{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T01:37:09Z","timestamp":1762393029229,"version":"build-2065373602"},"reference-count":9,"publisher":"Elsevier BV","issue":"35","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Case Reports"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jaccas.2025.105528","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T01:33:47Z","timestamp":1762392827000},"page":"105528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["NKX2-5 Mutation and ICD Implantation in a Pregnant AV Block Patient"],"prefix":"10.1016","volume":"30","author":[{"given":"Musa'ab Moh'd","family":"Alhmouz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa Jamal","family":"Saeid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.L.","family":"Jaabari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami H.","family":"Bany Ata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo'ath Bani","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghad","family":"Abuhalimeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Abuhalimeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dima","family":"Quraini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jaccas.2025.105528_bib1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1161\/CIRCRESAHA.114.303219","article-title":"Nkx2-5 suppresses the proliferation of atrial myocytes and conduction system","volume":"114","author":"Nakashima","year":"2014","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.jaccas.2025.105528_bib2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/chd.12317","article-title":"Familial atrial septal defect and sudden cardiac death: identification of a novel NKX2-5 mutation and a review of the literature","volume":"11","author":"Elles\u00f8e","year":"2016","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.jaccas.2025.105528_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.691203","article-title":"Case report: a novel Nkx2-5 mutation in a family with congenital heart defects, left ventricular non-compaction, conduction disease, and sudden cardiac death","volume":"8","author":"Morlanes-Gracia","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"10","key":"10.1016\/j.jaccas.2025.105528_bib4","doi-asserted-by":"crossref","first-page":"e175","DOI":"10.1016\/j.hrthm.2023.05.017","article-title":"2023 HRS expert consensus statement on the management of arrhythmias during pregnancy","volume":"20","author":"Joglar","year":"2023","journal-title":"Heart Rhythm"},{"issue":"9","key":"10.1016\/j.jaccas.2025.105528_bib5","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1136\/jmg.2003.017483","article-title":"Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease","volume":"41","author":"Reamon-Buettner","year":"2004","journal-title":"J Med Genet"},{"key":"10.1016\/j.jaccas.2025.105528_bib6","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06942","article-title":"NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets","volume":"4","author":"Bouveret","year":"2015","journal-title":"eLife"},{"issue":"21","key":"10.1016\/j.jaccas.2025.105528_bib7","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1016\/j.jacc.2016.08.064","article-title":"Cardiac phenotype and long-term follow-up of patients with mutations in NKX2-5 gene","volume":"68","author":"Maury","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.jaccas.2025.105528_bib8","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3892\/ijmm.2014.2029","article-title":"A novel NKX2-5 loss-of-function mutation predisposes to familial dilated cardiomyopathy and arrhythmias","volume":"35","author":"Yuan","year":"2015","journal-title":"Int J Mol Med"},{"issue":"7","key":"10.1016\/j.jaccas.2025.105528_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007502","article-title":"Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy","volume":"14","author":"Choquet","year":"2018","journal-title":"PloS Genet"}],"container-title":["JACC: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666084925023113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666084925023113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T01:34:00Z","timestamp":1762392840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666084925023113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":9,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2666084925023113"],"URL":"https:\/\/doi.org\/10.1016\/j.jaccas.2025.105528","relation":{},"ISSN":["2666-0849"],"issn-type":[{"value":"2666-0849","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NKX2-5 Mutation and ICD Implantation in a Pregnant AV Block Patient","name":"articletitle","label":"Article Title"},{"value":"JACC: Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaccas.2025.105528","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"105528"}}