{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:07:14Z","timestamp":1792192034519,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100024063","name":"National Health Service Corps","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: CardioOncology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jaccao.2025.01.019","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T22:25:10Z","timestamp":1744151110000},"page":"345-356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Fluoropyrimidine Chemotherapy and the Risk of Death and Cardiovascular Events in Patients With Gastrointestinal Cancer"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2304-3551","authenticated-orcid":false,"given":"Aderonke T.","family":"Abiodun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-6262","authenticated-orcid":false,"given":"Chengsheng","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freya","family":"Tyrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinkie","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizz","family":"Paley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Vernon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Goodwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ludman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"McDonagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Weston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Deanfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"de Belder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Rutherford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Slater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Keen","family":"Shiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Peake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Adlam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-7090","authenticated-orcid":false,"given":"Charlotte","family":"Manisty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaccao.2025.01.019_bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.annonc.2022.10.003","article-title":"Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"34","author":"Cervantes","year":"2022","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib2","unstructured":"National Institute for Health and Care Excellence. Colorectal cancer: diagnosis and management. Guidance and guidelines. Accessed March 4, 2024. https:\/\/www.nice.org.uk\/guidance\/cg131"},{"key":"10.1016\/j.jaccao.2025.01.019_bib3","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.annonc.2022.07.004","article-title":"Gastric cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"33","author":"Lordick","year":"2022","journal-title":"Annals of Oncology"},{"key":"10.1016\/j.jaccao.2025.01.019_bib4","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jaccao.2025.01.019_bib5","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jaccao.2022.03.004","article-title":"Prevalence of cardiovascular disease in patients with potentially curable malignancies: a national registry dataset analysis","volume":"4","author":"Battisti","year":"2022","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib6","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.ctrv.2013.03.005","article-title":"Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: a systematic review of incidence, manifestations and predisposing factors","volume":"39","author":"Polk","year":"2013","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.jaccao.2025.01.019_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1517\/14740330902733961","article-title":"Fluoropyrimidine-associated cardiotoxicity: Revisited","volume":"8","author":"Saif","year":"2009","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.jaccao.2025.01.019_bib8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12910-018-0253-x","article-title":"Ethical issues in pragmatic randomized controlled trials: a review of the recent literature identifies gaps in ethical argumentation","volume":"19","author":"Goldstein","year":"2018","journal-title":"BMC Med Ethics"},{"key":"10.1016\/j.jaccao.2025.01.019_bib9","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/aje\/kwv254","article-title":"Using big data to emulate a target trial when a randomized trial is not available","volume":"183","author":"Hern\u00e1n","year":"2016","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib10","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1093\/ije\/dyab082","article-title":"Data resource profile: the Virtual Cardio-Oncology Research Initiative (VICORI) linking national English cancer registration and cardiovascular audits","volume":"50","author":"Sweeting","year":"2021","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib11","article-title":"Data resource profile: the Systemic Anti-Cancer Therapy (SACT) dataset","volume":"49","author":"Bright","year":"2020","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib12","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.0452","article-title":"Estimates of overall survival in patients with cancer receiving different treatment regimens: emulating hypothetical target trials in the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database","volume":"3","author":"Petito","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jaccao.2025.01.019_bib13","unstructured":"National Institute for Health and Care Excellence. Colorectal cancer NICE guideline. Accessed March 4, 2024. https:\/\/www.nice.org.uk\/guidance\/cg131"},{"key":"10.1016\/j.jaccao.2025.01.019_bib14","unstructured":"National Institute for Health and Care Excellence. Recommendations. Oesophago-gastric cancer: assessment and management in adults. Guidance. Accessed June 4, 2024. https:\/\/www.nice.org.uk\/guidance\/cg131"},{"key":"10.1016\/j.jaccao.2025.01.019_bib15","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1001\/jama.2023.4221","article-title":"Emulation of randomized clinical trials with nonrandomized database analyses: results of 32 clinical trials","volume":"329","author":"Wang","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.jaccao.2025.01.019_bib16","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1093\/ije\/dyaa057","article-title":"Reflection on modern methods: trial emulation in the presence of immortal-time bias. Assessing the benefit of major surgery for elderly lung cancer patients using observational data","volume":"49","author":"Maringe","year":"2020","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jaccao.2023.05.003","article-title":"Interpreting nonrandomized evidence for clinical decision making in cardio-oncology","volume":"5","author":"Chatur","year":"2023","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jamaoncol.2017.2752","article-title":"Examining bias in studies of statin treatment and survival in patients with cancer","volume":"4","author":"Emilsson","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib19","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0021-9681(83)90165-0","article-title":"A