{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:17:28Z","timestamp":1791314248973,"version":"4.3.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.jaci.2007.04.032","type":"journal-article","created":{"date-parts":[[2007,6,12]],"date-time":"2007-06-12T07:11:25Z","timestamp":1181632285000},"page":"84-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood"],"prefix":"10.1016","volume":"120","author":[{"given":"Gary M.","family":"Hunninghake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel E.","family":"Soto-Quir\u00f3s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydiana","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn L.","family":"Demeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc P.","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody S.","family":"Sylvia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Klanderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Raby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin K.","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Celed\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2007.04.032_bib1","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1126\/science.282.5397.2258","article-title":"Interleukin-13: central mediator of allergic asthma","volume":"282","author":"Wills-Karp","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jaci.2007.04.032_bib2","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1073\/pnas.90.8.3735","article-title":"Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function","volume":"90","author":"McKenzie","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2007.04.032_bib3","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.4049\/jimmunol.174.2.1063","article-title":"Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production","volume":"174","author":"Gessner","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.04.032_bib4","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nm851","article-title":"Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity","volume":"9","author":"Akbari","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2007.04.032_bib5","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1073\/pnas.90.8.3730","article-title":"Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells","volume":"90","author":"Punnonen","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2007.04.032_bib6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/thx.2005.052399","article-title":"Evaluation of airway inflammation by quantitative Th1\/Th2 cytokine mRNA measurement in sputum of asthma patients","volume":"61","author":"Truyen","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2007.04.032_bib7","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0012-3692(15)52584-1","article-title":"Interleukin-13 and interleukin-5 in induced sputum of eosinophilic bronchitis: comparison with asthma","volume":"128","author":"Park","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2007.04.032_bib8","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.4049\/jimmunol.159.9.4506","article-title":"Mechanism of suppression of macrophage nitric oxide release by IL-13: influence of the macrophage population","volume":"159","author":"Bogdan","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.04.032_bib9","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.1085458","article-title":"Interleukin-4 and interleukin-13 signaling connections maps","volume":"300","author":"Kelly-Welch","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jaci.2007.04.032_bib10","doi-asserted-by":"crossref","first-page":"16921","DOI":"10.1074\/jbc.271.28.16921","article-title":"Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain","volume":"271","author":"Caput","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2007.04.032_bib11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nm1332","article-title":"IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis","volume":"12","author":"Fichtner-Feigl","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2007.04.032_bib12","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1056\/NEJM199510053331402","article-title":"Genetic susceptibility to asthma\u2013bronchial hyperresponsiveness coinherited with a major gene for atopy","volume":"333","author":"Postma","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2007.04.032_bib13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/ng0497-389","article-title":"A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The Collaborative Study on the Genetics of Asthma (CSGA)","volume":"15","year":"1997","journal-title":"Nat Genet"},{"issue":"suppl 1","key":"10.1016\/j.jaci.2007.04.032_bib14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1365-2222.1998.0280s1101.x","article-title":"The genetics of asthma: mapping genes for complex traits in founder populations","volume":"28","author":"Ober","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.04.032_bib15","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1006\/geno.1994.1524","article-title":"Evidence for a locus regulating total serum IgE levels mapping to chromosome 5","volume":"23","author":"Meyers","year":"1994","journal-title":"Genomics"},{"issue":"suppl 2","key":"10.1016\/j.jaci.2007.04.032_bib16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1365-2222.1995.tb00430.x","article-title":"Evidence for linkage of total serum IgE and bronchial hyperresponsiveness to chromosome 5q: a major regulatory locus important in asthma","volume":"25","author":"Bleecker","year":"1995","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.04.032_bib17","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1164\/rccm.200407-864OC","article-title":"Genomewide screen for pulmonary function in 200 families ascertained for asthma","volume":"172","author":"Postma","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.04.032_bib18","doi-asserted-by":"crossref","first-page":"8633","DOI":"10.4049\/jimmunol.177.12.8633","article-title":"Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammation","volume":"177","author":"Cameron","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.04.032_bib19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1172\/JCI200522818","article-title":"IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation","volume":"115","author":"Vladich","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2007.04.032_bib20","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1067\/mai.2002.124656","article-title":"Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma","volume":"109","author":"Arima","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.04.032_bib21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/hmg\/9.4.549","article-title":"Genetic variants of IL-13 signalling and human asthma and atopy","volume":"9","author":"Heinzmann","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jaci.2007.04.032_bib22","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1165\/ajrcmb.25.3.4483","article-title":"Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population","volume":"25","author":"Howard","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2007.04.032_bib23","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1164\/ajrccm.164.11.2101086","article-title":"Allelic frequencies and patterns of single-nucleotide polymorphisms in candidate genes for asthma and atopy in