{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:09:20Z","timestamp":1788379760466,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1016\/j.jaci.2004.08.029","type":"journal-article","created":{"date-parts":[[2004,12,10]],"date-time":"2004-12-10T14:36:13Z","timestamp":1102689373000},"page":"1376-1383","source":"Crossref","is-referenced-by-count":54,"title":["HLA-DQB1\u221703 in allergic fungal sinusitis and other chronic hypertrophic rhinosinusitis disorders"],"prefix":"10.1016","volume":"114","author":[{"given":"Mark S.","family":"Schubert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia S.","family":"Hutcheson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph J.","family":"Graff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond G.","family":"Slavin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2004.08.029_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0091-6749(99)70118-1","article-title":"Eosinophilic airway inflammation in nasal polyposis","volume":"14","author":"Lamblin","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1067\/mai.2000.109269","article-title":"Chronic sinusitis","volume":"106","author":"Hamilos","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib3","first-page":"27","article-title":"Noninfectious sinusitis","volume":"13","author":"Hamilos","year":"2001","journal-title":"ACI Int"},{"key":"10.1016\/j.jaci.2004.08.029_bib4","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/00005537-200204000-00026","article-title":"Polypoid mucosa with eosinophilia and glandular hyperplasia in chronic sinusitis: a histopathological and immunohistochemical study","volume":"112","author":"Berger","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2004.08.029_bib5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0091-6749(95)70298-9","article-title":"Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis","volume":"96","author":"Hamilos","year":"1995","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib6","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0091-6749(98)70333-1","article-title":"T lymphocytes that infiltrate nasal polyps have a specialized phenotype and produce a mixed TH1\/TH2 pattern of cytokines","volume":"102","author":"Sanchez-Segura","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2500\/108854196778662237","article-title":"Nasal polyps and immunoglobulin E (IgE)","volume":"17","author":"Settipane","year":"1996","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaci.2004.08.029_bib8","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/0091-6749(88)90038-3","article-title":"Sinusitis in adults and its relation to allergic rhinitis, asthma, and nasal polyps","volume":"82","author":"Slavin","year":"1985","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib9","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1067\/mhn.2000.110961","article-title":"Chronic rhinosinusitis: allergy and sinus computed tomography relationships","volume":"123","author":"Emanuel","year":"2000","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2004.08.029_bib10","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mai.2001.112374","article-title":"Total and specific IgE in nasal polyps is related to local eosinophilic inflammation","volume":"107","author":"Bachert","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0021-8707(67)90076-7","article-title":"Concerning the nature of intolerance to aspirin","volume":"40","author":"Samter","year":"1967","journal-title":"J Allergy"},{"key":"10.1016\/j.jaci.2004.08.029_bib12","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1067\/mai.2003.1487","article-title":"Aspirin-induced asthma: Advances in pathogenesis, diagnosis, and management","volume":"111","author":"Szczeklik","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0091-6749(83)90057-X","article-title":"Allergic Aspergillus sinusitis: a newly recognized form of sinusitis","volume":"72","author":"Katzenstein","year":"1983","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib14","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0091-6749(90)90097-N","article-title":"Allergic Bipolaris sinusitis: clinical and immunopathologic characteristics","volume":"85","author":"Gourley","year":"1990","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib15","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0194-5998(94)70525-9","article-title":"Diagnosis of allergic fungal sinusitis","volume":"111","author":"Bent","year":"1994","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2004.08.029_bib16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0091-6749(95)70029-3","article-title":"Diagnostic criteria for allergic fungal sinusitis","volume":"96","author":"deShazo","year":"1995","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0091-6749(98)70125-3","article-title":"Evaluation and treatment of allergic fungal sinusitis. I. Demographics and diagnosis","volume":"102","author":"Schubert","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S1081-1206(10)62445-3","article-title":"Medical treatment of allergic fungal sinusitis","volume":"85","author":"Schubert","year":"2000","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2500\/105065897782537269","article-title":"Allergic mucin sinusitis without fungus","volume":"11","author":"Ramadan","year":"1997","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.jaci.2004.08.029_bib20","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/00005537-200005000-00010","article-title":"Eosinophilic