{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:38:42Z","timestamp":1793500722113,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018430","name":"Fondazione dell'Istituto Europeo di Oncologia e del Centro Cardiologico Monzino","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018430","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: CardioOncology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jaccao.2026.06.005","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T19:31:50Z","timestamp":1787081510000},"page":"364-375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Simple Clinical Risk Score to Improve Prediction of Anthracycline-Induced Cardiotoxicity"],"prefix":"10.1016","volume":"8","author":[{"given":"Daniela","family":"Cardinale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Cosentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Morocutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Quaggiotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Marenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1712-4654","authenticated-orcid":false,"given":"Jes\u00fas","family":"Salda\u00f1a-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3414-7022","authenticated-orcid":false,"given":"Teresa","family":"L\u00f3pez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1022-4481","authenticated-orcid":false,"given":"Luca","family":"Piacentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Bonomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Marenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaccao.2026.06.005_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10557-016-6711-0","article-title":"Anthracycline chemotherapy and cardiotoxicity","volume":"31","author":"McGowan","year":"2017","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.jaccao.2026.06.005_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.annonc.2023.11.016","article-title":"Early breast cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up","volume":"35","author":"Loibl","year":"2024","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jaccao.2026.06.005_bib3","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jaccao.2024.07.016","article-title":"Anthracycline cardiotoxicity in adult cancer patients","volume":"6","author":"Camilli","year":"2024","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.jaccao.2026.06.005_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111708","article-title":"Doxorubicin-induced cardiotoxicity: an update on the molecular mechanism and novel therapeutic strategies for effective management","volume":"139","author":"Rawat","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jaccao.2026.06.005_bib5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fcvm.2020.00026","article-title":"Cardiotoxicity of anthracyclines","volume":"7","author":"Cardinale","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jaccao.2026.06.005_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.115.002661","article-title":"Cancer therapy-related cardiac dysfunction and heart failure: part 1: definitions, pathophysiology, risk factors, and imaging","volume":"9","author":"Bloom","year":"2016","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jaccao.2026.06.005_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jaccao.2022.01.101","article-title":"The role of cardioprotection in cancer therapy cardiotoxicity: JACC: cardiooncology state-of-the-art review","volume":"4","author":"Omland","year":"2022","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.jaccao.2026.06.005_bib8","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/ejhf.1957","volume":"22","author":"\u010celutkien\u0117","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jaccao.2026.06.005_bib9","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/ejhf.2017","article-title":"Role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies: a position statement from the Cardio-Oncology Study Group of the Heart Failure Association and the Cardio-Oncology Council of the European Society of Cardiology","volume":"22","author":"Pudil","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jaccao.2026.06.005_bib10","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1016\/j.amjcard.2013.08.026","article-title":"Review and meta-analysis of incidence and clinical predictors of anthracycline cardiotoxicity","volume":"112","author":"Lotrionte","year":"2013","journal-title":"Am J Cardiol"},{"issue":"8","key":"10.1016\/j.jaccao.2026.06.005_bib11","article-title":"Risk factors for anthracycline-induced cardiotoxicity","volume":"29","author":"Qiu","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jaccao.2026.06.005_bib12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41569-025-01126-1","article-title":"Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment","volume":"22","author":"Fabiani","year":"2025","journal-title":"Nat Rev Cardiol"},{"issue":"565","key":"10.1016\/j.jaccao.2026.06.005_bib13","article-title":"Early detection of anthracycline-induced cardiotoxicity","volume":"15","author":"Feng","year":"2025","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jaccao.2026.06.005_bib14","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1002\/ejhf.1920","volume":"22","author":"Lyon","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jaccao.2026.06.005_bib15","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1161\/CIRCULATIONAHA.114.013777","article-title":"Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy","volume":"131","author":"Cardinale","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jaccao.2026.06.005_bib16","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1093\/eurheartj\/ehaa006","article-title":"Classification, prevalence, and