{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:14:51Z","timestamp":1791231291616,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T00:00:00Z","timestamp":1549065600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.jacep.2017.11.020","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T17:57:30Z","timestamp":1517507850000},"page":"181-189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Improvement of Reverse Remodeling\u00a0Using Electrocardiogram Fusion-Optimized Intervals in Cardiac\u00a0Resynchronization Therapy"],"prefix":"10.1016","volume":"4","author":[{"given":"Emilce","family":"Trucco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Tolosana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Arbelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Doltra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Castel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Benito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Borr\u00e0s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Guasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Vidorreta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Montserrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sitges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Berruezo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Brugada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llu\u00eds","family":"Mont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacep.2017.11.020_bib1","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"MADITCRT Trial Investigators. Cardiac-resynchronization therapy for the prevention of heart-failure events","volume":"361","author":"Moss","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacep.2017.11.020_bib2","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.jacc.2008.08.027","article-title":"Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms","volume":"52","author":"Linde","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib3","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.amjcard.2005.02.009","article-title":"Predictors of lack of response to resynchronization therapy","volume":"95","author":"D\u00edaz-Infante","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.hfc.2016.07.019","article-title":"Cardiac resynchronization therapy: how to decrease nonresponders","volume":"13","author":"Tolosana","year":"2017","journal-title":"Heart Fail Clin"},{"key":"10.1016\/j.jacep.2017.11.020_bib5","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.hrthm.2012.07.025","article-title":"EHRA\/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management","volume":"9","author":"Daubert","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2017.11.020_bib6","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.hrthm.2004.07.006","article-title":"Randomized prospective trial of atrioventricular delay programming for cardiac resynchronization therapy","volume":"1","author":"Sawhney","year":"2004","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2017.11.020_bib7","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.amjcard.2007.04.046","article-title":"Optimizing the programation of cardiac resynchronization therapy devices in patients with heart failure and left bundle branch block","volume":"100","author":"Vidal","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1540-8167.2011.02235.x","article-title":"Optimization of cardiac resynchronization therapy: Importance of programmed parameters","volume":"23","author":"Cuoco","year":"2012","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib9","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1161\/01.CIR.0000145169.82004.CF","article-title":"Left ventricular pacing minimizes diastolic ventricular interaction, allowing improved preload-dependent systolic performance","volume":"110","author":"Bleasdale","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2017.11.020_bib10","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1161\/hc1102.105730","article-title":"Effects of long-term biventricular stimulation for resynchronization on echocardiographic measures of remodeling","volume":"105","author":"Saxon","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2017.11.020_bib11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/heart.84.6.579","article-title":"Multisite stimulation for correction of cardiac asynchrony","volume":"84","author":"Cazeau","year":"2000","journal-title":"Heart"},{"issue":"7","key":"10.1016\/j.jacep.2017.11.020_bib12","first-page":"1077","article-title":"Clinical relevance of systematic CRT device optimization","volume":"31","author":"Lunati","year":"2014","journal-title":"J\u00a0Atr Fibrillation"},{"key":"10.1016\/j.jacep.2017.11.020_bib13","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.amjcard.2013.12.006","article-title":"Meta-analysis of effects of optimization of cardiac resynchronization therapy on left ventricular function, exercise capacity, and quality of life in patients with heart failure","volume":"113","author":"Kosmala","year":"2014","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib14","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1093\/eurheartj\/eht150","article-title":"2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: The Task Force on Cardiac Pacing and Resynchronization Therapy of the European Society of Cardiology (ESC)","volume":"34","author":"Brignole","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2017.11.020_bib15","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.amjcard.2009.07.006","article-title":"Optimization of the interventricular delay in cardiac resynchronization therapy using the QRS width","volume":"104","author":"Tamborero","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib16","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/j.1540-8167.2011.02085.x","article-title":"Electrocardiographic versus echocardiographic optimization of the interventricular pacing delay in patients undergoing cardiac resynchronization therapy","volume":"22","author":"Tamborero","year":"2011","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib17","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/europace\/eup333","article-title":"Midterm \u201csuper-response\u201d to cardiac resynchronization therapy by biventricular pacing with fusion: Insights from electro-anatomical mapping","volume":"11","author":"Vatasescu","year":"2009","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2017.11.020_bib18","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1540-8167.2007.00983.x","article-title":"Electrocardiographic optimization of interventricular delay in cardiac resynchronization therapy: a simple method to optimize the device","volume":"18","author":"Vidal","year":"2007","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/jce.12322","article-title":"Fusion-optimized