{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:16:48Z","timestamp":1792729008593,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":801,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.jacep.2015.08.005","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T07:46:10Z","timestamp":1445759170000},"page":"465-474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Left Atrial Appendage Ligation in Nonvalvular Atrial Fibrillation Patients at High Risk for Embolic Events With Ineligibility for Oral\u00a0Anticoagulation"],"prefix":"10.1016","volume":"1","author":[{"given":"Horst","family":"Sievert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdi","family":"Rasekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kryzstof","family":"Bartus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remo L.","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Kuropka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Gafoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Heuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Safavi-Naeini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha F.","family":"Hue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitish","family":"Badhwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Massumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacep.2015.08.005_bib1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: the Framingham Study","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"key":"10.1016\/j.jacep.2015.08.005_bib2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1161\/01.STR.32.3.803","article-title":"Atrial fibrillation and stroke: concepts and controversies","volume":"32","author":"Hart","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.jacep.2015.08.005_bib3","doi-asserted-by":"crossref","first-page":"492","DOI":"10.7326\/0003-4819-131-7-199910050-00003","article-title":"Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-analysis","volume":"131","author":"Hart","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jacep.2015.08.005_bib4","doi-asserted-by":"crossref","first-page":"857","DOI":"10.7326\/0003-4819-146-12-200706190-00007","article-title":"Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation","volume":"146","author":"Hart","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jacep.2015.08.005_bib5","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1001\/archinte.1996.00440210043004","article-title":"National pattern of warfarin use in atrial fibrillation","volume":"156","author":"Stafford","year":"1996","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jacep.2015.08.005_bib6","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1161\/01.CIR.97.13.1231","article-title":"Recent national pattern of warfarin use in atrial fibrillation","volume":"97","author":"Stafford","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2015.08.005_bib7","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/archinte.1994.00420170093009","article-title":"Anticoagulation in atrial fibrillation: does efficacy in clinical trials translate into effectiveness in practice?","volume":"154","author":"Gottlieb","year":"1994","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jacep.2015.08.005_bib8","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1161\/01.STR.26.8.1471","article-title":"Oral anticoagulants and intracranial hemorrhage: facts and hypotheses","volume":"26","author":"Hart","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.jacep.2015.08.005_bib9","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.amjmed.2006.07.034","article-title":"Death and disability from warfarin-associated intracranial and extracranial hemorrhages","volume":"120","author":"Fang","year":"2007","journal-title":"Am J Med"},{"key":"10.1016\/j.jacep.2015.08.005_bib10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11239-010-0536-7","article-title":"The clinical impact of bleeding during oral anticoagulant therapy","volume":"31","author":"Guerrouij","year":"2011","journal-title":"J\u00a0Thromb Thrombolysis"},{"key":"10.1016\/j.jacep.2015.08.005_bib11","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa0905561","article-title":"Dabigatran versus warfarin in patients with atrial fibrillation","volume":"361","author":"Connolly","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacep.2015.08.005_bib12","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1009638","article-title":"Rivaroxaban versus warfarin in nonvalvular atrial fibrillation","volume":"365","author":"Patel","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacep.2015.08.005_bib13","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMoa1107039","article-title":"Apixaban versus warfarin in patients with atrial fibrillation","volume":"365","author":"Granger","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacep.2015.08.005_bib14","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1056\/NEJMoa1310907","article-title":"Edoxaban versus warfarin in patients with atrial fibrillation","volume":"369","author":"Giugliano","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacep.2015.08.005_bib15","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1056\/NEJMoa1007432","article-title":"Apixaban in patients with atrial fibrillation","volume":"364","author":"Connolly","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacep.2015.08.005_bib16","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials","volume":"383","author":"Ruff","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jacep.2015.08.005_bib17","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1161\/STROKEAHA.107.183689","volume":"38","author":"Broderick","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.jacep.2015.08.005_bib18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1212\/WNL.59.2.205","article-title":"Long-term prognosis after recovery from primary intracerebral hemorrhage","volume":"59","author":"Vermeer","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.jacep.2015.08.005_bib19","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1161\/01.STR.0000078311.18928.16","article-title":"Can patients be anticoagulated after intracerebral hemorrhage? A decision analysis","volume":"34","author":"Eckman","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.jacep.2015.08.005_bib20","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1161\/CIRCULATIONAHA.114.010942","article-title":"Age-specific incidence, outcome, cost, and projected future burden of atrial fibrillation-related embolic vascular events: a population-based study","volume":"130","author":"Yiin","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2015.08.005_bib21","first-page":"954","article-title":"Evaluation of costs and outcome in cardioembolic stroke or TIA","volume":"256","author":"Winter","year":"2009","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.jacep.2015.08.005_bib22","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0140-6736(09)61343-X","article-title":"Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial","volume":"374","author":"Holmes","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jacep.2015.08.005_bib23","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1161\/CIRCULATIONAHA.110.976449","article-title":"Safety of percutaneous left atrial appendage closure: results from the Watchman Left Atrial Appendage System for Embolic Protection in Patients with AF (PROTECT AF) clinical trial and the Continued Access Registry","volume":"123","author":"Reddy","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2015.08.005_bib24","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1001\/jama.2014.15192","article-title":"Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial","volume":"312","author":"Reddy","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jacep.2015.08.005_bib25","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jacc.2012.06.046","article-title":"Percutaneous left atrial appendage suture ligation using the Lariat in patients with atrial fibrillation: initial clinical experience","volume":"62","author":"Bartus","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2015.08.005_bib26","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.amjcard.2012.11.061","article-title":"Initial