{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:57:46Z","timestamp":1775080666774,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.jaci.2004.03.033","type":"journal-article","created":{"date-parts":[[2004,7,6]],"date-time":"2004-07-06T11:17:14Z","timestamp":1089112634000},"page":"97-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Lung eosinophilic inflammation and airway hyperreactivity are enhanced by murine anaphylactic, but not nonanaphylactic, IgG1 antibodies"],"prefix":"10.1016","volume":"114","author":[{"given":"Maria Fernanda","family":"Macedo-Soares","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise M","family":"Itami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adenir","family":"Perini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana L","family":"Faquim-Mauro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton A","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahasti S","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2004.03.033_BIB1","first-page":"477","article-title":"Basic mechanism in asthma","volume":"60","author":"Wasserman","year":"1988","journal-title":"Ann Allergy"},{"key":"10.1016\/j.jaci.2004.03.033_BIB2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0091-6749(92)90140-W","article-title":"The relationship between late asthmatic responses and antigen-specific immunoglobulin","volume":"90","author":"Wasserman","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB3","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/0952-7915(93)90111-5","article-title":"The late-phase reaction: role of IgE, its receptor and cytokines","volume":"5","author":"Zweiman","year":"1993","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1034\/j.1398-9995.1999.00085.x","article-title":"Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness\u2014a murine model","volume":"54","author":"Hamelmann","year":"1999","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2004.03.033_BIB5","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.4049\/jimmunol.169.4.2061","article-title":"IgE-dependent mast cell activation potentiates airway responses in murine asthma models","volume":"169","author":"Mayr","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB6","first-page":"614","article-title":"Characterization of inflammatory mediator release from purified human lung mast cells","volume":"133","author":"Schleimer","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2004.03.033_BIB7","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0091-6749(91)90158-K","article-title":"Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway","volume":"88","author":"Broide","year":"1991","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB8","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1164\/ajrccm\/142.5.1093","article-title":"IgG1 mediated acute pulmonary hypersensitivity response in the guinea-pig","volume":"142","author":"Watson","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2004.03.033_BIB9","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/370367a0","article-title":"Active anaphylaxis in IgE-deficient mice","volume":"370","author":"Oettgen","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2004.03.033_BIB10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1074-7613(00)80494-X","article-title":"Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc\u03b3RIII (CD16) deficient mice","volume":"5","author":"Hazenbos","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2004.03.033_BIB11","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1172\/JCI118560","article-title":"Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice","volume":"97","author":"Oshiba","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2004.03.033_BIB12","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1067\/mai.2002.123302","article-title":"Pathways of anaphylaxis in the mouse","volume":"109","author":"Strait","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB13","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.4049\/jimmunol.168.8.4050","article-title":"Early phase bronchoconstriction in the mouse requires allergen-specific IgG","volume":"168","author":"Crosby","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB14","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/0024-3205(68)90258-0","article-title":"Mouse homocytotropic antibodies: specific differentiation between 7S \u03b31 and mouse reagin-like antibodies","volume":"7","author":"Mota","year":"1968","journal-title":"Life Sci"},{"key":"10.1016\/j.jaci.2004.03.033_BIB15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0008-8749(80)90067-2","article-title":"Mast cell membrane antigens and Fc receptors in anaphylaxis. II. Functionally distinct receptors for IgG and IgE on mouse mast cells","volume":"49","author":"Daeron","year":"1980","journal-title":"Cell Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB16","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1172\/JCI119255","article-title":"Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc\u03b3RIII","volume":"99","author":"Miyajima","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2004.03.033_BIB17","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1046\/j.1365-2249.1998.00717.x","article-title":"IgG-mediated anaphylaxis via Fc gamma receptor in CD40-deficient mice","volume":"114","author":"Wakayama","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB18","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.4049\/jimmunol.150.5.1663","article-title":"B cell tolerance induction by cross-linking of membrane IgM but not IgD and synergy by cross-linking both isotypes","volume":"150","author":"Gaur","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB19","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1034\/j.1398-9995.2003.00206.x","article-title":"IgE is not required for but enhances airway inflammation and hyperresponsiveness","volume":"58","author":"Itami","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2004.03.033_BIB20","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.4049\/jimmunol.163.7.3572","article-title":"Mouse IgG1 antibodies comprise two functionally distinct types that are differentially regulated by IL-4 and IL-12","volume":"63","author":"Faquim-Mauro","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB21","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/intimm\/12.12.1733","article-title":"Induction of IL-4-dependent, anaphylactic-type and IL-4-independent, non-anaphylactic-type IgG1 antibodies is modulated by adjuvants","volume":"12","author":"Faquim-Mauro","year":"2000","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1078\/0171-2985-00231","article-title":"Anaphylactic and non-anaphylactic murine IgG1 differ in their ability to bind to mast cells: relevance of proper glycosylation of the molecule","volume":"207","author":"Faquim-Mauro","year":"2003","journal-title":"Immunobiology"},{"issue":"suppl II","key":"10.1016\/j.jaci.2004.03.033_BIB23","first-page":"58","article-title":"Characterization of anaphylactic and non-anaphylactic IgG1 antibodies: differential