{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:40:26Z","timestamp":1787802026637,"version":"build-2784847793"},"reference-count":24,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.jaci.2006.03.008","type":"journal-article","created":{"date-parts":[[2006,6,5]],"date-time":"2006-06-05T14:02:44Z","timestamp":1149516164000},"page":"1374-1381","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":186,"title":["Which aspects of the farming lifestyle explain the inverse association with childhood allergy?"],"prefix":"10.1016","volume":"117","author":[{"given":"Michael R.","family":"Perkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Strachan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl","key":"10.1016\/j.jaci.2006.03.008_bib1","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1097\/00001648-199607001-00115","article-title":"Lower risk of allergic sensitization and hay fever in farmers' children in Switzerland","volume":"7","author":"Braun-Fahrl\u00e4nder","year":"1996","journal-title":"Epidemiology"},{"key":"10.1016\/j.jaci.2006.03.008_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1046\/j.1365-2222.1999.00479.x","article-title":"Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community","volume":"29","author":"Braun-Fahrl\u00e4nder","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2006.03.008_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1046\/j.1365-2222.2000.00801.x","article-title":"Reduced risk of hay fever and asthma among children of farmers","volume":"30","author":"von Ehrenstein","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2006.03.008_bib4","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1046\/j.1365-2222.2000.00799.x","article-title":"Austrian children living on a farm have less hay fever, asthma and allergic sensitization","volume":"30","author":"Riedler","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2006.03.008_bib5","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(01)06252-3","article-title":"Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey","volume":"358","author":"Riedler","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2006.03.008_bib6","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJMoa020057","article-title":"Environmental exposure to endotoxin and its relation to asthma in school-age children","volume":"347","author":"Braun-Fahrl\u00e4nder","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2006.03.008_bib7","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1046\/j.1365-2222.2001.01070.x","article-title":"Having lived on a farm and protection against allergic diseases in Australia","volume":"31","author":"Downs","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2006.03.008_bib8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1046\/j.1365-2222.2000.00800.x","article-title":"Farm environment in childhood prevents the development of allergies","volume":"30","author":"Kilpel\u00e4inen","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2006.03.008_bib9","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1651-2227.2002.tb00122.x","article-title":"Does heredity modify the association between farming and allergy in children?","volume":"91","author":"Remes","year":"2002","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jaci.2006.03.008_bib10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1365-2222.2003.01566.x","article-title":"Which factors explain the lower prevalence of atopy amongst farmers' children?","volume":"33","author":"Remes","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2006.03.008_bib11","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1164\/ajrccm.161.5.9908119","article-title":"Relative scarcity of asthma and atopy among rural adolescents raised on a farm","volume":"161","author":"Ernst","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2006.03.008_bib12","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1183\/09031936.01.00027301","article-title":"Fewer allergic respiratory disorders among farmers' children in a closed birth cohort from Sweden","volume":"17","author":"Klintberg","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2006.03.008_bib13","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1034\/j.1398-9995.2002.t01-1-23644.x","article-title":"Farm residence and exposures and the risk of allergic diseases in New Zealand children","volume":"57","author":"Wickens","year":"2002","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2006.03.008_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1183\/09031936.95.08030483","article-title":"International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods","volume":"8","author":"Asher","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2006.03.008_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1398-9995.1993.tb04756.x","article-title":"Position paper: allergen standardization and skin tests","volume":"48","author":"EAACI","year":"1993","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2006.03.008_bib16","first-page":"2","article-title":"The impact of non-endotoxin LAL-reactive materials on Limulus amebocyte lysate analyses","volume":"51","author":"Cooper","year":"1997","journal-title":"PDA J Pharm Sci Technol"},{"key":"10.1016\/j.jaci.2006.03.008_bib17","first-page":"186","article-title":"Clottable protein in Limulus; its localization and kinetics of its coagulation by endotoxin","volume":"19","author":"Levin","year":"1968","journal-title":"Thromb Diath Haemorrh"},{"key":"10.1016\/j.jaci.2006.03.008_bib18","unstructured":"StataCorp. Stata Statistical Software: Release 8.0. College Station (TX): Stata Corp; 2003."},{"key":"10.1016\/j.jaci.2006.03.008_bib19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jaci.2003.09.037","article-title":"Asthma prevalence and morbidity among rural Iowa schoolchildren","volume":"113","author":"Chrischilles","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.03.008_bib20","first-page":"156","article-title":"Evaluation of the lipopolysaccharide (LPS) content as determined by the limulus test in milk and milk products II: raw milk and influences of technological procedures","volume":"41","author":"Suhren","year":"1986","journal-title":"Milchwissenschaft"},{"key":"10.1016\/j.jaci.2006.03.008_bib21","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1046\/j.1365-2222.2000.00943.x","article-title":"Probiotics in the management of atopic eczema","volume":"30","author":"Isolauri","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2006.03.008_bib22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.33321\/cdi.2002.26.42","article-title":"Outbreak of Cryptosporidium linked to drinking unpasteurised milk","volume":"26","author":"Harper","year":"2002","journal-title":"Commun Dis Intell"},{"key":"10.1016\/j.jaci.2006.03.008_bib23","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF01719576","article-title":"An outbreak of Campylobacter infection associated with the consumption of unpasteurised milk at a large festival in England","volume":"10","author":"Morgan","year":"1994","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jaci.2006.03.008_bib24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2807\/esm.06.10.00379-en","article-title":"Escherichia coli O157 infections and unpasteurised milk","volume":"6","author":"Allerberger","year":"2001","journal-title":"Euro Surveill"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906006518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906006518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:03:52Z","timestamp":1758776632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674906006518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0091674906006518"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2006.03.008","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Which aspects of the farming lifestyle explain the inverse association with childhood allergy?","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2006.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}