{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:26:01Z","timestamp":1790256361972,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.jaci.2006.08.041","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T07:12:37Z","timestamp":1164957157000},"page":"314-321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":265,"title":["Prevalence of viral respiratory tract infections in children with asthma"],"prefix":"10.1016","volume":"119","author":[{"given":"Nino","family":"Khetsuriani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Neely","family":"Kazerouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean D.","family":"Erdman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Redd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Gerald","family":"Teague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2006.08.041_bib1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/bmj.3.5822.323","article-title":"Infective factors in exacerbations of bronchitis and asthma","volume":"3","author":"Lambert","year":"1972","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2006.08.041_bib2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1001\/jama.1974.03230160020004","article-title":"Viruses\u00a0as precipitants of asthmatic attacks in children","volume":"227","author":"Minor","year":"1974","journal-title":"JAMA"},{"key":"10.1016\/j.jaci.2006.08.041_bib3","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1136\/thx.34.3.344","article-title":"Relationship of bacterial and viral infections to asthma","volume":"34","author":"Clarke","year":"1979","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2006.08.041_bib4","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1136\/thx.43.9.679","article-title":"Viral respiratory tract infections and exacerbations of asthma","volume":"43","author":"Beasley","year":"1988","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2006.08.041_bib5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2222.1992.tb03094.x","article-title":"Viruses as precipitants of asthma symptoms. I. Epidemiology","volume":"22","author":"Pattemore","year":"1992","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2006.08.041_bib6","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1001\/archinte.158.22.2453","article-title":"Respiratory tract viral infections in inner-city asthmatic adults","volume":"158","author":"Atmar","year":"1998","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jaci.2006.08.041_bib7","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1136\/bmj.310.6989.1225","article-title":"Community study of role of viral infections in exacerbations of asthma in 9-11 year old children","volume":"310","author":"Johnston","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2006.08.041_bib8","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1164\/ajrccm.159.3.9801052","article-title":"Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care: IgE and eosinophil analysis","volume":"159","author":"Rakes","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2006.08.041_bib9","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1086\/368411","article-title":"Asthma exacerbations in children associated with rhinovirus and not human metapneumovirus infection","volume":"187","author":"Rawlinson","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2006.08.041_bib10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jaci.2004.04.006","article-title":"Viral infections in relation to age, atopy and season of admission among children hospitalized for wheezing","volume":"114","author":"Heymann","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.08.041_bib11","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1136\/bmj.307.6910.982","article-title":"Respiratory viruses and exacerbations of asthma in adults","volume":"307","author":"Nicholson","year":"1993","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2006.08.041_bib12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1386-6532(99)00030-X","article-title":"Detection of viral, Chlamydia pneumoniae, and Mycoplasma pneumoniae infections in exacerbations of asthma in children","volume":"13","author":"Freymuth","year":"1999","journal-title":"J Clin Virol"},{"issue":"suppl","key":"10.1016\/j.jaci.2006.08.041_bib13","doi-asserted-by":"crossref","first-page":"S217","DOI":"10.1097\/01.inf.0000188164.33856.f9","article-title":"Role of viral infections, atopy and antiviral immunity in the etiology of wheezing exacerbations among children and young adults","volume":"24","author":"Heymann","year":"2005","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jaci.2006.08.041_bib14","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1099\/vir.0.79925-0","article-title":"Enterovirus 68 is associated with respiratory illness and shares biological features with both the enteroviruses and the rhinoviruses","volume":"85","author":"Oberste","year":"2004","journal-title":"J\u00a0Gen Virol"},{"key":"10.1016\/j.jaci.2006.08.041_bib15","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1086\/444392","article-title":"Human metapneumovirus infection plays etiologic role in acute asthma exacerbations requiring hospitalization in adults","volume":"192","author":"Williams","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2006.08.041_bib16","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.jaci.2005.02.001","article-title":"Human metapneumovirus infection in children hospitalized for wheezing","volume":"115","author":"Williams","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.08.041_bib17","doi-asserted-by":"crossref","first-page":"862","DOI":"10.3201\/eid1205.051523","article-title":"Human bocavirus in children","volume":"12","author":"Foulongne","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jaci.2006.08.041_bib18","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1128\/JCM.44.3.1132-1134.2006","article-title":"Detection of human bocavirus in Japanese children with lower respiratory tract infections","volume":"44","author":"Ma","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jaci.2006.08.041_bib19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jaci.2005.11.034","article-title":"The September epidemic of asthma hospitalization: school children as disease vectors","volume":"117","author":"Johnston","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.08.041_bib20","series-title":"Mandell, Douglas and Bennett's principles and practice of infectious diseases","first-page":"1782","article-title":"Respiratory syncytial virus","author":"Hall","year":"2000"},{"key":"10.1016\/j.jaci.2006.08.041_bib21","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/89098","article-title":"A newly discovered human pneumovirus isolated from young children with respiratory tract disease","volume":"7","author":"Van den Hoogen","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2006.08.041_bib22","doi-asserted-by":"crossref","first-page":"12891","DOI":"10.1073\/pnas.0504666102","article-title":"Cloning of a human parvovirus by molecular screening of respiratory tract samples","volume":"102","author":"Allander","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2006.08.041_bib23","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1086\/375069","article-title":"Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: results of 2 double-blind, randomized, placebo-controlled trials","volume":"36","author":"Hayden","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaci.2006.08.041_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3928\/0090-4481-20050101-12","article-title":"New considerations in the treatment and prevention of rhinovirus infections","volume":"34","author":"Turner","year":"2005","journal-title":"Pediatr