{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:57:38Z","timestamp":1791172658775,"version":"4.1.0"},"reference-count":132,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.jaci.2006.02.005","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T21:36:22Z","timestamp":1145655382000},"page":"725-738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":364,"title":["The Wiskott-Aldrich syndrome"],"prefix":"10.1016","volume":"117","author":[{"given":"Hans D.","family":"Ochs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian J.","family":"Thrasher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2006.02.005_bib1","first-page":"212","article-title":"Famili\u00e4rer, angeborener Morbus Werlhofii?","volume":"68","author":"Wiskott","year":"1937","journal-title":"Monatsschr Kinderheilkd"},{"key":"10.1016\/j.jaci.2006.02.005_bib2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1542\/peds.13.2.133","article-title":"Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea","volume":"13","author":"Aldrich","year":"1954","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2006.02.005_bib3","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S0022-3476(05)82002-5","article-title":"A multiinstitutional survey of the Wiskott-Aldrich syndrome","volume":"125","author":"Sullivan","year":"1994","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaci.2006.02.005_bib4","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0092-8674(94)90528-2","article-title":"Isolation of a novel gene mutated in Wiskott-Aldrich syndrome","volume":"78","author":"Derry","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2006.02.005_bib5","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/ng0495-414","article-title":"X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the WASP gene","volume":"9","author":"Villa","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2006.02.005_bib6","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1182\/blood.V99.6.2268","article-title":"Missense mutations of the WASP gene cause intermittent X-linked thrombocytopenia","volume":"99","author":"Notarangelo","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/85886","article-title":"Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia","volume":"27","author":"Devriendt","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2006.02.005_bib8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/BF00916954","article-title":"Primary immunodeficiencies in Switzerland: first report of the national registry in adults and children","volume":"8","author":"Ryser","year":"1988","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib9","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1023\/A:1026416017763","article-title":"Primary immunodeficiency diseases in Norway","volume":"20","author":"Stray-Pedersen","year":"2000","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib10","first-page":"379","article-title":"The Wiskott-Aldrich syndrome","volume":"4","author":"Ochs","year":"2002","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.jaci.2006.02.005_bib11","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1182\/blood-2003-05-1480","article-title":"Clinical course of patients with WASP gene mutations","volume":"103","author":"Imai","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib12","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1182\/blood-2003-05-1592","article-title":"Mutations of the Wiskott-Aldrich Syndrome Protein (WASP): hotspots, effect on transcription, and translation and phenotype\/genotype correlation","volume":"104","author":"Jin","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1182\/blood.V55.2.243.243","article-title":"The Wiskott-Aldrich syndrome: studies of lymphocytes, granulocytes, and platelets","volume":"55","author":"Ochs","year":"1980","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2249.2004.02409.x","article-title":"Early deficit of lymphocytes in Wiskott-Aldrich syndrome: possible role of WASP in human lymphocyte maturation","volume":"136","author":"Park","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib15","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1182\/blood.V94.11.3872","article-title":"Spontaneous apoptosis in lymphocytes from patients with Wiskott-Aldrich syndrome: correlation of accelerated cell death and attenuated bcl-2 expression","volume":"94","author":"Rawlings","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib16","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1182\/blood.V95.4.1283.004k44_1283_1292","article-title":"Actin cytoskeletal function is spared, but apoptosis is increased, in WAS patient hematopoietic cells","volume":"95","author":"Rengan","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2249.2005.02693.x","article-title":"Phenotypic perturbation of B cells in the Wiskott-Aldrich syndrome","volume":"139","author":"Park","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0002-9343(68)90051-X","article-title":"Wiskott-Aldrich syndrome. An immunologic deficiency disease involving the afferent limb of immunity","volume":"44","author":"Cooper","year":"1968","journal-title":"Am J Med"},{"key":"10.1016\/j.jaci.2006.02.005_bib19","series-title":"Primary immunodeficiency diseases, a molecular and genetic approach","first-page":"292","article-title":"The Wiskott-Aldrich syndrome","author":"Ochs","year":"1999"},{"key":"10.1016\/j.jaci.2006.02.005_bib20","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.4049\/jimmunol.151.8.4383","article-title":"T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses","volume":"151","author":"Molina","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/(SICI)1096-9896(199805)185:1<99::AID-PATH48>3.0.CO;2-L","article-title":"Defective actin polymerization in EBV-transformed B-cell lines from patients with the Wiskott-Aldrich syndrome","volume":"185","author":"Facchetti","year":"1998","journal-title":"J