{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:40:37Z","timestamp":1790350837808,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Netherlands Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.jacep.2024.03.003","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T08:04:56Z","timestamp":1711958696000},"page":"1326-1340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"P1","title":["Circulating BMP10 Levels Associate With Late Postoperative Atrial Fibrillation and Left Atrial Endomysial Fibrosis"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-3946","authenticated-orcid":false,"given":"Joris","family":"Winters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal J.","family":"Kawczynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn D.","family":"Gilbers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stef","family":"Zeemering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Bidar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Maesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Rienstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"van Gelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Verheule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos G.","family":"Maessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Schotten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacep.2024.03.003_bib1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2024.03.003_bib2","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1093\/eurheartj\/ehw054","article-title":"The ABC (age, biomarkers, clinical history) stroke risk score: a biomarker-based risk score for predicting stroke in atrial fibrillation","volume":"37","author":"Hijazi","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2024.03.003_bib3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/eurheartj\/ehx584","article-title":"A\u00a0biomarker-based risk score to predict death in patients with atrial fibrillation: the ABC (age, biomarkers, clinical history) death risk score","volume":"39","author":"Hijazi","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2024.03.003_bib4","article-title":"Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation","volume":"5","author":"Reyad","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jacep.2024.03.003_bib5","article-title":"Association of bone morphogenetic protein 10 and recurrent atrial fibrillation after catheter ablation","volume":"25","author":"Hennings","year":"2023","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2024.03.003_bib6","article-title":"Bone morphogenetic protein 10: a novel biomarker to predict adverse outcomes in patients with atrial fibrillation","volume":"12","author":"Hennings","year":"2023","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacep.2024.03.003_bib7","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/eurheartj\/ehac632","article-title":"Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation","volume":"44","author":"Hijazi","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2024.03.003_bib8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s12471-021-01538-x","article-title":"Reappraisal of Atrial fibrillation: interaction between hypercoagulability, Electrical remodelling and Vascular destabilization in the progression of AF (RACE V) Tissue Bank Project: study design","volume":"29","author":"Gilbers","year":"2021","journal-title":"Neth Heart J"},{"key":"10.1016\/j.jacep.2024.03.003_bib9","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1093\/eurheartj\/ehy815","article-title":"Data-driven discovery and validation of circulating blood-based biomarkers associated with prevalent atrial fibrillation","volume":"40","author":"Chua","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2024.03.003_bib10","doi-asserted-by":"crossref","first-page":"f321","DOI":"10.1093\/europace\/eux272","article-title":"Adapting detection sensitivity based on evidence of irregular sinus arrhythmia to improve atrial fibrillation detection in insertable cardiac monitors","volume":"20","author":"P\u00fcrerfellner","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2024.03.003_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76932-3","article-title":"JavaCyte, a novel open-source tool for automated quantification of key hallmarks of cardiac structural remodeling","volume":"10","author":"Winters","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacep.2024.03.003_bib12","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1093\/europace\/euab136","article-title":"Clinical and electrophysiological predictors of device-detected new-onset atrial fibrillation during 3 years after cardiac surgery","volume":"23","author":"Bidar","year":"2021","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2024.03.003_bib13","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/biomet\/81.3.515","article-title":"Proportional hazards tests and diagnostics based on weighted residuals","volume":"81","author":"Grambsch","year":"1994","journal-title":"Biometrical"},{"key":"10.1016\/j.jacep.2024.03.003_bib14","article-title":"Heart failure, female sex, and atrial fibrillation are the main drivers of human atrial cardiomyopathy: results from the CATCH ME consortium","volume":"12","author":"Winters","year":"2023","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacep.2024.03.003_bib15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/sj.hdy.6800717","article-title":"Adjusting multiple testing in multilogues analyses using the eigenvalues of a correlation matrix","volume":"95","author":"Li","year":"2005","journal-title":"Heredity (Edinb.)"