{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:47:10Z","timestamp":1768348030724,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007497","name":"Biosense Webster","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.jacep.2020.02.003","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T15:43:18Z","timestamp":1585150998000},"page":"773-782","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acute Hemoptysis Following Cryoballoon Pulmonary Vein Isolation"],"prefix":"10.1016","volume":"6","author":[{"given":"Julia","family":"Vogler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Fink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Sohns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Pott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tillman","family":"Dahme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Rottner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Sciacca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malte Maria","family":"Sieren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Barkhausen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Sano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Eitel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Metzner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifan","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Heinz","family":"Kuck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland Richard","family":"Tilz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian-Hendrik","family":"Heeger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacep.2020.02.003_bib1","first-page":"1100","article-title":"Cryoballoon or radiofrequency ablation for atrial fibrillation","volume":"375","author":"Kuck","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacep.2020.02.003_bib2","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1253\/circj.CJ-16-1334","article-title":"Three-year clinical outcome after 2nd-generation cryoballoon-based pulmonary vein isolation for the treatment of paroxysmal and persistent atrial fibrillation- a 2-center experience","volume":"81","author":"Heeger","year":"2017","journal-title":"Circ J"},{"key":"10.1016\/j.jacep.2020.02.003_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00392-015-0890-8","article-title":"Two-year outcome after pulmonary vein isolation using the second-generation 28-mm cryoballoon: lessons from the bonus freeze protocol","volume":"105","author":"Metzner","year":"2016","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/europace\/euy239","article-title":"Cryoballoon vs. radiofrequency ablation for atrial fibrillation: a study of outcome and safety based on the ESC-EHRA atrial fibrillation ablation long-term registry and the Swedish catheter ablation registry","volume":"21","author":"Mortsell","year":"2019","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2020.02.003_bib5","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1093\/europace\/euy131","article-title":"Cardiac tamponade in catheter ablation of atrial fibrillation: German-wide analysis of 21 141 procedures in the Helios atrial fibrillation ablation registry (SAFER)","volume":"20","author":"Bollmann","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2020.02.003_bib6","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/europace\/euw262","article-title":"Cryoballoon vs. radiofrequency ablation for paroxysmal atrial fibrillation: an updated meta-analysis of randomized and observational studies","volume":"19","author":"Buiatti","year":"2017","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2020.02.003_bib7","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1093\/europace\/eux219","article-title":"Is less more? Impact of different ablation protocols on periprocedural complications in second-generation cryoballoon based pulmonary vein isolation","volume":"20","author":"Rottner","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2020.02.003_bib8","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/jce.12358","article-title":"The incidence of phrenic nerve injury during pulmonary vein isolation using the second-generation 28\u00a0mm cryoballoon","volume":"25","author":"Metzner","year":"2014","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib9","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/europace\/euu320","article-title":"Incidence and characteristics of phrenic nerve palsy following pulmonary vein isolation with the second-generation as compared with the first-generation cryoballoon in 360 consecutive patients","volume":"17","author":"Furnkranz","year":"2015","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2020.02.003_bib10","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.117.005925","article-title":"Bronchial injury after atrial fibrillation ablation using the second-generation cryoballoon","volume":"11","author":"Bellmann","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib11","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1540-8167.2011.02031.x","article-title":"Hemoptysis after pulmonary vein isolation with a cryoballoon: an analysis of the potential etiology","volume":"22","author":"Bhagwandien","year":"2011","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib12","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.hrthm.2010.06.024","article-title":"Bronchial erosion and hemoptysis after pulmonary vein isolation by cryoballoon ablation","volume":"8","author":"van Opstal","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2020.02.003_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.hrthm.2016.10.012","article-title":"Bronchial effects of cryoballoon ablation for atrial fibrillation","volume":"14","author":"Verma","year":"2017","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2020.02.003_bib14","doi-asserted-by":"crossref","first-page":"e173","DOI":"10.1378\/chest.14-1600","article-title":"Hemoptysis after cryoablation for atrial fibrillation: truth or just a myth?","volume":"146","author":"Kumar","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.jacep.2020.02.003_bib15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1378\/chest.13-0761","article-title":"Pulmonary hemorrhage after cryoballoon ablation for pulmonary vein isolation in the treatment of atrial