{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:03:47Z","timestamp":1789506227157,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jacep.2025.08.002","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T19:47:43Z","timestamp":1757015263000},"page":"2660-2669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Risk of Breakthrough Cardiac Events Associated With Psychiatric Medications in Patients With Diagnosed and Clinically Treated Long QT Syndrome"],"prefix":"10.1016","volume":"11","author":[{"given":"Iuri","family":"Ferreira Felix","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Karlinski Vizentin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahej","family":"Bains","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Martijn","family":"Bos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Giudicessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ackerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jacep.2025.08.002_bib1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/0002-8703(75)90089-7","article-title":"The long Q-T syndrome","volume":"89","author":"Schwartz","year":"1975","journal-title":"Am Heart J"},{"issue":"18","key":"10.1016\/j.jacep.2025.08.002_bib2","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1161\/CIRCULATIONAHA.109.863209","article-title":"Prevalence of the congenital long-qt syndrome","volume":"120","author":"Schwartz","year":"2009","journal-title":"Circulation"},{"issue":"19","key":"10.1016\/j.jacep.2025.08.002_bib3","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1056\/NEJMoa022147","article-title":"Risk stratification in the long-QT syndrome","volume":"348","author":"Priori","year":"2003","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jacep.2025.08.002_bib4","first-page":"88","article-title":"Clinical applicability of molecular biology: the case of the long QT syndrome","volume":"1","author":"Schwartz","year":"2000","journal-title":"Curr Control Trials Cardiovasc Med"},{"issue":"4","key":"10.1016\/j.jacep.2025.08.002_bib5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jacc.2017.05.046","article-title":"Contemporary outcomes in patients with long QT syndrome","volume":"70","author":"Rohatgi","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"40","key":"10.1016\/j.jacep.2025.08.002_bib6","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1093\/eurheartj\/eht089","article-title":"The long QT syndrome: a transatlantic clinical approach to diagnosis and therapy","volume":"34","author":"Schwartz","year":"2013","journal-title":"Eur Heart J"},{"issue":"3","key":"10.1016\/j.jacep.2025.08.002_bib7","first-page":"168","article-title":"Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization\u2019s World Mental Health Survey Initiative","volume":"6","author":"Kessler","year":"2007","journal-title":"World Psychiatry"},{"issue":"7","key":"10.1016\/j.jacep.2025.08.002_bib8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1080\/07853890903037254","article-title":"Depressive symptoms in the congenital long QT syndrome","volume":"41","author":"Hintsa","year":"2009","journal-title":"Ann Med"},{"issue":"4","key":"10.1016\/j.jacep.2025.08.002_bib9","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/europace\/euab252","article-title":"Severity of congenital long QT syndrome disease manifestation and risk of depression, anxiety, and mortality: a nationwide study","volume":"24","author":"Kr\u00f8ll","year":"2022","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2025.08.002_bib11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.schres.2016.10.006","article-title":"QTc interval lengthening in first-episode schizophrenia (FES) patients in the earliest stages of antipsychotic treatment","volume":"179","author":"Zhai","year":"2017","journal-title":"Schizophr Res"},{"issue":"4","key":"10.1016\/j.jacep.2025.08.002_bib12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jpain.2014.01.494","article-title":"Methadone safety: a clinical practice guideline from the American Pain Society and College on Problems of Drug Dependence, in Collaboration With the Heart Rhythm Society","volume":"15","author":"Chou","year":"2014","journal-title":"J Pain"},{"issue":"2","key":"10.1016\/j.jacep.2025.08.002_bib13","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/ije\/dyu038","article-title":"The global prevalence of common mental disorders: a systematic review and meta-analysis 1980-2013","volume":"43","author":"Steel","year":"2014","journal-title":"Int J Epidemiol"},{"issue":"5","key":"10.1016\/j.jacep.2025.08.002_bib14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/acps.13083","article-title":"Is the global prevalence rate of adult mental illness increasing? Systematic review and meta-analysis","volume":"140","author":"Richter","year":"2019","journal-title":"Acta Psychiatr Scand"},{"issue":"9","key":"10.1016\/j.jacep.2025.08.002_bib15","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.amjmed.2023.04.036","article-title":"Association of depression and cardiovascular disease","volume":"136","author":"Krittanawong","year":"2023","journal-title":"Am J Med"},{"issue":"3","key":"10.1016\/j.jacep.2025.08.002_bib16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0165-1781(00)00119-0","article-title":"Increased