{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:58:41Z","timestamp":1789372721498,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.jaci.2005.10.002","type":"journal-article","created":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T07:42:00Z","timestamp":1133250120000},"page":"72-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":135,"title":["Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life"],"prefix":"10.1016","volume":"117","author":[{"given":"James E.","family":"Gern","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Daniel","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunling","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Tisler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"DaSilva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy A.","family":"Roberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance D.","family":"Mikus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis A.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole J.","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Shult","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhik","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Gangnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert F.","family":"Lemanske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2005.10.002_bib1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1056\/NEJM198810273191702","article-title":"Diminished lung function as a predisposing factor for wheezing respiratory illness in infants","volume":"319","author":"Martinez","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2005.10.002_bib2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1164\/ajrccm.160.1.9807104","article-title":"Predictors of repeated wheeze in the first year of life: the relative roles of cockroach, birth weight, acute lower respiratory illness, and maternal smoking","volume":"160","author":"Gold","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.10.002_bib3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1086\/317655","article-title":"Bronchiolitis-associated mortality and estimates of respiratory syncytial virus-associated deaths among US children, 1979-1997","volume":"183","author":"Shay","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2005.10.002_bib4","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jaci.2003.10.044","article-title":"Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy","volume":"113","author":"Hoffjan","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.10.002_bib5","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1086\/344310","article-title":"A common haplotype of interleukin-4 gene IL4 is associated with severe respiratory syncytial virus disease in Korean children","volume":"186","author":"Choi","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2005.10.002_bib6","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1086\/377587","article-title":"Variants of the chemokine receptor CCR5 are associated with severe bronchiolitis caused by respiratory syncytial virus","volume":"188","author":"Hull","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2005.10.002_bib7","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1136\/thorax.55.12.1023","article-title":"Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families","volume":"55","author":"Hull","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2005.10.002_bib8","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1203\/00006450-200206000-00006","article-title":"Surfactant protein D gene polymorphism associated with severe respiratory syncytial virus infection","volume":"51","author":"Lahti","year":"2002","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jaci.2005.10.002_bib9","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1164\/ajrccm.159.5.9805080","article-title":"Reduced inteferon-\u03b3 production in infants with bronchiolitis and asthma","volume":"159","author":"Renzi","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.10.002_bib10","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1164\/ajrccm.161.5.9904078","article-title":"Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a one-year follow-up study","volume":"161","author":"Bont","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.10.002_bib11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1164\/rccm.200312-1647OC","article-title":"Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life","volume":"170","author":"Copenhaver","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2005.10.002_bib12","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(94)91641-1","article-title":"Reduced interferon-\u03b3 production in neonates and subsequent atopy","volume":"344","author":"Tang","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2005.10.002_bib13","doi-asserted-by":"crossref","first-page":"6583","DOI":"10.1128\/IAI.70.12.6583-6588.2002","article-title":"Development of interleukin-12-producing capacity throughout childhood","volume":"70","author":"Upham","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2005.10.002_bib14","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1183\/09031936.02.00229302","article-title":"Interactions between respiratory tract infections and atopy in the aetiology of asthma","volume":"19","author":"Holt","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2005.10.002_bib15","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jaci.2003.12.585","article-title":"High IFN-gamma production by CD8+ T cells and early sensitization among infants at high risk of atopy","volume":"113","author":"Rowe","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.10.002_bib16","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1067\/mai.2000.106211","article-title":"Fetal and neonatal IL-13 production during pregnancy and at birth and subsequent development of atopic symptoms","volume":"105","author":"Williams","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.10.002_bib17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0140-6736(98)05104-6","article-title":"Development of allergen-specific T-cell memory in atopic and normal children","volume":"353","author":"Prescott","year":"1999","journal-title":"Lancet"},{"issue":"suppl 15","key":"10.1016\/j.jaci.2005.10.002_bib18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1034\/j.1399-3038.13.s.15.8.x","article-title":"The childhood origins of asthma (COAST) study","volume":"13","author":"Lemanske","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2005.10.002_bib19","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0091-6749(03)01868-2","article-title":"Developmental cytokine response profiles and the clinical and immunologic expression of atopy in infancy","volume":"112","author":"Neaville","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.10.002_bib20","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1034\/j.1399-3038.2002.01093.x","article-title":"Relationships among specific viral pathogens, virus-induced interleukin- 8, and respiratory symptoms in infancy","volume":"13","author":"Gern","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2005.10.002_bib21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.0105-2896.2004.00215.x","article-title":"Interleukin-13 in asthma pathogenesis","volume":"202","author":"Wills-Karp","year":"2004","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2005.10.002_bib22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jaci.2004.04.006","article-title":"Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing","volume":"114","author":"Heymann","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.10.002_bib23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life","volume":"332","author":"Martinez","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2005.10.002_bib24","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/362248a0","article-title":"Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses","volume":"362","author":"Minty","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2005.10.002_bib25","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.4049\/jimmunol.159.9.4506","article-title":"Mechanism of suppression of macrophage nitric oxide release by IL-13: influence of the macrophage population","volume":"159","author":"Bogdan","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2005.10.002_bib26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.immunol.21.120601.141142","article-title":"IL-13 effector functions","volume":"21","author":"Wynn","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2005.10.002_bib27","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mai.2002.128241","article-title":"Persistence of viral RNA in 2 rat strains differing in susceptibility to postbronchiolitis airway dysfunction","volume":"110","author":"Sorkness","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2005.10.002_bib28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1136\/adc.86.6.431","article-title":"A hypothesis: antenatal sensitisation to respiratory syncytial virus in viral bronchiolitis","volume":"86","author":"Legg","year":"2002","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2005.10.002_bib29","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1089\/0882824041310612","article-title":"Innate immune responses in respiratory syncytial virus infections","volume":"17","author":"Krishnan","year":"2004","journal-title":"Viral Immunol"},{"key":"10.1016\/j.jaci.2005.10.002_bib30","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/80833","article-title":"Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus","volume":"1","author":"Kurt-Jones","year":"2000","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2005.10.002_bib31","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1086\/344644","article-title":"Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways","volume":"186","author":"Haeberle","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2005.10.002_bib32","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1365-2222.1996.tb00608.x","article-title":"Peripheral blood mononuclear cell proliferative responses in the first year of life in babies born to allergic parents","volume":"26","author":"Miles","year":"1996","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2005.10.002_bib33","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1399-3038.1994.tb00240.x","article-title":"Altered T lymphocyte phenotype at birth in babies born to atopic parents","volume":"5","author":"Miles","year":"1994","journal-title":"Pediatr Allergy Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674905021378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674905021378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:01:42Z","timestamp":1758776502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674905021378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0091674905021378"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2005.10.002","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.8236.465726","asserted-by":"object"}]},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2005.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}