{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:50:04Z","timestamp":1772121004503,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.jaci.2005.09.053","type":"journal-article","created":{"date-parts":[[2006,1,28]],"date-time":"2006-01-28T07:10:36Z","timestamp":1138432236000},"page":"663-669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Is occupational asthma to diisocyanates a non\u2013IgE-mediated disease?"],"prefix":"10.1016","volume":"117","author":[{"given":"Meinir G.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Floyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayhan T.","family":"Nouri-Aria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikila R.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R.","family":"Durham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony Newman","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Cullinan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2005.09.053_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/oem.57.1.43","article-title":"Respiratory health surveillance in a toluene diisocyanate production unit, 1967-97: clinical observations and lung function analyses","volume":"57","author":"Ott","year":"2000","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.jaci.2005.09.053_bib2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/oem.54.4.272","article-title":"Physician based surveillance system for occupational respiratory diseases: the experience of PROPULSE, Quebec, Canada","volume":"54","author":"Provencher","year":"1997","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.jaci.2005.09.053_bib3","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/00043764-199907000-00006","article-title":"Prevalence of self-reported respiratory symptoms in workers exposed to isocyanates","volume":"41","author":"Sari-Minodier","year":"1999","journal-title":"J Occup Environ Med"},{"key":"10.1016\/j.jaci.2005.09.053_bib4","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1398-9995.1998.tb03822.x","article-title":"Prevalence of occupational asthma among automobile and furniture painters in the centre of Eskisehir (Turkey): the effects of atopy and smoking habits on occupational asthma","volume":"53","author":"Ucgun","year":"1998","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2005.09.053_bib5","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1136\/oem.57.12.823","article-title":"Reported incidence of occupational asthma in the United Kingdom, 1989-97","volume":"57","author":"McDonald","year":"2000","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.jaci.2005.09.053_bib6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1136\/oem.59.1.58","article-title":"Changes in rates and severity of compensation claims for asthma due to diisocyanates: a possible effect of medical surveillance measures","volume":"59","author":"Tarlo","year":"2002","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.jaci.2005.09.053_bib7","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0091-6749(98)70181-2","article-title":"Specific IgE to isocyanates: a useful diagnostic role in occupational asthma","volume":"101","author":"Tee","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.09.053_bib8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0091-6749(89)90364-3","article-title":"Specific serum antibodies against isocyanates: association with occupational asthma","volume":"84","author":"Cartier","year":"1989","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.09.053_bib9","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0091-6749(99)70297-6","article-title":"Specific IgG, but not specific IgE, antibodies to toluene diisocyanate-human serum albumin conjugate are associated with toluene diisocyanate bronchoprovocation test results","volume":"104","author":"Park","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.09.053_bib10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1365-2222.1988.tb02911.x","article-title":"Experiences of specific IgE in asthma due to diisocyanates","volume":"18","author":"Keskinen","year":"1988","journal-title":"Clin Allergy"},{"key":"10.1016\/j.jaci.2005.09.053_bib11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00130832-200104000-00009","article-title":"Recent developments in diisocyanate asthma","volume":"1","author":"Wisnewski","year":"2001","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.09.053_bib12","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1067\/mai.2001.114339","article-title":"Local expression of \u03b5 germline gene transcripts and RNA for the \u03b5 heavy chain of IgE in the bronchial mucosa in atopic and non atopic asthma","volume":"107","author":"Ying","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.09.053_bib13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0091-6749(91)90087-5","article-title":"Regulation of IgE synthesis in humans: a tale of two signals","volume":"88","author":"Vercelli","year":"1991","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.09.053_bib14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2222.1977.tb01448.x","article-title":"Bronchial reactivity to inhaled histamine: a method and clinical survey","volume":"7","author":"Cockroft","year":"1977","journal-title":"Clin Allergy"},{"key":"10.1016\/j.jaci.2005.09.053_bib15","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1164\/ajrccm\/146.1.170","article-title":"Immunohistology of the nasal mucosa following allergen-induced rhinitis. Identification of activated T lymphocytes, eosinophils, and neutrophils","volume":"146","author":"Varney","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2005.09.053_bib16","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/jcp.31.5.454","article-title":"Alkaline phosphatase and peroxidase for double immunising labelling of cellular contacts","volume":"31","author":"Mason","year":"1978","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jaci.2005.09.053_bib17","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4049\/jimmunol.141.12.4158","article-title":"The relationship between infiltrating CD4 positive lymphocytes, activated eosinophils and the magnitude of the allergen-induced late phase cutaneous reaction in man","volume":"141","author":"Frew","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2005.09.053_bib18","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1084\/jem.173.3.775","article-title":"Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5 and