{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:53:37Z","timestamp":1793138017913,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008375","name":"University of Basel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jacc.2025.12.056","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:08:35Z","timestamp":1771427315000},"page":"2261-2278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of the European Society of Cardiology 0\/1-Hour and High-Sensitivity Troponin in the Evaluation of Patients With Suspected Acute Coronary Syndrome 0\/2-or-0\/3-Hour Algorithms for Rapid Myocardial Infarction Diagnosis"],"prefix":"10.1016","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3606-0893","authenticated-orcid":false,"given":"Jonas","family":"Glaeser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Lopez-Ayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Kellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Boeddinghaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Nestelberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Koechlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7571-4847","authenticated-orcid":false,"given":"Nils A.","family":"S\u00f6rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7714-4446","authenticated-orcid":false,"given":"Paul M.","family":"Haller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2193-0509","authenticated-orcid":false,"given":"Paolo","family":"Bima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Crisanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3481-7666","authenticated-orcid":false,"given":"Carlos C.","family":"Spagnuolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Strebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Hure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2384-8250","authenticated-orcid":false,"given":"Maria","family":"Rubini Gimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Wildi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Wussler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Miro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Martin-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar I.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Christ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Twerenbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Kawecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Morawiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Munzk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Geigy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Rentsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samyut","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Breidthardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Lehmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Schock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bet\u00fcl","family":"Toprak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Thie\u00dfen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Martinez-Nadal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Fuenzalida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Calder\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Rodriguez Adrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Ganovsk\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Parenica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"von Eckardstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Campodarve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Gea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10258","key":"10.1016\/j.jacc.2025.12.056_bib1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Abbafati","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jacc.2025.12.056_bib2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"issue":"14","key":"10.1016\/j.jacc.2025.12.056_bib3","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/eurheartj\/ehaa575","article-title":"2020 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"42","author":"Collet","year":"2021","journal-title":"Eur Heart J"},{"issue":"23","key":"10.1016\/j.jacc.2025.12.056_bib4","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/j.jacc.2022.03.380","article-title":"Care models for acute chest pain that improve outcomes and efficiency: JACC State-of-the-Art Review","volume":"79","author":"Dawson","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.jacc.2025.12.056_bib5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/jamainternmed.2013.12199","article-title":"Sex-specific chest pain characteristics in the early diagnosis of acute myocardial infarction","volume":"174","author":"Gimenez","year":"2014","journal-title":"JAMA Intern Med"},{"issue":"4","key":"10.1016\/j.jacc.2025.12.056_bib6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.amjmed.2014.10.032","article-title":"Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T","volume":"128","author":"Reichlin","year":"2015","journal-title":"Am J Med"},{"issue":"4","key":"10.1016\/j.jacc.2025.12.056_bib7","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1016\/j.ijcard.2013.06.049","article-title":"Rapid rule out of acute myocardial infarction using undetectable levels of high-sensitivity cardiac troponin","volume":"168","author":"Rubini Gim\u00e9nez","year":"2013","journal-title":"Int J Cardiol"},{"issue":"10012","key":"10.1016\/j.jacc.2025.12.056_bib8","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/S0140-6736(15)00391-8","article-title":"High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study","volume":"386","author":"Shah","year":"2015","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jacc.2025.12.056_bib9","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/clinchem\/hvaa226","article-title":"Early rule-out strategies in the emergency department utilizing high-sensitivity cardiac troponin assays","volume":"67","author":"Lopez-Ayala","year":"2021","journal-title":"Clin Chem"},{"issue":"16","key":"10.1016\/j.jacc.2025.12.056_bib10","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1001\/archinternmed.2012.3698","article-title":"One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T","volume":"172","author":"Reichlin","year":"2012","journal-title":"Arch Intern Med"},{"issue":"1","key":"10.1016\/j.jacc.2025.12.056_bib11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.7326\/M21-1499","article-title":"Performance of the European Society of Cardiology 0\/1-hour, 0\/2-hour, and 0\/3-hour algorithms for rapid triage of acute myocardial infarction : an international