{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T12:40:51Z","timestamp":1777120851130,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jacep.2025.06.031","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:04:05Z","timestamp":1756281845000},"page":"2471-2480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Clinical Significance of Atrial Fibrillation in Non\u2013High-Risk Brugada Syndrome"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-1938","authenticated-orcid":false,"given":"Marco","family":"Bergonti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Sacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7468-2054","authenticated-orcid":false,"given":"Bernard","family":"Belhassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Sarquella-Brugada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0424-6393","authenticated-orcid":false,"given":"Elena","family":"Arbelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4295-6679","authenticated-orcid":false,"given":"Avi","family":"Sabbag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia","family":"Crotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Tfelt-Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Faccenda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Casella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos P.","family":"Letsas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0367-1048","authenticated-orcid":false,"given":"Peter J.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Monaco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Scheirlynck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9769-1511","authenticated-orcid":false,"given":"Luigi","family":"Pannone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Cal\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luce","family":"Caputo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1160-4064","authenticated-orcid":false,"given":"Paola","family":"Berne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Vicentini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tardu","family":"Oezkartal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Migliore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6683-6781","authenticated-orcid":false,"given":"Sergio","family":"Conti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1924-6548","authenticated-orcid":false,"given":"Paolo","family":"Compagnucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7739-4042","authenticated-orcid":false,"given":"Chiara","family":"Scrocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-6106","authenticated-orcid":false,"given":"Pedro","family":"Brugada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"de Asmundis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8500-8313","authenticated-orcid":false,"given":"Claudio","family":"Tondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Brugada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Probst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elijah R.","family":"Behr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2248-3456","authenticated-orcid":false,"given":"Giulio","family":"Conte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jacep.2025.06.031_bib1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jacc.2018.06.037","article-title":"Present status of Brugada syndrome: JACC State-of-the-Art Review","volume":"72","author":"Brugada","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"10.1016\/j.jacep.2025.06.031_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/europace\/euae288","article-title":"aTrial arrhythmias in inhEriTed aRrhythmIa Syndromes: results from the TETRIS study","volume":"26","author":"Conte","year":"2024","journal-title":"Europace"},{"issue":"2","key":"10.1016\/j.jacep.2025.06.031_bib3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.hrthm.2013.10.043","article-title":"Atrial fibrillation in a large population with Brugada electrocardiographic pattern: prevalence, management, and correlation with prognosis","volume":"11","author":"Giustetto","year":"2014","journal-title":"Heart Rhythm"},{"issue":"10","key":"10.1016\/j.jacep.2025.06.031_bib4","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.ehj.2004.01.004","article-title":"Incidence, clinical implications and prognosis of atrial arrhythmias in Brugada syndrome","volume":"25","author":"Bordachar","year":"2004","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.jacep.2025.06.031_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/anec.12676","article-title":"Atrial fibrillation and risk of major arrhythmic events in Brugada syndrome: a meta-analysis","volume":"24","author":"Kewcharoen","year":"2019","journal-title":"Ann Noninvasive Electrocardiol"},{"issue":"4","key":"10.1016\/j.jacep.2025.06.031_bib6","doi-asserted-by":"crossref","first-page":"e295","DOI":"10.1016\/j.hrthm.2016.05.024","article-title":"J-Wave syndromes expert consensus conference report: emerging concepts and gaps in knowledge","volume":"13","author":"Antzelevitch","year":"2016","journal-title":"Heart Rhythm"},{"issue":"1","key":"10.1016\/j.jacep.2025.06.031_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.122.011360","article-title":"Characteristics