Iceland","volume":"164","author":"Hakonarson","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.04.032_bib24","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1046\/j.1365-2222.2002.01348.x","article-title":"Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica","volume":"32","author":"Celedon","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.04.032_bib25","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1067\/mai.2000.104940","article-title":"A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children","volume":"105","author":"Graves","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.04.032_bib26","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/gepi.10182","article-title":"Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program","volume":"23","author":"DeMeo","year":"2002","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.jaci.2007.04.032_bib27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jaci.2005.10.024","article-title":"IL-4\/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma","volume":"117","author":"Kabesch","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.04.032_bib28","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.jaci.2005.12.1354","article-title":"Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes","volume":"117","author":"Maier","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.04.032_bib29","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1046\/j.1365-2222.2001.01212.x","article-title":"A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children","volume":"31","author":"Leung","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.04.032_bib30","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jaci.2006.12.609","article-title":"Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica","volume":"119","author":"Hunninghake","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"suppl 2","key":"10.1016\/j.jaci.2007.04.032_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2222.1995.tb00416.x","article-title":"Collaborative studies on the genetics of asthma: National Heart, Lung and Blood Institute","volume":"25","author":"Blumenthal","year":"1995","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.04.032_bib32","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1164\/ajrccm.152.3.7663792","article-title":"Standardization of spirometry, 1994 update. American Thoracic Society","volume":"152","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.04.032_bib33","first-page":"235","article-title":"A comparison of histamine, methacholine, and exercise airway reactivity in normal and asthmatic subjects","volume":"126","author":"Chatham","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2007.04.032_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0197-2456(98)00044-0","article-title":"The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Childhood Asthma Management Program Research Group","volume":"20","year":"1999","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.jaci.2007.04.032_bib35","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1056\/NEJM200010123431501","article-title":"Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group","volume":"343","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2007.04.032_bib36","doi-asserted-by":"crossref","first-page":"7276","DOI":"10.1073\/pnas.88.16.7276","article-title":"Detection of specific polymerase chain reaction product by utilizing the 5\u2032\u20143\u2032 exonuclease activity of Thermus aquaticus DNA polymerase","volume":"88","author":"Holland","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2007.04.032_bib37","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1086\/301904","article-title":"PedCheck: a program for identification of genotype incompatibilities in linkage analysis","volume":"63","author":"O'Connell","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaci.2007.04.032_bib38","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2007.04.032_bib39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/sj.gene.6363630","article-title":"An IL-13 promoter polymorphism associated with increased risk of allergic asthma","volume":"1","author":"van der Pouw Kraan","year":"1999","journal-title":"Genes Immun"},{"key":"10.1016\/j.jaci.2007.04.032_bib40","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/01.GIM.0000170994.24960.48","article-title":"Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and\/or atopy in African Americans","volume":"7","author":"Moissidis","year":"2005","journal-title":"Genet Med"},{"key":"10.1016\/j.jaci.2007.04.032_bib41","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/sj.gene.6363985","article-title":"Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children","volume":"4","author":"He","year":"2003","journal-title":"Genes Immun"},{"key":"10.1016\/j.jaci.2007.04.032_bib42","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1086\/381563","article-title":"PBAT: tools for family-based association studies","volume":"74","author":"Lange","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaci.2007.04.032_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/8702","article-title":"Freely associating","volume":"22","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2007.04.032_bib44","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1001\/jama.1974.03230160020004","article-title":"Viruses as precipitants of asthmatic attacks in children","volume":"227","author":"Minor","year":"1974","journal-title":"JAMA"},{"key":"10.1016\/j.jaci.2007.04.032_bib45","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/thx.2005.042523","article-title":"A study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospitalization in children","volume":"61","author":"Murray","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2007.04.032_bib46","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaci.2005.10.002","article-title":"Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life","volume":"117","author":"Gern","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.04.032_bib47","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1016\/j.micinf.2006.09.007","article-title":"IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse","volume":"8","author":"Zhou","year":"2006","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jaci.2007.04.032_bib48","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mai.2002.128241","article-title":"Persistence of viral RNA in 2 rat strains differing in susceptibility to postbronchiolitis airway dysfunction","volume":"110","author":"Sorkness","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.04.032_bib49","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1086\/499316","article-title":"Association between severe respiratory syncytial virus infection and IL13\/IL4 haplotypes","volume":"193","author":"Puthothu","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2007.04.032_bib50","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jaci.2006.12.655","article-title":"IL-13 genetic polymorphism identifies children with late wheezing after respiratory syncytial virus infection","volume":"119","author":"Ermers","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.04.032_bib51","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1067\/mai.2003.1416","article-title":"Inhibition of allergic airways inflammation and airway hyperresponsiveness in mice by dexamethasone: role of eosinophils, IL-5, eotaxin, and IL-13","volume":"111","author":"Eum","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.04.032_bib52","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10875-005-5625-6","article-title":"The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion","volume":"25","author":"Gibbons","year":"2005","journal-title":"J Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907008585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907008585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:10:30Z","timestamp":1758777030000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674907008585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0091674907008585"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2007.04.032","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2007.04.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}