{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:19:46Z","timestamp":1779250786126,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.jaci.2006.09.012","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T13:57:34Z","timestamp":1161698254000},"page":"150-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Respiratory illnesses in early life and asthma and atopy in childhood"],"prefix":"10.1016","volume":"119","author":[{"given":"Clare D.","family":"Ramsey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane R.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto A.","family":"Litonjua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane L.","family":"Sredl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Celed\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"227","key":"10.1016\/j.jaci.2006.09.012_bib1","article-title":"Summary health statistics for U.S. children: National Health Interview Survey, 2004. National Center for Health Statistics","volume":"10","author":"Bloom","year":"2006","journal-title":"Vital Health Stat"},{"key":"10.1016\/j.jaci.2006.09.012_bib2","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1164\/ajrccm\/146.4.888","article-title":"A community-based study of the epidemiology of asthma. Incidence rates, 1964-1983","volume":"146","author":"Yunginger","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2006.09.012_bib3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jaci.2004.05.025","article-title":"Characteristics of children with asthma who are enrolled in a Head Start program","volume":"114","author":"Vargas","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.09.012_bib4","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1056\/NEJMoa032097","article-title":"Results of a home-based environmental intervention among urban children with asthma","volume":"351","author":"Morgan","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2006.09.012_bib5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","article-title":"Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years","volume":"354","author":"Stein","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2006.09.012_bib6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/bmj.322.7283.390","article-title":"Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study","volume":"322","author":"Illi","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2006.09.012_bib7","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/oxfordjournals.aje.a115243","article-title":"The Tucson Children's Respiratory Study. II. Lower respiratory tract illness in the first year of life","volume":"129","author":"Wright","year":"1989","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jaci.2006.09.012_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/rccm.200406-730OC","article-title":"Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13","volume":"171","author":"Sigurs","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2006.09.012_bib9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/adc.76.4.315","article-title":"Respiratory status and allergy nine to 10 years after acute bronchiolitis","volume":"76","author":"Noble","year":"1997","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2006.09.012_bib10","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/ppul.1950060303","article-title":"Wheezing at 8 and 13 years: changing importance of bronchiolitis and passive smoking","volume":"6","author":"McConnochie","year":"1989","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaci.2006.09.012_bib11","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1136\/bmj.284.6330.1665","article-title":"Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy","volume":"284","author":"Pullan","year":"1982","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2006.09.012_bib12","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1542\/peds.95.4.500","article-title":"Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls","volume":"95","author":"Sigurs","year":"1995","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2006.09.012_bib13","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1183\/09031936.02.00019902","article-title":"RSV bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life","volume":"20","author":"Schauer","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2006.09.012_bib14","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1136\/bmj.282.6282.2086","article-title":"Atopy does not predispose to RSV bronchiolitis or postbronchiolitic wheezing","volume":"282","author":"Sims","year":"1981","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2006.09.012_bib15","first-page":"227","article-title":"The relationship between croup and asthma","volume":"41","author":"Konig","year":"1978","journal-title":"Ann Allergy"},{"key":"10.1016\/j.jaci.2006.09.012_bib16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s004310051062","article-title":"Croup and recurrent croup: their association with asthma and allergy. An epidemiological study on 5-8-year-old children","volume":"158","author":"Van Bever","year":"1999","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jaci.2006.09.012_bib17","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1111\/j.1651-2227.1996.tb13914.x","article-title":"Risk of asthma in children with a history of croup","volume":"85","author":"Nicolai","year":"1996","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jaci.2006.09.012_bib18","doi-asserted-by":"crossref","first-page":"E38","DOI":"10.1542\/peds.106.3.e38","article-title":"Early respiratory infections and childhood asthma","volume":"106","author":"Nafstad","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2006.09.012_bib19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1164\/ajrccm.160.1.9807104","article-title":"Predictors of repeated wheeze in the first year of life: the relative roles of cockroach, birth weight, acute lower respiratory illness, and maternal smoking","volume":"160","author":"Gold","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"suppl","key":"10.1016\/j.jaci.2006.09.012_bib20","first-page":"7","article-title":"Epidemiology standardization project. Recommended respiratory disease questionnaires for use with adults and children in epidemiological research","volume":"118","author":"Ferris","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2006.09.012_bib21","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1542\/peds.110.6.e77","article-title":"Bottle feeding in the bed or crib before sleep time and wheezing in early childhood","volume":"110","author":"Celed\u00f3n","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2006.09.012_bib22","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/(SICI)1099-0496(199912)28:6<394::AID-PPUL2>3.0.CO;2-6","article-title":"Race, socioeconomic factors, and area of residence are associated with asthma prevalence","volume":"28","author":"Litonjua","year":"1999","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaci.2006.09.012_bib23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1164\/ajrccm.158.1.9710014","article-title":"Parental history and the risk for childhood asthma. Does mother confer more risk that father?","volume":"158","author":"Litonjua","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2006.09.012_bib24","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1542\/peds.2003-0838-L","article-title":"Low-normal gestational age as a predictor of asthma at 6 years of age","volume":"114","author":"Raby","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2006.09.012_bib25","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1164\/rccm.200209-1063OC","article-title":"Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years","volume":"167","author":"Celed\u00f3n","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2006.09.012_bib26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1164\/rccm.2109074","article-title":"Lack of association between antibiotic use in the first year of life and asthma, allergic rhinitis, or eczema at age 5 years","volume":"166","author":"Celed\u00f3n","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2006.09.012_bib27","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0140-6736(02)09906-3","article-title":"Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life","volume":"360","author":"Celed\u00f3n","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2006.09.012_bib28","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1214\/aos\/1176345976","article-title":"Cox's