{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:20:05Z","timestamp":1790695205440,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005630","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Cardiologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005630","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003100","name":"F\u00e9d\u00e9ration Fran\u00e7aise de Cardiologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003100","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jacep.2018.04.017","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T20:01:30Z","timestamp":1529352090000},"page":"757-768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy\/Dysplasia Without an Implantable Cardioverter-Defibrillator"],"prefix":"10.1016","volume":"4","author":[{"given":"Carole","family":"Maupain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Badenco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Pousset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Waintraub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Duthoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Chastre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Himbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"H\u00e9bert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Hidden-Lucet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Gandjbakhch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacep.2018.04.017_bib1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1161\/01.CIR.65.2.384","article-title":"Right ventricular dysplasia: a report of 24 adult cases","volume":"65","author":"Marcus","year":"1982","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2018.04.017_bib2","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1016\/S0735-1097(00)00997-9","article-title":"Clinical profile and long-term follow-up of 37 families with arrhythmogenic right ventricular cardiomyopathy","volume":"36","author":"Nava","year":"2000","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2018.04.017_bib3","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1161\/CIRCULATIONAHA.110.988287","article-title":"Arrhythmogenic right ventricular dysplasia\/cardiomyopathy: pathogenic desmosome mutations in index-patients predict outcome of family screening: Dutch arrhythmogenic right ventricular dysplasia\/cardiomyopathy genotype-phenotype follow-up study","volume":"123","author":"Cox","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2018.04.017_bib4","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1161\/01.CIR.0000143375.93288.82","article-title":"Natural history and risk stratification of arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"110","author":"Hulot","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2018.04.017_bib5","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1253\/circj.67.925","article-title":"Arrhythmogenic right ventricular cardiomyopathy and sudden cardiac death in young Koreans","volume":"67","author":"Cho","year":"2003","journal-title":"Circ J"},{"key":"10.1016\/j.jacep.2018.04.017_bib6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jflm.2015.02.005","article-title":"Sudden adult death: an autopsy series of 534 cases with gender and control comparison","volume":"32","author":"Naneix","year":"2015","journal-title":"J\u00a0Forensic Leg Med"},{"key":"10.1016\/j.jacep.2018.04.017_bib7","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1161\/CIRCEP.113.000392","article-title":"Implantable cardioverter defibrillators in arrhythmogenic right ventricular dysplasia\/cardiomyopathy: patient outcomes, incidence of appropriate and inappropriate interventions, and complications","volume":"6","author":"Schinkel","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2018.04.017_bib8","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.jacc.2012.11.087","article-title":"Incremental value of cardiac magnetic resonance imaging in arrhythmic risk stratification of arrhythmogenic right ventricular dysplasia\/cardiomyopathy-associated desmosomal mutation carriers","volume":"62","author":"Te Riele","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2018.04.017_bib9","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1161\/CIRCULATIONAHA.109.913871","article-title":"Prophylactic implantable defibrillator in patients with arrhythmogenic right ventricular cardiomyopathy\/dysplasia and no prior ventricular fibrillation or sustained ventricular tachycardia","volume":"122","author":"Corrado","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2018.04.017_bib10","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1161\/01.CIR.0000103130.33451.D2","article-title":"Implantable cardioverter-defibrillator therapy for prevention of sudden death in patients with arrhythmogenic right ventricular cardiomyopathy\/dysplasia","volume":"108","author":"Corrado","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2018.04.017_bib11","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.jacc.2011.06.043","article-title":"Incidence and predictors of implantable cardioverter-defibrillator therapy in patients with arrhythmogenic right ventricular dysplasia\/cardiomyopathy undergoing implantable cardioverter-defibrillator implantation for primary prevention","volume":"58","author":"Bhonsale","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2018.04.017_bib12","first-page":"558","article-title":"Risk stratification in arrhythmic right ventricular cardiomyopathy without implantable cardioverter-defibrillators","volume":"2","author":"Brun","year":"2016","journal-title":"J\u00a0Am Coll Cardiol EP"},{"key":"10.1016\/j.jacep.2018.04.017_bib13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/CIRCULATIONAHA.115.017944","article-title":"Treatment of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: an International Task Force consensus statement","volume":"132","author":"Corrado","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2018.04.017_bib14","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/eurheartj\/ehq025","article-title":"Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: proposed modification of the Task Force Criteria","volume":"31","author":"Marcus","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2018.04.017_bib15","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"Lang","year":"2005","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jacep.2018.04.017_bib16","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1540-8167.2011.02288.x","article-title":"Long-term follow-up in patients with arrhythmogenic right ventricular