{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:13:56Z","timestamp":1790788436785,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence nationale de la recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"CNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009371","name":"Nantes University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009371","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jacep.2023.03.009","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T14:45:24Z","timestamp":1684939524000},"page":"1248-1261","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"P1","title":["Functional Epicardial Conduction Disturbances Due to a SCN5A Variant Associated With Brugada Syndrome"],"prefix":"10.1016","volume":"9","author":[{"given":"Estelle","family":"Renard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Walton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Benoist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Brette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9794-9295","authenticated-orcid":false,"given":"Gilles","family":"Bru-Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Chaigne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Charron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Constantin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Douard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Dubes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastien","family":"Guillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Magat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine E.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e9stor","family":"Pallares-Lupon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pasdois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"R\u00e9calde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Vaillant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Sacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Labrousse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Rogier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Kyndt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Baudic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Schott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Barc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Probst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Sarlandie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Marionneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse L.","family":"Ashton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9l\u00e8ze","family":"Hocini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Ha\u00efssaguerre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bernus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jacep.2023.03.009_bib1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jacc.2018.06.037","article-title":"Present status of Brugada syndrome: JACC state-of-the-art review","volume":"72","author":"Brugada","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.jacep.2023.03.009_bib2","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.115.003366","article-title":"ST-segment elevation and fractionated electrograms in Brugada syndrome patients arise from the same structurally abnormal subepicardial RVOT area but have a different mechanism","volume":"8","author":"Ten Sande","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"12","key":"10.1016\/j.jacep.2023.03.009_bib3","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1161\/CIRCULATIONAHA.110.972612","article-title":"Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium","volume":"123","author":"Nademanee","year":"2011","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.jacep.2023.03.009_bib4","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1093\/eurheartj\/ehaa942","article-title":"Brugada syndrome genetics is associated with phenotype severity","volume":"42","author":"Ciconte","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2023.03.009_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2018.09.037","article-title":"Electroanatomic and pathologic right ventricular outflow tract abnormalities in patients with Brugada syndrome","volume":"72","author":"Pieroni","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"18","key":"10.1016\/j.jacep.2023.03.009_bib6","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/j.jacc.2015.08.862","article-title":"Fibrosis, connexin-43, and conduction abnormalities in the Brugada syndrome","volume":"66","author":"Nademanee","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"18","key":"10.1016\/j.jacep.2023.03.009_bib7","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1161\/CIRCULATIONAHA.105.532614","article-title":"Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome","volume":"112","author":"Coronel","year":"2005","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.jacep.2023.03.009_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1161\/CIRCRESAHA.113.301565","article-title":"Reduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract","volume":"113","author":"Boukens","year":"2013","journal-title":"Circ Res"},{"issue":"11","key":"10.1016\/j.jacep.2023.03.009_bib9","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/eurheartj\/ehaa1051","article-title":"Brugada syndrome and reduced right ventricular outflow tract conduction reserve: a final common pathway?","volume":"42","author":"Behr","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2023.03.009_bib10","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.hrthm.2018.10.040","article-title":"Depolarization versus repolarization abnormality underlying inferolateral J-wave syndromes: new concepts in sudden cardiac death with apparently normal hearts","volume":"16","author":"Ha\u00efssaguerre","year":"2018","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2023.03.009_bib11","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.yjmcc.2010.07.012","article-title":"The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization","volume":"49","author":"Wilde","year":"2010","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jacep.2023.03.009_bib12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ccep.2018.02.009","article-title":"J-wave syndromes: electrocardiographic and clinical aspects","volume":"10","author":"Priori","year":"2018","journal-title":"Card Electrophysiol Clin"},{"issue":"19","key":"10.1016\/j.jacep.2023.03.009_bib13","first-page":"7155","article-title":"Update on genetic basis of Brugada syndrome: monogenic, polygenic or oligogenic?","volume":"21","author":"Campuzano","year":"2020","journal-title":"Int J Mil Ssi"},{"issue":"29","key":"10.1016\/j.jacep.2023.03.009_bib14","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1093\/eurheartj\/ehab254","article-title":"Functionally validated SCN5A variants allow interpretation of pathogenicity and prediction of lethal events in Brugada