{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:54:55Z","timestamp":1792274095785,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T00:00:00Z","timestamp":1614988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007497","name":"Biosense Webster","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jacep.2021.02.014","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T16:38:14Z","timestamp":1619627894000},"page":"614-627","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":553,"title":["Pulsed Field Ablation of Paroxysmal Atrial Fibrillation"],"prefix":"10.1016","volume":"7","author":[{"given":"Vivek Y.","family":"Reddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas R.","family":"Dukkipati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Neuzil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ante","family":"Anic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Petru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritoshi","family":"Funasako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Cochet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Minami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Breskovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Sikiric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Sediva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Chovanec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Koruth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Jais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacep.2021.02.014_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10439-005-8981-8","article-title":"Tissue ablation with irreversible electroporation","volume":"33","author":"Davalos","year":"2005","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.jacep.2021.02.014_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/153303460700600106","article-title":"Irreversible electroporation: a new ablation modality \u2013 clinical implications","volume":"6","author":"Rubinsky","year":"2007","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.jacep.2021.02.014_bib3","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1109\/TBME.2006.873745","article-title":"In\u00a0vivo results of a new focal tissue ablation technique: irreversible electroporation","volume":"53","author":"Edd","year":"2006","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1016\/j.jacep.2021.02.014_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1109\/MEI.2012.6268438","article-title":"Cell membrane electroporation - part 1: the phenomenon","volume":"28","author":"Kotnik","year":"2012","journal-title":"IEEE Electr Insul"},{"key":"10.1016\/j.jacep.2021.02.014_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4149\/gpb_2012_003","article-title":"Electroporation-induced changes in normal immature rat myoblasts (H9C2)","volume":"31","author":"Kaminska","year":"2012","journal-title":"Gen Physiol Biophys"},{"key":"10.1016\/j.jacep.2021.02.014_bib6","article-title":"The effects of irreversible electroporation on nerves","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jacep.2021.02.014_bib7","doi-asserted-by":"crossref","first-page":"e4757","DOI":"10.1371\/journal.pone.0004757","article-title":"Non thermal irreversible electroporation: novel technology for vascular smooth muscle cells ablation","volume":"4","author":"Maor","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jacep.2021.02.014_bib8","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.119.007781","article-title":"Preclinical evaluation of pulsed field ablation: electrophysiological and histological assessment of thoracic vein isolation","volume":"12","author":"Koruth","year":"2019","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib9","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.119.008303","article-title":"Pulsed field ablation vs radiofrequency ablation: esophageal injury in a novel porcine model","volume":"13","author":"Koruth","year":"2020","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib10","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1161\/CIRCEP.113.001111","article-title":"Pulmonary vein stenosis after catheter ablation: electroporation versus radiofrequency","volume":"7","author":"van Driel","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib11","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.hrthm.2015.05.012","article-title":"Low vulnerability of the right phrenic nerve to electroporation ablation","volume":"12","author":"van Driel","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2021.02.014_bib12","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.004672","article-title":"Acute and long-term effects of full-power electroporation ablation directly on the porcine esophagus","volume":"10","author":"Neven","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib13","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.hrthm.2018.10.030","article-title":"Intracardiac pulsed field ablation: proof of feasibility in a chronic porcine model","volume":"16","author":"Stewart","year":"2019","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2021.02.014_bib14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jacc.2019.04.021","article-title":"Pulsed field ablation for pulmonary vein isolation in atrial fibrillation","volume":"74","author":"Reddy","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib15","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.hrthm.2012.01.019","article-title":"The durability of pulmonary vein isolation using the visually guided laser balloon catheter: multicenter results of pulmonary vein remapping studies","volume":"9","author":"Dukkipati","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2021.02.014_bib16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/CIRCEP.113.000374","article-title":"Electrical reconnection after pulmonary vein isolation is contingent on contact force during initial treatment: results from the EFFICAS I study","volume":"6","author":"Nuezil","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib17","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1093\/europace\/euv057","article-title":"EFFICAS II: optimization of catheter contact force improves outcomes of pulmonary vein isolation for paroxysmal atrial fibrillation","volume":"17","author":"Kautzner","year":"2015","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2021.02.014_bib18","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/jce.12626","article-title":"Durability of pulmonary vein isolation with cryoballoon