{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:21:23Z","timestamp":1791037283320,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002336","name":"Daiichi Sankyo Co Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.jacep.2022.11.032","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T14:09:00Z","timestamp":1677074940000},"page":"569-580","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Risks of Heart Failure, Stroke, and Bleeding in Atrial Fibrillation According to Heart Failure Phenotypes"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4846-8529","authenticated-orcid":false,"given":"Riccardo M.","family":"Inciardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Giugliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Gun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Nordio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian T.","family":"Ruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Lanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott M.","family":"Antman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Braunwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacep.2022.11.032_bib1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","article-title":"Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study","volume":"129","author":"Chugh","year":"2014","journal-title":"Circulation"},{"issue":"9989","key":"10.1016\/j.jacep.2022.11.032_bib2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0140-6736(14)61774-8","article-title":"50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study","volume":"386","author":"Schnabel","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jacep.2022.11.032_bib3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/CIRCOUTCOMES.110.958165","article-title":"Estimation of total incremental health care costs in patients with atrial fibrillation in the United States","volume":"4","author":"Kim","year":"2011","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jacep.2022.11.032_bib4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/CIRCOUTCOMES.111.962688","article-title":"Incidence and prevalence of atrial fibrillation and associated mortality among Medicare beneficiaries, 1993-2007","volume":"5","author":"Piccini","year":"2012","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jacep.2022.11.032_bib5","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.amjmed.2016.02.028","article-title":"Mortality in patients with atrial fibrillation randomized to edoxaban or warfarin: insights from the ENGAGE AF-TIMI 48 Trial","volume":"129","author":"Giugliano","year":"2016","journal-title":"Am J Med"},{"issue":"5","key":"10.1016\/j.jacep.2022.11.032_bib6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/CIRCULATIONAHA.115.018614","article-title":"Atrial fibrillation begets heart failure and vice versa: temporal associations and differences in preserved versus reduced ejection fraction","volume":"133","author":"Santhanakrishnan","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2022.11.032_bib7","doi-asserted-by":"crossref","first-page":"i4482","DOI":"10.1136\/bmj.i4482","article-title":"Atrial fibrillation and risks of cardiovascular disease, renal disease, and death: systematic review and meta-analysis","volume":"354","author":"Odutayo","year":"2016","journal-title":"BMJ"},{"issue":"46","key":"10.1016\/j.jacep.2022.11.032_bib8","first-page":"3250","article-title":"Atrial fibrillation in heart failure: what should we do?","volume":"36","author":"Kotecha","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2022.11.032_bib9","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/CIRCHEARTFAILURE.111.962688","article-title":"Atrial fibrillation and mortality in heart failure: a community study","volume":"4","author":"Chamberlain","year":"2011","journal-title":"Circ Heart Fail"},{"issue":"23","key":"10.1016\/j.jacep.2022.11.032_bib10","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1161\/01.CIR.0000072767.89944.6E","article-title":"Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study","volume":"107","author":"Wang","year":"2003","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.jacep.2022.11.032_bib11","first-page":"1182","article-title":"Angiotensin-neprilysin inhibition in heart failure with preserved ejection fraction. Reply","volume":"382","author":"Solomon","year":"2020","journal-title":"N\u00a0Engl J Med"},{"issue":"20","key":"10.1016\/j.jacep.2022.11.032_bib12","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.jacc.2016.08.048","article-title":"Heart failure with preserved ejection fraction and atrial fibrillation: vicious twins","volume":"68","author":"Kotecha","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2022.11.032_bib13","doi-asserted-by":"crossref","first-page":"2D","DOI":"10.1016\/S0002-9149(02)03373-8","article-title":"Atrial fibrillation in heart failure: epidemiology, pathophysiology, and rationale for therapy","volume":"91","author":"Maisel","year":"2003","journal-title":"Am J Cardiol"},{"issue":"9","key":"10.1016\/j.jacep.2022.11.032_bib14","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1002\/ejhf.595","article-title":"Efficacy