{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:25:49Z","timestamp":1792193149449,"version":"4.4.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jacep.2026.03.024","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:22:41Z","timestamp":1776961361000},"page":"2089-2099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Trigger- vs Substrate-Based Purkinje De-Networking for Ventricular Fibrillation"],"prefix":"10.1016","volume":"12","author":[{"given":"Robert N.","family":"Kerley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry D.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uyanga","family":"Batnyam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Nazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esseim","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason S.","family":"Bradfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin H.","family":"Hayase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chau","family":"Vo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishnu P.","family":"Dhakal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Winterfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha B.","family":"Tedrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jacep.2026.03.024_bib1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nrcardio.2013.186","article-title":"Genetics of sudden cardiac death caused by ventricular arrhythmias","volume":"11","author":"Marsman","year":"2014","journal-title":"Nat Rev Cardiol"},{"issue":"9852","key":"10.1016\/j.jacep.2026.03.024_bib2","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/S0140-6736(12)61413-5","article-title":"Ventricular arrhythmias and sudden cardiac death","volume":"380","author":"John","year":"2012","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.jacep.2026.03.024_bib3","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1016\/j.jacep.2023.05.040","article-title":"Purkinje-related ventricular tachycardia and ventricular fibrillation","volume":"9","author":"Nogami","year":"2023","journal-title":"JACC Clin Electrophysiol"},{"issue":"8","key":"10.1016\/j.jacep.2026.03.024_bib4","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.jacep.2024.03.035","article-title":"Fascicular substrate modification to treat human ventricular fibrillation","volume":"10","author":"Bode Weeranun","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"issue":"10","key":"10.1016\/j.jacep.2026.03.024_bib5","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/pace.13782","article-title":"Prevention of ventricular fibrillation through de-networking of the Purkinje system: proof-of-concept paper on the substrate modification of the Purkinje network","volume":"42","author":"Imnadze","year":"2019","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.jacep.2026.03.024_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.956627","article-title":"Catheter ablation in patients with ventricular fibrillation by Purkinje de-networking","volume":"9","author":"Sciacca","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"7","key":"10.1016\/j.jacep.2026.03.024_bib7","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.jacep.2025.04.014","article-title":"Use of high-power, short-duration radiofrequency applications to target Purkinje tissue and ablate ventricular fibrillation","volume":"11","author":"Kerley","year":"2025","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.jacep.2026.03.024_bib8","doi-asserted-by":"crossref","DOI":"10.1007\/s10840-025-02171-z","article-title":"Utilizing stored implanted cardiac defibrillator electrograms to target localized fascicular denetworking in catheter ablation of ventricular fibrillation","author":"Kerley","year":"2025","journal-title":"J Interv Card Electrophysiol"},{"issue":"8","key":"10.1016\/j.jacep.2026.03.024_bib9","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jaccas.2021.04.023","article-title":"Successful substrate ablation for ventricular fibrillation in a patient with nonischemic cardiomyopathy","volume":"3","author":"Yamaguchi","year":"2021","journal-title":"JACC Case Rep"},{"issue":"12","key":"10.1016\/j.jacep.2026.03.024_bib10","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1093\/eurheartj\/ehab893","article-title":"Purkinje network and myocardial substrate at the onset of human ventricular fibrillation: implications for catheter ablation","volume":"43","author":"Haissaguerre","year":"2022","journal-title":"Eur Heart J"},{"issue":"4","key":"10.1016\/j.jacep.2026.03.024_bib11","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.hrthm.2013.12.030","article-title":"Catheter ablation of ventricular fibrillation: importance of left ventricular outflow tract and papillary muscle triggers","volume":"11","author":"Van Herendael","year":"2014","journal-title":"Heart Rhythm"},{"issue":"4","key":"10.1016\/j.jacep.2026.03.024_bib12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.hrthm.2021.10.025","article-title":"Empiric ablation of polymorphic ventricular tachycardia\/fibrillation in the absence of a mappable trigger: prospective feasibility and efficacy of pacemap matching to defibrillator electrograms","volume":"19","author":"Salazar","year":"2022","journal-title":"Heart Rhythm"},{"issue":"6","key":"10.1016\/j.jacep.2026.03.024_bib13","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jacc.2009.03.065","article-title":"Long-term follow-up of idiopathic ventricular fibrillation ablation: a multicenter study","volume":"54","author":"Knecht","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"10.1016\/j.jacep.2026.03.024_bib14","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1111\/jce.12478","article-title":"Ventricular fibrillation triggered by PVCs from papillary muscles: clinical features and ablation","volume":"25","author":"Santoro","year":"2014","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"5","key":"10.1016\/j.jacep.2026.03.024_bib15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMoa1707855","article-title":"Catheter ablation for atrial fibrillation with heart failure","volume":"378","author":"Marrouche","year":"2018","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.jacep.2026.03.024_bib16","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1540-8159.2008.02233.x","article-title":"Role of left ventricular scar and Purkinje-like potentials during mapping and ablation of ventricular fibrillation in dilated cardiomyopathy","volume":"32","author":"Sinha","year":"2009","journal-title":"Pacing Clin Electrophysiol"},{"issue":"7","key":"10.1016\/j.jacep.2026.03.024_bib17","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/pace.15215","article-title":"Fascicular\/Purkinje tissue colocalized with scar in cardiomyopathy patients undergoing ventricular fibrillation ablation","volume":"48","author":"Baskovski","year":"2025","journal-title":"Pacing Clin Electrophysiol"},{"issue":"5","key":"10.1016\/j.jacep.2026.03.024_bib18","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.hrthm.2016.01.011","article-title":"Cardiac Purkinje fibers and arrhythmias; the GK Moe Award Lecture 2015","volume":"13","author":"Boyden","year":"2016","journal-title":"Heart Rhythm"},{"issue":"4","key":"10.1016\/j.jacep.2026.03.024_bib19","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.RES.49.4.1043","article-title":"Preferential sensitivity of the left canine purkinje system to cardiac glycosides","volume":"49","author":"Reiser","year":"1981","journal-title":"Circ Res"},{"issue":"5","key":"10.1016\/j.jacep.2026.03.024_bib20","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.yjmcc.2011.05.020","article-title":"Anatomical and molecular mapping of the left and right ventricular His-Purkinje conduction networks","volume":"51","author":"Atkinson","year":"2011","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"10.1016\/j.jacep.2026.03.024_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1161\/01.RES.0000084851.60947.B5","article-title":"Canine ventricular KCNE2 expression resides predominantly in Purkinje fibers","volume":"93","author":"Pourrier","year":"2003","journal-title":"Circ Res"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X26002689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X26002689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:13:05Z","timestamp":1790896385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X26002689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2405500X26002689"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2026.03.024","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trigger- vs Substrate-Based Purkinje De-Networking for Ventricular Fibrillation","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2026.03.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}