fibrillation","volume":"145","author":"Marti-Almor","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.jacep.2020.02.003_bib16","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1513\/AnnalsATS.201503-135LE","article-title":"Bronchial injury post cryoablation for atrial fibrillation","volume":"12","author":"Desai","year":"2015","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jacep.2020.02.003_bib17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10840-018-0468-2","article-title":"Hemoptysis as a side effect of cryoballoon pulmonary vein isolation in atrial fibrillation: a retrospective case-control study","volume":"54","author":"Bullert","year":"2019","journal-title":"J\u00a0Interv Card Electrophysiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib18","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/CIRCEP.113.000228","article-title":"Increased incidence of esophageal thermal lesions using the second-generation 28-mm cryoballoon","volume":"6","author":"Metzner","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib19","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.jacc.2012.09.033","article-title":"Long-term outcomes after cryoballoon pulmonary vein isolation: results from a prospective study in 605 patients","volume":"61","author":"Vogt","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib20","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s00392-016-0987-8","article-title":"Bonus-freeze: benefit or risk? Two-year outcome and procedural comparison of a \u201cbonus-freeze\u201d and \u201cno bonus-freeze\u201d protocol using the second-generation cryoballoon for pulmonary vein isolation","volume":"105","author":"Heeger","year":"2016","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib21","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/europace\/euv024","article-title":"One-year clinical success of a 'no-bonus' freeze protocol using the second-generation 28\u00a0mm cryoballoon for pulmonary vein isolation","volume":"17","author":"Wissner","year":"2015","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2020.02.003_bib22","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/j.1540-8167.2012.02315.x","article-title":"Two versus one repeat freeze-thaw cycle(s) after cryoballoon pulmonary vein isolation: the alster extra pilot study","volume":"23","author":"Chun","year":"2012","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib23","doi-asserted-by":"crossref","first-page":"368","DOI":"10.5603\/CJ.a2018.0056","article-title":"Time-to-effect guided pulmonary vein isolation utilizing the third-generation versus second generation cryoballoon: one year clinical success","volume":"26","author":"Heeger","year":"2019","journal-title":"Cardiol J"},{"key":"10.1016\/j.jacep.2020.02.003_bib24","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/CIRCEP.113.001238","article-title":"Clinical experience with a novel electromyographic approach to preventing phrenic nerve injury during cryoballoon ablation in atrial fibrillation","volume":"7","author":"Mondesert","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1161\/CIRCEP.115.002734","article-title":"Electromyographic monitoring for prevention of phrenic nerve palsy in second-generation cryoballoon procedures","volume":"8","author":"Franceschi","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib26","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCEP.113.000517","article-title":"Novel electromyographic monitoring technique for prevention of right phrenic nerve palsy during cryoballoon ablation","volume":"6","author":"Franceschi","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib27","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.hrthm.2013.01.011","article-title":"Immediate balloon deflation for prevention of persistent phrenic nerve palsy during pulmonary vein isolation by balloon cryoablation","volume":"10","author":"Ghosh","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2020.02.003_bib28","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/jce.12983","article-title":"Impact of pulmonary vein cryoballoon ablation on bronchial injury","volume":"27","author":"Aryana","year":"2016","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib29","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.hrthm.2015.11.015","article-title":"Ice formation in the left mainstem bronchus during cryoballoon ablation for the treatment of atrial fibrillation","volume":"13","author":"Verma","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2020.02.003_bib30","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/j.1540-8167.2007.00915.x","article-title":"Close relationship between the bronchi and pulmonary veins: implications for the prevention of atriobronchial fistula after atrial fibrillation ablation","volume":"18","author":"Wu","year":"2007","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacep.2020.02.003_bib31","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/europace\/eur034","article-title":"Spatial relationship between left atrial roof or superior pulmonary veins and bronchi or pulmonary arteries by dual-source computed tomography: implication for preventing injury of bronchi and pulmonary arteries during atrial fibrillation ablation","volume":"13","author":"Li","year":"2011","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2020.02.003_bib32","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.hrthm.2017.05.003","article-title":"Acute efficacy, safety, and long-term clinical outcomes using the second-generation cryoballoon for pulmonary vein isolation in patients with a left common pulmonary vein: a multicenter study","volume":"14","author":"Heeger","year":"2017","journal-title":"Heart Rhythm"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X20301535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X20301535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:28:23Z","timestamp":1762500503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X20301535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S2405500X20301535"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2020.02.003","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute Hemoptysis Following Cryoballoon Pulmonary Vein Isolation","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2020.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}