1093\/eurheartj\/ehaf362","article-title":"Cardiac transthyretin amyloidosis treatment improves outcomes after aortic valve replacement for severe stenosis","volume":"46","author":"Nitsche","year":"2025","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib89","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.echo.2010.10.008","article-title":"Occurrence of atrial fibrillation during dobutamine stress echocardiography: incidence, risk factors, and outcomes","volume":"24","author":"Sheldon","year":"2011","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2025.10.074_bib90","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jacc.2017.11.052","article-title":"Dobutamine stress echocardiography for management of low-flow, low-gradient aortic stenosis","volume":"71","author":"Annabi","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib91","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/01.CIR.0000079171.43055.46","article-title":"Low-gradient aortic stenosis: operative risk stratification and predictors for long-term outcome: a multicenter study using dobutamine stress hemodynamics","volume":"108","author":"Monin","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.10.074_bib92","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/01.CIR.0000126825.50903.18","article-title":"Natriuretic peptides predict symptom-free survival and postoperative outcome in severe aortic stenosis","volume":"109","author":"Bergler-Klein","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.10.074_bib93","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.amjcard.2004.11.053","article-title":"Usefulness of serial measurement of N-terminal pro-brain natriuretic peptide plasma levels in asymptomatic patients with aortic stenosis to predict symptomatic deterioration","volume":"95","author":"Gerber","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib94","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.jacc.2014.02.581","article-title":"B-type natriuretic peptide clinical activation in aortic stenosis: impact on long-term survival","volume":"63","author":"Clavel","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib95","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1161\/CIRCULATIONAHA.125.074425","article-title":"Cardiac biomarkers in patients with asymptomatic severe aortic stenosis: analysis from the EARLY TAVR Trial","volume":"151","author":"Lindman","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.10.074_bib96","article-title":"Left ventricular health and TAVR timing in asymptomatic severe aortic stenosis: analysis from the EARLY TAVR Trial","author":"Lindman","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib97","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/j.jcin.2023.05.030","article-title":"Effectiveness of Pre-TAVR CTA as a screening tool for significant CAD before TAVR","volume":"16","author":"Kondoleon","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.10.074_bib98","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.125.015181","article-title":"Feasibility of computed tomography as a gatekeeper for invasive angiography before TAVR: a pragmatic real-world experience","volume":"18","author":"Phichaphop","year":"2025","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.10.074_bib99","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1007\/s00330-022-08603-y","article-title":"Diagnostic accuracy of coronary computed tomography angiography for the evaluation of obstructive coronary artery disease in patients referred for transcatheter aortic valve implantation: a systematic review and meta-analysis","volume":"32","author":"Gatti","year":"2022","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib100","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1161\/CIRCULATIONAHA.115.020279","article-title":"Gait speed predicts 30-day mortality after transcatheter aortic valve replacement: results from the Society of Thoracic Surgeons\/American College of Cardiology Transcatheter Valve Therapy Registry","volume":"133","author":"Alfredsson","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.10.074_bib101","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.jacc.2019.12.057","article-title":"TAVR in low-risk patients: FDA approval, the new NCD, and shared decision-making","volume":"75","author":"Coylewright","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib102","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1001\/jamacardio.2019.5719","article-title":"The learning curve for shared decision-making in symptomatic aortic stenosis","volume":"5","author":"Coylewright","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib103","article-title":"JACC: advances expert panel perspective: shared decision-making in multidisciplinary team-based cardiovascular care","volume":"3","author":"Perpetua","year":"2024","journal-title":"JACC Adv"},{"key":"10.1016\/j.jacc.2025.10.074_bib104","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0302378","article-title":"An interactive, online decision aid assessing patient goals and preferences for treatment of aortic stenosis to support physician-led shared decision-making: early feasibility pilot study","volume":"19","author":"Coylewright","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.jacc.2025.10.074_bib105","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1093\/eurheartj\/ehw096","article-title":"Low-gradient aortic stenosis","volume":"37","author":"Clavel","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib106","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1136\/hrt.2009.181982","article-title":"Inconsistent grading of aortic valve stenosis by current guidelines: haemodynamic studies in patients with apparently normal left ventricular function","volume":"96","author":"Minners","year":"2010","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2025.10.074_bib107","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1093\/ehjci\/jead153","article-title":"Multi-modality imaging in aortic stenosis: an EACVI clinical consensus document","volume":"24","author":"Dweck","year":"2023","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2025.10.074_bib108","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.124.017122","article-title":"Usefulness of aortic valve calcification in patients with low-flow aortic stenosis","volume":"18","author":"Mogensen","year":"2025","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2025.10.074_bib109","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.jcmg.2019.01.045","article-title":"Why and how to measure aortic valve calcification in patients with aortic stenosis","volume":"12","author":"Pawade","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2025.10.074_bib110","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jacc.2014.05.066","article-title":"Impact of aortic valve calcification, as measured by MDCT, on survival in patients with aortic stenosis: results of an international registry study","volume":"64","author":"Clavel","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib111","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.122.009712","article-title":"Target aortic stenosis: a national initiative