outcomes of anticancer therapy-induced cardiotoxicity: the CARDIOTOX registry","volume":"41","author":"L\u00f3pez-Send\u00f3n","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jaccao.2026.06.005_bib17","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jaccao.2026.06.005_bib18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/eurheartj\/ehab674","article-title":"Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement","volume":"43","author":"Herrmann","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jaccao.2026.06.005_bib19","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.jaccao.2026.06.005_bib20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jacc.2009.03.095","article-title":"Anthracycline-induced cardiomyopathy. Clinical relevance and response to pharmacologic therapy","volume":"55","author":"Cardinale","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jaccao.2026.06.005_bib21","first-page":"23","article-title":"Early- and late anthracycline-induced cardiac dysfunction: echocardiographic characterization and response to heart failure therapy","volume":"6","author":"Kamphuis","year":"2020","journal-title":"Cardio-Oncol"},{"key":"10.1016\/j.jaccao.2026.06.005_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/eurheartj\/ehae496","article-title":"Anthracycline-induced cardiovascular toxicity: validation of the Heart Failure Association and International Cardio-Oncology Society risk score","volume":"46","author":"Rivero-Santana","year":"2025","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jaccao.2026.06.005_bib23","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2459\/JCM.0000000000001589","article-title":"The added value of the HFA\/ICOS score in the prediction of chemotherapy-related cardiac dysfunction in breast cancer","volume":"25","author":"Di Lisi","year":"2024","journal-title":"J Cardiovasc Med"},{"key":"10.1016\/j.jaccao.2026.06.005_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ijcard.2021.11.059","article-title":"Baseline cardio-oncologic risk assessment in breast cancer women and occurrence of cardiovascular events: the HFA\/ICOS risk tool in real-world practice","volume":"349","author":"Tini","year":"2022","journal-title":"Int J Cardiol"},{"issue":"2","key":"10.1016\/j.jaccao.2026.06.005_bib25","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jaccao.2020.10.011","article-title":"Strain imaging in cardio-oncology","volume":"15","author":"Liu","year":"2020","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.jaccao.2026.06.005_bib26","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1161\/CIR.0000000000001174","article-title":"Cardiovascular imaging in contemporary cardiooncology: a scientific statement from the American Heart Association","volume":"148","author":"Addison","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jaccao.2026.06.005_bib27","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014708","article-title":"Changes in cardiovascular biomarkers with breast cancer therapy and associations with cardiac dysfunction","volume":"9","author":"Demissei","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jaccao.2026.06.005_bib28","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jaccao.2024.01.001","article-title":"Cancer therapy\u2013related cardiac dysfunction: expanding the horizon of cardiac troponin in clinical practice","volume":"6","author":"De Michieli","year":"2024","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.jaccao.2026.06.005_bib29","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1515\/cclm-2020-0362","article-title":"High-sensitivity cardiac troponin I and T methods for the early detection of myocardial injury in patients on chemotherapy","volume":"59","author":"Clerico","year":"2020","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jaccao.2026.06.005_bib30","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/ejhf.1631","article-title":"Troponins and brain natriuretic peptides for the prediction of cardiotoxicity in cancer patients: a meta-analysis","volume":"22","author":"Michel","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jaccao.2026.06.005_bib31","series-title":"Model List of Essential Medicines-23rd","year":"2023"}],"container-title":["JACC: CardioOncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666087326002103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666087326002103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:45:31Z","timestamp":1789515931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666087326002103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2666087326002103"],"URL":"https:\/\/doi.org\/10.1016\/j.jaccao.2026.06.005","relation":{},"ISSN":["2666-0873"],"issn-type":[{"value":"2666-0873","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Simple Clinical Risk Score to Improve Prediction of Anthracycline-Induced Cardiotoxicity","name":"articletitle","label":"Article Title"},{"value":"JACC: CardioOncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaccao.2026.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}