granulocyte\/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects","volume":"173","author":"Kay","year":"1991","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2005.09.053_bib19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0091-6749(93)90175-F","article-title":"Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma","volume":"92","author":"Robinson","year":"1993","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.09.053_bib20","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1164\/ajrccm.154.5.8912771","article-title":"IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and non atopic asthma: evidence against \u201cintrinsic\u201d asthma being a distinct immunopathologic entity","volume":"154","author":"Humbert","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.09.053_bib21","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/j.1365-2222.1997.tb01174.x","article-title":"Expression of interleukin (IL)-4 and IL-5 proteins in asthma induced by toluene diisocyanate (TDI)","volume":"27","author":"Maestrelli","year":"1997","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2005.09.053_bib22","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1046\/j.1365-2222.2000.00998.x","article-title":"Cytokine expression during allergen-induced late nasal responses: Il-4 and IL5 mRNA is expressed early (at 6 h) predominantly by eosinophils","volume":"30","author":"Nouri-aria","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2005.09.053_bib23","doi-asserted-by":"crossref","first-page":"376","DOI":"10.5271\/sjweh.1383","article-title":"CD8 T-cell clones producing interleukin-5 and interferon-gamma in bronchial mucosa of patients with asthma induced by toluene diisocyanate","volume":"20","author":"Maestrelli","year":"1994","journal-title":"Scan J Work Environ Health"},{"key":"10.1016\/j.jaci.2005.09.053_bib24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1165\/ajrcmb\/8.1.35","article-title":"Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for Interleukin-5 and granulocyte\/macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics","volume":"8","author":"Bentley","year":"1993","journal-title":"Am J respire Cell Mol Biol"},{"key":"10.1016\/j.jaci.2005.09.053_bib25","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1034\/j.1600-065X.2001.790118.x","article-title":"IL-5 induced airway eosinophilia\u2014the key to asthma?","volume":"179","author":"Hamelmann","year":"2001","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2005.09.053_bib26","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/0091-6749(92)90437-7","article-title":"Activated T-lymphocytes and eosinophils in the bronchial mucosa in isocyanate-induced asthma","volume":"89","author":"Bentley","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.09.053_bib27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1164\/ajrccm.158.1.9704061","article-title":"Immunization and challenge with toluene diisocyanate decrease tachykinin and calcitonin gene-related peptide immunoreactivity in guinea pigs central airways","volume":"158","author":"Mapp","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.09.053_bib28","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0006-8993(92)90692-3","article-title":"Nasal mucosa sensitization with toluene diisocyanate (TDI) increases preprotachkinin A (PPTA) and peproCGRP mRNAs in guinea pig trigeminal ganglion neurons","volume":"576","author":"Kalubi","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.jaci.2005.09.053_bib29","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1111\/j.1476-5381.1996.tb16087.x","article-title":"The involvement of sensory neuropeptides in toluene diisocyanate-induced tracheal hyperreactivity in the mouse airways","volume":"119","author":"Scheerens","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jaci.2005.09.053_bib30","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1164\/ajrccm.161.2.9812083","article-title":"Toluene diisocyanate enhances substance P in sensory neurons innervating the nasal mucosa","volume":"161","author":"Hunter","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.09.053_bib31","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1021\/tx990045h","article-title":"Intracellular S-glutathionyl adducts in murine lung and human bronchoepithelial cells after exposure to diisocyanate-toluene","volume":"12","author":"Lange","year":"1999","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jaci.2005.09.053_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1164\/ajrccm.162.6.2002086","article-title":"Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo","volume":"162","author":"Wisnewski","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.09.053_bib33","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00008571-200107000-00007","article-title":"Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure","volume":"11","author":"Piirila","year":"2001","journal-title":"Pharmacogenetics"},{"issue":"suppl","key":"10.1016\/j.jaci.2005.09.053_bib34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1081-1206(10)61647-X","article-title":"Recent developments in diisocyanate asthma","volume":"90","author":"Liu","year":"2003","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2005.09.053_bib35","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1164\/ajrccm.162.2.9909026","article-title":"Long-term follow up of hexamethylene diisocyanate-, diphenylmethane diisocyanate-, and toluene diisocyanate-induced asthma","volume":"162","author":"Piirila","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.09.053_bib36","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1067\/mai.2002.123234","article-title":"Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanantes","volume":"109","author":"Mapp","year":"2002","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674905023134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674905023134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:04:24Z","timestamp":1758776664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674905023134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0091674905023134"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2005.09.053","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.11418.468907","asserted-by":"object"}]},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is occupational asthma to diisocyanates a non\u2013IgE-mediated disease?","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2005.09.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}