{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:38:51Z","timestamp":1784831931108,"version":"3.55.0"},"reference-count":9,"publisher":"Elsevier BV","issue":"27","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Case Reports"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jaccas.2025.105137","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:51:47Z","timestamp":1757551907000},"page":"105137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["5-Fluorouracil\u2013Induced Microvascular Vasospasm Diagnosed by Coronary Functional Testing"],"prefix":"10.1016","volume":"30","author":[{"given":"Rimsha","family":"Rana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3662-2832","authenticated-orcid":false,"given":"Ryan L.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4063-9226","authenticated-orcid":false,"given":"Ron","family":"Waksman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayder D.","family":"Hashim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Case","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jaccas.2025.105137_bib1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/jcm13010040","article-title":"Colorectal cancer: current updates and future perspectives","volume":"13","author":"Marcellinaro","year":"2023","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.jaccas.2025.105137_bib2","first-page":"133","article-title":"FOLFOX and FOLFIRI use in stage IV colon cancer: analysis of SEER-medicare data","volume":"18","author":"Neugut","year":"2019","journal-title":"Clin Colorectal Cancer"},{"key":"10.1016\/j.jaccas.2025.105137_bib3","series-title":"StatPearls [Internet]","article-title":"Fluorouracil","author":"Casale","year":"2024"},{"issue":"5","key":"10.1016\/j.jaccas.2025.105137_bib4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00395-009-0037-z","article-title":"Coronary microvascular resistance: methods for its quantification in humans","volume":"104","author":"Knaapen","year":"2009","journal-title":"Basic Res Cardiol"},{"issue":"4","key":"10.1016\/j.jaccas.2025.105137_bib5","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jaccao.2020.06.012","article-title":"How to diagnose and manage patients with fluoropyrimidine-induced chest pain","volume":"2","author":"Padegimas","year":"2020","journal-title":"JACC CardioOncology"},{"issue":"1","key":"10.1016\/j.jaccas.2025.105137_bib6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1365-2125.2010.03892.x","article-title":"5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR\/MTRR genotypes","volume":"72","author":"Pardini","year":"2011","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"10.1016\/j.jaccas.2025.105137_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jaccao.2020.12.005","article-title":"The incidence, risk factors, and outcomes with 5-Fluorouracil-Associated coronary vasospasm","volume":"3","author":"Zafar","year":"2021","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.jaccas.2025.105137_bib8","series-title":"StatPearls [Internet]","article-title":"Coronary artery vasospasm","author":"Swarup","year":"2025"},{"issue":"12","key":"10.1016\/j.jaccas.2025.105137_bib9","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1093\/annonc\/mdx411","article-title":"DPYD genotype-guided dose individualization to improve patient safety of fluoropyrimidine therapy: call for a drug label update","volume":"28","author":"Henricks","year":"2017","journal-title":"Ann Oncol"}],"container-title":["JACC: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666084925019175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666084925019175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:52:05Z","timestamp":1757551925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666084925019175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":9,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2666084925019175"],"URL":"https:\/\/doi.org\/10.1016\/j.jaccas.2025.105137","relation":{},"ISSN":["2666-0849"],"issn-type":[{"value":"2666-0849","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"5-Fluorouracil\u2013Induced Microvascular Vasospasm Diagnosed by Coronary Functional Testing","name":"articletitle","label":"Article Title"},{"value":"JACC: Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaccas.2025.105137","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"105137"}}