{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T20:21:12Z","timestamp":1771532472738,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.jaci.2005.08.015","type":"journal-article","created":{"date-parts":[[2005,10,11]],"date-time":"2005-10-11T07:22:58Z","timestamp":1129015378000},"page":"1116-1122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Combination of corticosteroid therapy and allergen avoidance reverses allergen-induced airway remodeling in mice"],"prefix":"10.1016","volume":"116","author":[{"given":"Jae Youn","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsti","family":"McElwain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shauna","family":"McElwain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Broide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2005.08.015_bib1","series-title":"Global initiative for asthma: global strategy for asthma management and prevention: NHLBI\/WHO Workshop report","year":"1995"},{"issue":"suppl","key":"10.1016\/j.jaci.2005.08.015_bib2","first-page":"S141","article-title":"Expert panel report: guidelines for the diagnosis and management of asthma update on selected topics\u20142002","volume":"110","author":"National Asthma Education and Prevention Program","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.08.015_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001187.pub2","article-title":"House dust mite control measures for asthma","volume":"4","author":"G\u00f8tzsche","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jaci.2005.08.015_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1056\/NEJMoa023175","article-title":"Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma","volume":"349","author":"Woodcock","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2005.08.015_bib5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1056\/NEJMp030082","article-title":"Allergen avoidance in the treatment of asthma and rhinitis","volume":"349","author":"Platts-Mills","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2005.08.015_bib6","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1056\/NEJMoa032097","article-title":"Results of a home-based environmental intervention in urban children with asthma","volume":"351","author":"Morgan","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2005.08.015_bib7","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jaci.2004.05.041","article-title":"Improved bronchodilator effect of deep inhalation after allergen avoidance in asthmatic children","volume":"114","author":"Milanese","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.08.015_bib8","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0091-6749(96)70261-0","article-title":"Influence of allergen avoidance on the eosinophil phase of airway inflammation in children with allergic asthma","volume":"97","author":"Piacentini","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.08.015_bib9","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/thx.51.6.582","article-title":"Effect of allergen avoidance at high altitude on direct and indirect bronchial hyperresponsiveness and markers of inflammation in children with allergic asthma","volume":"51","author":"Van Velzen","year":"1996","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2005.08.015_bib10","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1046\/j.1365-2222.2002.01372.x","article-title":"Mite avoidance can reduce air trapping and airway inflammation in allergic asthmatic children","volume":"32","author":"Peroni","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2005.08.015_bib11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1046\/j.0905-6157.2003.00097.x","article-title":"Exhaled breath condensate eicosanoids and sputum eosinophils in asthmatic children: a pilot study","volume":"15","author":"Bodini","year":"2004","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2005.08.015_bib12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1172\/JCI19133","article-title":"Inhibition of airway remodeling in IL-5-deficient mice","volume":"113","author":"Cho","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2005.08.015_bib13","doi-asserted-by":"crossref","first-page":"7556","DOI":"10.4049\/jimmunol.173.12.7556","article-title":"Immunostimulatory DNA reverses established allergen-induced airway remodeling","volume":"173","author":"Cho","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2005.08.015_bib14","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1165\/rcmb.2003-0066OC","article-title":"Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling","volume":"30","author":"Cho","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2005.08.015_bib15","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1165\/rcmb.4853","article-title":"Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroids","volume":"28","author":"Ikeda","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2005.08.015_bib16","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1164\/ajrccm\/145.3.669","article-title":"Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma","volume":"145","author":"Djukanovic","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2005.08.015_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1164\/ajrccm.150.1.8025745","article-title":"Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma","volume":"150","author":"Trigg","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.08.015_bib18","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1164\/ajrccm.155.6.9196087","article-title":"Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodeling in mild asthma: a placebo-controlled study","volume":"155","author":"Olivieri","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.08.015_bib19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1164\/ajrccm.156.3.9610084","article-title":"Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid","volume":"156","author":"Laitinen","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.08.015_bib20","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0091-6749(99)70379-9","article-title":"Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma","volume":"104","author":"Hoshino","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.08.015_bib21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/thorax.57.4.309","article-title":"Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma","volume":"57","author":"Ward","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2005.08.015_bib22","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1164\/ajrccm.162.4.9910051","article-title":"Airway hyperresponsiveness, inflammation, and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma: influence of inhaled corticosteroids","volume":"162","author":"Boulet","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.08.015_bib23","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1067\/mai.2003.1557","article-title":"Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression","volume":"111","author":"Chakir","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.08.015_bib24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1165\/ajrcmb.23.2.3999","article-title":"Airway subepithelial fibrosis in a murine model of atopic asthma: suppression by dexamethasone or anti-interleukin-5 antibody","volume":"23","author":"Blyth","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2005.08.015_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1183\/09031936.04.00013303","article-title":"Increase in laminin expression in allergic airway remodelling and decrease by dexamethasone","volume":"24","author":"Christie","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2005.08.015_bib26","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1164\/ajrccm.163.3.2004160","article-title":"Fluticasone inhibits but does not reverse allergen-induced structural airway changes","volume":"163","author":"Vanacker","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.08.015_bib27","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1172\/JCI17974","article-title":"Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics","volume":"112","author":"Flood-Page","year":"2003","journal-title":"J Clin Invest"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674905018555?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674905018555?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:59:24Z","timestamp":1758776364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674905018555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0091674905018555"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2005.08.015","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combination of corticosteroid therapy and allergen avoidance reverses allergen-induced airway remodeling in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2005.08.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}