{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:11:35Z","timestamp":1778631095353,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.jaci.2006.12.645","type":"journal-article","created":{"date-parts":[[2007,3,29]],"date-time":"2007-03-29T07:16:59Z","timestamp":1175152619000},"page":"671-679","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Skin inflammation in RelB\u2212\/\u2212 mice leads to\u00a0defective immunity and impaired clearance\u00a0of vaccinia virus"],"prefix":"10.1016","volume":"119","author":[{"given":"Eva-Jasmin","family":"Freyschmidt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clinton B.","family":"Mathias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"MacArthur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amale","family":"Laouar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjunath","family":"Narasimhaswamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Falk","family":"Weih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans C.","family":"Oettgen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2006.12.645_bib1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/infdis\/122.4.303","article-title":"Complications of smallpox vaccination, 1968: results of ten statewide surveys","volume":"122","author":"Lane","year":"1970","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2006.12.645_bib2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1067\/mai.2002.128052","article-title":"Smallpox vaccination: risk considerations for patients with atopic dermatitis","volume":"110","author":"Engler","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.12.645_bib3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/01.all.0000136758.66442.28","article-title":"Smallpox, vaccination and adverse reactions to smallpox vaccine","volume":"4","author":"Wollenberg","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.12.645_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0091-6749(83)90546-8","article-title":"Characterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies","volume":"71","author":"Leung","year":"1983","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.12.645_bib5","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1034\/j.1398-9995.2001.00144.x","article-title":"Epidemiology, clinical features, and immunology of the \u201cintrinsic\u201d (nonIgE-mediated) type of atopic dermatitis (constitutional dermatitis)","volume":"56","author":"Schmid-Grendelmeier","year":"2001","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2006.12.645_bib6","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/0091-6749(94)90185-6","article-title":"Kinetics of cell infiltration and cytokine messenger RNA expression after intradermal challenge with allergen and tuberculin in the same atopic individuals","volume":"94","author":"Tsicopoulos","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2006.12.645_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0140-6736(94)90879-6","article-title":"Lesional expression of interferon-gamma in atopic eczema","volume":"343","author":"Grewe","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2006.12.645_bib8","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/intimm\/9.3.461","article-title":"Development of atopic dermatitis\u2013like skin lesion with IgE hyperproduction in NC\/Nga mice","volume":"9","author":"Matsuda","year":"1997","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2006.12.645_bib9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0092-8674(90)90011-3","article-title":"IL-4 induces allergic-like inflammatory disease and alters T\u00a0cell development in transgenic mice","volume":"62","author":"Tepper","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2006.12.645_bib10","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1046\/j.0022-202x.2001.01484.x","article-title":"Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopic dermatitis","volume":"117","author":"Chan","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2006.12.645_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0923-1811(99)00013-4","article-title":"Intradermal transfer of caspase-1 (CASP1) DNA into mouse dissects: role of CASP1 in interleukin-1beta associated skin inflammation and apoptotic cell death","volume":"21","author":"Asahi","year":"1999","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jaci.2006.12.645_bib12","doi-asserted-by":"crossref","first-page":"11340","DOI":"10.1073\/pnas.152337799","article-title":"IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE\/STAT6 under specific pathogen-free conditions","volume":"99","author":"Konishi","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2006.12.645_bib13","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/jb\/mvg216","article-title":"Association of cathepsin E deficiency with development of atopic dermatitis","volume":"134","author":"Tsukuba","year":"2003","journal-title":"J Biochem (Tokyo)"},{"key":"10.1016\/j.jaci.2006.12.645_bib14","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/1521-4141(2000)30:8<2323::AID-IMMU2323>3.0.CO;2-H","article-title":"Mice lacking the transcription factor RelB develop T cell\u2013dependent skin lesions similar to human atopic dermatitis","volume":"30","author":"Barton","year":"2000","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2006.12.645_bib15","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1172\/JCI1647","article-title":"Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice","volume":"101","author":"Spergel","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2006.12.645_bib16","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S1357-2725(99)00068-0","article-title":"New insights into the roles of ReL\/NF-kappa B transcription factors in immune function, hemopoiesis