{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:14:01Z","timestamp":1793258041971,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,9,8]],"date-time":"2027-09-08T00:00:00Z","timestamp":1820361600000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jacc.2025.12.032","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:08:25Z","timestamp":1771427305000},"page":"1050-1067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Polygenic Risk Based Detection and Treatment of Subclinical Coronary Atherosclerosis in the PROACT Clinical Trials"],"prefix":"10.1016","volume":"88","author":[{"given":"Roukoz","family":"Abou-Karam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Seo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Mi","family":"Jemma Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouad","family":"Bitar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoshana","family":"Gady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangzhou","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail Grace","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth W.","family":"Karlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8402-7435","authenticated-orcid":false,"given":"Pradeep","family":"Natarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick T.","family":"Ellinor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-4827","authenticated-orcid":false,"given":"Borek","family":"Foldyna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musie S.","family":"Ghebremichael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Atlas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1249-4522","authenticated-orcid":false,"given":"Paul M","family":"Ridker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akl C.","family":"Fahed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jacc.2025.12.032_bib1","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1161\/CIR.0000000000001077","article-title":"Polygenic risk scores for cardiovascular disease: a scientific statement from the American Heart Association","volume":"146","author":"O\u2019Sullivan","year":"2022","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.jacc.2025.12.032_bib2","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCRESAHA.115.306566","article-title":"Genetics of coronary artery disease","volume":"118","author":"McPherson","year":"2016","journal-title":"Circ Res"},{"issue":"12","key":"10.1016\/j.jacc.2025.12.032_bib3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s11883-016-0628-8","article-title":"Genetics\u2014current and future role in the prevention and management of coronary artery disease","volume":"18","author":"Roberts","year":"2016","journal-title":"Curr Atheroscler Rep"},{"issue":"1","key":"10.1016\/j.jacc.2025.12.032_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/ANNALS-24-00716","article-title":"Development and evaluation of a comprehensive prediction model for incident coronary heart disease using genetic, social, and lifestyle\u2013psychological factors: a prospective analysis of the UK Biobank","volume":"178","author":"Naderian","year":"2025","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.jacc.2025.12.032_bib5","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/clc.23627","article-title":"Genetics, its role in preventing the pandemic of coronary artery disease","volume":"44","author":"Roberts","year":"2021","journal-title":"Clin Cardiol"},{"issue":"10","key":"10.1016\/j.jacc.2025.12.032_bib6","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.jacc.2019.03.009","article-title":"2019 ACC\/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"74","author":"Arnett","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.jacc.2025.12.032_bib7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.atherosclerosis.2005.04.004","article-title":"Framingham risk equation underestimates subclinical atherosclerosis risk in asymptomatic women","volume":"184","author":"Michos","year":"2006","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.jacc.2025.12.032_bib8","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1161\/CIRCULATIONAHA.108.800235","article-title":"Prevalence and progression of subclinical atherosclerosis in younger adults with low short-term but high lifetime estimated risk for cardiovascular disease","volume":"119","author":"Berry","year":"2009","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.jacc.2025.12.032_bib9","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/CIRCULATIONAHA.109.192703","article-title":"Defining and setting national goals for cardiovascular health promotion and disease reduction","volume":"121","author":"Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"issue":"33","key":"10.1016\/j.jacc.2025.12.032_bib10","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1093\/eurheartj\/eht508","article-title":"Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the Multi-Ethnic Study of Atherosclerosis","volume":"35","author":"Silverman","year":"2014","journal-title":"Eur