{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:10:46Z","timestamp":1790856646154,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL136932"],"award-info":[{"award-number":["K23HL136932"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["1T32HG010464"],"award-info":[{"award-number":["1T32HG010464"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jacep.2022.08.022","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T16:50:32Z","timestamp":1666803032000},"page":"57-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Atrial Standstill in the Pediatric Population"],"prefix":"10.1016","volume":"9","author":[{"given":"Taylor S.","family":"Howard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Y.","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R.","family":"Ceresnak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie Beausejour","family":"Ladouceur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Whitehill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Czosek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy K.","family":"Knilans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnethe M.","family":"Ahnfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malene Lando","family":"Borresen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Jaeggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Udupa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto G.","family":"Galloti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug Y.","family":"Mah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago O.","family":"Valdes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna M.","family":"Milewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina Y.","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacep.2022.08.022_bib1","first-page":"159","article-title":"About an extraordinary case of permanent atrial palsy with Keith and Flack node degeneration","volume":"16","author":"Chavez","year":"1946","journal-title":"Arch Inst Cardiol Mex"},{"issue":"8","key":"10.1016\/j.jacep.2022.08.022_bib2","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1111\/j.1540-8159.1991.tb02867.x","article-title":"Persistent atrial standstill\u2014clinical, electrophysiological, and morphological study","volume":"14","author":"Talwar","year":"1991","journal-title":"Pacing Clin Electrophysiol"},{"issue":"8","key":"10.1016\/j.jacep.2022.08.022_bib3","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/0002-9149(82)90226-0","article-title":"Permanent atrial standstill: the clinical spectrum","volume":"49","author":"Woolliscroft","year":"1982","journal-title":"Am J Cardiol"},{"issue":"2","key":"10.1016\/j.jacep.2022.08.022_bib4","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1161\/01.CIR.44.2.220","article-title":"Transient and persistent atrial standstill with His bundle lesions. Electrophysiologic and pathologic correlations","volume":"44","author":"Rosen","year":"1971","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jacep.2022.08.022_bib5","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.hrthm.2010.10.014","article-title":"Homozygous mutation in SCN5A associated with atrial quiescence, recalcitrant arrhythmias, and poor capture thresholds","volume":"8","author":"Lopez","year":"2011","journal-title":"Heart Rhythm"},{"issue":"10","key":"10.1016\/j.jacep.2022.08.022_bib6","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.hrthm.2005.06.032","article-title":"Congenital atrial standstill associated with coinheritance of a novel SCN5A mutation and connexin 40 polymorphisms","volume":"2","author":"Makita","year":"2005","journal-title":"Heart Rhythm"},{"issue":"5","key":"10.1016\/j.jacep.2022.08.022_bib7","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.jpeds.2014.07.036","article-title":"Compound heterozygous mutations in the SCN5A-encoded Nav1.5 cardiac sodium channel resulting in atrial standstill and His-Purkinje system disease","volume":"165","author":"Baskar","year":"2014","journal-title":"J\u00a0Pediatr"},{"issue":"8","key":"10.1016\/j.jacep.2022.08.022_bib8","first-page":"356","article-title":"Long-term follow-up of permanent atrial standstill in a German family with mutation in the SCN5A gene","volume":"4","author":"Lehmann","year":"2018","journal-title":"Heart Case Rep"},{"key":"10.1016\/j.jacep.2022.08.022_bib9","author":"Ahnfeldt","year":"2019"},{"key":"10.1016\/j.jacep.2022.08.022_bib10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.yjmcc.2016.01.014","article-title":"A\u00a0novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias","volume":"92","author":"Wang","year":"2016","journal-title":"J\u00a0Mol