of patients with spontaneous versus drug-induced Brugada electrocardiogram: sub-analysis from the SABRUS","volume":"16","author":"Milman","year":"2023","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"40","key":"10.1016\/j.jacep.2025.06.031_bib8","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","article-title":"2022 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"43","author":"Zeppenfeld","year":"2022","journal-title":"Eur Heart J"},{"issue":"36","key":"10.1016\/j.jacep.2025.06.031_bib9","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"Van Gelder","year":"2024","journal-title":"Eur Heart J"},{"issue":"3","key":"10.1016\/j.jacep.2025.06.031_bib10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1542-474X.2008.00230.x","article-title":"Prevalence of supraventricular tachyarrhythmias in a cohort of 115 patients with Brugada syndrome","volume":"13","author":"Schimpf","year":"2008","journal-title":"Ann Noninvasive Electrocardiol"},{"issue":"10","key":"10.1016\/j.jacep.2025.06.031_bib11","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.jacep.2023.06.011","article-title":"Atrial abnormalities in Brugada syndrome: evaluation with ECG imaging","volume":"9","author":"Bisignani","year":"2023","journal-title":"JACC Clin Electrophysiol"},{"issue":"8","key":"10.1016\/j.jacep.2025.06.031_bib12","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0735-1097(02)02167-8","article-title":"Atrial fibrillation and atrial vulnerability in patients with Brugada syndrome","volume":"40","author":"Morita","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.jacep.2025.06.031_bib13","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.ccep.2014.07.006","article-title":"Atrial fibrillation and SCN5A variants","volume":"6","author":"Savio-Galimberti","year":"2014","journal-title":"Card Electrophysiol Clin"},{"issue":"4","key":"10.1016\/j.jacep.2025.06.031_bib14","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/jce.14361","article-title":"Atrial fibrillation in Brugada syndrome: current perspectives","volume":"31","author":"Vlachos","year":"2020","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"7","key":"10.1016\/j.jacep.2025.06.031_bib15","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1093\/europace\/eur011","article-title":"Facilitatory and inhibitory effects of SCN5A mutations on atrial fibrillation in Brugada syndrome","volume":"13","author":"Amin","year":"2011","journal-title":"Europace"},{"issue":"15","key":"10.1016\/j.jacep.2025.06.031_bib16","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1161\/CIRCULATIONAHA.107.757955","article-title":"Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation","volume":"117","author":"Darbar","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2025.06.031_bib17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijcard.2017.09.214","article-title":"Concealed abnormal atrial phenotype in patients with Brugada syndrome and no history of atrial fibrillation","volume":"253","author":"Conte","year":"2018","journal-title":"Int J Cardiol"},{"issue":"11","key":"10.1016\/j.jacep.2025.06.031_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euad334","article-title":"Identification of Brugada syndrome based on P-wave features: an artificial intelligence-based approach","volume":"25","author":"Zanchi","year":"2023","journal-title":"Europace"},{"issue":"12","key":"10.1016\/j.jacep.2025.06.031_bib19","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.jacc.2007.10.060","article-title":"Atrial fibrillation in patients with Brugada syndrome relationships of gene mutation, electrophysiology, and clinical backgrounds","volume":"51","author":"Kusano","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.jacep.2025.06.031_bib20","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/europace\/eum110","article-title":"Clinical predictors of atrial fibrillation in Brugada syndrome","volume":"9","author":"Babai Bigi","year":"2007","journal-title":"Europace"},{"issue":"12","key":"10.1016\/j.jacep.2025.06.031_bib21","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1111\/j.1540-8167.2007.00971.x","article-title":"Clinical characteristics and risk stratification in symptomatic and asymptomatic patients with Brugada syndrome: multicenter study in Japan","volume":"18","author":"Takagi","year":"2007","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"4","key":"10.1016\/j.jacep.2025.06.031_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.123.012374","article-title":"Genetic testing in Brugada syndrome: a 30-year experience","volume":"17","author":"Pannone","year":"2024","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"1","key":"10.1016\/j.jacep.2025.06.031_bib23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.15420\/aer.2019.4.2","article-title":"The atrial phenotype of the inherited primary arrhythmia syndromes","volume":"8","author":"Conte","year":"2019","journal-title":"Arrhythm Electrophysiol Rev"},{"issue":"9","key":"10.1016\/j.jacep.2025.06.031_bib24","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.amjcard.2017.01.039","article-title":"Long-term