mucin rhinosinusitis: a distinct clinicopathological entity","volume":"110","author":"Ferguson","year":"2000","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2004.08.029_bib21","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.5858\/2001-125-1442-AMWAWF","article-title":"Allergic mucin with and without fungus. A comparative clinicopathologic analysis","volume":"125","author":"Lara","year":"2001","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jaci.2004.08.029_bib22","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s11882-001-0018-2","article-title":"Fungal rhinosinusitis: diagnosis and therapy","volume":"1","author":"Schubert","year":"2001","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2004.08.029_bib23","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1056\/NEJM200009143431106","article-title":"The HLA system; second of two parts","volume":"343","author":"Klein","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2004.08.029_bib24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s004050050210","article-title":"HLA patterns in patients with nasal polyposis","volume":"257","author":"Luxenberger","year":"2000","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jaci.2004.08.029_bib25","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/00005537-200003000-00017","article-title":"HLA-DRB1, -DQA1, and -DQB1 genotypes in patients with nasal polyposis","volume":"110","author":"Molnar-Gabor","year":"2000","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2004.08.029_bib26","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1067\/mai.2000.109913","article-title":"Evidence for the involvement of two different MHC class II regions in susceptibility or protection in allergic bronchopulmonary aspergillosis","volume":"106","author":"Chauhan","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib27","first-page":"231","article-title":"Selective polysaccharide antibody deficiency in familial DiGeorge syndrome","volume":"69","author":"Schubert","year":"1992","journal-title":"Ann Allergy"},{"key":"10.1016\/j.jaci.2004.08.029_bib28","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2004.08.029_bib29","series-title":"The HLA system: a new approach","first-page":"142","article-title":"Distribution of HLA antigens in North American Caucasians, North American blacks and Orientals","author":"Lee","year":"1990"},{"key":"10.1016\/j.jaci.2004.08.029_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1399-0039.1974.tb00230.x","article-title":"HLA antigens and disease; statistical and genetic considerations","volume":"4","author":"Svejgaard","year":"1974","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.jaci.2004.08.029_bib31","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1073\/pnas.87.20.8051","article-title":"Structural requirements for recognition of the HLA-Dw14 class II epitope: a key HLA determinant associated with rheumatoid arthritis","volume":"87","author":"Hiraiwa","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2004.08.029_bib32","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0065-2776(08)60456-3","article-title":"The molecular basis of susceptibility to rheumatoid arthritis","volume":"56","author":"Winchester","year":"1994","journal-title":"Adv Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib33","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.4049\/jimmunol.158.7.3545","article-title":"Critical residues on HLA-DRB1\u22170402 HV3 peptide for HLA-DQ8 restricted immunogenicity: implications for rheumatoid arthritis predisposition","volume":"158","author":"Zanelli","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib34","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0198-8859(01)00226-9","article-title":"Protection against severe disease is conferred by DERAA-bearing HLA-DRB1 alleles among HLA-DQ3 and HLA-DQ5 positive rheumatoid arthritis patients","volume":"62","author":"Seidl","year":"2001","journal-title":"Hum Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1399-0039.1996.tb02512.x","article-title":"Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)","volume":"47","author":"Yasunaga","year":"1996","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.jaci.2004.08.029_bib36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0198-8859(97)00212-7","article-title":"T-cell recognition of human pre-proinsulin peptides depends on the polymorphism at HLA-DQ locus: a study using HLA-DQ8 and DQ6 transgenic mice","volume":"88","author":"Raju","year":"1997","journal-title":"Hum Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib37","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1084\/jem.191.1.97","article-title":"In vivo evidence for the contribution of human histocompatibility antigen (HLA-DQ) molecules to the development of diabetes","volume":"191","author":"Wen","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2004.08.029_bib38","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/ni835","article-title":"A functional and structural basis for TCR cross-reactivity in multiple sclerosis","volume":"3","author":"Lang","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib39","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/S0140-6736(03)12989-3","article-title":"Coeliac disease\u2014a meeting point for genetics, immunology, and protein