{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:47:59Z","timestamp":1792118879754,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jacep.2025.01.004","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T14:22:00Z","timestamp":1739370120000},"page":"894-903","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Burden of Premature Ventricular Complexes and Risk of Cardiomyopathy"],"prefix":"10.1016","volume":"11","author":[{"given":"Sarah","family":"Slaven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lohit","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafay","family":"Sabzwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Tumolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Cerbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6435-5746","authenticated-orcid":false,"given":"Amneet","family":"Sandhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Zipse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Tzou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacep.2025.01.004_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jacc.2015.04.062","article-title":"Ventricular ectopy as a predictor of heart failure and death","volume":"66","author":"Dukes","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2025.01.004_bib2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.7326\/0003-4819-117-12-990","article-title":"Prognostic implications of asymptomatic ventricular arrhythmias: the Framingham Heart Study","volume":"117","author":"Bikkina","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jacep.2025.01.004_bib3","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.amjcard.2005.11.067","article-title":"Ventricular arrhythmias and risk of death and acute myocardial infarction in apparently healthy subjects of age >or=55 years","volume":"97","author":"Sajadieh","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2025.01.004_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.amjcard.2011.08.009","article-title":"Relation of ventricular premature complexes to heart failure (from the Atherosclerosis Risk In Communities [ARIC] Study)","volume":"109","author":"Agarwal","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2025.01.004_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10840-019-00664-2","article-title":"2019 HRS\/EHRA\/APHRS\/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: executive summary","volume":"59","author":"Cronin","year":"2020","journal-title":"J Interv Card Electrophysiol"},{"issue":"14","key":"10.1016\/j.jacep.2025.01.004_bib6","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1016\/j.jacc.2017.10.054","volume":"72","author":"Al-Khatib","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2025.01.004_bib7","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1161\/CIRCULATIONAHA.119.042434","article-title":"Evaluation and management of premature ventricular complexes","volume":"141","author":"Marcus","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2025.01.004_bib8","first-page":"537","article-title":"Premature ventricular complex-induced cardiomyopathy","volume":"5","author":"Latchamsetty","year":"2019","journal-title":"J Am Coll Cardiol EP"},{"key":"10.1016\/j.jacep.2025.01.004_bib9","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.hrthm.2010.03.036","article-title":"Relationship between burden of premature ventricular complexes and left ventricular function","volume":"7","author":"Baman","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2025.01.004_bib10","first-page":"869","article-title":"\u2018Frequent\u2019 ventricular bigeminy\u2013a reversible cause of dilated cardiomyopathy. How frequent is \u2018frequent\u2019?","volume":"8","author":"Shanmugam","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2025.01.004_bib11","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/oxfordjournals.eurheartj.a015174","article-title":"Survival and incidence of myocardial infarction in men with ambulatory ECG-detected frequent and complex ventricular arrhythmias. 10 year follow-up of the 'Men born 1914' study in Malm\u00f6, Sweden","volume":"18","author":"Hedblad","year":"1997","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2025.01.004_bib12","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1056\/NEJM197710062971404","article-title":"Ventricular premature beats and mortality after myocardial infarction","volume":"297","author":"Ruberman","year":"1977","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacep.2025.01.004_bib13","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1001\/jama.288.24.3115","article-title":"Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial","volume":"288","author":"Wilkoff","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.jacep.2025.01.004_bib14","doi-asserted-by":"crossref","DOI":"10.2174\/2772432816666210901111616","article-title":"Pacemaker induced cardiomyopathy: an overview of current literature","volume":"18","author":"Gavaghan","year":"2022","journal-title":"Curr Cardiol Rev"},{"key":"10.1016\/j.jacep.2025.01.004_bib15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-1-4939-8597-5_24","article-title":"Canine model of pacing-induced heart failure","volume":"1816","author":"Powers","year":"2018","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jacep.2025.01.004_bib16","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0735-1097(96)00592-X","article-title":"Tachycardia-induced cardiomyopathy: a review of animal models and clinical studies","volume":"29","author":"Shinbane","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2025.01.004_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM199507133330201","article-title":"Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia","volume":"333","author":"Singh","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacep.2025.01.004_bib18","first-page":"116","article-title":"Multicenter outcomes for catheter ablation of idiopathic premature ventricular complexes","volume":"1","author":"Latchamsetty","year":"2015","journal-title":"J Am Coll Cardiol EP"},{"key":"10.1016\/j.jacep.2025.01.004_bib19","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0025-6196(11)63724-5","article-title":"Suppression of frequent premature ventricular contractions and improvement of left ventricular function in patients with presumed idiopathic dilated cardiomyopathy","volume":"73","author":"Duffee","year":"1998","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"10.1016\/j.jacep.2025.01.004_bib20","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1540-8167.2000.tb01802.x","article-title":"First evidence of premature ventricular complex-induced cardiomyopathy: a potentially reversible cause of heart failure","volume":"11","author":"Chugh","year":"2000","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacep.2025.01.004_bib21","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1253\/circj.66.1065","article-title":"A case of cardiomyopathy induced by premature ventricular complexes","volume":"66","author":"Shiraishi","year":"2002","journal-title":"Circ J"},{"issue":"9","key":"10.1016\/j.jacep.2025.01.004_bib22","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cpcardiol.2015.03.002","article-title":"Premature