ablation: results from the sustained PV isolation with Artic Front Advance (SUPIR) study","volume":"26","author":"Reddy","year":"2015","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib19","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.115.003879","article-title":"Quantitative analysis of the isolation area during the chronic phase after a 28-mm second generation cryoballoon ablation demarcated by high-resolution electroanatomic mapping","volume":"9","author":"Miyazaki","year":"2016","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib20","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jacc.2017.06.008","article-title":"Temperature-controlled radiofrequency ablation for pulmonary vein isolation in patients with atrial fibrillation","volume":"70","author":"Iwasawa","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib21","first-page":"602","article-title":"Pulmonary vein re-isolation as a routine strategy regardless of symptoms: the PRESSURE randomized controlled trial","volume":"3","author":"Das","year":"2017","journal-title":"J\u00a0Am Coll Cardiol EP"},{"key":"10.1016\/j.jacep.2021.02.014_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.118.006576","article-title":"Use of ablation index-guided ablation results in high rates of durable pulmonary vein isolation and freedom from arrhythmia in persistent atrial fibrillation patients: the PRAISE study results","volume":"11","author":"Hussein","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib23","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jacc.2005.06.016","article-title":"Predictors of non-pulmonary vein ectopic beats initiating paroxysmal atrial fibrillation: implications for catheter ablation","volume":"46","author":"Lee","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib24","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.hrthm.2015.10.023","article-title":"Prevalence and distribution of focal triggers in persistent and long-standing persistent atrial fibrillation","volume":"13","author":"Santangeli","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2021.02.014_bib25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.hrthm.2015.08.029","article-title":"Importance of non-pulmonary vein triggers ablation to achieve long-term freedom from paroxysmal atrial fibrillation in patients with low ejection fraction","volume":"13","author":"Zhao","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2021.02.014_bib26","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10840-017-0285-z","article-title":"Efficacy of ganglionated plexi ablation in addition to pulmonary vein isolation for paroxysmal versus persistent atrial fibrillation: a meta-analysis of randomized controlled clinical trials","volume":"50","author":"Kampaktsis","year":"2017","journal-title":"J\u00a0Interv Card Electrophysiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib27","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/jce.13860","article-title":"Electroporation of epicardial autonomic ganglia: safety and efficacy in medium-term canine models","volume":"30","author":"Padmanabhan","year":"2019","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib28","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMoa1602014","article-title":"Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation","volume":"374","author":"Kuck","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacep.2021.02.014_bib29","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.jacc.2015.07.036","article-title":"Pulmonary vein isolation using the visually guided laser balloon: A prospective, multicenter, and randomized comparison to standard radiofrequency ablation","volume":"66","author":"Dukkipati","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib30","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.hrthm.2018.09.027","article-title":"Temporal relationships between esophageal injury type and progression in patients undergoing atrial fibrillation catheter ablation","volume":"16","author":"Yarlagadda","year":"2019","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2021.02.014_bib31","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.hrthm.2014.10.033","article-title":"Reduced incidence of esophageal lesions by luminal esophageal temperature-guided second-generation cryoballoon ablation","volume":"12","author":"F\u00fcrnkranz","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2021.02.014_bib32","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.1016\/j.hrthm.2017.05.012","article-title":"2017 HRS\/EHRA\/ECAS\/APHRS\/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation","volume":"14","author":"Calkins","year":"2017","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2021.02.014_bib33","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.hrthm.2013.08.012","article-title":"Clinical outcomes after repair of left atrial esophageal fistulas occurring after atrial fibrillation ablation procedures","volume":"10","author":"Singh","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2021.02.014_bib34","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.hrthm.2020.04.040","article-title":"Ostial dimensional changes after pulmonary vein isolation: pulsed field ablation vs radiofrequency ablation","volume":"17","author":"Kuroki","year":"2020","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2021.02.014_bib35","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/CIRCEP.109.859116","article-title":"Updated worldwide survey on the methods, efficacy, and\u00a0safety of catheter ablation for human atrial fibrillation","volume":"3","author":"Cappato","year":"2010","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2021.02.014_bib36","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.jacc.2020.07.007","article-title":"Pulsed field ablation in patients with persistent atrial fibrillation","volume":"76","author":"Reddy","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X21001961?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X21001961?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:29:17Z","timestamp":1762500557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X21001961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S2405500X21001961"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2021.02.014","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pulsed Field Ablation of Paroxysmal Atrial Fibrillation","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2021.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}