intervals (FOI): a new method to achieve the narrowest QRS for optimization of the AV and VV intervals in patients undergoing cardiac resynchronization therapy","volume":"25","author":"Arbelo","year":"2014","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib20","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jacc.2008.10.032","article-title":"Long-term prognosis after cardiac resynchronization therapy is related to the extent of left\u00a0ventricular reverse remodelling at midterm follow-up","volume":"53","author":"Ypenburg","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib21","first-page":"919","article-title":"The 6min walk: a new measure of exercise capacity in patients with chronic heart failure","volume":"132","author":"Guyatt","year":"1985","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.jacep.2017.11.020_bib22","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/0002-9149(93)90582-W","article-title":"Validity of the Minnesota Living with Heart Failure questionnaire as a measure of therapeutic response to enalapril or placebo","volume":"71","author":"Rector","year":"1993","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib23","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0735-1097(95)00482-3","article-title":"Classification of death in antiarrhythmia trials","volume":"27","author":"Epstein","year":"1996","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib24","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1161\/CIRCULATIONAHA.110.992552","volume":"122","author":"Ellenbogen","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2017.11.020_bib25","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.ahj.2010.02.034","article-title":"Rationale and design of a randomized clinical trial to assess the safety and efficacy of frequent optimization of cardiac resynchronization therapy: the Frequent Optimization Study Using the QuickOpt Method (FREEDOM) trial","volume":"159","author":"Abraham","year":"2010","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacep.2017.11.020_bib26","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.hrthm.2012.07.009","article-title":"Investigation of a novel algorithm for synchronized left-ventricular pacing and ambulatory optimization of cardiac resynchronization therapy results of the adaptive CRT trial","volume":"9","author":"Martin","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2017.11.020_bib27","first-page":"730","article-title":"RESPOND CRT Investigators. Contractility sensor-guided optimization of cardiac resynchronization therapy: results from the RESPOND-CRT trial","volume":"38","author":"Brugada","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2017.11.020_bib28","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jelectrocard.2014.01.007","article-title":"The value of the 12-lead ECG for evaluation and optimization of cardiac resynchronization therapy in daily clinical practice","volume":"47","author":"Van Deursen","year":"2014","journal-title":"J\u00a0Electrocardiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib29","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1161\/hc5001.102229","article-title":"Effect of resynchronization therapy stimulation site on the systolic function of heart failure patients","volume":"104","author":"Butter","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2017.11.020_bib30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.hrthm.2011.11.009","article-title":"Prospective evaluation of electrocardiographic parameters in cardiac resynchronization therapy: detecting nonresponders by left ventricular pacing","volume":"9","author":"Kobe","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2017.11.020_bib31","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.amjcard.2004.02.061","article-title":"Effect of optimizing the VV interval on left ventricular contractility in cardiac resynchronization therapy","volume":"93","author":"Van Gelder","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib32","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/pace.13118","article-title":"The concept of triple wavefront fusion during biventricular pacing: using the EGM to produce the best acute hemodynamic improvement in CRT","volume":"40","author":"Ter Horst","year":"2017","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib33","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.amjcard.2007.04.043","article-title":"Comparison of the effects of cardiac resynchronization therapy in patients with class II versus class III and IV heart failure (from the InSync\/InSync ICD Italian Registry)","volume":"100","author":"Landolina","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib34","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.amjcard.2006.01.080","article-title":"Cardiac resynchronization therapy in patients with systolic left ventricular dysfunction and symptoms of mild heart failure secondary to ischemic or nonischemic cardiomyopathy","volume":"98","author":"Bleeker","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib35","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/j.jacc.2010.12.041","article-title":"Reverse remodelling and the risk of ventricular tachyarrhythmias in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy)","volume":"57","author":"Barsheshet","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2017.11.020_bib36","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1161\/CIRCULATIONAHA.110.955039","article-title":"Effect of cardiac resynchronization therapy on reverse remodelling and relation to outcome: multicenter automatic defibrillator implantation trial: cardiac resynchronization therapy","volume":"122","author":"Solomon","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2017.11.020_bib37","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/CIRCULATIONAHA.105.538272","article-title":"Left ventricular reverse remodelling but not clinical improvement predicts long-term survival after cardiac resynchronization therapy","volume":"112","author":"Yu","year":"2005","journal-title":"Circulation"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X17311763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X17311763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:25:37Z","timestamp":1762500337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X17311763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S2405500X17311763"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2017.11.020","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improvement of Reverse Remodeling\u00a0Using Electrocardiogram Fusion-Optimized Intervals in Cardiac\u00a0Resynchronization Therapy","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2017.11.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}