{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:01:03Z","timestamp":1792753263507,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Clinical Electrophysiology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jacep.2026.08.008","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T07:32:09Z","timestamp":1788161529000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Direct His\/LBB Pacing as an Alternative to Biventricular Pacing in Patients With HFrEF and a Typical LBBB"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-688X","authenticated-orcid":false,"given":"Michael","family":"Vinther","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit Thornvig","family":"Philbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper Hastrup","family":"Svendsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2101-5098","authenticated-orcid":false,"given":"Jesper James","family":"Linde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2165-9555","authenticated-orcid":false,"given":"Ulrik","family":"Winsl\u00f8w","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillah","family":"Saffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8206-7011","authenticated-orcid":false,"given":"Emil Anton","family":"Frandsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3678-1932","authenticated-orcid":false,"given":"Mohamed","family":"Zuhair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Kaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Whinnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-7358","authenticated-orcid":false,"given":"Daniel","family":"Keene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Risum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacep.2026.08.008_bib1","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJMoa050496","article-title":"The effect of cardiac resynchronization on morbidity and mortality in heart failure","volume":"352","author":"Cleland","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacep.2026.08.008_bib2","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa032423","article-title":"Cardiac resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure","volume":"350","author":"Bristow","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacep.2026.08.008_bib3","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events","volume":"361","author":"Moss","year":"2009","journal-title":"N Eng J Med"},{"key":"10.1016\/j.jacep.2026.08.008_bib4","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.jacc.2008.08.027","article-title":"Randomized Trial of Cardiac Resynchronization in Mildly Symptomatic Heart Failure Patients and in Asymptomatic Patients With Left Ventricular Dysfunction and Previous Heart Failure Symptoms","volume":"52","author":"Linde","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2026.08.008_bib5","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1016\/j.jacc.2018.09.073","article-title":"His resynchronization versus biventricular pacing in patients with heart failure and left bundle branch block","volume":"72","author":"Arnold","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2026.08.008_bib6","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1093\/europace\/euac245","article-title":"Comparison of methods for delivering cardiac resynchronization therapy: an acute electrical and haemodynamic within-patient comparison of left bundle branch area, His bundle, and biventricular pacing","volume":"25","author":"Ali","year":"2023","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2026.08.008_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jacc.2019.04.026","article-title":"others. His corrective pacing or biventricular pacing for cardiac resynchronization in heart failure","volume":"74","author":"Upadhyay","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2026.08.008_bib8","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.jacep.2021.04.003","article-title":"A randomized trial of His pacing versus biventricular pacing in symptomatic HF patients with left bundle branch block (His-alternative)","volume":"7","author":"Vinther","year":"2021","journal-title":"Clin Electrophysiol"},{"key":"10.1016\/j.jacep.2026.08.008_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacep.2026.02.016","article-title":"His Pacing vs Biventricular Pacing for Cardiac Resynchronization Therapy","author":"Frandsen","year":"2026","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.jacep.2026.08.008_bib10","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.jacc.2022.07.019","article-title":"others. Randomized trial of left bundle branch vs biventricular pacing for cardiac resynchronization therapy","volume":"80","author":"Wang","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacep.2026.08.008_bib11","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1016\/j.jacep.2023.08.003","article-title":"His-Purkinje Conduction System Pacing Optimized Trial of Cardiac Resynchronization Therapy vs Biventricular Pacing: HOT-CRT Clinical Trial","volume":"9","author":"Vijayaraman","year":"2023","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.jacep.2026.08.008_bib12","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.jacep.2025.03.024","article-title":"Clinical Response to Resynchronization Therapy","volume":"11","author":"Pujol-L\u00f3pez","year":"2025","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.jacep.2026.08.008_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euaf085.605","article-title":"Conduction system pacing versus biventricular pacing for cardiac resynchronization: the CSP-SYNC randomized single center study","volume":"27","author":"\u017di\u017eek","year":"2025","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2026.08.008_bib14","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1001\/jamacardio.2026.0083","article-title":"Long-Term Outcomes of Left Bundle-Branch Pacing vs Biventricular Pacing in Heart Failure","volume":"11","author":"Chen","year":"2026","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacep.2026.08.008_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehag225","article-title":"Left bundle branch area vs biventricular pacing for cardiac resynchronization therapy: the LEFT-BUNDLE-CRT trial","author":"Cano","year":"2026","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacep.2026.08.008_bib16","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/jamacardio.2026.0101","article-title":"Conduction System vs Biventricular Pacing in Heart Failure","volume":"11","author":"Zimerman","year":"2026","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacep.2026.08.008_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ahj.2026.107491","article-title":"Direct His\/LBB pacing as an alternative to biventricular pacing in patients with HFrEF and a typical LBBB: Design and rationale for the His-Alternative II trial","volume":"300","author":"Risum","year":"2026","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacep.2026.08.008_bib18","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.amjcard.2010.11.010","article-title":"Defining left bundle branch block in the era of cardiac resynchronization therapy","volume":"107","author":"Strauss","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacep.2026.08.008_bib19","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/europace\/euad043","article-title":"EHRA clinical consensus statement on conduction system pacing implantation: endorsed by the Asia Pacific Heart Rhythm Society (APHRS), Canadian Heart Rhythm Society (CHRS), and Latin American Heart Rhythm Society (LAHRS)","volume":"25","author":"Burri","year":"2023","journal-title":"Europace"},{"key":"10.1016\/j.jacep.2026.08.008_bib20","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.jacep.2022.08.001","article-title":"Conduction System Pacing vs Biventricular Pacing in Heart Failure and Wide QRS Patients","volume":"8","author":"Pujol-Lopez","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.jacep.2026.08.008_bib21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.hrcr.2024.05.002","article-title":"Late perforation of a left bundle branch area pacing lead causing ventricular fibrillation: A case report","volume":"10","author":"Vinther","year":"2024","journal-title":"HeartRhythm Case Rep"}],"container-title":["JACC: Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X26007784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405500X26007784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:24:07Z","timestamp":1788294247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405500X26007784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":21,"alternative-id":["S2405500X26007784"],"URL":"https:\/\/doi.org\/10.1016\/j.jacep.2026.08.008","relation":{},"ISSN":["2405-500X"],"issn-type":[{"value":"2405-500X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Direct His\/LBB Pacing as an Alternative to Biventricular Pacing in Patients With HFrEF and a Typical LBBB","name":"articletitle","label":"Article Title"},{"value":"JACC: Clinical Electrophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacep.2026.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier on behalf of the American College of Cardiology Foundation","name":"copyright","label":"Copyright"}]}}