{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:33:25Z","timestamp":1791092005637,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.jaci.2007.05.050","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T07:38:50Z","timestamp":1186645130000},"page":"835-841","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Low IFN-\u03b3 production in the first year of life as a predictor of wheeze during childhood"],"prefix":"10.1016","volume":"120","author":[{"given":"Debra A.","family":"Stern","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Halonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando D.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2007.05.050_bib1","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1056\/NEJMe030041","article-title":"Toward asthma prevention\u2014does all that really matters happen before we learn to read?","volume":"349","author":"Martinez","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2007.05.050_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaci.2005.04.017","article-title":"Contemporaneous maturation of immunologic and respiratory functions during early childhood: implications for development of asthma prevention strategies","volume":"116","author":"Holt","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.05.050_bib3","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/S0140-6736(00)02239-X","article-title":"Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of\u00a0asthma","volume":"355","author":"Gereda","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2007.05.050_bib4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1399-3038.1993.tb00068.x","article-title":"Interferon-gamma production by cord-blood mononuclear cells is reduced in newborns with a family history of atopic disease and is independent from cord blood IgE-levels","volume":"4","author":"Rinas","year":"1993","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2007.05.050_bib5","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1034\/j.1398-9995.2003.00263.x","article-title":"The value of perinatal immune responses in predicting allergic disease at 6 years of age","volume":"58","author":"Prescott","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2007.05.050_bib6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1172\/JCI114970","article-title":"Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells","volume":"87","author":"Lewis","year":"1991","journal-title":"J Clin Invest"},{"issue":"suppl 5","key":"10.1016\/j.jaci.2007.05.050_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1046\/j.1365-2222.1998.028s5039.x","article-title":"Reciprocal age-related patterns of allergen-specific T-cell immunity in normal vs. atopic infants","volume":"28","author":"Prescott","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.05.050_bib8","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(94)91641-1","article-title":"Reduced interferon-gamma secretion in neonates and subsequent atopy","volume":"344","author":"Tang","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2007.05.050_bib9","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S0140-6736(03)14542-4","article-title":"Association between antenatal cytokine production and the development of atopy and asthma at age 6 years","volume":"362","author":"Macaubas","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2007.05.050_bib10","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0091-6749(03)01868-2","article-title":"Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life","volume":"112","author":"Neaville","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.05.050_bib11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1164\/rccm.200304-499OC","article-title":"Reduced interferon gamma production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age","volume":"169","author":"Guerra","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.05.050_bib12","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S0091-6749(95)70264-4","article-title":"Association of interleukin-2 and interferon-gamma production by blood mononuclear cells in infancy with parental allergy skin tests and with subsequent development of atopy","volume":"96","author":"Martinez","year":"1995","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.05.050_bib13","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1056\/NEJM200008243430803","article-title":"Siblings, day-care attendance, and the risk of asthma and wheezing during childhood","volume":"343","author":"Ball","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2007.05.050_bib14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1067\/mai.2001.117797","article-title":"Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy","volume":"108","author":"Remes","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.05.050_bib15","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1034\/j.1398-9995.2003.00285.x","article-title":"Childhood asthma and continuous exposure to cats since the first year of life with cats allowed in the child's bedroom","volume":"58","author":"Oberle","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2007.05.050_bib16","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/oxfordjournals.aje.a115242","article-title":"The Tucson Children's Respiratory Study: I. Design and implementation of a prospective study of acute and chronic respiratory illness in children","volume":"129","author":"Taussig","year":"1989","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jaci.2007.05.050_bib17","first-page":"201","article-title":"A comparative analysis of cord blood and adult lymphocytes: interleukin-2 and interferon production, natural killer cell activity, and lymphocyte populations","volume":"4","author":"Kibler","year":"1986","journal-title":"Diagn Immunol"},{"key":"10.1016\/j.jaci.2007.05.050_bib18","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/BF00915168","article-title":"Immune function in chronic active Epstein-Barr virus infection","volume":"5","author":"Kibler","year":"1985","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2007.05.050_bib19","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","article-title":"Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years","volume":"354","author":"Stein","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2007.05.050_bib20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/1094428104263672","article-title":"Using generalized estimating equations for longitudinal data analysis","volume":"7","author":"Ballinger","year":"2004","journal-title":"Organizational Research Methods"},{"key":"10.1016\/j.jaci.2007.05.050_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/biomet\/73.1.13","article-title":"Longitudinal data analysis using generalized linear models","volume":"73","author":"Liang","year":"1986","journal-title":"Biometrika"},{"key":"10.1016\/j.jaci.2007.05.050_bib22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2307\/2531248","article-title":"Longitudinal data analysis for discrete and continuous outcomes","volume":"42","author":"Zeger","year":"1986","journal-title":"Biometrics"},{"key":"10.1016\/j.jaci.2007.05.050_bib23","series-title":"Generalized estimating equations","author":"Hardin","year":"2002"},{"key":"10.1016\/j.jaci.2007.05.050_bib24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.0006-341X.2001.00120.x","article-title":"Akaike's information criterion in generalized estimating equations","volume":"57","author":"Pan","year":"2001","journal-title":"Biometrics"},{"key":"10.1016\/j.jaci.2007.05.050_bib25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1086\/429418","article-title":"Gene-environment interaction effects on the development of immune responses in the 1st year of life","volume":"76","author":"Hoffjan","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaci.2007.05.050_bib26","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF00919134","article-title":"Serum interferon in Navajo children with severe combined immunodeficiency disease inhibits lymphoblastogenesis","volume":"3","author":"Jones","year":"1983","journal-title":"J Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907011955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907011955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:10:24Z","timestamp":1758777024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674907011955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0091674907011955"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2007.05.050","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low IFN-\u03b3 production in the first year of life as a predictor of wheeze during childhood","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2007.05.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}