to improve quality of care and outcomes for patients with aortic stenosis","volume":"16","author":"Lindman","year":"2023","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jacc.2025.10.074_bib112","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.jacc.2023.12.006","article-title":"2024 ACC\/AHA clinical performance and quality measures for adults with valvular and structural heart disease: a report of the American Heart Association\/American College of Cardiology Joint Committee on Performance Measures","volume":"83","author":"Jneid","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib113","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.125.043486","article-title":"Acute valve syndrome before aortic valve replacement: impact on clinical outcomes, health care costs, and resource use","volume":"14","author":"G\u00e9n\u00e9reux","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacc.2025.10.074_bib114","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1016\/j.jcin.2025.09.029","article-title":"Outcomes of early versus delayed aortic valve replacement: analysis of the EARLY TAVR valve-implant population","volume":"18","author":"G\u00e9n\u00e9reux","year":"2025","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.10.074_bib115","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1161\/CIRCULATIONAHA.104.495903","article-title":"Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up","volume":"111","author":"Pellikka","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.10.074_bib116","first-page":"35","article-title":"Asymptomatic patients with severe aortic stenosis and the impact of intervention","volume":"8","author":"\u00c7elik","year":"2021","journal-title":"J Cardiovasc Dev Dis"},{"key":"10.1016\/j.jacc.2025.10.074_bib117","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.athoracsur.2019.01.031","article-title":"Prognosis of severe asymptomatic aortic stenosis with and without surgery","volume":"108","author":"Campo","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2025.10.074_bib118","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.amjcard.2019.01.035","article-title":"Impact of valve replacement on long-term survival in asymptomatic patients with severe aortic stenosis","volume":"123","author":"Kim","year":"2019","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib119","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1016\/j.jacc.2018.09.049","article-title":"Asymptomatic severe aortic stenosis with preserved ejection fraction: early surgery versus conservative management","volume":"72","author":"Bohbot","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib120","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-016489","article-title":"Self-reported health status, treatment decision and survival in asymptomatic and symptomatic patients with aortic stenosis in a Western Norway population undergoing conservative treatment: a cross-sectional study with 18 months follow-up","volume":"7","author":"Oterhals","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.jacc.2025.10.074_bib121","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.004689","article-title":"Predictors of long-term outcomes in asymptomatic patients with severe aortic stenosis and preserved left ventricular systolic function undergoing exercise echocardiography","volume":"9","author":"Masri","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2025.10.074_bib122","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1016\/j.jacc.2015.10.001","article-title":"Initial surgical versus conservative strategies in patients with asymptomatic severe aortic stenosis","volume":"66","author":"Taniguchi","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib123","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s12471-012-0309-3","article-title":"Clinical course of patients diagnosed with severe aortic stenosis in the Rotterdam area: insights from the AVARIJN study","volume":"20","author":"Heuvelman","year":"2012","journal-title":"Neth Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib124","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1161\/CIRCULATIONAHA.109.909903","article-title":"Early surgery versus conventional treatment in asymptomatic very severe aortic stenosis","volume":"121","author":"Kang","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.10.074_bib125","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.athoracsur.2006.07.043","article-title":"Malignant natural history of asymptomatic severe aortic stenosis: benefit of aortic valve replacement","volume":"82","author":"Pai","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2025.10.074_bib126","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/j.athoracsur.2010.07.070","article-title":"Clinical outcome of asymptomatic severe aortic stenosis with medical and surgical management: importance of STS score at diagnosis","volume":"90","author":"Le Tourneau","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2025.10.074_bib127","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.114.002917","article-title":"Effect of left ventricular ejection fraction on postoperative outcome in patients with severe aortic stenosis undergoing aortic valve replacement","volume":"8","author":"Dahl","year":"2015","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2025.10.074_bib128","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.jacc.2011.12.054","article-title":"Outcome of patients with aortic stenosis, small valve area, and low-flow, low-gradient despite preserved left ventricular ejection fraction","volume":"60","author":"Clavel","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib129","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.jcin.2021.04.038","article-title":"Impact of surgical and transcatheter aortic valve replacement in low-gradient aortic stenosis: a meta-analysis","volume":"14","author":"Ueyama","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.10.074_bib130","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/ehjci\/jew133","article-title":"Role of a heart valve clinic programme in the management of patients with aortic stenosis","volume":"18","author":"Zilberszac","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2025.10.074_bib131","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1001\/jamacardio.2024.0595","article-title":"A multimodal video-based AI biomarker for aortic stenosis development and progression","volume":"9","author":"Oikonomou","year":"2024","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib132","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/ehjdh\/ztae085","article-title":"Use of artificial intelligence to predict outcomes in mild aortic valve stenosis","volume":"6","author":"Julakanti","year":"2025","journal-title":"Eur Heart J Digit Health"},{"key":"10.1016\/j.jacc.2025.10.074_bib133","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cger.2016.01.006","article-title":"Multimorbidity in older adults with aortic stenosis","volume":"32","author":"Lindman","year":"2016","journal-title":"Clin Geriatr Med"},{"key":"10.1016\/j.jacc.2025.10.074_bib134","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1161\/CIRCULATIONAHA.116.023997","article-title":"Medical