Pathol"},{"key":"10.1016\/j.jaci.2006.02.005_bib22","doi-asserted-by":"crossref","first-page":"11351","DOI":"10.1073\/pnas.162376099","article-title":"Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses","volume":"99","author":"Orange","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2006.02.005_bib23","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1182\/blood-2003-07-2621","article-title":"Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect","volume":"104","author":"Gismondi","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib24","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1182\/blood.V95.9.2943.009k17_2943_2946","article-title":"Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis","volume":"95","author":"Lorenzi","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib25","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.4049\/jimmunol.166.8.4831","article-title":"Cutting edge: the Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells","volume":"166","author":"Leverrier","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib26","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/path.1651","article-title":"Wiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cells","volume":"204","author":"Calle","year":"2004","journal-title":"J Pathol"},{"key":"10.1016\/j.jaci.2006.02.005_bib27","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S1357-2725(01)00162-5","article-title":"Restoration of podosomes and chemotaxis in Wiskott-Aldrich syndrome macrophages following induced expression of WASp","volume":"34","author":"Jones","year":"2002","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/cm.10163","article-title":"Maturation of DC is associated with changes in motile characteristics and adherence","volume":"57","author":"Burns","year":"2004","journal-title":"Cell Motil Cytoskeleton"},{"key":"10.1016\/j.jaci.2006.02.005_bib29","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1182\/blood-2004-04-1678","article-title":"Mechanisms of WASp-mediated hematologic and immunologic disease","volume":"104","author":"Burns","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib30","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/adc.75.5.436","article-title":"Intravenous immunoglobulin, splenectomy, and antibiotic prophylaxis in Wiskott-Aldrich syndrome","volume":"75","author":"Litzman","year":"1996","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2006.02.005_bib31","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1182\/blood.V94.2.509","article-title":"The thrombocytopenia of Wiskott Aldrich syndrome is not related to a defect in proplatelet formation","volume":"94","author":"Haddad","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2141.1969.tb01383.x","article-title":"Wiskott-Aldrich syndrome: qualitative platelet defects and short platelet survival","volume":"17","author":"Grottum","year":"1969","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaci.2006.02.005_bib33","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1056\/NEJM197203092861001","article-title":"Platelet size and kinetics in hereditary and acquired thrombocytopenia","volume":"286","author":"Murphy","year":"1972","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2006.02.005_bib34","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1046\/j.1365-2141.1999.01637.x","article-title":"Pathological events in platelets of Wiskott-Aldrich syndrome patients","volume":"106","author":"Shcherbina","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaci.2006.02.005_bib35","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0167-5699(98)01350-4","article-title":"Is Wiskott-Aldrich syndrome a cell trafficking disorder?","volume":"19","author":"Thrasher","year":"1998","journal-title":"Immunol Today"},{"key":"10.1016\/j.jaci.2006.02.005_bib36","doi-asserted-by":"crossref","first-page":"e622","DOI":"10.1542\/peds.111.5.e622","article-title":"Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients","volume":"111","author":"Dupuis-Girod","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2006.02.005_bib37","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1182\/blood.V85.9.2471.bloodjournal8592471","article-title":"Nonrandom inactivation of the X chromosome in early lineage hematopoietic cells in carriers of Wiskott-Aldrich syndrome","volume":"85","author":"Wengler","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib38","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1182\/blood.V93.2.756","article-title":"Flow cytometric analysis of Wiskott-Aldrich syndrome (WAS) protein in lymphocytes from WAS patients and their familial carriers","volume":"93","author":"Yamada","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib39","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0046-8177(81)80085-8","article-title":"Wiskott-Aldrich syndrome: histopathologic findings in the lymph nodes and spleens of 15 patients","volume":"12","author":"Snover","year":"1981","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jaci.2006.02.005_bib40","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/00000478-199902000-00007","article-title":"The spleen in the Wiskott-Aldrich syndrome: histopathologic abnormalities of the white pulp correlate with the clinical phenotype of the disease","volume":"23","author":"Vermi","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jaci.2006.02.005_bib41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0888-7543(91)90480-3","article-title":"Localization of the gene for the Wiskott-Aldrich syndrome between two flanking markers, TIMP and DXS255, on Xp11.22-Xp11.3","volume":"10","author":"Kwan","year":"1991","journal-title":"Genomics"},{"key":"10.1016\/j.jaci.2006.02.005_bib42","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1083\/jcb.200403127","article-title":"Regulation of WASP\/WAVE proteins: making a long story short","volume":"166","author":"Bompard","year":"2004","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib43","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tcb.2004.04.007","article-title":"Regulation of actin dynamics by WASP and WAVE family proteins","volume":"14","author":"Stradal","year":"2004","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib44","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.cellbio.18.040202.112133","article-title":"Cellular control of actin