{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:54:44Z","timestamp":1770288884113,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,26]],"date-time":"2027-01-26T00:00:00Z","timestamp":1800921600000},"content-version":"am","delay-in-days":390,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jacep.2025.08.016","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T04:18:30Z","timestamp":1759551510000},"page":"44-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adrenergic Hypersensitivity Drives Ventricular Arrhythmias Following Loss of Plexin-Mediated Cardiac Innervation"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5564-6050","authenticated-orcid":false,"given":"Ching","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Makita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio Y.","family":"Lucero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Jyothidasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhea","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7348-0509","authenticated-orcid":false,"given":"Jessica J.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard A.","family":"Rockman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyanam","family":"Shivkumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacep.2025.08.016_bib1","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1161\/01.CIR.98.21.2334","article-title":"Sudden cardiac death","volume":"98","author":"Zipes","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2025.08.016_bib2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pcad.2008.06.003","article-title":"Epidemiology of sudden cardiac death: clinical and research implications","volume":"51","author":"Chugh","year":"2008","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.jacep.2025.08.016_bib3","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.pcad.2008.01.003","article-title":"The role of the autonomic nervous system in sudden cardiac death","volume":"50","author":"Vaseghi","year":"2008","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.jacep.2025.08.016_bib4","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1172\/JCI26381","article-title":"Mechanisms of sudden cardiac death","volume":"115","author":"Rubart","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacep.2025.08.016_bib5","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1113\/JP272580","article-title":"Cardiac autonomic control in health and disease","volume":"594","author":"Shivkumar","year":"2016","journal-title":"J Physiol"},{"key":"10.1016\/j.jacep.2025.08.016_bib6","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCRESAHA.113.302549","article-title":"Role of the autonomic nervous system in modulating cardiac arrhythmias","volume":"114","author":"Shen","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.jacep.2025.08.016_bib7","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1056\/NEJMoa2409501","article-title":"Catheter ablation or antiarrhythmic drugs for ventricular tachycardia","volume":"392","author":"Sapp","year":"2025","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacep.2025.08.016_bib8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.hrthm.2013.11.028","article-title":"Cardiac sympathetic denervation in patients with refractory ventricular arrhythmias or electrical storm: intermediate and long-term follow-up","volume":"11","author":"Vaseghi","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2025.08.016_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jacc.2011.09.043","article-title":"Bilateral cardiac sympathetic denervation for the management of electrical storm","volume":"59","author":"Ajijola","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2025.08.016_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2174\/157340309789317904","article-title":"Cardiac innervation and sudden cardiac death","volume":"5","author":"Ieda","year":"2009","journal-title":"Current Cardiol Rev"},{"key":"10.1016\/j.jacep.2025.08.016_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003364","article-title":"A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation","volume":"9","author":"Nakano","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jacep.2025.08.016_bib12","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nm1570","article-title":"Sema3a maintains normal heart rhythm through sympathetic innervation patterning","volume":"13","author":"Ieda","year":"2007","journal-title":"Nature Med"},{"key":"10.1016\/j.jacep.2025.08.016_bib13","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/01.CIR.76.2.383","article-title":"Denervation supersensitivity of refractoriness in noninfarcted areas apical to transmural myocardial infarction","volume":"76","author":"Kammerling","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2025.08.016_bib14","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.153913","article-title":"High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zones","volume":"7","author":"Zhu","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.jacep.2025.08.016_bib15","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1161\/01.CIR.101.16.1960","article-title":"Relationship between regional cardiac hyperinnervation and ventricular arrhythmia","volume":"101","author":"Cao","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacep.2025.08.016_bib16","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1523\/JNEUROSCI.4523-03.2004","article-title":"Heterogeneous requirement of NGF for sympathetic target innervation in vivo","volume":"24","author":"Glebova","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.jacep.2025.08.016_bib17","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1242\/dev.087601","article-title":"Coronary veins determine the pattern of sympathetic innervation in the developing heart","volume":"140","author":"Nam","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.jacep.2025.08.016_bib18","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41583-021-00523-y","article-title":"The sympathetic nervous system in development and disease","volume":"22","author":"Scott-Solomon","year":"2021","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jacep.2025.08.016_bib19","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1113\/JP271840","article-title":"Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease","volume":"594","author":"Habecker","year":"2016","journal-title":"J Physiol"},{"key":"10.1016\/j.jacep.2025.08.016_bib20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1161\/01.RES.0000133678.22968.e3","article-title":"Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs","volume":"95","author":"Zhou","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.jacep.2025.08.016_bib21","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1161\/CIRCRESAHA.114.302589","article-title":"The autonomic nervous system and heart failure","volume":"114","author":"Florea","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.jacep.2025.08.016_bib22","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/jcmm.12035","article-title":"Overexpression of Sema3a in myocardial infarction border zone decreases vulnerability of ventricular tachycardia post-myocardial infarction in