{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T18:59:06Z","timestamp":1774119546968,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.jaci.2004.06.058","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T12:41:28Z","timestamp":1097584888000},"page":"831-837","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"title":["Randomized controlled trial of high-dose sublingual immunotherapy to treat seasonal allergic rhinitis"],"prefix":"10.1016","volume":"114","author":[{"given":"Helen","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkka","family":"Annila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Poole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Andre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Frew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2004.06.058_bib1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1136\/bmj.308.6933.897","article-title":"Incidence of allergic rhinitis in general practice, 1981-1992","volume":"308","author":"Ross","year":"1994","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2004.06.058_bib2","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1136\/bmj.304.6831.873","article-title":"Respiratory symptoms and atopy in Aberdeen schoolchildren: evidence from two surveys 25 years apart","volume":"304","author":"Ninan","year":"1992","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2004.06.058_bib3","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1034\/j.1398-9995.2000.00526.x","article-title":"Consensus statement on the treatment of allergic rhinitis","volume":"55","author":"van Cauwenberge","year":"2000","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2004.06.058_bib4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1046\/j.1365-2222.1998.00237.x","article-title":"Symptom control in patients with hay fever in UK general practice: how well are we doing and is there a need for allergen immunotherapy?","volume":"28","author":"White","year":"1998","journal-title":"Clin Exp Allergy"},{"issue":"suppl 14","key":"10.1016\/j.jaci.2004.06.058_bib5","first-page":"7","article-title":"Immunotherapy. EAACI position paper","volume":"48","author":"Malling","year":"1993","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2004.06.058_bib6","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0091-6749(98)70271-4","article-title":"Allergen immunotherapy: therapeutic vaccines for allergic diseases","volume":"102","author":"Bousquet","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.06.058_bib7","first-page":"948","article-title":"CSM update: immunotherapy","volume":"293","author":"Committee on the Safety of Medicines","year":"1986","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2004.06.058_bib8","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/j.1398-9995.1998.tb03793.x","article-title":"Local immunotherapy (position paper)","volume":"53","author":"Malling","year":"1998","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2004.06.058_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1398-9995.1994.tb02273.x","article-title":"A double blind placebo controlled trial by the sublingual route of immunotherapy with a standardised grass pollen extract","volume":"49","author":"Sabbah","year":"1994","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2004.06.058_bib10","first-page":"305","article-title":"Double blind placebo controlled clinical trial of pre-seasonal treatment with allergenic extracts of Olea europaea pollen administered sublingually","volume":"4","author":"Casanovas","year":"1994","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2004.06.058_bib11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1398-9995.1998.tb04086.x","article-title":"Clinical efficacy of sublingual-swallow immunotherapy: a double blind, placebo controlled trial of standardised five grass pollen extract in rhinitis","volume":"53","author":"Clavel","year":"1998","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2004.06.058_bib12","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1398-9995.1998.tb03952.x","article-title":"Double-blind, placebo-controlled evaluation of sublingual immunotherapy with standardised olive pollen extract in paediatric patients with allergic rhinoconjunctivitis and mild asthma due to olive pollen sensitisation","volume":"53","author":"Vourdas","year":"1998","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2004.06.058_bib13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0091-6749(99)70362-3","article-title":"Sublingual immunotherapy","volume":"104","author":"Frew","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.06.058_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-2222.1987.tb02046.x","article-title":"Efficacy of grass maize pollen oral immunotherapy in patients with seasonal hay-fever: a double blind study","volume":"17","author":"Van Nierkerk","year":"1987","journal-title":"Clin Allergy"},{"key":"10.1016\/j.jaci.2004.06.058_bib15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1034\/j.1398-9995.1999.00916.x","article-title":"Sublingual-swallow immunotherapy in patients with asthma due to house dust mites: a double-blind, placebo-controlled study","volume":"54","author":"Bousquet","year":"1999","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2004.06.058_bib16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000024322","article-title":"Safety of sublingual-swallow immunotherapy in children and adults","volume":"121","author":"Andre","year":"2000","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2004.06.058_bib17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S1081-1206(10)62726-3","article-title":"Comparison of subcutaneous and sublingual immunotherapy in mite-sensitive patients with rhinitis and asthma\u2014a placebo-controlled study","volume":"82","author":"Mungan","year":"1999","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2004.06.058_bib18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1056\/NEJM199908123410702","article-title":"Long-term clinical efficacy of grass pollen immunotherapy","volume":"341","author":"Durham","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2004.06.058_bib19","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1046\/j.1365-2222.2003.01587.x","article-title":"Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10 year prospective study","volume":"33","author":"Di Rienzo","year":"2003","journal-title":"Clin Exp Allergy"},{"issue":"suppl 5","key":"10.1016\/j.jaci.2004.06.058_bib20","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1067\/mai.2001.118891","article-title":"Allergic rhinitis and its impact on asthma","volume":"108","author":"Bousquet","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.06.058_bib21","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/j.1365-2222.1996.tb00522.x","article-title":"Sublingual versus injective immunotherapy in grass pollen allergic patients","volume":"26","author":"Quirino","year":"1996","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2004.06.058_bib22","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0091-6749(97)70069-1","article-title":"Immunotherapy with a standardised Dermatophagoides pteronyssinus extract, VI: specific immunotherapy prevents the onset of new sensitisations in children","volume":"99","author":"Des Roches","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.06.058_bib23","first-page":"165","article-title":"Efficacy, safety and kinetics of oral ragweed immunotherapy in the treatment of allergic seasonal rhinitis","volume":"85","author":"Creticos","year":"1990","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.06.058_bib24","first-page":"234","article-title":"Sublingual immunotherapy with a standardised grass pollen extract: a double-blind placebo-controlled study","volume":"26","author":"Hordijk","year":"1998","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.jaci.2004.06.058_bib25","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1172\/JCI2250","article-title":"Role of IL-10 in specific immunotherapy","volume":"102","author":"Akdis","year":"1998","journal-title":"J Clin Invest"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674904022316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674904022316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:54:36Z","timestamp":1758776076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674904022316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S0091674904022316"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2004.06.058","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Randomized controlled trial of high-dose sublingual immunotherapy to treat seasonal allergic rhinitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2004.06.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}