nucleation","volume":"18","author":"Welch","year":"2002","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib45","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1074-7613(01)00178-9","article-title":"Wasp recruitment to the T cell: APC contact site occurs independently of Cdc42 activation","volume":"15","author":"Cannon","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2006.02.005_bib46","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1093\/emboj\/20.20.5603","article-title":"A WASp-VASP complex regulates actin polymerization at the plasma membrane","volume":"20","author":"Castellano","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.jaci.2006.02.005_bib47","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1091\/mbc.e02-05-0294","article-title":"Motility determinants in WASP family proteins","volume":"13","author":"Yarar","year":"2002","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jaci.2006.02.005_bib48","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1074-7613(02)00516-2","article-title":"The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse","volume":"18","author":"Badour","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2006.02.005_bib49","doi-asserted-by":"crossref","first-page":"5725","DOI":"10.1128\/MCB.15.10.5725","article-title":"Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains","volume":"15","author":"Rivero-Lezcano","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib50","doi-asserted-by":"crossref","first-page":"26448","DOI":"10.1074\/jbc.M103856200","article-title":"Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2\/3 pathway","volume":"276","author":"Rohatgi","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2006.02.005_bib51","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1091\/mbc.8.9.1709","article-title":"Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells","volume":"8","author":"She","year":"1997","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jaci.2006.02.005_bib52","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0960-9822(02)00642-5","article-title":"Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases","volume":"6","author":"Banin","year":"1996","journal-title":"Curr Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib53","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1182\/blood.V93.6.2003.406k13_2003_2012","article-title":"Involvement of Wiskott-Aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway","volume":"93","author":"Baba","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib54","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.4049\/jimmunol.157.9.3791","article-title":"Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways","volume":"157","author":"Cory","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib55","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.20030976","article-title":"Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation","volume":"199","author":"Badour","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2006.02.005_bib56","doi-asserted-by":"crossref","first-page":"5765","DOI":"10.1074\/jbc.273.10.5765","article-title":"Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein","volume":"273","author":"Wu","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2006.02.005_bib57","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/ncb1001-927","article-title":"Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP","volume":"3","author":"Hussain","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib58","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1084\/jem.194.12.1777","article-title":"The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis","volume":"194","author":"McGavin","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2006.02.005_bib59","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1093\/emboj\/cdf604","article-title":"Syndapins integrate N-WASP in receptor-mediated endocytosis","volume":"21","author":"Kessels","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.jaci.2006.02.005_bib60","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1091\/mbc.e03-05-0315","article-title":"Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells","volume":"14","author":"Da Costa","year":"2003","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jaci.2006.02.005_bib61","doi-asserted-by":"crossref","first-page":"6461","DOI":"10.1074\/jbc.M207433200","article-title":"Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor","volume":"278","author":"Otsuki","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2006.02.005_bib62","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/ncb1304","article-title":"Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes","volume":"7","author":"Innocenti","year":"2005","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib63","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.1093\/emboj\/17.22.6516","article-title":"The essential role of profilin in the assembly of actin for microspike formation","volume":"17","author":"Suetsugu","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.jaci.2006.02.005_bib64","doi-asserted-by":"crossref","first-page":"7854","DOI":"10.1074\/jbc.275.11.7854","article-title":"Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules","volume":"275","author":"Tian","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2006.02.005_bib65","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev.cellbio.19.050103.103356","article-title":"Ena\/VASP proteins: regulators of the actin cytoskeleton and cell migration","volume":"19","author":"Krause","year":"2003","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib66","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0960-9822(02)00423-2","article-title":"Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome","volume":"6","author":"Aspenstrom","year":"1996","journal-title":"Curr Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib67","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/34208","article-title":"Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP","volume":"391","author":"Miki","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2006.02.005_bib68","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/20726","article-title":"Structure of Cdc42 