{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:13:31Z","timestamp":1787793211707,"version":"build-2784847793"},"reference-count":33,"publisher":"Elsevier BV","issue":"25","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jacc.2026.03.075","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:19:28Z","timestamp":1779891568000},"page":"3592-3607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Risk-Based Nurse-Managed Personalized Heart Failure Interventions"],"prefix":"10.1016","volume":"87","author":[{"given":"Javed","family":"Butler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5009-2909","authenticated-orcid":false,"given":"Rami","family":"Kahwash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shahzeb","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Dukes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhu","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Basuray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Gharib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Gerritse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee","family":"Laechelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Wehking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantanu","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Van Dorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirav","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verla","family":"Laager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Zile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jacc.2026.03.075_bib1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jacc.2008.03.061","article-title":"Heart failure-related hospitalization in the U.S., 1979 to 2004","volume":"52","author":"Fang","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.jacc.2026.03.075_bib2","first-page":"157","article-title":"Burden of hospitalization for heart failure in the United States: a systematic literature review","volume":"28","author":"Osenenko","year":"2022","journal-title":"J Manag Care Spec Pharm"},{"issue":"10","key":"10.1016\/j.jacc.2026.03.075_bib3","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.cardfail.2023.07.006","article-title":"Heart failure epidemiology and outcomes statistics: a report of the Heart Failure Society of America","volume":"29","author":"Bozkurt","year":"2023","journal-title":"J Card Fail"},{"key":"10.1016\/j.jacc.2026.03.075_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1350846","article-title":"Systems of care for ambulatory management of decompensated heart failure","volume":"11","author":"Badrish","year":"2024","journal-title":"Front Cardiovasc Med"},{"issue":"4","key":"10.1016\/j.jacc.2026.03.075_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jacc.2018.04.070","article-title":"Medical therapy for heart failure with reduced ejection fraction: the CHAMP-HF registry","volume":"72","author":"Greene","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"20","key":"10.1016\/j.jacc.2026.03.075_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.035501","article-title":"Personalized intervention strategy based on a risk score generated from subcutaneous insertable cardiac monitor: results from phase 1 of ALLEVIATE-HF","volume":"13","author":"Kahwash","year":"2024","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"10.1016\/j.jacc.2026.03.075_bib7","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s10741-025-10529-8","article-title":"Subcutaneous sensors for monitoring congestion and to reduce heart failure hospitalizations-a viable middle ground between deep implantable intravascular monitoring devices and wearable technologies?","volume":"30","author":"Wetterling","year":"2025","journal-title":"Heart Fail Rev"},{"issue":"suppl C","key":"10.1016\/j.jacc.2026.03.075_bib8","doi-asserted-by":"crossref","first-page":"C344","DOI":"10.1093\/eurheartjsupp\/suad031","article-title":"The implantable cardiac monitor in heart failure patient: a possible new indication?","volume":"25","author":"Cicogna","year":"2023","journal-title":"Eur Heart J Suppl"},{"issue":"1","key":"10.1016\/j.jacc.2026.03.075_bib9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jchf.2023.09.014","article-title":"A novel heart failure diagnostic risk score using a minimally invasive subcutaneous insertable cardiac monitor","volume":"12","author":"Zile","year":"2024","journal-title":"JACC Heart Fail"},{"issue":"4","key":"10.1016\/j.jacc.2026.03.075_bib10","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/ejhf.3595","article-title":"Continuous risk monitoring and management of heart failure: rationale and design of the ALLEVIATE-HF trial","volume":"27","author":"Butler","year":"2025","journal-title":"Eur J Heart Fail"},{"issue":"2","key":"10.1016\/j.jacc.2026.03.075_bib11","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/eurheartj\/ehr352","article-title":"The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities","volume":"33","author":"Pocock","year":"2012","journal-title":"Eur Heart J"},{"issue":"11","key":"10.1016\/j.jacc.2026.03.075_bib12","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/(SICI)1097-0258(19990615)18:11<1341::AID-SIM129>3.0.CO;2-7","article-title":"Combining mortality and longitudinal measures in clinical trials","volume":"18","author":"Finkelstein","year":"1999","journal-title":"Stat Med"},{"issue":"22","key":"10.1016\/j.jacc.2026.03.075_bib13","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1161\/CIRCULATIONAHA.124.070251","article-title":"Hierarchical composite outcomes and win ratio methods in cardiovascular trials: a review and consequent guidance","volume":"151","author":"Gregson","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2026.03.075_bib14","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/1467-9868.00259","article-title":"Semiparametric regression for the mean and rate functions of recurrent events","volume":"62","author":"Lin","year":"2000","journal-title":"J R Stat Soc Series B Stat Methodol"},{"issue":"17","key":"10.1016\/j.jacc.2026.03.075_bib15","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.jacc.2026.03.075_bib16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jacc.2022.11.023","article-title":"Worsening heart failure: nomenclature, epidemiology, and future directions: JACC review topic of the