syndrome","volume":"42","author":"Ishikawa","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2023.03.009_bib15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41588-021-01007-6","article-title":"Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility","volume":"54","author":"Barc","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacep.2023.03.009_bib16","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/ng.2712","article-title":"Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death","volume":"45","author":"Bezzina","year":"2013","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.jacep.2023.03.009_bib17","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/eurheartj\/ehaa994","article-title":"Illuminating the path from genetics to clinical outcome in Brugada syndrome","volume":"42","author":"Postema","year":"2021","journal-title":"Eur Heart J"},{"issue":"11","key":"10.1016\/j.jacep.2023.03.009_bib18","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.jacc.2005.08.043","article-title":"High risk for bradyarrhythmic complications in patients with Brugada syndrome caused by SCN5A gene mutations","volume":"46","author":"Makiyama","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.jacep.2023.03.009_bib19","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.117.006120","article-title":"Localized structural alterations underlying a subset of unexplained sudden cardiac death","volume":"11","author":"Ha\u00efssaguerre","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"19","key":"10.1016\/j.jacep.2023.03.009_bib20","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.jacc.2014.01.067","article-title":"Abnormal repolarization as the basis for late potentials and fractionated electrograms recorded from epicardium in experimental models of Brugada syndrome","volume":"63","author":"Sz\u00e9l","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.jacep.2023.03.009_bib21","first-page":"353","article-title":"Mechanisms underlying epicardial radiofrequency ablation to suppress arrhythmogenesis in experimental models of Brugada syndrome","volume":"3","author":"Patocskai","year":"2017","journal-title":"J\u00a0Am Col Cardiol EP"},{"key":"10.1016\/j.jacep.2023.03.009_bib22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/978-3-319-17641-3_12","article-title":"Optical imaging of cardiac action potential","volume":"859","author":"Pertsov","year":"2015","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10.1016\/j.jacep.2023.03.009_bib23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1161\/01.CIR.98.1.54","article-title":"High-resolution, three-dimensional fluorescent imaging reveals multilayer conduction pattern in the atrioventricular node","volume":"98","author":"Efimov","year":"1998","journal-title":"Circulation"},{"issue":"31","key":"10.1016\/j.jacep.2023.03.009_bib24","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehy412","article-title":"SCN5A mutations in 442 neonates and children: genotype-phenotype correlation and identification of higher-risk subgroups","volume":"39","author":"Baruteau","year":"2018","journal-title":"Eur Heart J"},{"issue":"12","key":"10.1016\/j.jacep.2023.03.009_bib25","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/j.hrthm.2012.08.011","article-title":"The diagnostic and therapeutic aspects of loss-of-function cardiac sodium channelopathies in children","volume":"9","author":"Chockalingam","year":"2012","journal-title":"Heart Rhythm"},{"issue":"5373","key":"10.1016\/j.jacep.2023.03.009_bib26","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.281.5373.108","article-title":"Congenital heart disease caused by mutations in the transcription factor NKX2-5","volume":"281","author":"Schott","year":"1998","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jacep.2023.03.009_bib27","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1038\/s41467-020-19150-9","article-title":"Nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac Purkinje fiber network","volume":"11","author":"Choquet","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jacep.2023.03.009_bib28","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/s41467-018-03714-x","article-title":"NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network","volume":"9","author":"Anderson","year":"2018","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.jacep.2023.03.009_bib29","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/CIRCRESAHA.108.171835","article-title":"Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects","volume":"103","author":"Briggs","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.jacep.2023.03.009_bib30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.gene.2003.08.011","article-title":"Analysis of the rat connexin 43 proximal promoter in neonatal cardiomyocytes","volume":"322","author":"Teunissen","year":"2003","journal-title":"Gene"},{"issue":"9","key":"10.1016\/j.jacep.2023.03.009_bib31","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1093\/cvr\/cvaa082","article-title":"Heritable arrhythmia syndromes associated with abnormal cardiac sodium channel function: ionic and non-ionic mechanisms","volume":"116","author":"Rivaud","year":"2020","journal-title":"Cardiovasc Res"},{"issue":"6","key":"10.1016\/j.jacep.2023.03.009_bib32","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.120.002911","article-title":"SCN5A mutation type and a genetic risk score associate variably with Brugada syndrome phenotype in SCN5A families","volume":"13","author":"Wijeyeratne","year":"2020","journal-title":"Circ Genom Precis Med"},{"issue":"15","key":"10.1016\/j.jacep.2023.03.009_bib33","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1161\/01.CIR.0000032002.22105.7A","article-title":"Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males","volume":"106","author":"Di Diego","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2023.03.009_bib34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jelectrocard.2018.11.011","article-title":"Lack of influence of sex hormones on\u00a0Brugada syndrome-associated mutant Nav1.5\u00a0sodium channel","volume":"52","author":"Yang","year":"2019","journal-title":"J\u00a0Electrocardiol"},{"issue":"9","key":"10.1016\/j.jacep.2023.03.009_bib35","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1161\/01.RES.85.9.803","article-title":"Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent","volume":"85","author":"Dumaine","year":"1999","journal-title":"Circ Res"},{"issue":"10","key":"10.1016\/j.jacep.2023.03.009_bib36","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nrcardio.2014.85","article-title":"Cardiac sodium channel mutations: why so many phenotypes?","volume":"11","author":"Liu","year":"2014","journal-title":"Nat Rev Cardiol"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X23002074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X23002074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:32:26Z","timestamp":1762500746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X23002074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2405500X23002074"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2023.03.009","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional Epicardial Conduction Disturbances Due to a SCN5A Variant Associated With Brugada Syndrome","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2023.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}