ventricular complexes and premature ventricular complex induced cardiomyopathy","volume":"40","author":"Latchamsetty","year":"2015","journal-title":"Curr Probl Cardiol"},{"key":"10.1016\/j.jacep.2025.01.004_bib23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.hrthm.2011.08.015","article-title":"Relation of symptoms and symptom duration to premature ventricular complex-induced cardiomyopathy","volume":"9","author":"Yokokawa","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2025.01.004_bib24","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.hrthm.2012.04.036","article-title":"Impact of QRS duration of frequent premature ventricular complexes on the development of cardiomyopathy","volume":"9","author":"Yokokawa","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2025.01.004_bib25","first-page":"1283","article-title":"Post-extrasystolic potentiation as a predictor of recovery of left ventricular dysfunction after radiofrequency catheter ablation","volume":"3","author":"Krishnan","year":"2017","journal-title":"J Am Coll Cardiol EP"},{"key":"10.1016\/j.jacep.2025.01.004_bib26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.hrthm.2013.10.055","article-title":"Ventricular premature depolarization QRS duration as a new marker of risk for the development of ventricular premature depolarization\u2013induced cardiomyopathy","volume":"11","author":"Pol","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2025.01.004_bib27","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1540-8167.2011.02021.x","article-title":"Characteristics of premature ventricular complexes as correlates of reduced left ventricular systolic function: study of the burden, duration, coupling interval, morphology and site of origin of PVCs","volume":"22","author":"Del Carpio Munoz","year":"2011","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"5","key":"10.1016\/j.jacep.2025.01.004_bib28","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1161\/CIRCEP.115.003047","article-title":"Abnormal left ventricular mechanics of ventricular ectopic beats: insights into origin and coupling interval in premature ventricular contraction\u2013induced cardiomyopathy","volume":"8","author":"Potfay","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacep.2025.01.004_bib29","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.hroo.2023.07.008","article-title":"Left ventricular remodeling in premature ventricular contraction\u2013induced cardiomyopathy: effect of coupling intervals and atrioventricular dissociation","volume":"4","author":"Shoureshi","year":"2023","journal-title":"Heart Rhythm O2"},{"key":"10.1016\/j.jacep.2025.01.004_bib30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1023\/A:1025418531853","article-title":"The influence of premature ventricular contractions on left ventricular function in asymptomatic children without structural heart disease: an echocardiographic evaluation","volume":"19","author":"Sun","year":"2003","journal-title":"Int J Cardiovasc Imaging"},{"issue":"1","key":"10.1016\/j.jacep.2025.01.004_bib31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.15420\/aer.2015.29.2","article-title":"Post-extrasystolic potentiation: link between Ca2+ homeostasis and heart failure?","volume":"5","author":"Sprenkeler","year":"2016","journal-title":"Arrhythm Electrophysiol Rev"},{"key":"10.1016\/j.jacep.2025.01.004_bib32","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/europace\/euaa025","article-title":"Post-extrasystolic potentiation as a predictor of premature ventricular contraction\u2013cardiomyopathy in an animal model","volume":"22","author":"Kowlgi","year":"2020","journal-title":"EP Europace"},{"key":"10.1016\/j.jacep.2025.01.004_bib33","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1016\/j.jacc.2018.09.059","article-title":"Left ventricular dyssynchrony predicts the cardiomyopathy associated with premature ventricular contractions","volume":"72","author":"Walters","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2025.01.004_bib34","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.hrthm.2014.07.022","article-title":"Cellular mechanism of premature ventricular contraction\u2013induced cardiomyopathy","volume":"11","author":"Wang","year":"2014","journal-title":"Heart Rhythm"},{"issue":"10","key":"10.1016\/j.jacep.2025.01.004_bib35","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.hrthm.2024.03.1813","article-title":"Catheter ablation of parahisian premature ventricular complexes in patients with and without cardiac scar","volume":"21","author":"Simpson","year":"2024","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2025.01.004_bib36","doi-asserted-by":"crossref","first-page":"128","DOI":"10.15420\/aer.2018.23.2","article-title":"Premature ventricular complex-induced cardiomyopathy","volume":"7","author":"Panizo","year":"2018","journal-title":"Arrhythm Electrophysiol Rev"},{"key":"10.1016\/j.jacep.2025.01.004_bib37","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.hrthm.2015.07.038","article-title":"Effect of circadian variability in frequency of premature ventricular complexes on left ventricular function","volume":"13","author":"Bas","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2025.01.004_bib38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.hrthm.2017.07.034","article-title":"Circadian variability patterns predict and guide premature ventricular contraction ablation procedural inducibility and outcomes","volume":"15","author":"Hamon","year":"2018","journal-title":"Heart Rhythm"},{"issue":"2","key":"10.1016\/j.jacep.2025.01.004_bib39","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.004662","article-title":"Incidence of idiopathic ventricular arrhythmias: a population-based study","volume":"10","author":"Sirichand","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"4","key":"10.1016\/j.jacep.2025.01.004_bib40","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1540-8159.2011.03324.x","article-title":"Late gadolinium enhancement CMR in patients with tachycardia-induced cardiomyopathy caused by idiopathic ventricular arrhythmias","volume":"35","author":"Hasdemir","year":"2012","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.jacep.2025.01.004_bib41","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/CIRCEP.111.962381","article-title":"Left ventricular systolic dysfunction induced by ventricular ectopy: a novel model for premature ventricular contraction-induced cardiomyopathy","volume":"4","author":"Huizar","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X25000143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X25000143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:33:00Z","timestamp":1777707180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X25000143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2405500X25000143"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2025.01.004","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Burden of Premature Ventricular Complexes and Risk of Cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2025.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}