treatment of aortic stenosis","volume":"134","author":"Marquis-Gravel","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.10.074_bib135","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jacc.2019.04.065","article-title":"Staging cardiac damage in patients with asymptomatic aortic valve stenosis","volume":"74","author":"Tastet","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2024.100959","article-title":"Cardiac damage staging predicts outcomes in aortic valve stenosis after aortic valve replacement: meta-analysis","volume":"3","author":"Abdelfattah","year":"2024","journal-title":"JACC Adv"},{"key":"10.1016\/j.jacc.2025.10.074_bib137","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jacc.2022.11.059","article-title":"Cardiac damage and quality of life after aortic valve replacement in the PARTNER Trials","volume":"81","author":"G\u00e9n\u00e9reux","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib138","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.124.014860","article-title":"Evolution of cardiac damage following SAVR in asymptomatic severe aortic stenosis","volume":"18","author":"Jacob","year":"2025","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.10.074_bib139","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.124.014945","article-title":"Health care cost and resource utilization after aortic valve replacement according to the extent of cardiac damage","volume":"18","author":"G\u00e9n\u00e9reux","year":"2025","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.10.074_bib140","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.jacc.2018.01.045","article-title":"Reduced left ventricular ejection fraction in patients with aortic stenosis","volume":"71","author":"Ito","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib141","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"2022 AHA\/ACC\/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib142","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib143","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jacc.2020.11.006","article-title":"Prevalence and outcomes of concomitant aortic stenosis and cardiac amyloidosis","volume":"77","author":"Nitsche","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib144","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1093\/eurheartj\/ehx350","article-title":"Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement","volume":"38","author":"Casta\u00f1o","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib145","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.carrev.2025.02.005","article-title":"Outcomes of aortic stenosis in patients with cardiac amyloidosis: a systematic review and meta-analysis","volume":"73","author":"Ahmad","year":"2025","journal-title":"Cardiovasc Revasc Med"},{"key":"10.1016\/j.jacc.2025.10.074_bib146","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1016\/j.jacc.2021.09.1367","article-title":"Evaluating medical therapy for calcific aortic stenosis: JACC State-of-the-Art Review","volume":"78","author":"Lindman","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib147","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jacc.2025.06.049","article-title":"The pathophysiologic basis and management of calcific aortic valve stenosis: JACC State-of-the-Art Review","volume":"86","author":"Desai","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib148","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.036657","article-title":"Clinical outcomes according to aortic stenosis management: insights from real-world practice","volume":"13","author":"Coisne","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacc.2025.10.074_bib149","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.020490","article-title":"Association between patient survival and clinician variability in treatment rates for aortic valve stenosis","volume":"10","author":"Brennan","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacc.2025.10.074_bib150","first-page":"E431","article-title":"Ten year follow-up of high-risk patients treated during the early experience with transcatheter aortic valve replacement","volume":"97","author":"Sathananthan","year":"2021","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.10.074_bib151","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jacc.2024.11.048","article-title":"Predictors of outcomes of reintervention after transcatheter aortic valve replacement: FRANCE 2 and FRANCE TAVI Registries","volume":"85","author":"Durand","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib152","author":"Kaneko"},{"key":"10.1016\/j.jacc.2025.10.074_bib153","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1093\/eurheartj\/ehae043","article-title":"Transcatheter or surgical aortic valve implantation: 10-year outcomes of the NOTION trial","volume":"45","author":"Thyregod","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2025.10.074_bib154","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1056\/NEJMoa2307447","article-title":"Transcatheter aortic-valve replacement in low-risk patients at five years","volume":"389","author":"Mack","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.10.074_bib155","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.jacc.2025.03.004","article-title":"5-Year outcomes after transcatheter or surgical aortic valve replacement in low-risk patients with aortic stenosis","volume":"85","author":"Forrest","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib156","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1161\/01.CIR.95.9.2262","article-title":"Prospective study of asymptomatic valvular aortic stenosis. Clinical, echocardiographic, and exercise predictors of outcome","volume":"95","author":"Otto","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.10.074_bib157","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jacc.2020.07.005","article-title":"Bicuspid aortic valve morphology and outcomes after transcatheter aortic valve replacement","volume":"76","author":"Yoon","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.10.074_bib158","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jcin.2022.11.018","article-title":"Coronary obstruction from TAVR in native aortic stenosis: development and validation of multivariate prediction model","volume":"16","author":"Khan","year":"2023","journal-title":"JACC Cardiovasc Interv"}],"container-title":["JACC"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109725101575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109725101575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:34:12Z","timestamp":1770132852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109725101575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":158,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0735109725101575"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2025.10.074","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proactive Management and Treatment of Aortic Stenosis","name":"articletitle","label":"Article Title"},{"value":"JACC","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2025.10.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}