week","volume":"81","author":"Greene","year":"2023","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.jacc.2026.03.075_bib17","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/ejhf.3618","article-title":"Clinical management and therapeutic optimization of patients with heart failure with reduced ejection fraction and low blood pressure. A clinical consensus statement of the Heart Failure Association (HFA) of the ESC","volume":"27","author":"Skouri","year":"2025","journal-title":"Eur J Heart Fail"},{"issue":"6","key":"10.1016\/j.jacc.2026.03.075_bib18","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1093\/ije\/dyv183","article-title":"Randomized study designs for lifestyle interventions: a tutorial","volume":"44","author":"Younge","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"5","key":"10.1016\/j.jacc.2026.03.075_bib19","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/CIRCULATIONAHA.115.018614","article-title":"Atrial fibrillation begets heart failure and vice versa: temporal associations and differences in preserved versus reduced ejection fraction","volume":"133","author":"Santhanakrishnan","year":"2016","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jacc.2026.03.075_bib20","doi-asserted-by":"crossref","DOI":"10.2196\/34301","article-title":"Barriers and considerations in the design and implementation of digital behavioral interventions: qualitative analysis","volume":"24","author":"Marcu","year":"2022","journal-title":"J Med Internet Res"},{"issue":"9","key":"10.1016\/j.jacc.2026.03.075_bib21","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.3390\/ijerph17093069","article-title":"Dimensions of the complexity of health interventions: what are we talking about? A review","volume":"17","author":"Trompette","year":"2020","journal-title":"Int J Environ Res Public Health"},{"issue":"9","key":"10.1016\/j.jacc.2026.03.075_bib22","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.cardfail.2024.11.012","article-title":"Where's the remote? Failure to report clinical workflows in heart failure remote monitoring studies","volume":"31","author":"Shalowitz","year":"2025","journal-title":"J Card Fail"},{"key":"10.1016\/j.jacc.2026.03.075_bib23","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jacc.2007.10.061","article-title":"Randomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure: the COMPASS-HF Study","volume":"51","author":"Bourge","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"10.1016\/j.jacc.2026.03.075_bib24","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/clc.20250","article-title":"Reducing Events in Patients With Chronic Heart Failure (REDUCEhf) study design: continuous hemodynamic monitoring with an implantable defibrillator","volume":"30","author":"Adamson","year":"2007","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jacc.2026.03.075_bib25","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0140-6736(11)60101-3","article-title":"Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial","volume":"377","author":"Abraham","year":"2011","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.jacc.2026.03.075_bib26","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.jchf.2024.05.017","article-title":"Seated pulmonary artery pressure monitoring in patients with heart failure: results of the PROACTIVE-HF trial","volume":"12","author":"Guichard","year":"2024","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jacc.2026.03.075_bib27","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1161\/CIRCULATIONAHA.111.043042","article-title":"Intrathoracic impedance, audible patient alerts, and outcome in heart failure","volume":"124","author":"Van Veldhuisen","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2026.03.075_bib28","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jchf.2022.08.012","article-title":"Hemodynamically-guided management of heart failure across the ejection fraction spectrum: the GUIDE-HF trial","volume":"10","author":"Zile","year":"2022","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jacc.2026.03.075_bib29","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.cardfail.2016.09.012","article-title":"Hemodynamic monitoring in advanced heart failure: results from the LAPTOP-HF trial","volume":"22","author":"Abraham","year":"2016","journal-title":"J Cardiac Failure"},{"issue":"41","key":"10.1016\/j.jacc.2026.03.075_bib30","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1093\/eurheartj\/ehw099","article-title":"Fluid status telemedicine alerts for heart failure: a randomized controlled trial","volume":"37","author":"B\u00f6hm","year":"2016","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.jacc.2026.03.075_bib31","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.120.008693","article-title":"Remote monitoring with appropriate reaction to alerts was associated with improved outcomes in chronic heart failure: results from the OptiLink HF study","volume":"14","author":"Wintrich","year":"2021","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacc.2026.03.075_bib32","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1001\/jama.2017.10565","article-title":"Effect of natriuretic peptide\u2013guided therapy on hospitalization or cardiovascular mortality in high-risk patients with heart failure and reduced ejection fraction: a randomized clinical trial","volume":"318","author":"Felker","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2026.03.075_bib33","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/S0140-6736(22)02076-1","article-title":"Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial","volume":"400","author":"Mebazaa","year":"2022","journal-title":"Lancet"}],"container-title":["JACC"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109726059814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109726059814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T20:26:13Z","timestamp":1786393573000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109726059814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":33,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0735109726059814"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2026.03.075","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk-Based Nurse-Managed Personalized Heart Failure Interventions","name":"articletitle","label":"Article Title"},{"value":"JACC","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2026.03.075","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}