regression model for counting processes: a large sample study","volume":"10","author":"Andersen","year":"1982","journal-title":"Ann Stat"},{"key":"10.1016\/j.jaci.2006.09.012_bib29","series-title":"Multiple events per subject. In: Modeling survival data: extending the Cox model (Statistics for Biology and Health)","first-page":"185","article-title":"Multiple events per subject","author":"Therneau","year":"2000"},{"key":"10.1016\/j.jaci.2006.09.012_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1067\/mai.2002.125697","article-title":"T(H)2 cytokine expression in atopic children with otitis media with effusion","volume":"110","author":"Sobol","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.09.012_bib31","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1046\/j.1365-2222.1998.00284.x","article-title":"Atopy in children with otitis media with effusion","volume":"28","author":"Caffarelli","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2006.09.012_bib32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0165-5876(92)90137-E","article-title":"Atopy and environmental factors in upper respiratory infections: an epidemiological survey on 2304 school children","volume":"24","author":"Porro","year":"1992","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10.1016\/j.jaci.2006.09.012_bib33","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1203\/00006450-198805000-00015","article-title":"Risk factors for infantile recurrent otitis media: atopy but not type of feeding","volume":"23","author":"Tainio","year":"1988","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jaci.2006.09.012_bib34","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1378\/chest.125.5.1685","article-title":"History of ear infections and prevalence of asthma in a National sample of children aged 2 to 11 years: the third national health and nutrition examination survey, 1988 to 1994","volume":"125","author":"Eldeirawi","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2006.09.012_bib35","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1136\/adc.88.7.566","article-title":"Airway infections in infancy and the presence of allergy and asthma in school age children","volume":"88","author":"Nja","year":"2003","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2006.09.012_bib36","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/00006454-200107000-00004","article-title":"Bacteriology of acute otitis media in a cohort of Finnish children followed for the first two years of life","volume":"20","author":"Kilpi","year":"2001","journal-title":"Pediatr Infect Dis J"},{"issue":"suppl","key":"10.1016\/j.jaci.2006.09.012_bib37","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/00006454-199208001-00002","article-title":"Ten-year review of otitis media pathogens","volume":"11","author":"Bluestone","year":"1992","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jaci.2006.09.012_bib38","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0966-842X(97)82906-X","article-title":"Understanding the role of Th1\/Th2 cells in infection","volume":"4","author":"Romagnani","year":"1996","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.jaci.2006.09.012_bib39","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0140-6736(04)15592-X","article-title":"Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease","volume":"363","author":"Ling","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2006.09.012_bib40","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1084\/jem.20032058","article-title":"Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T\u00a0helper 2 cells","volume":"199","author":"Akdis","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2006.09.012_bib41","first-page":"239","article-title":"Relationship between recurrent croup and airway hyperreactivity","volume":"65","author":"Litmanovitch","year":"1990","journal-title":"Ann Allergy"},{"key":"10.1016\/j.jaci.2006.09.012_bib42","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1136\/adc.56.5.336","article-title":"Croup, recurrent group, allergy, and airways hyper-reactivity","volume":"56","author":"Zach","year":"1981","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2006.09.012_bib43","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1542\/peds.107.3.512","article-title":"Relation of two different subtypes of croup before age three to wheezing, atopy, and pulmonary function during childhood: a\u00a0prospective study","volume":"107","author":"Castro-Rodriguez","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2006.09.012_bib44","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaci.2005.10.002","article-title":"Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life","volume":"117","author":"Gern","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.09.012_bib45","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0091-6749(03)01868-2","article-title":"Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life","volume":"112","author":"Neaville","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.09.012_bib46","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0891-5245(04)00268-8","article-title":"Viral croup: a current perspective","volume":"18","author":"Leung","year":"2004","journal-title":"J Pediatr Health Care"},{"key":"10.1016\/j.jaci.2006.09.012_bib47","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1542\/peds.94.6.895","article-title":"Epidemiology of physician-diagnosed allergic rhinitis in childhood","volume":"94","author":"Wright","year":"1994","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2006.09.012_bib48","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1651-2227.1988.tb10735.x","article-title":"Risk factors for occasional and recurrent wheezing after RSV infection in infancy","volume":"77","author":"Rylander","year":"1988","journal-title":"Acta Paediatr Scand"},{"key":"10.1016\/j.jaci.2006.09.012_bib49","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1136\/adc.87.5.417","article-title":"Reduced lung function both before bronchiolitis and at 11 years","volume":"87","author":"Turner","year":"2002","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2006.09.012_bib50","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ppul.20058","article-title":"Respiratory morbidity 20 years after RSV infection in infancy","volume":"38","author":"Korppi","year":"2004","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaci.2006.09.012_bib51","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1542\/peds.104.3.495","article-title":"Day care attendance in the first year of life and illnesses of the upper and lower respiratory tract in children with a familial history of atopy","volume":"104","author":"Celed\u00f3n","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2006.09.012_bib52","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0091-6749(99)70465-3","article-title":"Childhood environment and adult atopy: results from the European community respiratory health survey","volume":"103","author":"Svanes","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.09.012_bib53","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1136\/bmj.38435.582975.AE","article-title":"Changes in atopy over a quarter of a century, based on cross sectional data at three time periods","volume":"330","author":"Law","year":"2005","journal-title":"BMJ"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906019129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906019129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:06:12Z","timestamp":1758776772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674906019129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0091674906019129"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2006.09.012","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1085767.538684","asserted-by":"object"}]},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Respiratory illnesses in early life and asthma and atopy in childhood","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2006.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}