in complex with the GTPase-binding domain of the \u201cWiskott-Aldrich syndrome\u201d protein","volume":"399","author":"Abdul-Manan","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2006.02.005_bib69","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)80732-1","article-title":"The interaction between N-WASP and the Arp2\/3 complex links Cdc42-dependent signals to actin assembly","volume":"97","author":"Rohatgi","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2006.02.005_bib70","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1083\/jcb.150.6.1311","article-title":"Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2\/3 complex","volume":"150","author":"Higgs","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib71","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.cellbio.21.020604.150721","article-title":"Rho GTPases: biochemistry and biology","volume":"21","author":"Jaffe","year":"2005","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib72","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/35004513","article-title":"Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein","volume":"404","author":"Kim","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2006.02.005_bib73","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.molcel.2005.08.036","article-title":"An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins","volume":"20","author":"Hemsath","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.jaci.2006.02.005_bib74","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cell.2004.06.027","article-title":"Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex","volume":"118","author":"Ho","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2006.02.005_bib75","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1083\/jcb.152.3.471","article-title":"A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2\/3 complex activation independent of Cdc42","volume":"152","author":"Fukuoka","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib76","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1126\/science.290.5492.801","article-title":"Integration of multiple signals through cooperative regulation of the N-WASP-Arp2\/3 complex","volume":"290","author":"Prehoda","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jaci.2006.02.005_bib77","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1083\/jcb.150.6.1299","article-title":"Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate","volume":"150","author":"Rohatgi","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib78","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.molcel.2004.11.054","article-title":"A polybasic motif allows N-WASP to act as a sensor of PIP(2) density","volume":"17","author":"Papayannopoulos","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.jaci.2006.02.005_bib79","doi-asserted-by":"crossref","first-page":"14671","DOI":"10.1073\/pnas.94.26.14671","article-title":"WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells","volume":"94","author":"Ramesh","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2006.02.005_bib80","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(02)01076-0","article-title":"Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich syndrome","volume":"111","author":"Volkman","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2006.02.005_bib81","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/S0960-9822(02)01112-0","article-title":"The WH1 and EVH1 domains of WASP and Ena\/VASP family members bind distinct sequence motifs","volume":"12","author":"Zettl","year":"2002","journal-title":"Curr Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib82","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/35017080","article-title":"A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization","volume":"2","author":"Moreau","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib83","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S1097-2765(02)00728-1","article-title":"Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation","volume":"10","author":"Sasahara","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/j.jaci.2006.02.005_bib84","doi-asserted-by":"crossref","first-page":"45115","DOI":"10.1074\/jbc.M203346200","article-title":"Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein","volume":"277","author":"Cory","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2006.02.005_bib85","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/S1097-2765(03)00139-4","article-title":"Contingent phosphorylation\/dephosphorylation provides a mechanism of molecular memory in WASP","volume":"11","author":"Torres","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.jaci.2006.02.005_bib86","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1074\/jbc.M509416200","article-title":"Protein tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)\/neuronal WASP","volume":"281","author":"Torres","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2006.02.005_bib87","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S1097-2765(03)00172-2","article-title":"Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2\/3 complex and enhances actin polymerization by WASP","volume":"11","author":"Cory","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.jaci.2006.02.005_bib88","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.4049\/jimmunol.161.2.1026","article-title":"Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenylalanine","volume":"161","author":"Badolato","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib89","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1046\/j.1365-2141.1998.00767.x","article-title":"Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome","volume":"101","author":"Zicha","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaci.2006.02.005_bib90","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1002\/(SICI)1521-4141(199810)28:10<3259::AID-IMMU3259>3.0.CO;2-B","article-title":"Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome","volume":"28","author":"Binks","year":"1998","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib91","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1182\/blood.V98.4.1142","article-title":"Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation","volume":"98","author":"Burns","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib92","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nri1222","article-title":"Homing