{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:31:30Z","timestamp":1791174690139,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.jaci.2007.06.009","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T07:38:50Z","timestamp":1186645130000},"page":"932-940","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":141,"title":["Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection"],"prefix":"10.1016","volume":"120","author":[{"given":"Hermelijn H.","family":"Smits","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamida","family":"Hammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno","family":"van Nimwegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Soullie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique A.","family":"Willart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Lievers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Kadouch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Kool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke","family":"Kos-van Oosterhoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 M.","family":"Deelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart N.","family":"Lambrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Yazdanbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2007.06.009_bib1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.coi.2005.09.001","article-title":"Infections and allergy\u2014helminths, hygiene and host immune regulation","volume":"17","author":"Maizels","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/01.all.0000182541.52971.eb","article-title":"The role of helminth infections in protection from atopic disorders","volume":"5","author":"Yazdanbakhsh","year":"2005","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib3","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1164\/rccm.2107020","article-title":"Ascaris lumbricoides infection is associated with increased risk of childhood asthma and atopy in rural China","volume":"165","author":"Palmer","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.06.009_bib4","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/j.1365-2222.2006.02479.x","article-title":"Respiratory atopic disease, Ascaris-immunoglobulin E and tuberculin testing in urban South African children","volume":"36","author":"Obihara","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.06.009_bib5","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1183\/09031936.97.10071467","article-title":"Relationship between allergic manifestations and Toxocara seropositivity: a cross-sectional study among elementary school children","volume":"10","author":"Buijs","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2007.06.009_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000091603","article-title":"Toxocara infection seroprevalence and its relationship with atopic features in a general adult population","volume":"139","author":"Gonzalez-Quintela","year":"2006","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.0105-2896.2004.00187.x","article-title":"Th2 response polarization during infection with the helminth parasite Schistosoma mansoni","volume":"201","author":"Pearce","year":"2004","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2007.06.009_bib8","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/S0140-6736(00)03206-2","article-title":"Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10","volume":"356","author":"van den Biggelaar","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2007.06.009_bib9","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1086\/517832","article-title":"Antigen-specific proliferation and interferon-gamma and interleukin-5 production are down-regulated during Schistosoma haematobium infection","volume":"177","author":"Grogan","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2007.06.009_bib10","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1073\/pnas.90.3.948","article-title":"Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance","volume":"90","author":"Actor","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2007.06.009_bib11","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.4049\/jimmunol.148.10.3264","article-title":"Infection with Schistosoma mansoni alters Th1\/Th2 cytokine responses to a non-parasite antigen","volume":"148","author":"Kullberg","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/infdis\/173.1.269","article-title":"Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni","volume":"173","author":"Sabin","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2007.06.009_bib13","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.vaccine.2004.09.038","article-title":"Schistosoma mansoni infection reduces the protective efficacy of BCG vaccination against virulent Mycobacterium tuberculosis","volume":"23","author":"Elias","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.jaci.2007.06.009_bib14","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1084\/jem.20042572","article-title":"Suppression of allergic airway inflammation by helminth-induced regulatory T cells","volume":"202","author":"Wilson","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2007.06.009_bib15","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.4049\/jimmunol.177.3.1628","article-title":"Intestinal helminths protect in a murine model of asthma","volume":"177","author":"Kitagaki","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib16","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1167\/iovs.04-0899","article-title":"Differential modulation of allergic eye disease by chronic and acute ascaris infection","volume":"46","author":"Schopf","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jaci.2007.06.009_bib17","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1046\/j.1365-2222.2002.01506.x","article-title":"Eosinophilic inflammation and airway hyper-responsiveness are profoundly inhibited by a helminth (Ascaris suum) extract in a murine model of asthma","volume":"32","author":"Lima","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.06.009_bib18","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/intimm\/dxh062","article-title":"Helminth infection modulates the development of allergen-induced airway inflammation","volume":"16","author":"Wohlleben","year":"2004","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib19","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4049\/jimmunol.176.1.138","article-title":"Helminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness","volume":"176","author":"Mangan","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib20","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1128\/IAI.71.5.2607-2614.2003","article-title":"Changes in pulmonary function and parasite burden in rats infected with Strongyloides venezuelensis concomitant with induction of allergic airway inflammation","volume":"71","author":"Negrao-Correa","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2007.06.009_bib21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1046\/j.1365-2222.2001.01044.x","article-title":"Infection of mice with the helminth Strongyloides stercoralis suppresses pulmonary allergic responses to ovalbumin","volume":"31","author":"Wang","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.06.009_bib22","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.0105-2896.2004.00176.x","article-title":"Immunopathogenesis of schistosomiasis","volume":"201","author":"Wynn","year":"2004","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2007.06.009_bib23","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib24","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/82717","article-title":"Reciprocal regulation of polarized cytokine production by effector B and T cells","volume":"1","author":"Harris","year":"2000","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/0091-6749(93)90119-Z","article-title":"Effect of anthelmintic treatment on the allergic reactivity of children in a tropical slum","volume":"92","author":"Lynch","year":"1993","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib26","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1086\/381767","article-title":"Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren","volume":"189","author":"van den Biggelaar","year":"2004","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2007.06.009_bib27","first-page":"703","article-title":"Two distinct pathological syndromes in male CBA\/J inbred mice with chronic Schistosoma mansoni infections","volume":"142","author":"Henderson","year":"1993","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2007.06.009_bib28","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/infdis\/144.2.148","article-title":"Immunopathology of murine infection with Schistosoma mansoni: relationship of genetic background to hepatosplenic disease and modulation","volume":"144","author":"Fanning","year":"1981","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2007.06.009_bib29","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S1286-4579(02)00014-X","article-title":"Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis)","volume":"4","author":"Satoguina","year":"2002","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jaci.2007.06.009_bib30","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/intimm\/12.5.623","article-title":"Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3\/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shift","volume":"12","author":"Doetze","year":"2000","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib31","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.4049\/jimmunol.176.10.5839","article-title":"Regulatory T cell responses develop in parallel to Th responses and control the magnitude and phenotype of the Th effector population","volume":"176","author":"Taylor","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib32","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.4049\/jimmunol.172.5.3157","article-title":"The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells","volume":"172","author":"Hesse","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib33","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.4049\/jimmunol.176.9.5374","article-title":"Naturally occurring CD4+Foxp3+ regulatory T cells are an essential, IL-10-independent part of the immunoregulatory network in Schistosoma mansoni egg-induced inflammation","volume":"176","author":"Baumgart","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib34","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/eji.200323501","article-title":"IL-10 is crucial for the transition from acute to chronic disease state during infection of mice with Schistosoma mansoni","volume":"33","author":"Sadler","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib35","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.4049\/jimmunol.160.9.4473","article-title":"IL-10 regulates liver pathology in acute murine Schistosoma mansoni but is not required for immune down-modulation of chronic disease","volume":"160","author":"Wynn","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib36","doi-asserted-by":"crossref","first-page":"48122","DOI":"10.1074\/jbc.M206941200","article-title":"A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization","volume":"277","author":"van der Kleij","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2007.06.009_bib37","doi-asserted-by":"crossref","first-page":"6346","DOI":"10.4049\/jimmunol.173.10.6346","article-title":"Helminth infection protects mice from anaphylaxis via IL-10-producing B cells","volume":"173","author":"Mangan","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.06.009_bib38","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1084\/jem.187.4.619","article-title":"CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling","volume":"187","author":"Jankovic","year":"1998","journal-title":"J Exp Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907010512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907010512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:09:37Z","timestamp":1758776977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674907010512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0091674907010512"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2007.06.009","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2007.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}