and human disease","volume":"31","author":"Grossmann","year":"1999","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jaci.2006.12.645_bib17","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.4049\/jimmunol.175.4.2102","article-title":"Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation","volume":"175","author":"Corn","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.12.645_bib18","series-title":"Preparation of cell cultures and vaccinia virus stocks","year":"1998"},{"key":"10.1016\/j.jaci.2006.12.645_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0092-8674(95)90416-6","article-title":"Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B\/Rel family","volume":"80","author":"Weih","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2006.12.645_bib20","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1126\/science.8456301","article-title":"Immune response in mice that lack the interferon-gamma receptor","volume":"259","author":"Huang","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.jaci.2006.12.645_bib21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.immuni.2006.02.006","article-title":"Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus","volume":"24","author":"Howell","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2006.12.645_bib22","doi-asserted-by":"crossref","first-page":"8233","DOI":"10.1073\/pnas.95.14.8233","article-title":"Targeted\u00a0disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice","volume":"95","author":"Lu","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2006.12.645_bib23","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1126\/science.8009221","article-title":"Functional role of type I and type II interferons in antiviral defense","volume":"264","author":"Muller","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.jaci.2006.12.645_bib24","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1126\/science.7690156","article-title":"Inhibition of viral replication by interferon-gamma\u2013induced nitric oxide synthase","volume":"261","author":"Karupiah","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.jaci.2006.12.645_bib25","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1128\/JVI.72.9.7703-7706.1998","article-title":"Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection","volume":"72","author":"Karupiah","year":"1998","journal-title":"J Virol"},{"key":"10.1016\/j.jaci.2006.12.645_bib26","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.immunol.15.1.749","article-title":"Cellular responses to interferon-gamma","volume":"15","author":"Boehm","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2006.12.645_bib27","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.4049\/jimmunol.158.11.5211","article-title":"Multifocal defects in immune responses in RelB-deficient mice","volume":"158","author":"Weih","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.12.645_bib28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.iy.10.040192.002125","article-title":"Regulation of immunity to parasites by T cells and T cell\u2013derived cytokines","volume":"10","author":"Sher","year":"1992","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2006.12.645_bib29","doi-asserted-by":"crossref","first-page":"8672","DOI":"10.1128\/jvi.71.11.8672-8677.1997","article-title":"Overexpression of interleukin-4 delays virus clearance in mice infected with respiratory syncytial virus","volume":"71","author":"Fischer","year":"1997","journal-title":"J Virol"},{"key":"10.1016\/j.jaci.2006.12.645_bib30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4049\/jimmunol.164.1.371","article-title":"IL-4 and IL-10 antagonize IL-12\u2013mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2","volume":"164","author":"van Den Broek","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2006.12.645_bib31","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1099\/0022-1317-82-9-2107","article-title":"Construction and characterization of recombinant vaccinia viruses co-expressing a respiratory syncytial virus protein and a cytokine","volume":"82","author":"Johnson","year":"2001","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jaci.2006.12.645_bib32","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.1128\/jvi.70.10.7103-7107.1996","article-title":"Interleukin-4 mediates down regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo","volume":"70","author":"Sharma","year":"1996","journal-title":"J Virol"},{"key":"10.1016\/j.jaci.2006.12.645_bib33","doi-asserted-by":"crossref","first-page":"8944","DOI":"10.1128\/JVI.73.11.8944-8949.1999","article-title":"Interleukin-4 diminishes CD8(+) respiratory syncytial virus-specific cytotoxic T-lymphocyte activity in vivo","volume":"73","author":"Aung","year":"1999","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jaci.2006.12.645_bib34","doi-asserted-by":"crossref","first-page":"12798","DOI":"10.1128\/JVI.79.20.12798-12806.2005","article-title":"T-bet is required for protection against vaccinia virus infection","volume":"79","author":"Matsui","year":"2005","journal-title":"J Virol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906039157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674906039157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:08:17Z","timestamp":1758776897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674906039157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0091674906039157"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2006.12.645","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Skin inflammation in RelB\u2212\/\u2212 mice leads to\u00a0defective immunity and impaired clearance\u00a0of vaccinia virus","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2006.12.645","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}