follow-up of probands with Brugada syndrome","volume":"119","author":"de Asmundis","year":"2017","journal-title":"Am J Cardiol"},{"issue":"20","key":"10.1016\/j.jacep.2025.06.031_bib25","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.jacc.2014.01.072","article-title":"Electrocardiographic parameters and fatal arrhythmic events in patients with Brugada syndrome: combination of depolarization and repolarization abnormalities","volume":"63","author":"Tokioka","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"10.1016\/j.jacep.2025.06.031_bib26","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.jacc.2016.01.024","article-title":"A new electrocardiographic marker of sudden death in Brugada syndrome: the S-wave in lead I","volume":"67","author":"Cal\u00f2","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"14","key":"10.1016\/j.jacep.2025.06.031_bib27","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.jacc.2019.01.048","article-title":"Characterization and management of arrhythmic events in young patients with Brugada syndrome","volume":"73","author":"Michowitz","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2025.06.031_bib28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ijcard.2020.05.007","article-title":"Incidence and predictors of atrial fibrillation in a Chinese cohort of Brugada syndrome","volume":"314","author":"Tse","year":"2020","journal-title":"Int J Cardiol"},{"issue":"10","key":"10.1016\/j.jacep.2025.06.031_bib29","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jacc.2024.04.070","article-title":"Continuous rhythm monitoring with implanted loop recorders in children and adolescents with Brugada syndrome","volume":"84","author":"Bergonti","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2025.06.031_bib30","doi-asserted-by":"crossref","DOI":"10.12659\/AJCR.943506","article-title":"Relationship between Brugada syndrome and ischemic stroke: a case report and comprehensive literature review","volume":"25","author":"Arango-Granados","year":"2024","journal-title":"Am J Case Rep"},{"issue":"2","key":"10.1016\/j.jacep.2025.06.031_bib31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2459\/JCM.0000000000000723","article-title":"Abnormally high risk of stroke in Brugada syndrome","volume":"20","author":"de Asmundis","year":"2019","journal-title":"J Cardiovasc Med (Hagerstown)"},{"issue":"5","key":"10.1016\/j.jacep.2025.06.031_bib32","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1253\/circj.68.473","article-title":"Sinus node function in patients with Brugada-type ECG","volume":"68","author":"Morita","year":"2004","journal-title":"Circ J"},{"issue":"3","key":"10.1016\/j.jacep.2025.06.031_bib33","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/joa3.12046","article-title":"Brugada syndrome and sinus node dysfunction","volume":"34","author":"Hayashi","year":"2018","journal-title":"J Arrhythm"},{"issue":"21","key":"10.1016\/j.jacep.2025.06.031_bib34","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/j.jacc.2014.02.574","article-title":"Drug-induced Brugada syndrome in children: clinical features, device-based management, and long-term follow-up","volume":"63","author":"Conte","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.jacep.2025.06.031_bib35","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/CIRCEP.113.001340","article-title":"Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics","volume":"7","author":"Abe","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"14","key":"10.1016\/j.jacep.2025.06.031_bib36","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/eurheartj\/ehae133","article-title":"Implantable loop recorders in patients with Brugada syndrome: the BruLoop study","volume":"45","author":"Bergonti","year":"2024","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.jacep.2025.06.031_bib37","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.hrthm.2024.10.057","article-title":"Long-term prognosis of patients with an SCN5A loss-of-function variant and progressive cardiac conduction disorder or Brugada syndrome","volume":"22","author":"Tuijnenburg","year":"2025","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2025.06.031_bib38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.amjcard.2021.11.030","article-title":"Etiology and outcome of catheter ablation in patients with onset of atrial fibrillation <45 years of age","volume":"166","author":"Tijskens","year":"2022","journal-title":"Am J Cardiol"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X2500533X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X2500533X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:54:49Z","timestamp":1777118089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X2500533X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2405500X2500533X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2025.06.031","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Clinical Significance of Atrial Fibrillation in Non\u2013High-Risk Brugada Syndrome","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2025.06.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}