collaborative meta-analysis","volume":"175","author":"Chiang","year":"2022","journal-title":"Ann Intern Med"},{"issue":"19","key":"10.1016\/j.jacc.2025.12.056_bib12","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/CIRCULATIONAHA.119.042891","article-title":"A randomized trial of a 1-hour troponin T protocol in suspected acute coronary syndromes","volume":"140","author":"Chew","year":"2019","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.jacc.2025.12.056_bib13","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jacc.2018.05.040","article-title":"Prospective validation of the 0\/1-h algorithm for early diagnosis of myocardial infarction","volume":"72","author":"Twerenbold","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.jacc.2025.12.056_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jacc.2019.05.046","article-title":"Outcome of applying the ESC 0\/1-hour algorithm in patients with suspected myocardial infarction","volume":"74","author":"Twerenbold","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.jacc.2025.12.056_bib15","first-page":"39","article-title":"RAPID-CPU: a prospective study on implementation of the ESC 0\/1-hour algorithm and safety of discharge after rule-out of myocardial infarction","volume":"9","author":"Stoyanov","year":"2020","journal-title":"Eur Hear J Acute Cardiovasc Care"},{"issue":"10151","key":"10.1016\/j.jacc.2025.12.056_bib16","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(18)31923-8","article-title":"High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial","volume":"392","author":"Shah","year":"2018","journal-title":"Lancet"},{"issue":"23","key":"10.1016\/j.jacc.2025.12.056_bib17","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1161\/CIRCULATIONAHA.120.052380","article-title":"High-sensitivity cardiac troponin on presentation to rule out myocardial infarction a stepped-wedge cluster randomized controlled trial","volume":"143","author":"Anand","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.12.056_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/eurheartj\/ehv320","article-title":"2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: task force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"37","author":"Roffi","year":"2016","journal-title":"Eur Heart J"},{"issue":"38","key":"10.1016\/j.jacc.2025.12.056_bib19","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC guidelines for the management of acute coronary syndromes: developed by the task force on the management of acute coronary syndromes of the European Society of Cardiology (ESC)","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur Heart J"},{"issue":"8","key":"10.1016\/j.jacc.2025.12.056_bib20","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.amjmed.2015.01.046","article-title":"One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I","volume":"128","author":"Rubini Gimenez","year":"2015","journal-title":"Am J Med"},{"key":"10.1016\/j.jacc.2025.12.056_bib21","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1373\/clinchem.2019.304725","article-title":"Clinical use of a new high-sensitivity cardiac troponin I assay in patients with suspected myocardial infarction","volume":"65","author":"Boeddinghaus","year":"2019","journal-title":"Clin Chem"},{"issue":"9","key":"10.1016\/j.jacc.2025.12.056_bib22","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1373\/clinchem.2018.286906","article-title":"Clinical validation of a novel high-sensitivity cardiac troponin I assay for early diagnosis of acute myocardial infarction","volume":"64","author":"Boeddinghaus","year":"2018","journal-title":"Clin Chem"},{"issue":"17","key":"10.1016\/j.jacc.2025.12.056_bib23","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1161\/CIRCULATIONAHA.116.025021","article-title":"Comparison of the efficacy and safety of early rule-out pathways for acute myocardial infarction","volume":"135","author":"Chapman","year":"2017","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.jacc.2025.12.056_bib24","first-page":"616","article-title":"Novel high-sensitivity cardiac troponin I assay in patients with suspected acute coronary syndrome","volume":"105","author":"Chapman","year":"2019","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2025.12.056_bib25","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jacc.2019.12.036","article-title":"Risk stratification using high-sensitivity cardiac troponin T in patients with suspected acute coronary syndrome","volume":"75","author":"Chapman","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.12.056_bib26","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.jacc.2024.11.009","article-title":"2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI guideline for the management of patients with acute coronary syndromes: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"85","author":"Rao","year":"2025","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.jacc.2025.12.056_bib27","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/CIRCULATIONAHA.120.052982","article-title":"Novel criteria for the observe-zone of the ESC 0\/1h-hs-cTnT algorithm","volume":"144","author":"Lopez-Ayala","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.12.056_bib28","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijcard.2016.01.112","article-title":"Characterization of the observe zone of the ESC 2015 high-sensitivity cardiac troponin 0 h\/1 h-algorithm for the early diagnosis of acute myocardial infarction","volume":"207","author":"Nestelberger","year":"2016","journal-title":"Int J Cardiol"},{"issue":"4","key":"10.1016\/j.jacc.2025.12.056_bib29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/jamacardio.2016.0695","article-title":"Diagnosis of myocardial infarction using a high-sensitivity troponin I 1-hour algorithm","volume":"1","author":"Neumann","year":"2016","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2025.12.056_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijcard.2018.12.001","article-title":"Evaluation of a new ultra-sensitivity troponin I assay in patients with suspected myocardial infarction","volume":"283","author":"Neumann","year":"2019","journal-title":"Int J Cardiol"},{"issue":"2","key":"10.1016\/j.jacc.2025.12.056_bib31","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2337\/dc19-1327","article-title":"Performance of the ESC 0\/1-h and 0\/3-h algorithm for the rapid identification of myocardial infarction without ST-elevation in patients with