cardiomyopathy","volume":"23","author":"Li","year":"2012","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacep.2018.04.017_bib17","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1136\/hrt.2008.149823","article-title":"Arrhythmogenic right ventricular cardiomyopathy: an update","volume":"95","author":"Corrado","year":"2009","journal-title":"Heart"},{"key":"10.1016\/j.jacep.2018.04.017_bib18","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jacc.2007.03.049","article-title":"Long-term efficacy of catheter ablation of ventricular tachycardia in patients with arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"50","author":"Dalal","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2018.04.017_bib19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.hrthm.2015.09.010","article-title":"Implantable cardioverter-defibrillator harm in young patients with inherited arrhythmia syndromes: a systematic review and meta-analysis of inappropriate shocks and complications","volume":"13","author":"Olde Nordkamp","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2018.04.017_bib20","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ijcard.2005.03.049","article-title":"Ventricular tachycardia in arrhythmogenic right ventricular dysplasia\/cardiomyopathy: clinical presentation, risk stratification and results of long-term follow-up","volume":"107","author":"Pezawas","year":"2006","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacep.2018.04.017_bib21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2459\/01.JCM.0000278450.35107.b3","article-title":"Long-term follow-up and risk assessment of arrhythmogenic right ventricular dysplasia\/cardiomyopathy: personal experience from different primary and tertiary centres","volume":"8","author":"Peters","year":"2007","journal-title":"J\u00a0Cardiovasc Med (Hagerstown)"},{"key":"10.1016\/j.jacep.2018.04.017_bib22","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/eurheartj\/ehr040","article-title":"Prognostic predictors in arrhythmogenic right ventricular cardiomyopathy: results from a 10-year registry","volume":"32","author":"Pinamonti","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2018.04.017_bib23","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1136\/hrt.2004.038620","article-title":"Predictors of adverse outcome in patients with arrhythmogenic right ventricular dysplasia\/cardiomyopathy: long term experience of a tertiary care centre","volume":"91","author":"Lemola","year":"2005","journal-title":"Heart"},{"key":"10.1016\/j.jacep.2018.04.017_bib24","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1093\/eurheartj\/ehv110","article-title":"Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy","volume":"36","author":"Ruwald","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2018.04.017_bib25","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.jacc.2013.06.033","article-title":"Exercise increases age-related penetrance and arrhythmic risk in arrhythmogenic right ventricular dysplasia\/cardiomyopathy-associated desmosomal mutation carriers","volume":"62","author":"James","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2018.04.017_bib26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1161\/CIRCULATIONAHA.110.938282","article-title":"Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training","volume":"123","author":"Benito","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2018.04.017_bib27","first-page":"e273","volume":"132","author":"Maron","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2018.04.017_bib28","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.hrthm.2009.08.018","article-title":"Clinical features, survival experience, and profile of plakophylin-2 gene mutations in participants of the arrhythmogenic right ventricular cardiomyopathy registry of South Africa","volume":"6","author":"Watkins","year":"2009","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2018.04.017_bib29","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s00399-013-0291-5","article-title":"Risk stratification in arrhythmogenic right ventricular cardiomyopathy","volume":"24","author":"Silvano","year":"2013","journal-title":"Herzschrittmachertherapie Elektrophysiologie"},{"key":"10.1016\/j.jacep.2018.04.017_bib30","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.jacc.2004.01.030","article-title":"Implantable cardioverter-defibrillators in patients with arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"43","author":"Roguin","year":"2004","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2018.04.017_bib31","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/europace\/euv061","article-title":"Arrhythmic risk assessment in genotyped families with arrhythmogenic right ventricular cardiomyopathy","volume":"18","author":"Protonotarios","year":"2016","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2018.04.017_bib32","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/eurheartj\/ehu509","article-title":"Impact of genotype on clinical course in arrhythmogenic right ventricular dysplasia\/cardiomyopathy-associated mutation carriers","volume":"36","author":"Bhonsale","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2018.04.017_bib33","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.jacc.2015.01.045","article-title":"Exercise triggers ARVC phenotype in mice expressing a disease-causing mutated version of human plakophilin-2","volume":"65","author":"Cruz","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2018.04.017_bib34","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1016\/j.jacc.2016.09.951","article-title":"Arrhythmogenic right ventricular cardiomyopathy: clinical course and predictors of arrhythmic risk","volume":"68","author":"Mazzanti","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2018.04.017_bib35","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.hrthm.2005.08.022","article-title":"Predictors of appropriate implantable defibrillator therapies in patients with arrhythmogenic right ventricular dysplasia","volume":"2","author":"Piccini","year":"2005","journal-title":"Heart Rhythm"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X18303876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X18303876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:25:45Z","timestamp":1762500345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X18303876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S2405500X18303876"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2018.04.017","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy\/Dysplasia Without an Implantable Cardioverter-Defibrillator","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2018.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}