and safety of edoxaban compared with warfarin in patients with atrial fibrillation and heart failure: insights from ENGAGE AF-TIMI 48","volume":"18","author":"Magnani","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacep.2022.11.032_bib15","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1056\/NEJMoa1310907","article-title":"Edoxaban versus warfarin in patients with atrial fibrillation","volume":"369","author":"Giugliano","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.jacep.2022.11.032_bib16","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.004267","article-title":"Stroke and mortality risk in patients with various patterns of atrial fibrillation: results from the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)","volume":"10","author":"Link","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"17","key":"10.1016\/j.jacep.2022.11.032_bib17","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.jacep.2022.11.032_bib18","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1538-7836.2009.03678.x","volume":"8","author":"Schulman","year":"2010","journal-title":"J\u00a0Thromb Haemost"},{"issue":"4","key":"10.1016\/j.jacep.2022.11.032_bib19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/eurheartj\/eht483","article-title":"Clinical course of atrial fibrillation in older adults: the importance of cardiovascular events beyond stroke","volume":"35","author":"Piccini","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2022.11.032_bib20","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/eurheartj\/ehi694","article-title":"Incidence and mortality risk of congestive heart failure in atrial fibrillation patients: a community-based study over two decades","volume":"27","author":"Miyasaka","year":"2006","journal-title":"Eur Heart J"},{"issue":"8","key":"10.1016\/j.jacep.2022.11.032_bib21","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/eurjhf\/hft041","article-title":"Risk assessment for incident heart failure in individuals with atrial fibrillation","volume":"15","author":"Schnabel","year":"2013","journal-title":"Eur J Heart Fail"},{"issue":"5","key":"10.1016\/j.jacep.2022.11.032_bib22","first-page":"923","article-title":"Relative importance of heart failure events compared to stroke and bleeding in AF patients","volume":"10","author":"Ninni","year":"2021","journal-title":"J\u00a0Clin Med"},{"issue":"3","key":"10.1016\/j.jacep.2022.11.032_bib23","article-title":"ROCKET AF Steering Committee & Investigators; ROCKET AF Steering Committee Investigators. Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrillation: data from ROCKET AF","volume":"5","author":"Pokorney","year":"2016","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"20","key":"10.1016\/j.jacep.2022.11.032_bib24","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1161\/CIRCULATIONAHA.112.000491","article-title":"Causes of death and influencing factors in patients with atrial fibrillation: a competing-risk analysis from the randomized evaluation of long-term anticoagulant therapy study","volume":"128","author":"Marijon","year":"2013","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.jacep.2022.11.032_bib25","first-page":"689","article-title":"Atrial fibrillation in heart failure with preserved ejection fraction: the TOPCAT trial","volume":"6","author":"Cikes","year":"2018","journal-title":"J\u00a0Am Coll Cardiol HF"},{"issue":"12","key":"10.1016\/j.jacep.2022.11.032_bib26","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/ejhf.1606","article-title":"Left atrial structure and function and the risk of death or heart failure in atrial fibrillation","volume":"21","author":"Inciardi","year":"2019","journal-title":"Eur J Heart Fail"},{"issue":"11","key":"10.1016\/j.jacep.2022.11.032_bib27","first-page":"1366","article-title":"Sex-specific prevalence, incidence, and mortality associated with atrial fibrillation in heart failure","volume":"7","author":"Barillas-Lara","year":"2021","journal-title":"J\u00a0Am Coll Cardiol EP"},{"issue":"11","key":"10.1016\/j.jacep.2022.11.032_bib28","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.120.006511","article-title":"Cardiovascular- and bleeding-related hospitalization rates with edoxaban versus warfarin in patients with atrial fibrillation based on results of the ENGAGE AF-TIMI 48 trial","volume":"13","author":"Vilain","year":"2020","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"3","key":"10.1016\/j.jacep.2022.11.032_bib29","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.amjmed.2009.06.033","article-title":"Atrial fibrillation in heart failure: a comprehensive review","volume":"123","author":"Deedwania","year":"2010","journal-title":"Am J Med"},{"issue":"18","key":"10.1016\/j.jacep.2022.11.032_bib30","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1161\/CIRCULATIONAHA.108.821306","article-title":"Atrial fibrillation and heart failure: treatment considerations for a dual epidemic","volume":"119","author":"Anter","year":"2009","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.jacep.2022.11.032_bib31","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.amjmed.2016.06.045","article-title":"Causes