Heart J"},{"issue":"9","key":"10.1016\/j.jacc.2025.12.032_bib11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1056\/NEJMoa1311890","article-title":"Cardiovascular risk and events in 17 low-, middle-, and high-income countries","volume":"371","author":"Yusuf","year":"2014","journal-title":"N Engl J Med"},{"issue":"20","key":"10.1016\/j.jacc.2025.12.032_bib12","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1001\/jama.1986.03380200097028","article-title":"Coronary disease among United States soldiers killed in action in Korea: preliminary report","volume":"256","author":"Enos","year":"1986","journal-title":"JAMA"},{"issue":"13","key":"10.1016\/j.jacc.2025.12.032_bib13","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.jacc.2020.08.004","article-title":"\u201cCholesterol-Years\u201d for ASCVD Risk Prediction and Treatment","volume":"76","author":"Shapiro","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.jacc.2025.12.032_bib14","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1038\/s41591-023-02429-x","article-title":"A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease","volume":"29","author":"Patel","year":"2023","journal-title":"Nat Med"},{"issue":"18","key":"10.1016\/j.jacc.2025.12.032_bib15","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1093\/eurheartj\/ehac093","article-title":"A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study","volume":"43","author":"Lu","year":"2022","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.jacc.2025.12.032_bib16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1001\/jamacardio.2022.4466","article-title":"Predictive utility of a coronary artery disease polygenic risk score in primary prevention","volume":"8","author":"Marston","year":"2023","journal-title":"JAMA Cardiol"},{"issue":"34","key":"10.1016\/j.jacc.2025.12.032_bib17","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1093\/eurheartj\/ehae342","article-title":"Polygenic risk score adds to a clinical risk score in the prediction of cardiovascular disease in a clinical setting","volume":"45","author":"Samani","year":"2024","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.jacc.2025.12.032_bib18","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1038\/s41467-023-42897-w","article-title":"Ancestry-specific polygenic risk scores are risk enhancers for clinical cardiovascular disease assessments","volume":"14","author":"Busby","year":"2023","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.jacc.2025.12.032_bib19","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/jama.2019.22241","article-title":"Predictive accuracy of a polygenic risk score\u2013enhanced prediction model vs a clinical risk score for coronary artery disease","volume":"323","author":"Elliott","year":"2020","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.jacc.2025.12.032_bib20","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1161\/CIRCULATIONAHA.119.043805","article-title":"Predicting benefit from evolocumab therapy in patients with atherosclerotic disease using a genetic risk score: results from the FOURIER trial","volume":"141","author":"Marston","year":"2020","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.jacc.2025.12.032_bib21","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCULATIONAHA.119.044434","article-title":"Patients with high genome-wide polygenic risk scores for coronary artery disease may receive greater clinical benefit from alirocumab treatment in the ODYSSEY OUTCOMES trial","volume":"141","author":"Damask","year":"2020","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jacc.2025.12.032_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-30675-z","article-title":"The potential of polygenic scores to improve cost and efficiency of clinical trials","volume":"13","author":"Fahed","year":"2022","journal-title":"Nat Commun"},{"issue":"22","key":"10.1016\/j.jacc.2025.12.032_bib23","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1161\/CIRCULATIONAHA.116.024436","article-title":"Polygenic risk score identifies subgroup with higher burden of atherosclerosis and greater relative benefit from statin therapy in the primary prevention setting","volume":"135","author":"Natarajan","year":"2017","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jacc.2025.12.032_bib24","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/s41591-025-03533-w","article-title":"Endothelial cell-related genetic variants identify LDL cholesterol-sensitive individuals who derive greater benefit from aggressive lipid lowering","volume":"31","author":"Marston","year":"2025","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.jacc.2025.12.032_bib25","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.124.004968","article-title":"Effect of disclosing a polygenic risk score for coronary heart disease on adverse cardiovascular events","volume":"18","author":"Naderian","year":"2025","journal-title":"Circ Genomic Precis