{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:56:18Z","timestamp":1775253378901,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.jaci.2006.01.034","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T21:36:22Z","timestamp":1145655382000},"page":"878-882","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Etanercept treatment of cutaneous granulomas in common variable immunodeficiency"],"prefix":"10.1016","volume":"117","author":[{"given":"Joann H.","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron","family":"Liebhaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeb","family":"Dyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Richard","family":"Stiehm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2006.01.034_bib1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1046\/j.1365-2222.2001.01117.x","article-title":"Current perspectives on common variable immunodeficiency (CVID)","volume":"31","author":"Spickett","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2006.01.034_bib2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1067\/mai.2002.122466","article-title":"Primary immunodeficiency disorders: antibody deficiency","volume":"109","author":"Ballow","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.01.034_bib3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"Common variable immunodeficiency: clinical and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2006.01.034_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00005792-199609000-00002","article-title":"Sarcoidosis and common variable immunodeficiency. Report of 8 cases and review of the literature","volume":"75","author":"Fasano","year":"1996","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jaci.2006.01.034_bib5","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1182\/blood.V87.2.674.bloodjournal872674","article-title":"Persistent activation of the tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency\u2014possible immunologic and clinical consequences","volume":"87","author":"Aukrust","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.01.034_bib6","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1046\/j.1365-2133.2001.04092.x","article-title":"Common variable immunodeficiency treated with a recombinant human IgG, tumour necrosis factor-alpha receptor fusion protein","volume":"144","author":"Smith","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2006.01.034_bib7","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0190-9622(08)80965-6","article-title":"Cutaneous granulomas in children with combined immunodeficiency","volume":"25","author":"Siegfried","year":"1991","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2006.01.034_bib8","series-title":"Harrison's principles of internal medicine","first-page":"1683","article-title":"Sarcoidosis","author":"Crystal","year":"1994"},{"key":"10.1016\/j.jaci.2006.01.034_bib9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1525-1470.1995.tb00147.x","article-title":"Caseating cutaneous granulomas in a child with common variable immunodeficiency","volume":"12","author":"Torrelo","year":"1995","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.jaci.2006.01.034_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1440-0960.2004.00031.x","article-title":"Granulomas in common variable immunodeficiency: a diagnostic dilemma","volume":"45","author":"Lun","year":"2004","journal-title":"Australas J Dermatol"},{"key":"10.1016\/j.jaci.2006.01.034_bib11","first-page":"326","article-title":"Cutaneous granulomatous masquerading as tuberculoid leprosy in a patient with congenital combined immunodeficiency","volume":"68","author":"Krupnick","year":"2001","journal-title":"Mt Sinai J Med"},{"key":"10.1016\/j.jaci.2006.01.034_bib12","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1365-2249.2004.02558.x","article-title":"Development of granulomatous common variable immunodeficiency subsequent to infection with Toxoplasma gondii","volume":"137","author":"Mrusek","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2006.01.034_bib13","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0954-6111(06)80024-7","article-title":"Speculations on sarcoidosis","volume":"86","author":"O'Conner","year":"1992","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2006.01.034_bib14","doi-asserted-by":"crossref","first-page":"613","DOI":"10.7326\/0003-4819-127-8_Part_1-199710150-00005","article-title":"Granulomatous disease in common variable immunodeficiency","volume":"127","author":"Mechanic","year":"1997","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaci.2006.01.034_bib15","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1182\/blood.V76.10.2046.2046","article-title":"Characterization of common variable immunodeficiency: identification of a subset of patients with distinctive immunophenotypic and clinical features","volume":"76","author":"Wright","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.01.034_bib16","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.4049\/jimmunol.159.12.6236","article-title":"TNF and Lymphotoxin alpha polymorphisms associated with common variable immunodeficiency: role in the pathogenesis of granulomatous disease","volume":"159","author":"Mullighan","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.01.034_bib17","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1002\/art.21197","article-title":"Decreased incidence of anterior uveitis in patients with ankylosing spondylitis treated with the anti-tumor necrosis factor agents infliximab and etanercept","volume":"52","author":"Braun","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2006.01.034_bib18","first-page":"98","article-title":"Short term trial of etanercept in Behcet's disease: a double blind, placebo controlled study","volume":"32","author":"Melikoglu","year":"2005","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jaci.2006.01.034_bib19","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1001\/archderm.141.6.680","article-title":"Successful treatment of recalcitrant pemphigus vulgaris and pemphigus vegetans with etanercept and carbon dioxide laser","volume":"141","author":"Lin","year":"2005","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaci.2006.01.034_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/archderm.141.1.13","article-title":"Silicone granulomas treated with etanercept","volume":"141","author":"Pasternack","year":"2005","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaci.2006.01.034_bib21","unstructured":"Etanercept: drug Information. UpToDate. Available at: www.uptodate.com. Accessed 2005."},{"key":"10.1016\/j.jaci.2006.01.034_bib22","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1128\/IAI.69.3.1847-1855.2001","article-title":"Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology","volume":"69","author":"Mohan","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2006.01.034_bib23","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1086\/421494","article-title":"Tuberculosis following the use of etanercept, a tumor necrosis factor inhibitor","volume":"39","author":"Mohan","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaci.2006.01.034_bib24","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jaci.2005.08.041","article-title":"Caseating granulomatous disease in common variable immunodeficiency treated with infliximab","volume":"116","author":"Hatab","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.01.034_bib25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1081-1206(10)61228-8","article-title":"Infliximab treatment for severe granulomatous disease in common variable immunodeficiency: a case report and review of the literature","volume":"95","author":"Thatayatikom","year":"2005","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906002934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906002934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:03:45Z","timestamp":1758776625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674906002934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0091674906002934"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2006.01.034","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Etanercept treatment of cutaneous granulomas in common variable immunodeficiency","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2006.01.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}