of death and influencing factors in patients with atrial fibrillation","volume":"129","author":"Fauchier","year":"2016","journal-title":"Am J Med"},{"issue":"10","key":"10.1016\/j.jacep.2022.11.032_bib32","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.amjcard.2005.07.050","article-title":"Effect of atrial fibrillation pattern on survival in a community-based cohort","volume":"96","author":"Keating","year":"2005","journal-title":"Am J Cardiol"},{"issue":"7","key":"10.1016\/j.jacep.2022.11.032_bib33","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.amjcard.2013.12.024","article-title":"Prognosis in patients hospitalized with permanent and nonpermanent atrial fibrillation in heart failure","volume":"113","author":"Taillandier","year":"2014","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2022.11.032_bib34","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrcardio.2017.153","article-title":"The ABC pathway: an integrated approach to improve AF management","volume":"14","author":"Lip","year":"2017","journal-title":"Nat Rev Cardiol"},{"issue":"11","key":"10.1016\/j.jacep.2022.11.032_bib35","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1093\/europace\/euac082","article-title":"Evaluation of the atrial fibrillation better care pathway in the ENGAGE AF-TIMI 48 trial","volume":"24","author":"Patel","year":"2022","journal-title":"Europace"},{"issue":"5","key":"10.1016\/j.jacep.2022.11.032_bib36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS)","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J"},{"issue":"8","key":"10.1016\/j.jacep.2022.11.032_bib37","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/ejhf.1946","article-title":"What should the C ('congestive heart failure') represent in the CHA2 DS2 -VASc score?","volume":"22","author":"Mulder","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacep.2022.11.032_bib38","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/CIRCHEARTFAILURE.113.000212","article-title":"Efficacy and safety of rivaroxaban in patients with heart failure and non-valvular atrial fibrillation: insights from ROCKET AF","volume":"6","author":"van Diepen","year":"2013","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacep.2022.11.032_bib39","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/eurjhf\/hft111","article-title":"Dabigatran compared with warfarin in patients with atrial fibrillation and symptomatic heart failure: a subgroup analysis of the RE-LY trial","volume":"15","author":"Ferreira","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacep.2022.11.032_bib40","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1161\/CIRCHEARTFAILURE.112.000143","article-title":"Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation: insights from the ARISTOTLE trial","volume":"6","author":"McMurray","year":"2013","journal-title":"Circ Heart Fail"},{"issue":"11","key":"10.1016\/j.jacep.2022.11.032_bib41","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.amjcard.2017.02.050","article-title":"Effect of atrial fibrillation on mortality, stroke risk, and quality-of-life scores in patients with heart failure (from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation [ORBIT-AF])","volume":"119","author":"Cherian","year":"2017","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2022.11.032_bib42","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ijcard.2015.10.220","article-title":"Atrial fibrillation and heart failure due to reduced versus preserved ejection fraction: a systematic review and meta-analysis of death and adverse outcomes","volume":"203","author":"Kotecha","year":"2016","journal-title":"Int J Cardiol"},{"issue":"5","key":"10.1016\/j.jacep.2022.11.032_bib43","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.hrthm.2017.12.001","article-title":"Catheter ablation of atrial fibrillation in patients with heart failure and preserved ejection fraction","volume":"15","author":"Black-Maier","year":"2018","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2022.11.032_bib44","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.amjcard.2020.11.039","article-title":"Meta-analysis of the usefulness of catheter ablation of atrial fibrillation in patients with heart failure with preserved ejection fraction","volume":"142","author":"Aldaas","year":"2021","journal-title":"Am J Cardiol"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X2201088X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X2201088X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:31:28Z","timestamp":1762500688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X2201088X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S2405500X2201088X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2022.11.032","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risks of Heart Failure, Stroke, and Bleeding in Atrial Fibrillation According to Heart Failure Phenotypes","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2022.11.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}