{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:26:24Z","timestamp":1791779184262,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.jacep.2023.10.012","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T14:32:05Z","timestamp":1700663525000},"page":"270-283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Severity of Ischemic Stroke After Left\u00a0Atrial Appendage Closure vs Nonwarfarin Oral Anticoagulants"],"prefix":"10.1016","volume":"10","author":[{"given":"Mohit K.","family":"Turagam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwanari","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Neuzil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shephal","family":"Doshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Valderrabano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Hala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-3462","authenticated-orcid":false,"given":"Domenico","family":"Della Rocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritoshi","family":"Funasako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1634-0996","authenticated-orcid":false,"given":"Bridget","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Musikantow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Flautt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Dukkipati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5487-0728","authenticated-orcid":false,"given":"Andrea","family":"Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut E.","family":"Gurol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Halperin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek Y.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacep.2023.10.012_bib1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.amjcard.2012.11.026","article-title":"Frequency, patient characteristics, treatment strategies, and resource usage of atrial fibrillation (from the Italian Survey of Atrial Fibrillation Management [ISAF] study)","volume":"111","author":"Zoni-Berisso","year":"2013","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2023.10.012_bib2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1161\/01.STR.0000153002.56324.8c","article-title":"Are cost benefits of anticoagulation for stroke prevention in atrial fibrillation underestimated?","volume":"36","author":"Miller","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.jacep.2023.10.012_bib3","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials","volume":"383","author":"Ruff","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jacep.2023.10.012_bib4","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/ijs.12473","article-title":"Antithrombotic treatment at onset of stroke with atrial fibrillation, functional outcome, and fatality: a systematic review and meta-analysis","volume":"10","author":"Hannon","year":"2015","journal-title":"Int J Stroke"},{"issue":"12","key":"10.1016\/j.jacep.2023.10.012_bib5","first-page":"3563","article-title":"Admission severity of atrial-fibrillation-related acute ischemic stroke in patients under anticoagulation treatment: a systematic review and meta-analysis","volume":"11","author":"Garcia","year":"2022","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.jacep.2023.10.012_bib6","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1055\/s-0038-1675602","article-title":"Stroke severity in patients on non-vitamin k antagonist oral anticoagulants with a standard or insufficient dose","volume":"118","author":"Jung","year":"2018","journal-title":"Thromb Haem"},{"key":"10.1016\/j.jacep.2023.10.012_bib7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/europace\/eux087","article-title":"Non-vitamin K-dependent oral anticoagulants have a positive impact on ischaemic stroke severity in patients with atrial fibrillation","volume":"20","author":"Hellwig","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2023.10.012_bib8","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1001\/jama.2017.1371","article-title":"Association of preceding antithrombotic treatment with acute ischemic stroke severity and in-hospital outcomes among patients with atrial fibrillation","volume":"317","author":"Xian","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jacep.2023.10.012_bib9","article-title":"Association between inappropriately dosed anticoagulation therapy with stroke severity and outcomes in patients with atrial fibrillation","volume":"11","author":"Vinding","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacep.2023.10.012_bib10","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1161\/STROKEAHA.120.030138","article-title":"Initial stroke severity in patients with atrial fibrillation according to antithrombotic therapy before ischemic stroke","volume":"51","author":"Jung","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.jacep.2023.10.012_bib11","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1016\/j.jacc.2020.08.089","article-title":"Left atrial appendage closure versus oral anticoagulants in atrial fibrillation: a meta-analysis of randomized trials","volume":"76","author":"Turagam","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2023.10.012_bib12","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1016\/j.jacc.2017.10.021","article-title":"5-year outcomes after left atrial appendage closure: from the PREVAIL and PROTECT AF Trials","volume":"70","author":"Reddy","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2023.10.012_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2021.10.023","article-title":"4-year outcomes after left atrial appendage closure versus nonwarfarin oral anticoagulation for atrial fibrillation","volume":"79","author":"Osmancik","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2023.10.012_bib14","article-title":"Hemorrhagic transformation in patients with acute ischemic stroke and atrial fibrillation: time to initiation of oral anticoagulant therapy and outcomes","volume":"7","author":"Paciaroni","year":"2018","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacep.2023.10.012_bib15","first-page":"4","article-title":"Percutaneous left atrial appendage occlusion: the Munich consensus document on definitions, endpoints, and data collection requirements for clinical studies","volume":"19","author":"Tzikas","year":"2017","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2023.10.012_bib16","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1161\/STROKEAHA.107.510321","article-title":"Early