{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:02:16Z","timestamp":1779217336366,"version":"3.51.4"},"reference-count":9,"publisher":"Elsevier BV","issue":"32","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Case Reports"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jaccas.2025.105430","type":"journal-article","created":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T05:07:18Z","timestamp":1757826438000},"page":"105430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exacerbation of Postural Orthostatic Tachycardia Syndrome With Tirzepatide Prescribed for Weight Loss"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9507-4533","authenticated-orcid":false,"given":"Eric T.","family":"Hedge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon R.","family":"Grappe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Vernino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime P.","family":"Almandoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin D.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaccas.2025.105430_bib1","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jacc.2018.11.059","article-title":"Postural orthostatic tachycardia syndrome: JACC Focus Seminar","volume":"73","author":"Bryarly","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jaccas.2025.105430_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/ajh.27162","article-title":"Determinants and reference values for blood volume and total hemoglobin mass in women and men","volume":"99","author":"Oberholzer","year":"2024","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jaccas.2025.105430_bib3","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.57232","article-title":"Longitudinal analysis of obesity drug use and public awareness","volume":"8","author":"Berning","year":"2025","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jaccas.2025.105430_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1056\/NEJMoa2206038","article-title":"Tirzepatide once weekly for the treatment of obesity","volume":"387","author":"Jastreboff","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaccas.2025.105430_bib5","doi-asserted-by":"crossref","first-page":"880","DOI":"10.2337\/db16-0762","article-title":"Bariatric surgery enhances splanchnic vascular responses in patients with type 2 diabetes","volume":"66","author":"Honka","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.jaccas.2025.105430_bib6","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2337\/db25-0149","article-title":"Glucose-dependent insulinotropic polypeptide is involved in postprandial regulation of splanchnic blood supply","volume":"74","author":"Rasmussen","year":"2025","journal-title":"Diabetes"},{"key":"10.1016\/j.jaccas.2025.105430_bib7","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13073","article-title":"Glucagon-like peptide-1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men","volume":"5","author":"Asmar","year":"2017","journal-title":"Physiol Rep"},{"key":"10.1016\/j.jaccas.2025.105430_bib8","doi-asserted-by":"crossref","first-page":"H235","DOI":"10.1152\/ajpheart.00809.2024","article-title":"Heart and health behavior responses to GLP-1 receptor agonists: a 12-wk study using wearable technology and causal inference","volume":"328","author":"Grosicki","year":"2025","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jaccas.2025.105430_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0735-1097(24)02017-5","article-title":"Can GLP-1 agonist for weight loss cause cardiac dysautonomia? A study of the FAERS database","volume":"83","author":"Katapadi","year":"2024","journal-title":"J Am Coll Cardiol"}],"container-title":["JACC: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666084925022132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666084925022132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T23:57:23Z","timestamp":1762387043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666084925022132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":9,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S2666084925022132"],"URL":"https:\/\/doi.org\/10.1016\/j.jaccas.2025.105430","relation":{},"ISSN":["2666-0849"],"issn-type":[{"value":"2666-0849","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exacerbation of Postural Orthostatic Tachycardia Syndrome With Tirzepatide Prescribed for Weight Loss","name":"articletitle","label":"Article Title"},{"value":"JACC: Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaccas.2025.105430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"105430"}}