{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:10:17Z","timestamp":1790197817632,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jacc.2026.02.5126","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:18:28Z","timestamp":1776867508000},"page":"42-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Focal and Diffuse Coronary Artery Disease Patterns and Placebo-Controlled Angina Relief With Percutaneous Coronary Intervention"],"prefix":"10.1016","volume":"88","author":[{"given":"Kayla","family":"Chiew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0330-5542","authenticated-orcid":false,"given":"Michael J.","family":"Foley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayna","family":"Chotai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Naderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Rajkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiyyaz","family":"Ahmed-Jushuf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentina A.","family":"Simader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmananthan","family":"Ganesananthan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishaanth","family":"Nagaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachur","family":"Khandelwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Hartley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Keeble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Ruparelia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Seligman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrel P.","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1179-0867","authenticated-orcid":false,"given":"Matthew J.","family":"Shun-Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha K.","family":"Al-Lamee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.jacc.2026.02.5126_bib1","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1016\/j.jcin.2022.09.048","article-title":"Differential improvement in angina and health-related quality of life after PCI in focal and diffuse coronary artery disease","volume":"15","author":"Collet","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"issue":"25","key":"10.1016\/j.jacc.2026.02.5126_bib2","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1056\/NEJMoa2310610","article-title":"A placebo-controlled trial of percutaneous coronary intervention for stable angina","volume":"389","author":"Rajkumar","year":"2023","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.jacc.2026.02.5126_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jacc.2024.04.016","article-title":"Symptoms as a predictor of the placebo-controlled efficacy of PCI in stable coronary artery disease","volume":"84","author":"Simader","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"18","key":"10.1016\/j.jacc.2026.02.5126_bib4","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.jacc.2025.02.034","article-title":"Ischemia on dobutamine stress echocardiography predicts efficacy of PCI: results from the ORBITA-2 Trial","volume":"85","author":"Ahmed-Jushuf","year":"2025","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.jacc.2026.02.5126_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.122.012511","article-title":"Angina after percutaneous coronary intervention: patient and procedural predictors","volume":"16","author":"Collison","year":"2023","journal-title":"Circ Cardiovasc Interv"},{"issue":"3","key":"10.1016\/j.jacc.2026.02.5126_bib6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1161\/CIRCULATIONAHA.124.072281","article-title":"Fractional flow reserve and instantaneous wave-free ratio as predictors of the placebo-controlled response to percutaneous coronary intervention in stable coronary artery disease","volume":"151","author":"Foley","year":"2025","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.jacc.2026.02.5126_bib7","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.jcin.2014.06.015","article-title":"Pre-angioplasty instantaneous wave-free ratio pullback provides virtual intervention and predicts hemodynamic outcome for serial lesions and diffuse coronary artery disease","volume":"7","author":"Nijjer","year":"2014","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2026.02.5126_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1501576","article-title":"Differences in severity of diffuse and focal coronary stenosis between visual and quantitative assessment","volume":"11","author":"Wang","year":"2024","journal-title":"Front Cardiovasc Med"},{"issue":"2","key":"10.1016\/j.jacc.2026.02.5126_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1001\/jamainternmed.2017.7821","article-title":"Comparison of physician visual assessment with quantitative coronary angiography in assessment of stenosis severity in China","volume":"178","author":"Zhang","year":"2018","journal-title":"JAMA Intern Med"},{"issue":"15","key":"10.1016\/j.jacc.2026.02.5126_bib10","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1161\/01.CIR.101.15.1840","article-title":"Pressure-derived fractional flow reserve to assess serial epicardial stenoses","volume":"101","author":"De Bruyne","year":"2000","journal-title":"Circulation"},{"issue":"13","key":"10.1016\/j.jacc.2026.02.5126_bib11","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.jcin.2025.05.033","article-title":"Randomized comparison of fractional flow reserve and instantaneous wave free ratio in serial disease","volume":"18","author":"Li Kam Wa","year":"2025","journal-title":"JACC Cardiovasc Interv"},{"issue":"15","key":"10.1016\/j.jacc.2026.02.5126_bib12","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.3390\/diagnostics13152612","article-title":"Fractional flow reserve-guided stent optimization in focal and diffuse coronary artery disease","volume":"13","author":"Ohashi","year":"2023","journal-title":"Diagnostics (Basel)"},{"issue":"5","key":"10.1016\/j.jacc.2026.02.5126_bib13","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.032605","article-title":"Intravascular imaging findings after PCI in patients with focal and diffuse coronary artery disease","volume":"13","author":"Ohashi","year":"2024","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.jacc.2026.02.5126_bib14","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1038\/s41598-025-85872-9","article-title":"Diffuseness of coronary artery disease impacts on immediate hemodynamic and predicted clinical outcomes","volume":"15","author":"Kageyama","year":"2025","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.jacc.2026.02.5126_bib15","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s00392-024-02500-8","article-title":"Angiography-derived physiological patterns of coronary artery disease: implications with post-stenting physiology and long-term clinical outcomes","volume":"113","author":"Fezzi","year":"2024","journal-title":"Clin Res Cardiol"},{"issue":"18","key":"10.1016\/j.jacc.2026.02.5126_bib16","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.4244\/EIJ-D-21-00649","article-title":"A double-blind randomised placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina without antianginal medications: design and rationale of the ORBITA-2 trial","volume":"17","author":"Nowbar","year":"2022","journal-title":"EuroIntervention"},{"issue":"2","key":"10.1016\/j.jacc.2026.02.5126_bib17","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/ehjdh\/ztac015","article-title":"Daily angina documentation versus subsequent recall: development of a symptom smartphone app","volume":"3","author":"Nowbar","year":"2022","journal-title":"Eur Heart J Digit Health"},{"key":"10.1016\/j.jacc.2026.02.5126_bib18","author":"Harrell"},{"issue":"36","key":"10.1016\/j.jacc.2026.02.5126_bib19","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.jacc.2026.02.5126_bib20","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.118.007494","article-title":"Physiological pattern of disease assessed by pressure-wire pullback has an influence on fractional flow reserve\/instantaneous wave-free ratio discordance","volume":"12","author":"Warisawa","year":"2019","journal-title":"Circ Cardiovasc Interv"},{"issue":"8","key":"10.1016\/j.jacc.2026.02.5126_bib21","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.120.009891","article-title":"Placebo-controlled efficacy of percutaneous coronary intervention for focal and diffuse patterns of stable coronary artery disease","volume":"14","author":"Rajkumar","year":"2021","journal-title":"Circ Cardiovasc Interv"},{"issue":"6","key":"10.1016\/j.jacc.2026.02.5126_bib22","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jacc.2008.04.035","article-title":"The effects of medications on myocardial perfusion","volume":"52","author":"Zoghbi","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.jacc.2026.02.5126_bib23","first-page":"1518","article-title":"Development, validation, and reproducibility of the pullback pressure gradient (PPG) derived from manual fractional flow reserve pullbacks","volume":"99","author":"Sonck","year":"2022","journal-title":"Catheter Cardiovasc Interv"},{"issue":"5","key":"10.1016\/j.jacc.2026.02.5126_bib24","first-page":"E647","article-title":"Hyperemic hemodynamic characteristics of serial coronary lesions assessed by pullback pressure gradients","volume":"98","author":"Candreva","year":"2021","journal-title":"Catheter Cardiovasc Interv"},{"issue":"14","key":"10.1016\/j.jacc.2026.02.5126_bib25","doi-asserted-by":"crossref","first-page":"e820","DOI":"10.4244\/EIJ-D-25-00025","article-title":"Validation of the pullback pressure gradient in resting conditions","volume":"21","author":"Sakai","year":"2025","journal-title":"EuroIntervention"},{"issue":"24","key":"10.1016\/j.jacc.2026.02.5126_bib26","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1161\/01.CIR.103.24.2928","article-title":"Fractional flow reserve to determine the appropriateness of angioplasty in moderate coronary stenosis","volume":"103","author":"Bech","year":"2001","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jacc.2026.02.5126_bib27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1056\/NEJMoa0807611","article-title":"Fractional flow reserve versus angiography for guiding percutaneous coronary intervention","volume":"360","author":"Tonino","year":"2009","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.jacc.2026.02.5126_bib28","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1915922","article-title":"Initial invasive or conservative strategy for stable coronary disease","volume":"382","author":"Maron","year":"2020","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.jacc.2026.02.5126_bib29","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1056\/NEJMoa070829","article-title":"Optimal medical therapy with or without PCI for stable coronary disease","volume":"356","author":"Boden","year":"2007","journal-title":"N Engl J Med"}],"container-title":["JACC"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109726057323?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109726057323?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:53:50Z","timestamp":1790196830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109726057323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0735109726057323"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2026.02.5126","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Focal and Diffuse Coronary Artery Disease Patterns and Placebo-Controlled Angina Relief With Percutaneous Coronary Intervention","name":"articletitle","label":"Article Title"},{"value":"JACC","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2026.02.5126","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}