Med"},{"issue":"12","key":"10.1016\/j.jacc.2025.12.032_bib26","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1161\/CIRCULATIONAHA.115.020109","article-title":"Incorporating a genetic risk score into coronary heart disease risk estimates: effect on low-density lipoprotein cholesterol levels (the MI-GENES clinical trial)","volume":"133","author":"Kullo","year":"2016","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jacc.2025.12.032_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2022.100068","article-title":"Clinical implementation of combined monogenic and polygenic risk disclosure for coronary artery disease","volume":"1","author":"Maamari","year":"2022","journal-title":"JACC Adv"},{"issue":"13","key":"10.1016\/j.jacc.2025.12.032_bib28","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1200\/JCO.23.00295","article-title":"Comprehensive inherited risk estimation for risk-based breast cancer screening in women","volume":"42","author":"Mars","year":"2024","journal-title":"J Clin Oncol"},{"issue":"14","key":"10.1016\/j.jacc.2025.12.032_bib29","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1056\/NEJMoa2407934","article-title":"Assessment of a polygenic risk score in screening for prostate cancer","volume":"392","author":"McHugh","year":"2025","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.jacc.2025.12.032_bib30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1001\/jamacardio.2024.5644","article-title":"Coronary artery calcium testing\u2014too early, too late, too often","volume":"10","author":"Zheutlin","year":"2025","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2025.12.032_bib31","article-title":"Coronary inflammation and atherosclerosis by CCTA in young adults (aged 18-45)","volume":"22","author":"Filtz","year":"2025","journal-title":"Am J Prev Cardiol"},{"issue":"6","key":"10.1016\/j.jacc.2025.12.032_bib32","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jcmg.2024.12.004","article-title":"Vulnerable or high-risk plaque","volume":"18","author":"Vergallo","year":"2025","journal-title":"JACC Cardiovasc Imaging"},{"issue":"2","key":"10.1016\/j.jacc.2025.12.032_bib33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jcmg.2023.05.011","article-title":"Age- and sex-specific nomographic CT quantitative plaque data from a large international cohort","volume":"17","author":"Tzimas","year":"2024","journal-title":"JACC Cardiovasc Imaging"},{"issue":"22","key":"10.1016\/j.jacc.2025.12.032_bib34","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/j.jacc.2023.09.814","article-title":"Determinants of progression and regression of subclinical atherosclerosis over 6 years","volume":"82","author":"Mendieta","year":"2023","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"10.1016\/j.jacc.2025.12.032_bib35","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.jacc.2019.08.012","article-title":"From subclinical atherosclerosis to plaque progression and acute coronary events","volume":"74","author":"Ahmadi","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.12.032_bib36","article-title":"Decoding genetics, ancestry, and geospatial context for precision health","author":"Koyama","year":"2023","journal-title":"Preprint"},{"issue":"5","key":"10.1016\/j.jacc.2025.12.032_bib37","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1161\/CIR.0000000000001078","article-title":"Life\u2019s Essential 8: updating and enhancing the American Heart Association\u2019s construct of cardiovascular health: a presidential advisory from the American Heart Association","volume":"146","author":"Lloyd-Jones","year":"2022","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.jacc.2025.12.032_bib38","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/jhn.12451","article-title":"Evaluation of a dietary screener: the Mediterranean Eating Pattern for Americans tool","volume":"30","author":"Cerwinske","year":"2017","journal-title":"J Hum Nutr Diet"},{"issue":"9","key":"10.1016\/j.jacc.2025.12.032_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2025.102041","article-title":"Electrocardiogram-based artificial intelligence to identify coronary artery disease","volume":"4","author":"Kany","year":"2025","journal-title":"JACC Adv"},{"issue":"6","key":"10.1016\/j.jacc.2025.12.032_bib40","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jcct.2022.07.002","volume":"16","author":"Cury","year":"2022","journal-title":"J Cardiovasc Comput Tomogr"},{"issue":"6","key":"10.1016\/j.jacc.2025.12.032_bib41","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jcct.2016.10.002","article-title":"SCCT guidelines for the performance and acquisition of coronary computed tomographic angiography: a report of the Society of Cardiovascular Computed Tomography Guidelines Committee: Endorsed by the North American Society for Cardiovascular Imaging (NASCI)","volume":"10","author":"Abbara","year":"2016","journal-title":"J Cardiovasc Comput Tomogr"},{"issue":"40","key":"10.1016\/j.jacc.2025.12.032_bib42","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1093\/eurheartj\/ehaa652","article-title":"Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: final results of the EVAPORATE trial","volume":"41","author":"Budoff","year":"2020","journal-title":"Eur Heart J"},{"issue":"18","key":"10.1016\/j.jacc.2025.12.032_bib43","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1161\/CIRCULATIONAHA.119.044720","article-title":"Low-attenuation noncalcified plaque on coronary computed tomography angiography predicts myocardial infarction","volume":"141","author":"Williams","year":"2020","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.jacc.2025.12.032_bib44","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1016\/S2352-3018(14)00032-0","article-title":"Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial","volume":"2","author":"Lo","year":"2015","journal-title":"Lancet HIV"},{"issue":"2 Pt 2","key":"10.1016\/j.jacc.2025.12.032_bib45","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jcmg.2017.08.013","article-title":"Colchicine therapy and plaque stabilization in patients with acute coronary syndrome: a CT coronary angiography study","volume":"11","author":"Vaidya","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"issue":"7","key":"10.1016\/j.jacc.2025.12.032_bib46","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1001\/jama.2016.21043","article-title":"Testosterone treatment and coronary artery plaque volume in older men with low testosterone","volume":"317","author":"Budoff","year":"2017","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.jacc.2025.12.032_bib47","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1056\/NEJMsr1809937","article-title":"The \u201cAll of Us\u201d research program","volume":"381","year":"2019","journal-title":"N Engl J Med"},{"issue":"7726","key":"10.1016\/j.jacc.2025.12.032_bib48","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"issue":"25_suppl_2","key":"10.1016\/j.jacc.2025.12.032_bib49","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1161\/01.cir.0000437741.48606.98","article-title":"2013 ACC\/AHA guideline on the assessment of cardiovascular risk","volume":"129","author":"Goff","year":"2014","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.jacc.2025.12.032_bib50","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/CIRCULATIONAHA.122.060911","article-title":"Status of cardiovascular health in US adults and children using the American Heart Association\u2019s new \u201cLife\u2019s Essential 8\u201d metrics: prevalence estimates from the National Health and Nutrition Examination Survey (NHANES), 2013 through 2018","volume":"146","author":"Lloyd-Jones","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.12.032_bib51","article-title":"Prevalence of American Heart Association\u2019s \u201cLife\u2019s Essential 8\u201d in a cohort of Latino women","volume":"22","author":"Varleta","year":"2025","journal-title":"Am J Prev Cardiol"},{"issue":"2","key":"10.1016\/j.jacc.2025.12.032_bib52","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.120.003304","article-title":"Integrated polygenic tool substantially enhances coronary artery disease prediction","volume":"14","author":"Riveros-Mckay","year":"2021","journal-title":"Circ Genomic Precis Med"},{"issue":"1","key":"10.1016\/j.jacc.2025.12.032_bib53","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1038\/s41467-022-30675-z","article-title":"The potential of polygenic scores to improve cost and efficiency of clinical trials","volume":"13","author":"Fahed","year":"2022","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jacc.2025.12.032_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41746-022-00590-0","article-title":"Cohort design and natural language processing to reduce bias in electronic health records research","volume":"5","author":"Khurshid","year":"2022","journal-title":"Npj Digit Med"},{"issue":"9","key":"10.1016\/j.jacc.2025.12.032_bib55","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.jcmg.2022.03.010","article-title":"Coronary atherosclerosis in an asymptomatic U.S. population","volume":"15","author":"Nasir","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"issue":"8","key":"10.1016\/j.jacc.2025.12.032_bib56","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1056\/NEJMoa2304146","article-title":"Pitavastatin to prevent cardiovascular disease in HIV infection","volume":"389","author":"Grinspoon","year":"2023","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.jacc.2025.12.032_bib57","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1001\/jamacardio.2023.5661","article-title":"Effects of pitavastatin on coronary artery disease and inflammatory biomarkers in HIV: mechanistic substudy of the REPRIEVE randomized clinical trial","volume":"9","author":"Lu","year":"2024","journal-title":"JAMA Cardiol"},{"issue":"25","key":"10.1016\/j.jacc.2025.12.032_bib58","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1016\/j.jacc.2021.05.006","article-title":"Multi-Ethnic Study of Atherosclerosis (MESA): JACC