{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:51:05Z","timestamp":1761058265273,"version":"3.44.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.jaci.2005.01.028","type":"journal-article","created":{"date-parts":[[2005,4,4]],"date-time":"2005-04-04T09:28:54Z","timestamp":1112606934000},"page":"S526-S531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"S","title":["Diversity of asthma: Evolving concepts of pathophysiology and lessons from genetics"],"prefix":"10.1016","volume":"115","author":[{"given":"Craig M.","family":"Lilly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2005.01.028_bib1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1183\/09031936.95.08030483","article-title":"International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods","volume":"8","author":"Asher","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2005.01.028_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1067\/mai.2001.112262","article-title":"The health economics of asthma and rhinitis. I. Assessing the economic impact","volume":"107","author":"Weiss","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.028_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1081\/JAS-100000023","article-title":"Increasing U.S. asthma mortality rates: who is really dying?","volume":"38","author":"Moorman","year":"2001","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2005.01.028_bib4","first-page":"163","article-title":"The rising tide of asthma. Trends in the epidemiology of morbidity and mortality from asthma","volume":"1","author":"Kussin","year":"1995","journal-title":"Respir Care Clin N Am"},{"key":"10.1016\/j.jaci.2005.01.028_bib5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/00063198-200001000-00002","article-title":"Epidemiology of asthma: the year in review","volume":"6","author":"Hartert","year":"2000","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.jaci.2005.01.028_bib6","first-page":"145","article-title":"Asthma prevalence and control characteristics by race\/ethnicity\u2014United States, 2002","volume":"53","author":"Centers for Disease Control and Prevention (CDC)","year":"2004","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jaci.2005.01.028_bib7","first-page":"52","article-title":"Asthma hospitalizations in Wisconsin: a missed opportunity for prevention","volume":"99","author":"Fiore","year":"2000","journal-title":"World Med J"},{"key":"10.1016\/j.jaci.2005.01.028_bib8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1067\/mai.2000.109426","article-title":"Trends in the cost of illness for asthma in the United States, 1985-1994","volume":"106","author":"Weiss","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.028_bib9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1056\/NEJM200102013440507","article-title":"Asthma","volume":"344","author":"Busse","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2005.01.028_bib10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1056\/NEJM200101043440106","article-title":"Allergy and allergic diseases. First of two parts","volume":"344","author":"Kay","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2005.01.028_bib11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1056\/NEJM200101113440206","article-title":"Allergy and allergic diseases. Second of two parts","volume":"344","author":"Kay","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2005.01.028_bib12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00281-003-0143-1","article-title":"T cell directives for transcriptional regulation in asthma","volume":"25","author":"Finotto","year":"2004","journal-title":"Springer Semin Immunopathol"},{"key":"10.1016\/j.jaci.2005.01.028_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4419-9194-2_1","article-title":"Leukotrienes in asthma","volume":"525","author":"Drazen","year":"2003","journal-title":"Adv Exp Med Biol"},{"issue":"suppl","key":"10.1016\/j.jaci.2005.01.028_bib14","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1067\/mai.2003.25","article-title":"Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling","volume":"111","author":"Holgate","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.028_bib15","article-title":"5-Lipoxygenase inhibition by zileuton causes acute bronchodilation in asthma","volume":"145","author":"Israel","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2005.01.028_bib16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.7326\/0003-4819-130-6-199903160-00005","article-title":"Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized, controlled trial. Montelukast\/Beclomethasone Study Group","volume":"130","author":"Malmstrom","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaci.2005.01.028_bib17","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0090-6980(02)00055-2","article-title":"Function of prostanoid receptors: studies on knockout mice","volume":"68-69","author":"Kobayashi","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jaci.2005.01.028_bib18","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1126\/science.287.5460.2013","article-title":"Prostaglandin D2 as a mediator of allergic asthma","volume":"287","author":"Matsuoka","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jaci.2005.01.028_bib19","doi-asserted-by":"crossref","first-page":"L599","DOI":"10.1152\/ajplung.00324.2002","article-title":"Receptors and pathways mediating the effects of prostaglandin E2 on airway tone","volume":"284","author":"Tilley","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2005.01.028_bib20","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1152\/jappl.2000.88.6.2214","article-title":"EP(2) receptor mediates bronchodilation by PGE(2) in mice","volume":"88","author":"Sheller","year":"2000","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jaci.2005.01.028_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1183\/09031936.03.00017003a","article-title":"Biomarkers of lipid peroxidation, airway inflammation and asthma","volume":"21","author":"Wood","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2005.01.028_bib22","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature00878","article-title":"Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness","volume":"418","author":"Van Eerdewegh","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2005.01.028_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/ng1166","article-title":"Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma","volume":"34","author":"Zhang","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2005.01.028_bib24","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1056\/NEJMcibr022144","article-title":"ADAM-33 surfaces as an asthma gene","volume":"347","author":"Shapiro","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2005.01.028_bib25","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/ng1256","article-title":"Positional cloning of a novel gene influencing asthma from chromosome 2q14","volume":"355","author":"Allen","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2005.01.028_bib26","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1056\/NEJMoa012705","article-title":"Mast-cell infiltration of airway smooth muscle in asthma","volume":"346","author":"Brightling","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2005.01.028_bib27","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1067\/mai.2001.119919","article-title":"Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP","volume":"108","author":"Gervais","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.028_bib28","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1164\/ajrccm\/145.6.1251","article-title":"A model of airway narrowing in asthma and in chronic obstructive pulmonary disease","volume":"145","author":"Wiggs","year":"1992","journal-title":"Am Rev Respir Dis"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674905001491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674905001491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:56:21Z","timestamp":1758776181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674905001491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0091674905001491"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2005.01.028","relation":{},"ISSN":["0091-6749"],"issn-type":[{"type":"print","value":"0091-6749"}],"subject":[],"published":{"date-parts":[[2005,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diversity of asthma: Evolving concepts of pathophysiology and lessons from genetics","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2005.01.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}