chemistry","volume":"361","author":"Mowat","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2004.08.029_bib40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0198-8859(98)00095-0","article-title":"An endogenous retroviral long terminal repeat at the HLA-DQB1 gene locus confers susceptibility to rheumatoid arthritis","volume":"60","author":"Seidl","year":"1999","journal-title":"Hum Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib41","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s002510100307","article-title":"Distribution of HERV-LTR elements in the 5\u2032-flanking region of HLA-DQB1 and association with autoimmunity","volume":"53","author":"Pascual","year":"2001","journal-title":"Immunogenetics"},{"key":"10.1016\/j.jaci.2004.08.029_bib42","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00125-001-0753-x","article-title":"A retroviral long terminal repeat adjacent to the HLA DQB1 gene (DQ-LTR13) modifies Type I diabetes susceptibility on high risk DQ haplotypes","volume":"45","author":"Bieda","year":"2002","journal-title":"Diabetologica"},{"key":"10.1016\/j.jaci.2004.08.029_bib43","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1046\/j.1365-2265.2002.t01-1-01548.x","article-title":"Preliminary evidence that an endogenous retroviral long-terminal repeat (LTR13) at the HLA-DQB1 gene locus confers susceptibility to Addison's disease","volume":"56","author":"Pani","year":"2002","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.jaci.2004.08.029_bib44","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0014-5793(00)01460-5","article-title":"Solitary HERV-K LTRs possess bi-directional promoter activity and contain a negative regulatory element in the U5 region","volume":"472","author":"Domansky","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jaci.2004.08.029_bib45","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1073\/pnas.87.13.4927","article-title":"Endogenous retroviral long terminal repeats within the HLA-DQ locus","volume":"87","author":"Kambhu","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2004.08.029_bib46","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1073\/pnas.93.11.5177","article-title":"The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences","volume":"93","author":"Lower","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2004.08.029_bib47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/jmbi.1998.2018","article-title":"Large-scale sequence comparisons reveal unusually high levels of variation in the HLA-DQB1 locus in the class II region of the human MHC","volume":"282","author":"Horton","year":"1998","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jaci.2004.08.029_bib48","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0092-8674(00)80338-4","article-title":"A human endogenous retroviral superantigen as candidate autoimmune gene in type I diabetes","volume":"90","author":"Conrad","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2004.08.029_bib49","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1074-7613(01)00212-6","article-title":"Interferon-alpha-induced endogenous superantigen: a model linking environment and autoimmunity","volume":"15","author":"Stauffer","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2004.08.029_bib50","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S1074-7613(01)00210-2","article-title":"Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen","volume":"15","author":"Sutkowski","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2004.08.029_bib51","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.iy.13.040195.002331","article-title":"Superantigens of mouse mammary tumor virus","volume":"13","author":"Acha-Orbea","year":"1995","journal-title":"Ann Rev Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib52","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/13550280390173328","article-title":"Multiple sclerosis-associated retrovirus particles cause T lymphocyte-dependent death with brain hemorrhage in humanized SCID mice model","volume":"9","author":"Firouzi","year":"2003","journal-title":"J Neurovirol"},{"key":"10.1016\/j.jaci.2004.08.029_bib53","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1081-1206(10)62222-3","article-title":"A superantigen hypothesis for the pathogenesis of chronic hypertrophic rhinosinusitis, allergic fungal sinusitis, and related disorders","volume":"87","author":"Schubert","year":"2001","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2004.08.029_bib54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF02786471","article-title":"Immune response to staphylococcal superantigens","volume":"20","author":"Krakauer","year":"1999","journal-title":"Immunol Res"},{"key":"10.1016\/j.jaci.2004.08.029_bib55","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/nm1202-800","article-title":"An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections","volume":"8","author":"Kotb","year":"2002","journal-title":"Nat Med"}],"updated-by":[{"DOI":"10.1016\/j.jaci.2004.12.002","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000}}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674904022535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674904022535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T20:37:46Z","timestamp":1682887066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674904022535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S0091674904022535"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2004.08.029","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}