Cell Cardiol"},{"issue":"7","key":"10.1016\/j.jacep.2022.08.022_bib11","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1172\/JCI200318062","article-title":"Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)","volume":"112","author":"Benson","year":"2003","journal-title":"J\u00a0Clin Invest"},{"issue":"9","key":"10.1016\/j.jacep.2022.08.022_bib12","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.hrthm.2009.04.026","article-title":"Atrial standstill associated with loss of atrial myocytes: a rare cause of fetal bradyarrhythmia","volume":"6","author":"Jaeggi","year":"2009","journal-title":"Heart Rhythm"},{"issue":"5","key":"10.1016\/j.jacep.2022.08.022_bib13","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1161\/CIRCEP.115.003098","article-title":"Loss-of-function SCN5A mutations associated with sinus node dysfunction, atrial arrhythmias, and poor pacemaker capture","volume":"8","author":"Chiang","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"OCT","key":"10.1016\/j.jacep.2022.08.022_bib14","first-page":"1","article-title":"SCN5A variants: association with cardiac disorders","volume":"9","author":"Li","year":"2018","journal-title":"Front Physiol"},{"issue":"11","key":"10.1016\/j.jacep.2022.08.022_bib15","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1093\/europace\/eun267","article-title":"SCN5A overlap syndromes: no end to disease complexity?","volume":"10","author":"Remme","year":"2008","journal-title":"Europace"},{"issue":"5","key":"10.1016\/j.jacep.2022.08.022_bib16","first-page":"569","article-title":"Clinical spectrum of SCN5A Mutations: long QT syndrome, Brugada syndrome, and cardiomyopathy","volume":"4","author":"Wilde","year":"2018","journal-title":"J\u00a0Am Coll Cardiol EP"},{"issue":"2","key":"10.1016\/j.jacep.2022.08.022_bib17","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/europace\/euv098","article-title":"Atrial standstill in sinus node disease due to extensive atrial fibrosis: impact on dual chamber pacemaker implantation","volume":"18","author":"Bellmann","year":"2016","journal-title":"Europace"},{"issue":"9","key":"10.1016\/j.jacep.2022.08.022_bib18","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.hrthm.2009.05.016","article-title":"A\u00a0novel SCN5A mutation V1340I in Brugada syndrome augmenting arrhythmias during febrile illness","volume":"6","author":"Samani","year":"2009","journal-title":"Heart Rhythm"},{"issue":"1","key":"10.1016\/j.jacep.2022.08.022_bib19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1080\/08998280.2017.11929530","article-title":"A\u00a0variant of Brugada syndrome","volume":"30","author":"Switzer","year":"2017","journal-title":"Baylor Univ Med Cent Proc"},{"issue":"3","key":"10.1016\/j.jacep.2022.08.022_bib20","doi-asserted-by":"crossref","first-page":"311a","DOI":"10.1016\/j.bpj.2009.12.1690","article-title":"Mutation in Nav1.5 associated with Brugada syndrome - a mutational hotspot?","volume":"98","author":"Schmitt","year":"2010","journal-title":"Biophys J"},{"issue":"3","key":"10.1016\/j.jacep.2022.08.022_bib21","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0008-6363(99)00350-8","article-title":"Human SCN5A gene mutations alter cardiac sodium channel kinetics and are associated with the Brugada syndrome","volume":"44","author":"Rook","year":"1999","journal-title":"Cardiovasc Res"},{"issue":"5","key":"10.1016\/j.jacep.2022.08.022_bib22","article-title":"SCN5A (NaV1.5) variant functional perturbation and clinical presentation: variants of a certain significance","volume":"11","author":"Kroncke","year":"2018","journal-title":"Circ Genomic Precis Med"},{"issue":"6","key":"10.1016\/j.jacep.2022.08.022_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008862","article-title":"A\u00a0Bayesian method to estimate variant-induced disease penetrance","volume":"16","author":"Kroncke","year":"2020","journal-title":"PLoS Genet"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X22007332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X22007332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:31:03Z","timestamp":1762500663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X22007332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S2405500X22007332"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2022.08.022","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atrial Standstill in the Pediatric Population","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2022.08.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}