Focus Seminar 5\/8","volume":"77","author":"Blaha","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.jacc.2025.12.032_bib59","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1001\/jamacardio.2017.4973","article-title":"Use of high-risk coronary atherosclerotic plaque detection for risk stratification of patients with stable chest pain: a secondary analysis of the PROMISE randomized clinical trial","volume":"3","author":"Ferencik","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"398","key":"10.1016\/j.jacc.2025.12.032_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal2658","article-title":"Detecting human coronary inflammation by imaging perivascular fat","volume":"9","author":"Antonopoulos","year":"2017","journal-title":"Sci Transl Med"},{"issue":"10151","key":"10.1016\/j.jacc.2025.12.032_bib61","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0140-6736(18)31114-0","article-title":"Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data","volume":"392","author":"Oikonomou","year":"2018","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jacc.2025.12.032_bib62","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jacc.2018.10.066","article-title":"Coronary artery plaque characteristics associated with adverse outcomes in the SCOT-HEART study","volume":"73","author":"Williams","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.jacc.2025.12.032_bib63","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.jcmg.2018.01.023","article-title":"Identification of high-risk plaques destined to cause acute coronary syndrome using coronary computed tomographic angiography and computational fluid dynamics","volume":"12","author":"Lee","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"issue":"6","key":"10.1016\/j.jacc.2025.12.032_bib64","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/eurheartj\/ehz474","article-title":"Imaging residual inflammatory cardiovascular risk","volume":"41","author":"Antoniades","year":"2020","journal-title":"Eur Heart J"},{"issue":"9","key":"10.1016\/j.jacc.2025.12.032_bib65","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/jamacardio.2018.1997","article-title":"Pericoronary adipose tissue computed tomography attenuation and high-risk plaque characteristics in acute coronary syndrome compared with stable coronary artery disease","volume":"3","author":"Goeller","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"10","key":"10.1016\/j.jacc.2025.12.032_bib66","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.jcmg.2018.11.032","article-title":"Peri-coronary adipose tissue density is associated with 18F-sodium fluoride coronary uptake in stable patients with high-risk plaques","volume":"12","author":"Kwiecinski","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"issue":"3","key":"10.1016\/j.jacc.2025.12.032_bib67","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jcmg.2023.05.020","article-title":"AI-guided quantitative plaque staging predicts long-term cardiovascular outcomes in patients at risk for atherosclerotic CVD","volume":"17","author":"Nurmohamed","year":"2024","journal-title":"JACC Cardiovasc Imaging"},{"issue":"6","key":"10.1016\/j.jacc.2025.12.032_bib68","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jcct.2021.05.004","article-title":"CT Evaluation by Artificial Intelligence for Atherosclerosis, Stenosis and Vascular Morphology (CLARIFY): a multi-center, international study","volume":"15","author":"Choi","year":"2021","journal-title":"J Cardiovasc Comput Tomogr"},{"issue":"2","key":"10.1016\/j.jacc.2025.12.032_bib69","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jcmg.2021.10.020","article-title":"AI evaluation of stenosis on coronary CTA, comparison with quantitative coronary angiography and fractional flow reserve","volume":"16","author":"Griffin","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"issue":"10456","key":"10.1016\/j.jacc.2025.12.032_bib70","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0140-6736(24)01689-1","article-title":"Polygenic risk scores for genomics and population screening","volume":"404","author":"Perrott","year":"2024","journal-title":"Lancet"}],"container-title":["JACC"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109725105639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109725105639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:26:25Z","timestamp":1788877585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109725105639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":70,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0735109725105639"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2025.12.032","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polygenic Risk Based Detection and Treatment of Subclinical Coronary Atherosclerosis in the PROACT Clinical Trials","name":"articletitle","label":"Article Title"},{"value":"JACC","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2025.12.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}