},{"key":"10.1016\/j.jacep.2024.03.003_bib16","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1038\/s41598-022-05769-9","article-title":"Biomarkers associated with rhythm status after cardioversion in patients with atrial fibrillation","volume":"12","author":"Meyre","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacep.2024.03.003_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-42331-7","article-title":"An angiopoietin 2, FGF23, and BMP10 biomarker signature differentiates atrial fibrillation from other concomitant cardiovascular conditions","volume":"13","author":"Chua","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacep.2024.03.003_bib18","doi-asserted-by":"crossref","first-page":"19877","DOI":"10.1074\/jbc.RA119.010943","article-title":"BMP10 preserves cardiac function through its dual activation of SMAD-mediated and STAT3-mediated pathways","volume":"294","author":"Qu","year":"2019","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jacep.2024.03.003_bib19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41420-021-00788-3","article-title":"Gs\u03b1 deficiency facilitates cardiac remodeling via CREB\/ Bmp10-mediated signaling","volume":"7","author":"Yin","year":"2021","journal-title":"Cell Death Disco"},{"key":"10.1016\/j.jacep.2024.03.003_bib20","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00078-2019","article-title":"Finding the needle in the haystack: BMP9 and 10 emerge from the genome in pulmonary arterial hypertension","volume":"53","author":"Morrell","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jacep.2024.03.003_bib21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3390\/diagnostics13020242","article-title":"Identification of BMP10 as a novel gene contributing to dilated cardiomyopathy","volume":"13","author":"Gu","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.jacep.2024.03.003_bib22","first-page":"1868","article-title":"Bone morphogenetic protein-10 induces cardiomyocyte proliferation and improves cardiac function after myocardial infarction","volume":"115","author":"Sun","year":"2014","journal-title":"J\u00a0Cell Beachem"},{"key":"10.1016\/j.jacep.2024.03.003_bib23","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1161\/HYPERTENSIONAHA.111.00562","article-title":"Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy","volume":"61","author":"Sun","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.jacep.2024.03.003_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1125642","article-title":"Insights into bone morphogenetic proteins in cardiovascular diseases","volume":"14","author":"Ye","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jacep.2024.03.003_bib25","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/s41467-020-15425-3","article-title":"Molecular basis of ALK1-mediated signaling by BMP9\/BMP10 and their prodomain-bound forms","volume":"11","author":"Salmon","year":"2020","journal-title":"Nat Common"},{"key":"10.1016\/j.jacep.2024.03.003_bib26","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.12659\/MSM.897560","article-title":"Bone morphogenetic protein-7 antagonizes myocardial fibrosis induced by atrial fibrillation by restraining transforming growth factor-\u03b2 (TGF-\u03b2)\/Smad\u2019s signaling","volume":"22","author":"Chen","year":"2016","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.jacep.2024.03.003_bib27","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.3390\/ijms24021756","article-title":"Signaling pathways and potential therapeutic strategies in cardiac fibrosis","volume":"24","author":"Bertaud","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jacep.2024.03.003_bib28","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1111\/j.1582-4934.2012.01538.x","article-title":"Up-regulation of BMP-2 antagonizes TGF-\u03b21\/ROCK-enhanced cardiac fibrotic signaling through activation of Smurf1\/Smad6 complex","volume":"16","author":"Wang","year":"2012","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1016\/j.jacep.2024.03.003_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112910","article-title":"BMP7-based peptide agonists of BMPR1A protect the left ventricle against pathological remodeling induced by pressure overload","volume":"149","author":"Salido-Medina","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jacep.2024.03.003_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1620\/tjem.244.1","article-title":"Exogenous BMP-7 facilitates the recovery of cardiac function after acute myocardial infarction through counteracting TGF\u03b21 signaling pathway","volume":"244","author":"Jin","year":"2018","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.jacep.2024.03.003_bib31","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/CIRCULATIONAHA.117.031635","article-title":"Bone morphogenetic protein 9 reduces cardiac fibrosis and improves cardiac function in heart failure","volume":"138","author":"Morine","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2024.03.003_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173291","article-title":"New insights into BMP9 signaling in organ fibrosis","volume":"882","author":"Tang","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jacep.2024.03.003_bib33","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/europace\/euac026","article-title":"Endomysial fibrosis, rather than overall connective tissue content, is the main determinant of conduction disturbances in human atrial fibrillation","volume":"24","author":"Maesen","year":"2022","journal-title":"Europace\/"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X24001841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X24001841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T03:27:43Z","timestamp":1738034863000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X24001841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2405500X24001841"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2024.03.003","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating BMP10 Levels Associate With Late Postoperative Atrial Fibrillation and Left Atrial Endomysial Fibrosis","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2024.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}