and cellular traffic in lymph nodes","volume":"3","author":"von Andrian","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib93","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1182\/blood-2004-06-2332","article-title":"Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein","volume":"105","author":"de Noronha","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib94","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1189\/jlb.0804444","article-title":"WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo","volume":"77","author":"Snapper","year":"2005","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib95","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1083\/jcb.141.5.1147","article-title":"A role for Cdc42 in macrophage chemotaxis","volume":"141","author":"Allen","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib96","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4049\/jimmunol.165.1.221","article-title":"The polarization defect of Wiskott-Aldrich syndrome macrophages is linked to dislocalization of the Arp2\/3 complex","volume":"165","author":"Linder","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib97","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1083\/jcb.99.5.1696","article-title":"Cell-substratum interaction of cultured avian osteoclasts is mediated by specific adhesion structures","volume":"99","author":"Marchisio","year":"1984","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2006.02.005_bib98","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/jbmr.5650030405","article-title":"Adhesion patterns and cytoskeleton of rabbit osteoclasts on bone slices and glass","volume":"3","author":"Turksen","year":"1988","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jaci.2006.02.005_bib99","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0014-4827(89)90266-8","article-title":"Immunocytochemical distribution of extracellular matrix receptors in human osteoclasts: a beta 3 integrin is colocalized with vinculin and talin in the podosomes of osteoclastoma giant cells","volume":"182","author":"Zambonin-Zallone","year":"1989","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jaci.2006.02.005_bib100","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/jbmr.5650060806","article-title":"Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro","volume":"6","author":"Lakkakorpi","year":"1991","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jaci.2006.02.005_bib101","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.1991.261.1.C1","article-title":"Clear zone in osteoclast function: role of podosomes in regulation of bone-resorbing activity","volume":"261","author":"Teti","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jaci.2006.02.005_bib102","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1182\/blood-2003-04-1259","article-title":"WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption","volume":"103","author":"Calle","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib103","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1182\/blood.V97.1.33","article-title":"The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis","volume":"97","author":"Haddad","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib104","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/intimm\/dxh310","article-title":"WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1\u03b1","volume":"18","author":"Gallego","year":"2006","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib105","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1182\/blood-2004-03-1003","article-title":"Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response","volume":"105","author":"Westerberg","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib106","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1182\/blood.V90.1.70.70_70_75","article-title":"Expression of Wiskott-Aldrich syndrome protein (WASP) gene during hematopoietic differentiation","volume":"90","author":"Parolini","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib107","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1182\/blood.V96.4.1591","article-title":"Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region","volume":"96","author":"Marshall","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib108","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1182\/blood-2002-07-2099","article-title":"A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome","volume":"102","author":"Lacout","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib109","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1182\/blood.V90.8.3089","article-title":"Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation","volume":"90","author":"Gallego","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib110","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1074-7613(02)00360-6","article-title":"Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation","volume":"17","author":"Dupre","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2006.02.005_bib111","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.4049\/jimmunol.173.3.1658","article-title":"Differential roles for Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production","volume":"173","author":"Cannon","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib112","doi-asserted-by":"crossref","first-page":"726","DOI":"10.4049\/jimmunol.173.2.726","article-title":"Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells","volume":"173","author":"Morales-Tirado","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib113","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1182\/blood-2004-01-0380","article-title":"NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs","volume":"104","author":"Borg","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib114","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.4049\/jimmunol.174.5.2602","article-title":"The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-kappa