experience with a novel percutaneous left atrial appendage exclusion device in patients with atrial fibrillation, increased stroke risk, and contraindications to anticoagulation","volume":"111","author":"Massumi","year":"2013","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2015.08.005_bib27","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1001\/jama.285.22.2864","article-title":"Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation","volume":"285","author":"Gage","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jacep.2015.08.005_bib28","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1161\/01.CIR.0000145172.55640.93","article-title":"Selecting patients with atrial fibrillation for anticoagulation: stroke risk stratification in patients taking aspirin","volume":"110","author":"Gage","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2015.08.005_bib29","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1161\/01.CIR.0000015698.54752.6D","article-title":"Percutaneous left atrial appendage transcatheter occlusion to prevent stroke in high-risk patients with\u00a0atrial fibrillation: early clinical experience","volume":"105","author":"Sievert","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2015.08.005_bib30","article-title":"Left atrial appendage occlusion for stroke prevention in atrial fibrillation: multicentre experience with the Amplatzer Cardiac Plug","author":"Tzikas","year":"2015","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jacep.2015.08.005_bib31","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1016\/j.jacc.2013.03.035","article-title":"Left atrial appendage closure with the Watchman device in patients with a contraindication for oral anticoagulation: the ASAP study (ASA Plavix Feasibility Study With Watchman Left Atrial Appendage Closure Technology)","volume":"61","author":"Reddy","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2015.08.005_bib32","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.amjcard.2014.11.011","article-title":"Overview of the Food and Drug Administration circulatory system devices panel meetings on Watchman left atrial appendage closure therapy","volume":"115","author":"Waksman","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2015.08.005_bib33","first-page":"397","article-title":"Left atrial appendage thrombus outside of a \u201csuccessful\u201d ligation","volume":"9","author":"Donnino","year":"2008","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.jacep.2015.08.005_bib34","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0003-4975(95)00885-3","article-title":"Thoracoscopic obliteration of the left atrial appendage: potential for stroke reduction?","volume":"61","author":"Odell","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacep.2015.08.005_bib35","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/S0003-4975(03)00738-0","article-title":"Assessment of different procedures for surgical left atrial appendage exclusion","volume":"76","author":"Pennec","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacep.2015.08.005_bib36","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1161\/CIRCEP.113.001084","article-title":"Anatomic analysis of the left atrial appendage following closure with the Lariat device","volume":"7","author":"Bartus","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2015.08.005_bib37","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.hrthm.2014.01.019","article-title":"The effects of LAA ligation on LAA electrical activity","volume":"11","author":"Han","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2015.08.005_bib38","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.jacc.2015.01.052","article-title":"Left atrial thrombus formation after successful left atrial appendage ligation: case series from a nationwide survey","volume":"65","author":"Lakkireddy","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2015.08.005_bib39","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.hrthm.2015.03.020","article-title":"Endocardial (Watchman) versus epicardial (Lariat) left atrial appendage exclusion devices: understanding the differences in the location and type of leaks and their clinical implications","volume":"12","author":"Pillarisetti","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2015.08.005_bib40","first-page":"661","article-title":"Successful closure of residual leak following Lariat procedure in a patient with high risk of stroke and hemorrhage","volume":"83","author":"Yeow","year":"2014","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jacep.2015.08.005_bib41","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/j.hrthm.2014.06.035","article-title":"Initial experience with post Lariat left atrial appendage leak closure with Amplatzer septal occluder device and repeat Lariat application","volume":"11","author":"Pillai","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2015.08.005_bib42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jacc.2005.03.042","article-title":"Percutaneous left atrial appendage transcatheter occlusion (PLAATO system) to prevent stroke in high-risk patients with non-rheumatic atrial fibrillation: results from the international multi-center feasibility trials","volume":"46","author":"Ostermayer","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2015.08.005_bib43","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","article-title":"Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery","volume":"363","author":"Leon","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacep.2015.08.005_bib44","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1586\/14779072.2015.1057123","article-title":"Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation","volume":"13","author":"Le","year":"2015","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"10.1016\/j.jacep.2015.08.005_bib45","first-page":"121","article-title":"Early results with the Lariat device for left atrial appendage exclusion in patients with atrial fibrillation at high risk\u00a0for stroke and anticoagulation","volume":"86","author":"Stone","year":"2015","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jacep.2015.08.005_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2014.03.057","article-title":"Early safety and efficacy of percutaneous left atrial appendage suture ligation: results from the U.S. transcatheter LAA ligation consortium","author":"Price","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2015.08.005_bib47","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.hrthm.2014.07.032","article-title":"Multicenter study on acute and long-term safety and efficacy of percutaneous left atrial appendage closure using an epicardial suture snaring device","volume":"11","author":"Miller","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2015.08.005_bib48","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.hrthm.2014.01.022","article-title":"LAA ligation using the Lariat suture delivery device: tips and tricks for a successful procedure","volume":"11","author":"Koneru","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2015.08.005_bib49","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1161\/CIRCEP.115.002921","article-title":"Differences in complication rates between large bore needle and a long micropuncture needle during epicardial access: time to change clinical practice?","volume":"8","author":"Gunda","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X15003266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X15003266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:34:30Z","timestamp":1762500870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X15003266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S2405500X15003266"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2015.08.005","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Left Atrial Appendage Ligation in Nonvalvular Atrial Fibrillation Patients at High Risk for Embolic Events With Ineligibility for Oral\u00a0Anticoagulation","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2015.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}