comparison of the logistic risk function and the proportional hazards model in prospective epidemiologic studies","volume":"36","author":"Green","year":"1983","journal-title":"J Chronic Dis"},{"key":"10.1016\/j.jaccao.2025.01.019_bib20","doi-asserted-by":"crossref","first-page":"v38","DOI":"10.1093\/annonc\/mdw350","article-title":"Gastric cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"27","author":"Smyth","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib21","article-title":"Association of pre-existing cardiovascular disease with administration of fluoropyrimidine chemotherapy in patients with gastrointestinal malignancies","volume":"3","author":"Abiodun","year":"2024","journal-title":"BMJ Oncol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib22","doi-asserted-by":"crossref","DOI":"10.1177\/1758835918780140","article-title":"5-Fluorouracil and cardiotoxicity: a review","volume":"10","author":"Sara","year":"2018","journal-title":"Ther Adv Med Oncol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib23","first-page":"44","article-title":"Fluoropyrimidine cardiotoxicity: time for a contemporaneous appraisal","volume":"18","author":"Upshaw","year":"2019","journal-title":"Clin Colorectal Cancer"},{"key":"10.1016\/j.jaccao.2025.01.019_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa055531","article-title":"Perioperative chemotherapy vs surgery alone for resectable gastroesophageal cancer","volume":"355","author":"Cunningham","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaccao.2025.01.019_bib25","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jaccao.2021.11.001","article-title":"Risk for myocardial infarction following 5-fluorouracil treatment in patients with gastrointestinal cancer: a nationwide registry-based study","volume":"3","author":"Shanmuganathan","year":"2021","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib26","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.6004\/jnccn.2022.7042","article-title":"Incident cardiovascular diseases among survivors of high-risk stage II-III colorectal cancer: a cluster-wide cohort study","volume":"20","author":"Lee","year":"2022","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.jaccao.2025.01.019_bib27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jaccao.2022.01.100","article-title":"Incident cardiovascular disease among adults with cancer: a population-based cohort study","volume":"4","author":"Paterson","year":"2022","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jacc.2022.04.042","article-title":"Cardiovascular disease risk among cancer survivors: the Atherosclerosis Risk in Communities (ARIC) study","volume":"80","author":"Florido","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib29","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3390\/ph16040510","article-title":"Redefining the incidence and profile of fluoropyrimidine-associated cardiotoxicity in cancer patients: a systematic review and meta-analysis","volume":"16","author":"Lu","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jaccao.2025.01.019_bib30","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40880-018-0292-1","article-title":"Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study","volume":"38","author":"Peng","year":"2018","journal-title":"Cancer Commun"},{"key":"10.1016\/j.jaccao.2025.01.019_bib31","first-page":"430","article-title":"A retrospective study of cardiotoxicities induced by 5-fluouracil (5-FU) and 5-FU based chemotherapy regimens in pakistani adult cancer patients at shaukat khanum memorial cancer hospital & research center","volume":"62","author":"Khan","year":"2012","journal-title":"J Pak Med Assoc"},{"key":"10.1016\/j.jaccao.2025.01.019_bib32","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1056\/NEJM199002083220602","article-title":"Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma","volume":"322","author":"Moertel","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaccao.2025.01.019_bib33","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/00001648-200009000-00011","article-title":"Marginal structural models and causal inference in epidemiology","volume":"11","author":"Robins","year":"2000","journal-title":"Epidemiology"},{"key":"10.1016\/j.jaccao.2025.01.019_bib34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/EDE.0b013e3181d61eeb","article-title":"Negative controls: a tool for detecting confounding and bias in observational studies","volume":"21","author":"Lipsitch","year":"2010","journal-title":"Epidemiology"},{"key":"10.1016\/j.jaccao.2025.01.019_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.canep.2021.101971","article-title":"Validity of chemotherapy information derived from routinely collected healthcare data: a national cohort study of colon cancer patients","volume":"73","author":"Boyle","year":"2021","journal-title":"Cancer Epidemiol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.canep.2023.102337","article-title":"Concordance of cancer drug therapy information derived from routinely collected hospital admissions data and the Systemic Anti-Cancer Therapy (SACT) dataset, for older women diagnosed with early invasive breast cancer in England","volume":"83","author":"Gannon","year":"2023","journal-title":"Cancer Epidemiol"},{"key":"10.1016\/j.jaccao.2025.01.019_bib37","doi-asserted-by":"crossref","first-page":"349","DOI":"10.7326\/0003-4819-136-5-200203050-00007","article-title":"Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with node-positive colon cancer","volume":"136","author":"Sundararajan","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaccao.2025.01.019_bib39","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1053\/j.seminoncol.2021.11.004","article-title":"Treating patients with dihydropyrimidine dehydrogenase (DPD) deficiency with fluoropyrimidine chemotherapy since the onset of routine prospective testing-the experience of a large oncology center in the United Kingdom","volume":"49","author":"Wang","year":"2022","journal-title":"Semin Oncol"}],"container-title":["JACC: CardioOncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666087325000894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666087325000894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:22:07Z","timestamp":1762636927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666087325000894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S2666087325000894"],"URL":"https:\/\/doi.org\/10.1016\/j.jaccao.2025.01.019","relation":{},"ISSN":["2666-0873"],"issn-type":[{"value":"2666-0873","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluoropyrimidine Chemotherapy and the Risk of Death and Cardiovascular Events in Patients With Gastrointestinal Cancer","name":"articletitle","label":"Article Title"},{"value":"JACC: CardioOncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaccao.2025.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}