Ann"},{"key":"10.1016\/j.jaci.2006.08.041_bib25","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S1359-6446(04)03239-8","article-title":"Respiratory infections and asthma: current treatment strategies","volume":"9","author":"Weinberger","year":"2004","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.jaci.2006.08.041_bib26","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1378\/chest.124.5.1805","article-title":"Spirometric reference values for the 6-s FVC maneuver","volume":"124","author":"Hankinson","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2006.08.041_bib27","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1128\/JCM.41.9.4298-4303.2003","article-title":"GeneScan reverse transcriptase-PCR assay for detection of six common respiratory viruses in young children hospitalized with acute respiratory illness","volume":"41","author":"Erdman","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jaci.2006.08.041_bib28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3201\/eid1002.030752","article-title":"SARS surveillance during emergency public health response, United States, March-July 2003","volume":"10","author":"Schrag","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jaci.2006.08.041_bib29","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1086\/381207","article-title":"Frequent detection of human coronaviruses in clinical specimens from patients with respiratory tract infection by use of a novel real-time reverse-transcriptase polymerase chain reaction","volume":"189","author":"Van Elden","year":"2004","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2006.08.041_bib30","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1128\/JCM.00889-06","article-title":"Real-time PCR assays for detection of bocavirus in human specimens","volume":"44","author":"Lu","year":"2006","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.jaci.2006.08.041_bib31","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jaci.2006.08.041_bib32","series-title":"Applied logistic regression","author":"Hosmer","year":"2000"},{"key":"10.1016\/j.jaci.2006.08.041_bib33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jaci.2004.09.025","article-title":"The September epidemic of asthma exacerbations in children: a search for etiology","volume":"115","author":"Johnston","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.08.041_bib34","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.prrv.2004.04.002","article-title":"Mechanisms of rhinovirus-induced asthma","volume":"5","author":"Papadopulos","year":"2004","journal-title":"Pediatr Respir Rev"},{"key":"10.1016\/j.jaci.2006.08.041_bib35","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/bmj.324.7340.763","article-title":"Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study","volume":"324","author":"Green","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2006.08.041_bib36","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1084\/jem.20041901","article-title":"Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus","volume":"201","author":"Wark","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2006.08.041_bib37","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0140-6736(02)07953-9","article-title":"Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study","volume":"359","author":"Corne","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2006.08.041_bib38","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jmv.20027","article-title":"Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children","volume":"72","author":"Jartti","year":"2004","journal-title":"J Med Virol"},{"key":"10.1016\/j.jaci.2006.08.041_bib39","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/jmv.20588","article-title":"Picornavirus infections in children diagnosed by RT-PCR during longitudinal surveillance with weekly sampling: association with symptomatic illness and effect of season","volume":"78","author":"Winter","year":"2006","journal-title":"J Med Virol"},{"key":"10.1016\/j.jaci.2006.08.041_bib40","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1164\/ajrccm.155.6.9196088","article-title":"Rhinovirus infection preferentially increases lower airway responsiveness in allergic subjects","volume":"155","author":"Gern","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2006.08.041_bib41","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1067\/mai.2003.1396","article-title":"Experimental rhinovirus challenges in adults with mild asthma: response to infection in relation to IgE","volume":"111","author":"Zambrano","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.08.041_bib42","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1164\/rccm.200212-1520OC","article-title":"Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure?","volume":"168","author":"De Kluijver","year":"2003","journal-title":"Am J Respir\u00a0Crit Care Med"},{"key":"10.1016\/j.jaci.2006.08.041_bib43","doi-asserted-by":"crossref","DOI":"10.1136\/thx.2005.056291","article-title":"Non-random distribution of pathogenic bacteria and viruses in induced sputum or pharyngeal secretions of adults with stable asthma","author":"Harju","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2006.08.041_bib44","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1183\/09031936.00.16598000","article-title":"Peak expiratory flow changes during experimental rhinovirus infection","volume":"16","author":"Bardin","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2006.08.041_bib45","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1086\/503809","article-title":"The relationship of rhinovirus-associated asthma hospitalizations with inhaled corticosteroids and smoking","volume":"193","author":"Venarske","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2006.08.041_bib46","series-title":"Mandell, Douglas and Bennett's principles and practice of infectious diseases","first-page":"1940","article-title":"Rhinovirus","author":"Gwaltney","year":"2000"},{"key":"10.1016\/j.jaci.2006.08.041_bib47","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.rmed.2005.08.025","article-title":"Respiratory infections and asthma","volume":"100","author":"Pelaia","year":"2006","journal-title":"Respir Med"},{"issue":"suppl","key":"10.1016\/j.jaci.2006.08.041_bib48","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1097\/01.inf.0000188158.27840.7c","article-title":"Human metapneumovirus: a ubiquitous and long-standing respiratory pathogen","volume":"24","author":"Hamelin","year":"2005","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jaci.2006.08.041_bib49","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s00134-005-2861-4","article-title":"A virologic survey of patients admitted to a critical care unit for acute cardiorespiratory failure","volume":"32","author":"Carrat","year":"2006","journal-title":"Intensive Care Med"},{"issue":"suppl","key":"10.1016\/j.jaci.2006.08.041_bib50","doi-asserted-by":"crossref","first-page":"S188","DOI":"10.1097\/01.inf.0000144660.53024.64","article-title":"Epidemiology of respiratory infections in young children: insights from the new vaccine surveillance network","volume":"23","author":"Griffin","year":"2004","journal-title":"Pediatr Infect Dis J"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906021294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906021294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:08:22Z","timestamp":1758776902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674906021294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0091674906021294"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2006.08.041","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence of viral respiratory tract infections in children with asthma","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2006.08.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}