{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:54:50Z","timestamp":1785419690891,"version":"3.56.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jacep.2023.06.011","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T14:05:36Z","timestamp":1691589936000},"page":"2096-2105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Atrial Abnormalities in Brugada\u00a0Syndrome"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3938-4948","authenticated-orcid":false,"given":"Antonio","family":"Bisignani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9769-1511","authenticated-orcid":false,"given":"Luigi","family":"Pannone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6672-4931","authenticated-orcid":false,"given":"Alvise","family":"Del Monte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Eltsov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Anna","family":"Cappello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Monaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gezim","family":"Bala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Mouram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-3462","authenticated-orcid":false,"given":"Domenico Giovanni","family":"Della Rocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Str\u00f6ker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Overeinder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Almorad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Pappaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Gauthey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomy","family":"de Ravel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Van Dooren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0078-9393","authenticated-orcid":false,"given":"Antonio","family":"Sorgente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"La Meir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sarkozy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-6106","authenticated-orcid":false,"given":"Pedro","family":"Brugada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian-Battista","family":"Chierchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9351-0760","authenticated-orcid":false,"given":"Carlo","family":"de Asmundis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jacep.2023.06.011_bib1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","article-title":"Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report","volume":"20","author":"Brugada","year":"1992","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"15","key":"10.1016\/j.jacep.2023.06.011_bib2","first-page":"1","article-title":"Long-term outcomes of pulmonary vein isolation in patients with Brugada syndrome and paroxysmal atrial fibrillation","volume":"11","author":"Bisignani","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"4","key":"10.1016\/j.jacep.2023.06.011_bib3","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1093\/europace\/eut309","article-title":"Pulmonary vein isolation in patients with Brugada syndrome and atrial fibrillation: a 2-year follow-up","volume":"16","author":"Conte","year":"2014","journal-title":"Europace"},{"issue":"3","key":"10.1016\/j.jacep.2023.06.011_bib4","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/europace\/euw428","article-title":"Long-term outcome of pulmonary vein isolation in patients with paroxysmal atrial fibrillation and Brugada syndrome","volume":"20","author":"Mugnai","year":"2018","journal-title":"Europace"},{"issue":"12","key":"10.1016\/j.jacep.2023.06.011_bib5","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1161\/CIRCULATIONAHA.110.972612","article-title":"Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium","volume":"123","author":"Nademanee","year":"2011","journal-title":"Circulation"},{"issue":"19","key":"10.1016\/j.jacep.2023.06.011_bib6","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.jacc.2014.01.067","article-title":"Abnormal repolarization as the basis for late potentials and fractionated electrograms recorded from epicardium in experimental models of Brugada syndrome","volume":"63","author":"Sz\u00e9l","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.jacep.2023.06.011_bib7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.hrthm.2021.09.032","article-title":"High-density epicardial mapping in Brugada syndrome: depolarization and repolarization abnormalities","volume":"19","author":"Pannone","year":"2022","journal-title":"Heart Rhythm"},{"issue":"4","key":"10.1016\/j.jacep.2023.06.011_bib8","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/jce.14361","article-title":"Atrial fibrillation in Brugada syndrome: current perspectives","volume":"31","author":"Vlachos","year":"2020","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"issue":"4","key":"10.1016\/j.jacep.2023.06.011_bib9","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.ccep.2014.07.006","article-title":"Atrial fibrillation and SCN5A variants","volume":"6","author":"Savio-Galimberti","year":"2014","journal-title":"Card Electrophysiol Clin"},{"issue":"6","key":"10.1016\/j.jacep.2023.06.011_bib10","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.hrthm.2022.01.034","article-title":"SCN5A mutation in Brugada syndrome is associated with substrate severity detected by electrocardiographic imaging and high-density electroanatomic mapping","volume":"19","author":"Pannone","year":"2022","journal-title":"Heart Rhythm"},{"issue":"2","key":"10.1016\/j.jacep.2023.06.011_bib11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/CIRCEP.108.789081","article-title":"Cardiac ion channels","volume":"2","author":"Grant","year":"2009","journal-title":"Circ Arrhythmia Electrophysiol"},{"issue":"8","key":"10.1016\/j.jacep.2023.06.011_bib12","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0735-1097(02)02167-8","article-title":"Atrial fibrillation and atrial vulnerability in patients with Brugada