{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:51:07Z","timestamp":1761058267081,"version":"3.44.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.jaci.2005.01.037","type":"journal-article","created":{"date-parts":[[2005,4,2]],"date-time":"2005-04-02T07:14:54Z","timestamp":1112426094000},"page":"676-684","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Advances in upper airway diseases and allergen immunotherapy"],"prefix":"10.1016","volume":"115","author":[{"given":"Harold S.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2005.01.037_bib1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jaci.2003.10.010","article-title":"Association between asthma and rhinitis according to atopic sensitization in a population-based study","volume":"113","author":"Leynaert","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jaci.2003.09.047","article-title":"Allergic rhinitis: a disease remodeling the upper airways?","volume":"113","author":"Bousquet","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib3","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jaci.2004.07.061","article-title":"Similar allergic inflammation in the middle ear and the upper airway: evidence linking otitis media with effusion to the united airways concept","volume":"114","author":"Nguyen","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jaci.2003.11.034","article-title":"Rhinitis therapy and the prevention of hospital care for asthma: a case-control study","volume":"113","author":"Corren","year":"2004","journal-title":"J Allergy Clin Immunol"},{"issue":"suppl 6","key":"10.1016\/j.jaci.2005.01.037_bib5","first-page":"S156","article-title":"Rhinosinusitis: establishing definitions for clinical research and patient care","volume":"114","author":"Meltzer","year":"2004","journal-title":"J Allergy Clin Immunology"},{"key":"10.1016\/j.jaci.2005.01.037_bib6","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.jaci.2004.09.036","article-title":"Chronic sinusitis consensus and the way foreword","volume":"114","author":"Platts-Mills","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib7","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.jaci.2004.08.012","article-title":"Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi","volume":"114","author":"Shin","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1258\/0022215021910708","article-title":"Effect of anti-fungal nasal lavage with amphotericin B on nasal polyposis","volume":"116","author":"Ricchetti","year":"2002","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.jaci.2005.01.037_bib9","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1067\/mai.2002.130051","article-title":"Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis","volume":"110","author":"Ponikau","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib10","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.jaci.2004.03.038","article-title":"Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trail","volume":"113","author":"Weschta","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib11","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.jaci.2004.08.029","volume":"114","author":"Schubert","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib12","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jaci.2004.04.052","article-title":"Gene expression profiles in human nasal polyp tissues studied by means of DNA microarray","volume":"114","author":"Liu","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jaci.2004.04.051","article-title":"Antigen stimulation of TH2 cells augments acute bacterial sinusitis in mice","volume":"114","author":"Yu","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib14","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.jaci.2004.08.039","article-title":"Remission of allergic rhinitis: an 8-year observational study","volume":"114","author":"Bodtger","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib15","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jaci.2004.07.008","article-title":"Health-related quality of life in adult rhinitis: the role of perceived control of disease","volume":"114","author":"Chen","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib16","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jaci.2003.12.589","article-title":"Changes in daytime sleepiness, quality of life and objective sleep patterns in seasonal allergic rhinitis: a controlled clinical trail","volume":"113","author":"Stuck","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib17","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1016\/j.jaci.2004.08.044","article-title":"The correlation between allergic rhinitis and sleep disturbance","volume":"114","author":"Craig","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib18","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jaci.2004.07.010","article-title":"Nasal mucosal immunoexpression of the mast cell chemoattractants TGF-\u03b2, eotaxin, and stem cell factor and their receptors in allergic rhinitis","volume":"114","author":"Salib","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib19","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.jaci.2004.05.070","article-title":"Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis","volume":"114","author":"Bachert","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib20","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jaci.2004.01.773","article-title":"Levocetirizine better protects than desloratadine in a nasal provocation with allergen","volume":"113","author":"Deruaz","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jaci.2003.11.044","article-title":"Omalizumab rapidly decreases nasal allergic response and Rc\u03b5RI on basophils","volume":"113","author":"Lin","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib22","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jaci.2004.05.026","article-title":"Heparin attenuates symptoms and mast cell degranulation induced by AMP nasal provocation","volume":"114","author":"Zeng","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jaci.2003.10.065","article-title":"Vernal keratoconjunctivitis: result of a novel therapy with 0.1% topical ophthalmic FK-506 ointment","volume":"113","author":"Vichyanond","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib24","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jaci.2004.04.017","article-title":"Status of immunotherapy: current and future","volume":"113","author":"Casale","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib25","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jaci.2004.03.020","article-title":"Immunotherapy: 1999-2004","volume":"113","author":"Norman","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib26","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jaci.2004.03.024","article-title":"Mechanisms of