QT variability in patients with panic disorder and depression","volume":"93","author":"Yeragani","year":"2000","journal-title":"Psychiatry Res"},{"issue":"2","key":"10.1016\/j.jacep.2025.08.002_bib17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0002-8703(85)90626-X","article-title":"Idiopathic long QT syndrome: progress and questions","volume":"109","author":"Schwartz","year":"1985","journal-title":"Am Heart J"},{"issue":"14","key":"10.1016\/j.jacep.2025.08.002_bib18","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1016\/j.jacc.2017.10.054","volume":"72","author":"Al-Khatib","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.jacep.2025.08.002_bib19","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.120.009726","article-title":"Management of congenital long-QT syndrome: commentary from the experts","volume":"14","author":"Kaufman","year":"2021","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"4","key":"10.1016\/j.jacep.2025.08.002_bib20","doi-asserted-by":"crossref","first-page":"E24","DOI":"10.1161\/01.CIR.103.4.e24","article-title":"Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome","volume":"103","author":"Gow","year":"2001","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.jacep.2025.08.002_bib21","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1001\/jama.292.11.1341","article-title":"Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers","volume":"292","author":"Priori","year":"2004","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.jacep.2025.08.002_bib22","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/jce.16293","article-title":"Utilizing median and maximum QTc values improves prediction of breakthrough cardiac events in pediatric long QT syndrome","volume":"35","author":"Rohatgi","year":"2024","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"2","key":"10.1016\/j.jacep.2025.08.002_bib23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1034\/j.1600-0447.2003.02078.x","article-title":"Antipsychotics and QT prolongation","volume":"107","author":"Taylor","year":"2003","journal-title":"Acta Psychiatr Scand"},{"issue":"6","key":"10.1016\/j.jacep.2025.08.002_bib24","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1001\/archpsyc.1997.01830180067009","article-title":"Quetiapine in patients with schizophrenia: a high- and low-dose double-blind comparison with placebo","volume":"54","author":"Small","year":"1997","journal-title":"Arch Gen Psychiatry"},{"issue":"3","key":"10.1016\/j.jacep.2025.08.002_bib25","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.hrthm.2023.10.027","article-title":"Incidences, risk factors, and clinical correlates of severe QT prolongation after the use of quetiapine or haloperidol","volume":"21","author":"Wang","year":"2024","journal-title":"Heart Rhythm"},{"issue":"10","key":"10.1016\/j.jacep.2025.08.002_bib26","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/jce.12739","article-title":"Long-QT syndrome and therapy for attention deficit\/hyperactivity disorder","volume":"26","author":"Zhang","year":"2015","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"1","key":"10.1016\/j.jacep.2025.08.002_bib27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/01.jcp.0000104913.75206.62","article-title":"A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition","volume":"24","author":"Harrigan","year":"2004","journal-title":"J Clin Psychopharmacol"},{"issue":"8","key":"10.1016\/j.jacep.2025.08.002_bib28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/j.1540-8167.2010.01737.x","article-title":"Beta-blocker efficacy in high-risk patients with the congenital long-QT syndrome types 1 and 2: implications for patient management","volume":"21","author":"Goldenberg","year":"2010","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"1","key":"10.1016\/j.jacep.2025.08.002_bib29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jacc.2010.07.038","article-title":"Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals","volume":"57","author":"Goldenberg","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.jacep.2025.08.002_bib30","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.hrthm.2015.04.043","article-title":"Stimulant therapy in children with attention-deficit\/hyperactivity disorder and concomitant long QT syndrome: a safe combination?","volume":"12","author":"Rohatgi","year":"2015","journal-title":"Heart Rhythm"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X25006413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X25006413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:36:43Z","timestamp":1779953803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X25006413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2405500X25006413"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2025.08.002","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Risk of Breakthrough Cardiac Events Associated With Psychiatric Medications in Patients With Diagnosed and Clinically Treated Long QT Syndrome","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2025.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}