syndrome","volume":"40","author":"Morita","year":"2002","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"12","key":"10.1016\/j.jacep.2023.06.011_bib13","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1253\/circj.70.1574","article-title":"Atrial electrophysiological abnormality in patients with Brugada syndrome assessed by P-wave signal-averaged ECG and programmed atrial stimulation","volume":"70","author":"Yamada","year":"2006","journal-title":"Circ J"},{"issue":"5","key":"10.1016\/j.jacep.2023.06.011_bib14","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/CIRCRESAHA.112.279315","article-title":"Noninvasive electrocardiographic imaging of arrhythmogenic substrates in humans","volume":"112","author":"Rudy","year":"2013","journal-title":"Circ Res"},{"issue":"10","key":"10.1016\/j.jacep.2023.06.011_bib15","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.jacc.2013.03.082","article-title":"Validation of novel 3-dimensional electrocardiographic mapping of atrial tachycardias by invasive mapping and ablation: A multicenter study","volume":"62","author":"Shah","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.jacep.2023.06.011_bib16","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.005105","article-title":"Electrical and structural substrate of arrhythmogenic right ventricular cardiomyopathy determined using noninvasive electrocardiographic imaging and late gadolinium magnetic resonance imaging","volume":"10","author":"Andrews","year":"2017","journal-title":"Circ Arrhythmia Electrophysiol"},{"issue":"12","key":"10.1016\/j.jacep.2023.06.011_bib17","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1093\/europace\/euab140","article-title":"Non-invasive body surface electrocardiographic imaging for diagnosis of atrial cardiomyopathy","volume":"23","author":"Eichenlaub","year":"2021","journal-title":"Europace"},{"issue":"2","key":"10.1016\/j.jacep.2023.06.011_bib18","article-title":"Ajmaline-induced abnormalities in Brugada syndrome: evaluation with ECG imaging","volume":"11","author":"Pannone","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"40","key":"10.1016\/j.jacep.2023.06.011_bib19","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","article-title":"2022 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"43","author":"Zeppenfeld","year":"2022","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.jacep.2023.06.011_bib20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.jacep.2023.06.011_bib21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijcard.2017.09.214","article-title":"Concealed abnormal atrial phenotype in patients with Brugada syndrome and no history of atrial fibrillation","volume":"253","author":"Conte","year":"2018","journal-title":"Int J Cardiol"},{"issue":"5","key":"10.1016\/j.jacep.2023.06.011_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2023.06.011_bib23","doi-asserted-by":"crossref","first-page":"h3868","DOI":"10.1136\/bmj.h3868","article-title":"How to develop a more accurate risk prediction model when there are few events","volume":"351","author":"Pavlou","year":"2015","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.jacep.2023.06.011_bib24","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1177\/0962280216680383","article-title":"The choice of methods in determining the optimal cut-off value for quantitative diagnostic test evaluation","volume":"27","author":"Hajian-Tilaki","year":"2018","journal-title":"Stat Methods Med Res"},{"issue":"8","key":"10.1016\/j.jacep.2023.06.011_bib25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11886-015-0616-6","article-title":"Non-invasive mapping of cardiac arrhythmias","volume":"17","author":"Shah","year":"2015","journal-title":"Curr Cardiol Rep"},{"issue":"1","key":"10.1016\/j.jacep.2023.06.011_bib26","first-page":"75","article-title":"Frontiers in non-invasive cardiac mapping: future implications for arrhythmia treatment","volume":"66","author":"Frontera","year":"2018","journal-title":"Minerva Cardioangiol"},{"issue":"2","key":"10.1016\/j.jacep.2023.06.011_bib27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2459\/JCM.0000000000000723","article-title":"Abnormally high risk of stroke in Brugada syndrome","volume":"20","author":"de Asmundis","year":"2019","journal-title":"J\u00a0Cardiovasc Med"},{"issue":"9","key":"10.1016\/j.jacep.2023.06.011_bib28","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/j.1540-8159.2011.03122.x","article-title":"Increased intraatrial conduction abnormality assessed by P-wave signal-averaged electrocardiogram in patients with Brugada syndrome","volume":"34","author":"Furukawa","year":"2011","journal-title":"Pacing Clin Electrophysiol"},{"issue":"12","key":"10.1016\/j.jacep.2023.06.011_bib29","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.jacc.2007.10.060","article-title":"Atrial fibrillation in patients with Brugada syndrome. relationships of gene mutation, electrophysiology, and clinical backgrounds","volume":"51","author":"Kusano","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.jacep.2023.06.011_bib30","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1093\/europace\/eur011","article-title":"Facilitatory and inhibitory effects of SCN5A mutations on atrial fibrillation in Brugada syndrome","volume":"13","author":"Amin","year":"2011","journal-title":"Europace"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X23004462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X23004462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:32:33Z","timestamp":1762500753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X23004462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S2405500X23004462"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2023.06.011","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atrial Abnormalities in Brugada\u00a0Syndrome","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2023.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}