immunotherapy","volume":"113","author":"Till","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib27","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.jaci.2003.12.003","article-title":"Lowell and Franklin on double-blind hyposensitization therapy for ragweed hay fever: the people","volume":"113","author":"Cohen","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib28","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.jaci.2004.03.041","article-title":"Lowell and Franklin on double-blind hyposensitization therapy for ragweed hay fever: the paper","volume":"113","author":"Dworetzky","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib29","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jaci.2003.12.586","article-title":"Effect of specific immunotherapy added to pharmacologic treatment and allergen avoidance in asthmatic patients allergic to house dust mite","volume":"113","author":"Maestrelli","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1067\/mai.2003.41","article-title":"A double-blind, placebo-controlled immunotherapy dose-response study with standardized cat extract","volume":"111","author":"Ewbank","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib31","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.jaci.2004.08.049","article-title":"Dose dependence and time course of the immunologic response to administration of standardized cat allergen extract","volume":"114","author":"Nanda","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib32","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.jaci.2004.06.058","article-title":"Randomized controlled trial of high-dose sublingual immunotherapy to treat seasonal allergic rhinitis","volume":"114","author":"Smith","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib33","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jaci.2004.07.012","article-title":"Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis","volume":"114","author":"Novembre","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib34","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.jaci.2004.03.013","article-title":"Quantitative assessment of the adherence to sublingual immunotherapy","volume":"113","author":"Lombardi","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib35","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.jaci.2004.02.006","article-title":"Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990-2001","volume":"113","author":"Bernstein","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib36","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.jaci.2004.01.756","article-title":"Incorrect allergy injections: allergists' experiences and recommendations for prevention","volume":"113","author":"Aaronson","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib37","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jaci.2004.03.003","article-title":"Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA","volume":"113","author":"Simons","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib38","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jaci.2003.11.001","article-title":"Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response","volume":"113","author":"Tulic","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib39","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jaci.2004.04.035","article-title":"Plasmacytoid dendritic cells activate allergen-specific TH2 memory cells: modulation by CpG oligodeoxynucleotides","volume":"114","author":"Farkas","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib40","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jaci.2003.11.024","article-title":"Manufacturing and standardizing fugal allergen products","volume":"113","author":"Esch","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib41","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jaci.2004.02.041","article-title":"Allergen immunotherapy induces a suppressive memory response medicated by IL-10 in a mouse asthma model","volume":"113","author":"Vissers","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib42","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jaci.2004.06.013","article-title":"Prevention of long-term IgE antibody production by gene gun-mediated DNA vaccination","volume":"114","author":"Ludwig-Portugall","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib43","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jaci.2004.05.065","article-title":"Modulation of allergic responses in mice by using biodegradable poly (lactide-col-glycolide) microspheres","volume":"114","author":"Jilek","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib44","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.jaci.2004.08.010","article-title":"M cell targeting with Aleuria aurantia lectin as a novel approach for oral allergen immunotherapy","volume":"114","author":"Roth-Walter","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib45","doi-asserted-by":"crossref","unstructured":"Mitman G. Oren C Durham. J Allergy Clin Immunol 2004;114:1229-30.","DOI":"10.1016\/j.jaci.2004.07.041"},{"key":"10.1016\/j.jaci.2005.01.037_bib46","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.jaci.2004.08.016","article-title":"A history of pollen mapping and surveillance: the relations between natural history and clinical allergy","volume":"114","author":"Mitman","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib47","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.jaci.2004.07.062","article-title":"The National Allergy Bureau: pollen and spore reporting today","volume":"114","author":"Portnoy","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib48","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jaci.2004.05.011","article-title":"Interpretation of isolated positive skin test results for mesquite tree pollen","volume":"114","author":"Kelso","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.01.037_bib49","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.jaci.2004.01.566","article-title":"Comparison of multiheaded devices for allergy skin testing","volume":"113","author":"Nelson","year":"2004","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674905001594?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674905001594?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:56:48Z","timestamp":1758776208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674905001594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0091674905001594"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2005.01.037","relation":{},"ISSN":["0091-6749"],"issn-type":[{"type":"print","value":"0091-6749"}],"subject":[],"published":{"date-parts":[[2005,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances in upper airway diseases and allergen immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2005.01.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}