diabetes","volume":"43","author":"Haller","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jacc.2025.12.056_bib32","article-title":"STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies","volume":"351","author":"Bossuyt","year":"2015","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.jacc.2025.12.056_bib33","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/eurheartj\/ehy462","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"40","author":"Thygesen","year":"2019","journal-title":"Eur Heart J"},{"issue":"4","key":"10.1016\/j.jacc.2025.12.056_bib34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7326\/0003-4819-145-4-200608150-00004","article-title":"Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate","volume":"145","author":"Levey","year":"2006","journal-title":"Ann Intern Med"},{"issue":"10","key":"10.1016\/j.jacc.2025.12.056_bib35","doi-asserted-by":"crossref","first-page":"715","DOI":"10.7326\/M16-2562","article-title":"Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin t measurement below the limit of detection: a collaborative meta-analysis","volume":"166","author":"Pickering","year":"2017","journal-title":"Ann Intern Med"},{"issue":"13","key":"10.1016\/j.jacc.2025.12.056_bib36","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.jacc.2011.06.026","article-title":"Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay","volume":"58","author":"Body","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"158","key":"10.1016\/j.jacc.2025.12.056_bib37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/01621459.1927.10502953","article-title":"Probable inference, the law of succesion, and statistical inference","volume":"22","author":"Wilson","year":"1927","journal-title":"J Am Stat Assoc"},{"issue":"6","key":"10.1016\/j.jacc.2025.12.056_bib38","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/sim.5587","article-title":"A weighted generalized score statistic for comparison of predictive values of diagnostic tests","volume":"32","author":"Kosinski","year":"2013","journal-title":"Stat Med"},{"issue":"5","key":"10.1016\/j.jacc.2025.12.056_bib39","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/sim.1781","article-title":"Simple improved confidence intervals for comparing matched proportions","volume":"24","author":"Agresti","year":"2005","journal-title":"Stat Med"},{"issue":"6","key":"10.1016\/j.jacc.2025.12.056_bib40","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nmeth.3414","article-title":"Sampling distributions and the bootstrap","volume":"12","author":"Kulesa","year":"2015","journal-title":"Nat Methods"},{"issue":"7","key":"10.1016\/j.jacc.2025.12.056_bib41","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1373\/clinchem.2018.300061","article-title":"High-sensitivity cardiac troponin I assay for early diagnosis of acute myocardial infarction","volume":"65","author":"Boeddinghaus","year":"2019","journal-title":"Clin Chem"},{"issue":"42","key":"10.1016\/j.jacc.2025.12.056_bib42","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1093\/eurheartj\/ehy514","article-title":"Impact of age on the performance of the ESC 0\/1h-algorithms for early diagnosis of myocardial infarction","volume":"39","author":"Boeddinghaus","year":"2018","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.jacc.2025.12.056_bib43","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1161\/CIRCULATIONAHA.117.028901","article-title":"0\/1-Hour triage algorithm for myocardial infarction in patients with renal dysfunction","volume":"137","author":"Twerenbold","year":"2018","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.jacc.2025.12.056_bib44","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1001\/jamacardio.2023.0031","article-title":"Performance of the European Society of Cardiology 0\/1-hour algorithm with high-sensitivity cardiac troponin T among patients with known coronary artery disease","volume":"8","author":"Ashburn","year":"2023","journal-title":"JAMA Cardiol"},{"issue":"3","key":"10.1016\/j.jacc.2025.12.056_bib45","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ijcard.2012.09.171","article-title":"What is an acceptable risk of major adverse cardiac event in chest pain patients soon after discharge from the emergency department? A clinical survey","volume":"166","author":"Than","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2025.12.056_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ahj.2025.107299","article-title":"Prospective evaluation of the European Society of Cardiology 0\/1h-algorithm`s safety and efficacy for triage of patients with suspected myocardial infarction (PRESC1SE-MI): rationale and design of a prospective international multicenter stepped-wedge clus","volume":"292","author":"Boeddinghaus","year":"2026","journal-title":"Am Heart J"},{"issue":"30","key":"10.1016\/j.jacc.2025.12.056_bib47","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1093\/eurheartj\/ehad376","article-title":"Troponin in early presenters to rule out myocardial infarction","volume":"44","author":"Lowry","year":"2023","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.jacc.2025.12.056_bib48","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/s41591-023-02325-4","article-title":"Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations","volume":"29","author":"Doudesis","year":"2023","journal-title":"Nat Med"},{"issue":"14","key":"10.1016\/j.jacc.2025.12.056_bib49","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1161\/CIRCULATIONAHA.123.066917","article-title":"Machine learning for myocardial infarction compared with guideline-recommended diagnostic pathways","volume":"149","author":"Boeddinghaus","year":"2024","journal-title":"Circulation"}],"container-title":["JACC"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109725105883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109725105883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:06:35Z","timestamp":1778753195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109725105883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":49,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0735109725105883"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2025.12.056","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the European Society of Cardiology 0\/1-Hour and High-Sensitivity Troponin in the Evaluation of Patients With Suspected Acute Coronary Syndrome 0\/2-or-0\/3-Hour Algorithms for Rapid Myocardial Infarction Diagnosis","name":"articletitle","label":"Article Title"},{"value":"JACC","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2025.12.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}