hemorrhagic transformation of brain infarction: rate, predictive factors, and influence on clinical outcome: results of a prospective multicenter study","volume":"39","author":"Paciaroni","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.jacep.2023.10.012_bib17","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.ehj.2004.06.030","article-title":"Stroke patients with atrial fibrillation have a worse prognosis than patients without: data from the Austrian Stroke registry","volume":"25","author":"Steger","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2023.10.012_bib18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/01.STR.32.2.392","article-title":"Characteristics, outcome, and care of stroke associated with atrial fibrillation in Europe: data from a multicenter multinational hospital-based registry (The European Community Stroke Project)","volume":"32","author":"Lamassa","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.jacep.2023.10.012_bib19","article-title":"Ischemic stroke severity and mortality in patients with and without atrial fibrillation","volume":"11","author":"Vinding","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacep.2023.10.012_bib20","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0002-9343(02)01063-X","article-title":"Stroke severity in patients with atrial fibrillation","volume":"112","author":"Penado","year":"2002","journal-title":"Am J Med"},{"key":"10.1016\/j.jacep.2023.10.012_bib21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1159\/000316886","article-title":"Pathophysiological determinants of worse stroke outcome in atrial fibrillation","volume":"30","author":"Tu","year":"2010","journal-title":"Cerebrovasc Dis (Basel, Switzerland)"},{"key":"10.1016\/j.jacep.2023.10.012_bib22","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.09.019","article-title":"Adequate adherence to direct oral anticoagulant is associated with reduced ischemic stroke severity in patients with atrial fibrillation","volume":"28","author":"Yamashiro","year":"2019","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.jacep.2023.10.012_bib23","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/ana.21456","article-title":"Admission international normalized ratio and acute infarct volume in ischemic stroke","volume":"64","author":"Ay","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jacep.2023.10.012_bib24","article-title":"Prior direct oral anticoagulant therapy is related to small infarct volume and no major artery occlusion in patients with stroke and non-valvular atrial fibrillation","volume":"7","author":"Sakamoto","year":"2018","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacep.2023.10.012_bib25","first-page":"E23","article-title":"Favorable neurological outcome after ischemic cerebrovascular events in patients treated with percutaneous left atrial appendage occlusion compared with warfarin","volume":"94","author":"Lee","year":"2019","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jacep.2023.10.012_bib26","doi-asserted-by":"crossref","first-page":"626","DOI":"10.4070\/kcj.2020.0527","article-title":"Percutaneous left atrial appendage occlusion yields favorable neurological outcomes in patients with non-valvular atrial fibrillation","volume":"51","author":"Lee","year":"2021","journal-title":"Kor Circ J"},{"key":"10.1016\/j.jacep.2023.10.012_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jcin.2020.09.051","article-title":"Clinical outcomes associated with left atrial appendage occlusion versus direct oral anticoagulation in atrial fibrillation","volume":"14","author":"Nielsen-Kudsk","year":"2021","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacep.2023.10.012_bib28","article-title":"Percutaneous left atrial appendage occlusion in comparison to non-vitamin K antagonist oral anticoagulant among patients with atrial fibrillation","volume":"11","author":"Noseworthy","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacep.2023.10.012_bib29","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/CIRCULATIONAHA.122.062765","article-title":"Comparative effectiveness of left atrial appendage occlusion versus oral anticoagulation by sex","volume":"147","author":"Zeitler","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2023.10.012_bib30","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/ene.12126","article-title":"Hemorrhagic transformation in patients with acute ischaemic stroke and an indication for anticoagulation","volume":"20","author":"Marsh","year":"2013","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.jacep.2023.10.012_bib31","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1185\/03007990903196422","article-title":"Retrospective study of total healthcare costs associated with chronic nonvalvular atrial fibrillation and the occurrence of a first transient ischemic attack, stroke or major bleed","volume":"25","author":"Boccuzzi","year":"2009","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.jacep.2023.10.012_bib32","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1212\/WNL.0b013e31826e9b9d","article-title":"Breaking down barriers to identify hemorrhagic transformation in ischemic stroke","volume":"79","author":"Jickling","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.jacep.2023.10.012_bib33","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1161\/01.STR.0000028456.18614.93","article-title":"Anticoagulants and antiplatelet agents in acute ischemic stroke: report of the Joint Stroke Guideline Development Committee of the American Academy of Neurology and the American Stroke Association (a division of the American Heart Association)","volume":"33","author":"Coull","year":"2002","journal-title":"Stroke"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X23008034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X23008034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:33:33Z","timestamp":1762500813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X23008034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S2405500X23008034"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2023.10.012","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Severity of Ischemic Stroke After Left\u00a0Atrial Appendage Closure vs Nonwarfarin Oral Anticoagulants","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2023.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}