{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:31:18Z","timestamp":1767375078695,"version":"3.44.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.jaci.2007.05.015","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T07:08:39Z","timestamp":1182409719000},"page":"631-637","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice"],"prefix":"10.1016","volume":"120","author":[{"given":"Fu-Gang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekambar R.","family":"Kandimalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhir","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2003","series-title":"Report of the Expert Panel Report on Food Allergy Research","key":"10.1016\/j.jaci.2007.05.015_bib1"},{"key":"10.1016\/j.jaci.2007.05.015_bib2","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0091-6749(03)02026-8","article-title":"Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study","volume":"112","author":"Sicherer","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.05.015_bib3","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0091-6749(92)90080-L","article-title":"Treatment of peanut allergy with rush immunotherapy","volume":"90","author":"Oppenheimer","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.05.015_bib4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1067\/mai.2001.118787","article-title":"Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model","volume":"108","author":"Li","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.05.015_bib5","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1056\/NEJMoa022613","article-title":"Effect of anti-IgE therapy in patients with peanut allergy","volume":"348","author":"Leung","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2007.05.015_bib6","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A\u00a0Toll-like receptor recognizes bacterial DNA","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2007.05.015_bib7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s11882-996-0012-9","article-title":"Update on toll-like receptor ligands and allergy: implications for immunotherapy","volume":"6","author":"Horner","year":"2006","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2007.05.015_bib8","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jaci.2005.08.050","article-title":"Perspectives in asthma: molecular use of microbial products in asthma prevention and treatment","volume":"116","author":"Racila","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.05.015_bib9","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.4049\/jimmunol.161.12.7054","article-title":"Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice","volume":"161","author":"Broide","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.05.015_bib10","doi-asserted-by":"crossref","first-page":"6978","DOI":"10.4049\/jimmunol.172.11.6978","article-title":"Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy","volume":"172","author":"Bashir","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.05.015_bib11","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1016\/S0960-894X(00)00537-0","article-title":"Accessible 5\u2032-end of CpG-containing phosphorothioate oligodeoxynucleotides is essential for immunostimulatory activity","volume":"10","author":"Yu","year":"2000","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jaci.2007.05.015_bib12","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1093\/nar\/gkf582","article-title":"\u201cImmunomers\u201d\u2014novel 3\u2032-3\u2032-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents","volume":"30","author":"Yu","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2007.05.015_bib13","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1021\/bc0200374","article-title":"Conjugation of ligands at the 5\u2032-end of CpG DNA affects immunostimulatory activity","volume":"13","author":"Kandimalla","year":"2002","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.jaci.2007.05.015_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0006-291X(02)02127-7","article-title":"Potent CpG oligonucleotides containing phosphodiester linkages: in vitro and in vivo immunostimulatory properties","volume":"297","author":"Yu","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaci.2007.05.015_bib15","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1093\/nar\/gkg343","article-title":"Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles","volume":"31","author":"Kandimalla","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2007.05.015_bib16","doi-asserted-by":"crossref","first-page":"14303","DOI":"10.1073\/pnas.2335947100","article-title":"A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif","volume":"100","author":"Kandimalla","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2007.05.015_bib17","doi-asserted-by":"crossref","first-page":"6925","DOI":"10.1073\/pnas.0501729102","article-title":"Immunomodulatory oligonucleotides containing a cytosine-phosphate-2\u2032-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists","volume":"102","author":"Kandimalla","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2007.05.015_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.intimp.2003.11.005","article-title":"Novel immunomodulatory oligonucleotides (IMOs) prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma","volume":"4","author":"Agrawal","year":"2004","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jaci.2007.05.015_bib19","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.intimp.2004.03.009","article-title":"Modulation of ovalbumin-induced Th2 responses by second-generation immunomodulatory oligonucleotides in mice","volume":"4","author":"Zhu","year":"2004","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jaci.2007.05.015_bib20","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1083\/jcb.135.1.279","article-title":"Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype","volume":"135","author":"Friend","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2007.05.015_bib21","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1172\/JCI200316142","article-title":"Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts","volume":"111","author":"Turcanu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2007.05.015_bib22","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1164\/ajrccm.162.1.9906136","article-title":"Synthetic oligodeoxynucleotides inhibit IgE induction in human lymphocytes","volume":"162","author":"Fujieda","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.05.015_bib23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jaci.2003.11.001","article-title":"Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response","volume":"113","author":"Tulic","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.05.015_bib24","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jaci.2004.03.003","article-title":"Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA","volume":"113","author":"Simons","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.05.015_bib25","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.1073\/pnas.88.17.7595","article-title":"Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice","volume":"88","author":"Agrawal","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2007.05.015_bib26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0006-2952(95)00160-2","article-title":"Absorption, tissue distribution and in vivo stability of a hybrid antisense oligonucleotide following oral administration","volume":"50","author":"Agrawal","year":"1995","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jaci.2007.05.015_bib27","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1016\/j.vaccine.2004.11.028","article-title":"Oral administration of second-generation immunomodulatory oligonucleotides induces mucosal Th1 immune responses and adjuvant activity","volume":"23","author":"Wang","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.jaci.2007.05.015_bib28","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.4049\/jimmunol.170.7.3898","article-title":"Intranasal immunotherapy is more effective than intradermal immunotherapy for\u00a0the induction of airway allergen tolerance in Th2-sensitized mice","volume":"170","author":"Takabayashi","year":"2003","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaci.2007.05.015_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1067\/mai.2003.1622","article-title":"Persistent protective effect of heat-killed Escherichia coli producing \u201cengineered,\u201d recombinant peanut proteins in a murine model of peanut allergy","volume":"112","author":"Li","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.05.015_bib30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/clim.2001.5122","article-title":"Oral administration of IL-12 suppresses anaphylactic reactions in a murine model of peanut hypersensitivity","volume":"101","author":"Lee","year":"2001","journal-title":"Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907009657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907009657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:09:01Z","timestamp":1758776941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674907009657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0091674907009657"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2007.05.015","relation":{},"ISSN":["0091-6749"],"issn-type":[{"type":"print","value":"0091-6749"}],"subject":[],"published":{"date-parts":[[2007,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2007.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}