{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:03:30Z","timestamp":1760979810317,"version":"3.44.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.jaci.2004.07.050","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T12:41:28Z","timestamp":1097584888000},"page":"814-819","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Dynamics of COX-2 in nasal mucosa and nasal polyps from aspirin-tolerant and aspirin-intolerant patients with asthma"],"prefix":"10.1016","volume":"114","author":[{"given":"Laura","family":"Pujols","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim","family":"Mullol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isam","family":"Alobid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Roca-Ferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Xaubet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"Picado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2004.07.050_bib1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1067\/mai.2003.1487","article-title":"Aspirin-induced asthma: Advances in pathogenesis, diagnosis, and management","volume":"111","author":"Szczeklik","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.07.050_bib2","first-page":"15","article-title":"Etiology of nasal polyps associated with aspirin-sensitive asthma","volume":"8","author":"Yamashita","year":"1989","journal-title":"Rhinol Suppl"},{"key":"10.1016\/j.jaci.2004.07.050_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/00016489950181819","article-title":"Arachidonic acid metabolism in nasal tissue and peripheral blood cells in aspirin intolerant asthmatics","volume":"119","author":"Schmid","year":"1999","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.jaci.2004.07.050_bib4","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1183\/09031936.99.13363899","article-title":"Dynamics of eicosanoids in peripheral blood cells during bronchial provocation in aspirin-intolerant asthmatics","volume":"13","author":"Sch\u00e4fer","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2004.07.050_bib5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1164\/ajrccm.161.2.9902034","article-title":"Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients","volume":"161","author":"Kowalski","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2004.07.050_bib6","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1067\/mai.2003.1491","article-title":"Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma","volume":"111","author":"Pierzchalska","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.07.050_bib7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.biochem.69.1.145","article-title":"Cyclooxygenases: structural, cellular, and molecular biology","volume":"69","author":"Smith","year":"2000","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jaci.2004.07.050_bib8","doi-asserted-by":"crossref","first-page":"7384","DOI":"10.1073\/pnas.89.16.7384","article-title":"Human cyclooxygenase-2 cDNA","volume":"89","author":"Hla","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2004.07.050_bib9","doi-asserted-by":"crossref","first-page":"9049","DOI":"10.1016\/S0021-9258(18)52976-8","article-title":"Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines","volume":"268","author":"Jones","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2004.07.050_bib10","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1046\/j.1365-2222.2000.00891.x","article-title":"Regulation of cyclooxygenase-1 and -2 in human nasal mucosa: effects of cytokines and dexamethasone","volume":"30","author":"Fernandez-Morata","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2004.07.050_bib11","doi-asserted-by":"crossref","first-page":"13926","DOI":"10.1073\/pnas.162468699","article-title":"COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic\/antipyretic drugs: cloning, structure, and expression","volume":"99","author":"Chandrasekharan","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2004.07.050_bib12","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s11882-002-0089-8","article-title":"Aspirin intolerance and nasal polypsosis","volume":"2","author":"Picado","year":"2002","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2004.07.050_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1164\/ajrccm.160.1.9808048","article-title":"Cycloxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics","volume":"160","author":"Picado","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2004.07.050_bib14","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/thx.52.11.940","article-title":"Enhanced expression of cyclooxygenase isoenzyme 2 (COX-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma","volume":"52","author":"Sousa","year":"1997","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2004.07.050_bib15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev.bi.60.070191.001433","article-title":"Primary response genes induced by growth factors and tumor promoters","volume":"60","author":"Herschman","year":"1991","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jaci.2004.07.050_bib16","series-title":"Eicosanoids, aspirin, and asthma","first-page":"129","article-title":"Cyclooxygenase gene expression and regulation","author":"Wu","year":"1998"},{"key":"10.1016\/j.jaci.2004.07.050_bib17","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1067\/mai.2002.123534","article-title":"Cyclooxygenase 1 and cyclooxygenase 2 expression is abnormally regulated in human nasal polyps","volume":"109","author":"Mullol","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.07.050_bib18","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/thorax.55.11.921","article-title":"Intranasal challenge with aspirin in the diagnosis of aspirin intolerant asthma: evaluation of nasal response by acoustic rhinometry","volume":"55","author":"Casadevall","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2004.07.050_bib19","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1034\/j.1398-9995.2003.23792.x","article-title":"Nuclear factor-\u03baB activity is downregulated in nasal polyps from aspirin-sensitive asthmatics","volume":"58","author":"Picado","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2004.07.050_bib20","doi-asserted-by":"crossref","first-page":"L619","DOI":"10.1152\/ajplung.00416.2002","article-title":"PAR-2 activation, PGE2, and COX-2 in human asthmatic and nonasthmatic airway smooth muscle cells","volume":"285","author":"Chambers","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2004.07.050_bib21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1164\/rccm.2101021","article-title":"Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin-induced asthma","volume":"166","author":"Antczak","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2004.07.050_bib22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.it.2003.11.001","article-title":"The lung as a privileged site for the beneficial actions of PGE2","volume":"25","author":"Vancheri","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2004.07.050_bib23","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1046\/j.1365-2222.1998.00212.x","article-title":"Expression of cyclooxygenase 1 and 2 proteins in upper respiratory mucosa","volume":"28","author":"Demoly","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2004.07.050_bib24","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1164\/ajrccm.155.2.9032211","article-title":"Prostaglandin H synthase 1 and 2 immunoreactivities in the bronchial mucosa of asthmatics","volume":"155","author":"Demoly","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2004.07.050_bib25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/thorax.56.5.351","article-title":"Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment","volume":"56","author":"Redington","year":"2001","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2004.07.050_bib26","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1164\/ajrccm.161.2.9811063","article-title":"Prostaglandin H synthase 2 expression in airway cells from patients with asthma and chronic obstructive pulmonary disease","volume":"161","author":"Taha","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2004.07.050_bib27","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1172\/JCI13271","article-title":"Why there are two cyclooxygenase isozymes","volume":"107","author":"Smith","year":"2001","journal-title":"J Clin Invest"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674904021694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674904021694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:54:26Z","timestamp":1758776066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674904021694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S0091674904021694"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2004.07.050","relation":{},"ISSN":["0091-6749"],"issn-type":[{"type":"print","value":"0091-6749"}],"subject":[],"published":{"date-parts":[[2004,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamics of COX-2 in nasal mucosa and nasal polyps from aspirin-tolerant and aspirin-intolerant patients with asthma","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2004.07.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}