rats","volume":"17","author":"Chen","year":"2013","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jacep.2025.08.016_bib23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12872-016-0192-8","article-title":"Semaphorin 3A attenuates cardiac autonomic disorders and reduces inducible ventricular arrhythmias in rats with experimental myocardial infarction","volume":"16","author":"Hu","year":"2016","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.jacep.2025.08.016_bib24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00395-017-0630-5","article-title":"Sema3A promotes the resolution of cardiac inflammation after myocardial infarction","volume":"112","author":"Rienks","year":"2017","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jacep.2025.08.016_bib25","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.neuron.2005.01.013","article-title":"Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 semaphorins","volume":"45","author":"Yaron","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.jacep.2025.08.016_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.42528","article-title":"Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin","volume":"8","author":"Poltavski","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jacep.2025.08.016_bib27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ydbio.2008.01.002","article-title":"Plexin-A3 and plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors","volume":"315","author":"Waimey","year":"2008","journal-title":"Dev Biol"},{"key":"10.1016\/j.jacep.2025.08.016_bib28","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2014.10.010","article-title":"iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging","volume":"159","author":"Renier","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jacep.2025.08.016_bib29","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nn.2928","article-title":"Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain","volume":"14","author":"Hama","year":"2011","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jacep.2025.08.016_bib30","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/s41598-018-38263-2","article-title":"ElectroMap: high-throughput open-source software for analysis and mapping of cardiac electrophysiology","volume":"9","author":"O\u2019Shea","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacep.2025.08.016_bib31","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41586-021-03855-y","article-title":"Rare variant contribution to human disease in 281,104 UK Biobank exomes","volume":"597","author":"Wang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jacep.2025.08.016_bib32","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/nbt.2749","article-title":"Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data","volume":"31","author":"Denny","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jacep.2025.08.016_bib33","first-page":"H815","article-title":"Mechanisms of denervation supersensitivity in regionally denervated canine hearts","volume":"264","author":"Warner","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jacep.2025.08.016_bib34","doi-asserted-by":"crossref","first-page":"H1838","DOI":"10.1152\/ajpheart.01106.2011","article-title":"Sympathetic stimulation increases dispersion of repolarization in humans with myocardial infarction","volume":"302","author":"Vaseghi","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacep.2025.08.016_bib35","first-page":"899","article-title":"The role of the axonal guidance cue Semaphorin 3A in innervation of the postnatal heart in health and disease","volume":"41","author":"Koppel","year":"2025","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jacep.2025.08.016_bib36","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.008853","article-title":"Role of semaphorin signaling during cardiovascular development","volume":"7","author":"Sun","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacep.2025.08.016_bib37","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.hrthm.2024.08.047","article-title":"SEMA3A as a biomarker of primary ventricular fibrillation complicating STEMI","volume":"22","author":"Boiteux","year":"2025","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacep.2025.08.016_bib38","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s003800300005","article-title":"Histological study on the distribution of autonomic nerves in the human heart","volume":"18","author":"Kawano","year":"2003","journal-title":"Heart Vessels"},{"key":"10.1016\/j.jacep.2025.08.016_bib39","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1113\/JP271870","article-title":"Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics","volume":"594","author":"Shivkumar","year":"2016","journal-title":"J Physiol (Lond)"},{"key":"10.1016\/j.jacep.2025.08.016_bib40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tcm.2003.12.006","article-title":"Studying cardiac arrhythmias in the mouse\u2014a reasonable model for probing mechanisms?","volume":"14","author":"Nerbonne","year":"2004","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.jacep.2025.08.016_bib41","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1113\/jphysiol.2014.279380","article-title":"Misinterpretation of the mouse ECG: \u2018musing the waves of Mus musculus.\u2019","volume":"592","author":"Boukens","year":"2014","journal-title":"J Physiol"},{"key":"10.1016\/j.jacep.2025.08.016_bib42","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1161\/CIRCRESAHA.118.313406","article-title":"Mouse models of cardiac arrhythmias","volume":"123","author":"Dobrev","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.jacep.2025.08.016_bib43","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.jacc.2012.01.036","article-title":"Ventricular arrhythmias in the absence of structural heart disease","volume":"59","author":"Prystowsky","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2025.08.016_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2012.08.005","article-title":"Determinants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromes","volume":"161","author":"Giudicessi","year":"2013","journal-title":"Transl Res"},{"key":"10.1016\/j.jacep.2025.08.016_bib45","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.jacep.2019.06.009","article-title":"Neuromodulation for ventricular tachycardia and atrial fibrillation: a clinical scenario-based review","volume":"5","author":"Zhu","year":"2019","journal-title":"JACC Clin Electrophysiol"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X2500711X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X2500711X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:36:27Z","timestamp":1770237387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X2500711X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2405500X2500711X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2025.08.016","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adrenergic Hypersensitivity Drives Ventricular Arrhythmias Following Loss of Plexin-Mediated Cardiac Innervation","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2025.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier on behalf of the American College of Cardiology Foundation","name":"copyright","label":"Copyright"}]}}