binding to mast cell FcgammaRIII and to lectins","volume":"34","author":"Faquim-Mauro","year":"2001","journal-title":"Rev Soc Bras Med Trop"},{"key":"10.1016\/j.jaci.2004.03.033_BIB24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0022-1759(81)90094-6","article-title":"A simple and effective method to assess murine delayed-type hypersensitivity to proteins","volume":"45","author":"Titus","year":"1981","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jaci.2004.03.033_BIB25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0022-1759(85)90242-X","article-title":"Detection of eosinophils using an eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors","volume":"83","author":"Strath","year":"1985","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jaci.2004.03.033_BIB26","series-title":"Biostatistical analysis","author":"Zar","year":"1984"},{"key":"10.1016\/j.jaci.2004.03.033_BIB27","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1084\/jem.182.4.1169","article-title":"Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo","volume":"182","author":"Collins","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2004.03.033_BIB28","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1164\/ajrccm\/142.2.434","article-title":"Mucosal inflammation in asthma","volume":"142","author":"Djukanovic","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2004.03.033_BIB29","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1073\/pnas.94.4.1344","article-title":"Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma","volume":"94","author":"Mehlhop","year":"1997","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jaci.2004.03.033_BIB30","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1165\/ajrcmb.16.4.9115756","article-title":"Successful transfer of late phase eosinophil infiltration in the lung by infusion of helper T cell clones","volume":"16","author":"Kaminuma","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB31","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1172\/JCI119234","article-title":"Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice","volume":"99","author":"Mould","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2004.03.033_BIB32","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1172\/JCI2686","article-title":"Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia","volume":"102","author":"Wang","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2004.03.033_BIB33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000024049","article-title":"T cells and chronic asthma","volume":"118","author":"Kon","year":"1999","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB34","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/physrev.1997.77.4.1033","article-title":"Mast cells","volume":"77","author":"Metcalfe","year":"1997","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jaci.2004.03.033_BIB35","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1084\/jem.193.5.563","article-title":"Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction","volume":"193","author":"Yuasa","year":"2001","journal-title":"J Exp Med"},{"issue":"suppl 1","key":"10.1016\/j.jaci.2004.03.033_BIB36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000070473","article-title":"Role of IgE in Th2 cell-mediated allergic airway inflammation","volume":"131","author":"Maezawa","year":"2003","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB37","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000072140","article-title":"Association of interleukin-5 and eotaxin with acute exacerbation of asthma","volume":"131","author":"Park","year":"2003","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB38","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1172\/JCI119045","article-title":"Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines and adhesion receptors","volume":"98","author":"Gonzalo","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2004.03.033_BIB39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev.me.44.020193.000505","article-title":"The biology of the eosinophilic leukocyte","volume":"44","author":"Gleich","year":"1993","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jaci.2004.03.033_BIB40","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1172\/JCI118505","article-title":"In vivo neutralization of eosinophil-derived major basic protein inhibits antigen-induced bronchial hyperreactivity in sensitized guinea pigs","volume":"97","author":"Lefort","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2004.03.033_BIB41","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1172\/JCI115155","article-title":"Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates","volume":"87","author":"Gundel","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2004.03.033_BIB42","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1365-2222.1996.tb00590.x","article-title":"Role of mast cells, eosinophils and IL-5 in development of airway hyperresponsiveness in sensitized mice","volume":"26","author":"Nagai","year":"1996","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2004.03.033_BIB43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1084\/jem.183.1.109","article-title":"Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity","volume":"183","author":"Corry","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2004.03.033_BIB44","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.4049\/jimmunol.164.7.3855","article-title":"An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model","volume":"164","author":"Kobayachi","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB45","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1084\/jem.183.1.195","article-title":"Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model","volume":"183","author":"Foster","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2004.03.033_BIB46","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.4049\/jimmunol.161.3.1501","article-title":"A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB\/c mice independently of IL-4 and IL-5","volume":"161","author":"Hogan","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2004.03.033_BIB47","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1084\/jem.192.3.455","article-title":"Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice","volume":"192","author":"Williams","year":"2000","journal-title":"J Exp Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674904011650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674904011650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:52:27Z","timestamp":1758775947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674904011650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0091674904011650"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2004.03.033","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lung eosinophilic inflammation and airway hyperreactivity are enhanced by murine anaphylactic, but not nonanaphylactic, IgG1 antibodies","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2004.03.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}