{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:57:15Z","timestamp":1793087835809,"version":"4.5.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"32","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Case Reports"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jaccas.2025.105344","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:49:41Z","timestamp":1757551781000},"page":"105344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unmasking Cancer Risk in Heritable PAH"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1069-6019","authenticated-orcid":false,"given":"Bel\u00e9n","family":"Biscotti Rodil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-4037","authenticated-orcid":false,"given":"Alejandro","family":"Cruz-Utrilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Mart\u00edn de Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Barriuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Arribas Ynsaurriaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Escribano Sub\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jaccas.2025.105344_bib1","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01324-2024","article-title":"Definition, classification and diagnosis of pulmonary hypertension","volume":"64","author":"Kovacs","year":"2024","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1016\/j.jaccas.2025.105344_bib2","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01370-2024","article-title":"Genetics and precision genomics approaches to pulmonary hypertension","volume":"64","author":"Austin","year":"2024","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.jaccas.2025.105344_bib3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1053\/j.gastro.2023.03.006","article-title":"BMPR2 as a novel predisposition gene for hereditary colorectal polyposis","volume":"165","author":"Bonjoch","year":"2023","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.jaccas.2025.105344_bib4","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/ijc.26047","article-title":"Genetic variation in bone morphogenetic protein and colon and rectal cancer","volume":"130","author":"Slattery","year":"2012","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.jaccas.2025.105344_bib5","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/cncr.23160","article-title":"The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer","volume":"112","author":"Kodach","year":"2008","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.jaccas.2025.105344_bib6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molonc.2014.08.004","article-title":"BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation","volume":"9","author":"Pickup","year":"2015","journal-title":"Mol Oncol"},{"issue":"24 Suppl","key":"10.1016\/j.jaccas.2025.105344_bib7","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1158\/0008-5472.SABCS-09-3039","article-title":"BMPR-II mediates positive regulation on in vitro cell growth, the potential implications for breast cancer","volume":"69","author":"Bokobza","year":"2009","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.jaccas.2025.105344_bib8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3233\/CBM-150494","article-title":"Transcriptional up-regulation of BMP-4 and BMPR-II genes in the peripheral blood of breast cancer patients: a pilot study","volume":"15","author":"Gul","year":"2015","journal-title":"Cancer Biomark"},{"key":"10.1016\/j.jaccas.2025.105344_bib9","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s10528-023-10445-2","article-title":"Bioinformatics analysis of the genetic and epigenetic alterations of bone morphogenetic protein receptors in metastatic breast cancer","volume":"62","author":"Hermawan","year":"2024","journal-title":"Biochem Genet"},{"key":"10.1016\/j.jaccas.2025.105344_bib10","series-title":"Cancer Figures in Spain 2024","year":"2024"}],"container-title":["JACC: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666084925021266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666084925021266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T23:57:13Z","timestamp":1762387033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666084925021266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":10,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S2666084925021266"],"URL":"https:\/\/doi.org\/10.1016\/j.jaccas.2025.105344","relation":{},"ISSN":["2666-0849"],"issn-type":[{"value":"2666-0849","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unmasking Cancer Risk in Heritable PAH","name":"articletitle","label":"Article Title"},{"value":"JACC: Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaccas.2025.105344","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"105344"}}