{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:01:26Z","timestamp":1791478886433,"version":"4.3.4"},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.jaci.2006.02.026","type":"journal-article","created":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T09:09:41Z","timestamp":1146647381000},"page":"1411-1414","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":130,"title":["Tryptase genetics and anaphylaxis"],"prefix":"10.1016","volume":"117","author":[{"given":"George H.","family":"Caughey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2006.02.026_bib1","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.4049\/jimmunol.138.8.2611","article-title":"Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells","volume":"138","author":"Schwartz","year":"1987","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.026_bib2","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1056\/NEJM198706253162603","article-title":"Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis","volume":"316","author":"Schwartz","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2006.02.026_bib3","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0161-5890(02)00087-1","article-title":"New developments in the genetics and activation of mast cell proteases","volume":"38","author":"Caughey","year":"2002","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaci.2006.02.026_bib4","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1074\/jbc.274.6.3355","article-title":"Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3","volume":"274","author":"Pallaoro","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2006.02.026_bib5","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1046\/j.1365-2222.2002.01416.x","article-title":"Genetic deficiency of human mast cell \u03b1-tryptase","volume":"32","author":"Soto","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2006.02.026_bib6","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.4049\/jimmunol.170.11.5667","article-title":"Tryptase precursors are preferentially and spontaneously released, whereas mature tryptase is retained by HMC-1 Cells, Mono-Mac-6 Cells, and human skin-derived mast cells","volume":"170","author":"Schwartz","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.026_bib7","doi-asserted-by":"crossref","first-page":"5145","DOI":"10.4049\/jimmunol.169.9.5145","article-title":"Delta tryptase is expressed in multiple human tissues, and a recombinant form has proteolytic activity","volume":"169","author":"Wang","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.026_bib8","doi-asserted-by":"crossref","first-page":"6566","DOI":"10.4049\/jimmunol.164.12.6566","article-title":"Characterization of human g-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families","volume":"164","author":"Caughey","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.026_bib9","doi-asserted-by":"crossref","first-page":"41906","DOI":"10.1074\/jbc.M205868200","volume":"277","author":"Wong","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2006.02.026_bib10","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1073\/pnas.87.10.3811","article-title":"Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family","volume":"87","author":"Vanderslice","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2006.02.026_bib11","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1172\/JCI118523","article-title":"A novel heparin-dependent processing pathway for human tryptase: autocatalysis followed by activation with dipeptidyl peptidase I","volume":"97","author":"Sakai","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2006.02.026_bib12","doi-asserted-by":"crossref","first-page":"19670","DOI":"10.1074\/jbc.274.28.19670","article-title":"Human tryptases alpha and beta\/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft","volume":"274","author":"Huang","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2006.02.026_bib13","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1172\/JCI114051","article-title":"Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis","volume":"83","author":"Schwartz","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2006.02.026_bib14","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0091-6749(06)80017-5","article-title":"Insect-sting challenge in 138 patients: relation between clinical severity of anaphylaxis and mast cell activation","volume":"90","author":"van der Linden","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.02.026_bib15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000083954","article-title":"Indolent systemic mastocytosis with elevated serum tryptase, absence of skin lesions, and recurrent severe anaphylactoid episodes","volume":"136","author":"Florian","year":"2005","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2006.02.026_bib16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0379-0738(02)00383-3","article-title":"Mast cell tryptase and hemolysis after trauma","volume":"131","author":"Edston","year":"2003","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.jaci.2006.02.026_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/0470861193.ch9","article-title":"Patterns of anaphylaxis: acute and late phase features of allergic reactions","volume":"257","author":"Golden","year":"2004","journal-title":"Novartis Found Symp"},{"key":"10.1016\/j.jaci.2006.02.026_bib18","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1172\/JCI19785","article-title":"Mast cells are required for experimental oral allergen-induced diarrhea","volume":"112","author":"Brandt","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2006.02.026_bib19","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1084\/jem.182.6.1871","article-title":"Release of the mucosal mast cell granule chymase, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum","volume":"182","author":"Scudamore","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2006.02.026_bib20","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.4049\/jimmunol.168.4.1992","article-title":"Tryptase inhibition blocks airway inflammation in a mouse asthma model","volume":"168","author":"Oh","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.02.026_bib21","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1067\/mai.2001.115631","article-title":"Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma","volume":"107","author":"Krishna","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.02.026_bib22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1164\/ajrccm.154.3.8810600","article-title":"Inhaled tryptase causes bronchoconstriction in sheep via histamine release","volume":"154","author":"Molinari","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2006.02.026_bib23","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1021\/bi972119z","article-title":"Human mast cell tryptase fibrinogenolysis: kinetics, anticoagulation mechanism, and cell adhesion disruption","volume":"37","author":"Thomas","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.jaci.2006.02.026_bib24","doi-asserted-by":"crossref","first-page":"9416","DOI":"10.1016\/S0021-9258(17)36896-5","article-title":"Human mast cell tryptase activates single-chain urinary-type plasminogen activator (pro-urokinase)","volume":"269","author":"Stack","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2006.02.026_bib25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1183\/09031936.97.10010038","article-title":"Mast cell tryptase potentiates histamine-induced contraction in human sensitized bronchus","volume":"10","author":"Johnson","year":"1997","journal-title":"Eur Respir J"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906004428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906004428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:04:14Z","timestamp":1758776654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674906004428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0091674906004428"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2006.02.026","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tryptase genetics and anaphylaxis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2006.02.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}