B (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement","volume":"174","author":"Huang","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib115","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1084\/jem.190.9.1329","article-title":"Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes","volume":"190","author":"Zhang","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2006.02.005_bib116","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1182\/blood.V98.4.1086","article-title":"Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes","volume":"98","author":"Westerberg","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib117","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1046\/j.1365-2567.2003.01668.x","article-title":"Efficient antigen presentation of soluble, but not particulate, antigen in the absence of Wiskott-Aldrich syndrome protein","volume":"109","author":"Westerberg","year":"2003","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2006.02.005_bib118","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1074-7613(00)80590-7","article-title":"Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation","volume":"9","author":"Snapper","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2006.02.005_bib119","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1182\/blood.V86.10.3797.bloodjournal86103797","article-title":"The Wiskott-Aldrich syndrome and X-linked congenital thrombocytopenia are caused by mutations of the same gene","volume":"86","author":"Zhu","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib120","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.4049\/jimmunol.166.8.5245","article-title":"Spontaneous in vivo reversion of an inherited mutation in the Wiskott-Aldrich syndrome","volume":"166","author":"Ariga","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.005_bib121","doi-asserted-by":"crossref","first-page":"8697","DOI":"10.1073\/pnas.151260498","article-title":"Somatic mosaicism in Wiskott-Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism","volume":"98","author":"Wada","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2006.02.005_bib122","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI15485","article-title":"Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings","volume":"111","author":"Wada","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2006.02.005_bib123","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1182\/blood-2003-05-1739","article-title":"Differential contribution of Wiskott-Aldrich syndrome protein to selective advantage in T- and B-cell lineages","volume":"103","author":"Konno","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib124","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1182\/blood-2004-12-4724","article-title":"Mosaicism of NK cells in a patient with Wiskott-Aldrich syndrome","volume":"106","author":"Lutskiy","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib125","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1182\/blood.V97.6.1598","article-title":"Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant Registry and the National Marrow Donor Program","volume":"97","author":"Filipovich","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib126","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1517\/14712598.5.9.1175","article-title":"Gene therapy for severe combined immunodeficiencies","volume":"5","author":"Thrasher","year":"2005","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.jaci.2006.02.005_bib127","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1182\/blood-2002-11-3489","article-title":"Defects in T-cell-mediated immunity to influenza virus in murine Wiskott-Aldrich syndrome are corrected by oncoretroviral vector-mediated gene transfer into repopulating hematopoietic cells","volume":"102","author":"Strom","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib128","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.ymthe.2004.08.008","article-title":"Lentiviral vector-mediated gene transfer in T cells from Wiskott-Aldrich syndrome patients leads to functional correction","volume":"10","author":"Dupre","year":"2004","journal-title":"Mol Ther"},{"key":"10.1016\/j.jaci.2006.02.005_bib129","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/sj.gt.3302457","article-title":"Lentiviral vectors transcriptionally targeted to hematopoietic cells by WASP gene proximal promoter sequences","volume":"12","author":"Martin","year":"2005","journal-title":"Gene Ther"},{"key":"10.1016\/j.jaci.2006.02.005_bib130","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/sj.gt.3301950","article-title":"Functional correction of T cells derived from patients with the Wiskott-Aldrich syndrome (WAS) by transduction with an oncoretroviral vector encoding the WAS protein","volume":"10","author":"Strom","year":"2003","journal-title":"Gene Ther"},{"key":"10.1016\/j.jaci.2006.02.005_bib131","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1182\/blood-2002-05-1423","article-title":"Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice","volume":"101","author":"Klein","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2006.02.005_bib132","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/sj.gt.3302440","article-title":"A lentiviral vector encoding the human Wiskott-Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice","volume":"12","author":"Charrier","year":"2005","journal-title":"Gene Ther"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906003162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906003162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:02:54Z","timestamp":1758776574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674906003162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":132,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0091674906003162"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2006.02.005","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Wiskott-Aldrich syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2006.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}