{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:38:34Z","timestamp":1773286714811,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.jaci.2007.06.024","type":"journal-article","created":{"date-parts":[[2007,8,28]],"date-time":"2007-08-28T07:18:35Z","timestamp":1188285515000},"page":"1082-1088","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["A critical role for Pin1 in allergic pulmonary eosinophilia in rats"],"prefix":"10.1016","volume":"120","author":[{"given":"Stephane","family":"Esnault","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis A.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Jian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie B.","family":"Sedgwick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee J.","family":"Szakaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald L.","family":"Sorkness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Malter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2007.06.024_bib1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJM199010113231505","article-title":"Eosinophilic inflammation in asthma","volume":"323","author":"Bousquet","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2007.06.024_bib2","first-page":"1","article-title":"The eosinophil","volume":"24","author":"Rothenberg","year":"2005","journal-title":"Annu Rev Immunol"},{"issue":"suppl","key":"10.1016\/j.jaci.2007.06.024_bib3","doi-asserted-by":"crossref","first-page":"S502","DOI":"10.1067\/mai.2003.94","article-title":"6. Asthma","volume":"111","author":"Lemanske","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.06.024_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1164\/rccm.200208-789OC","article-title":"Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway","volume":"167","author":"Flood-Page","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.06.024_bib5","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1126\/science.1099472","article-title":"Defining a link with asthma in mice congenitally deficient in eosinophils","volume":"305","author":"Lee","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jaci.2007.06.024_bib6","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1126\/science.1100283","article-title":"A critical role for eosinophils in allergic airways remodeling","volume":"305","author":"Humbles","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jaci.2007.06.024_bib7","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0161-5890(02)00013-5","article-title":"Cytokines and chemoattractants in allergic inflammation","volume":"38","author":"Romagnani","year":"2002","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaci.2007.06.024_bib8","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1182\/blood.V73.6.1504.1504","article-title":"Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF","volume":"73","author":"Clutterbuck","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2007.06.024_bib9","doi-asserted-by":"crossref","first-page":"799","DOI":"10.4049\/jimmunol.154.2.799","article-title":"IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells","volume":"154","author":"Bochner","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.06.024_bib10","doi-asserted-by":"crossref","first-page":"16418","DOI":"10.1073\/pnas.0607863103","article-title":"A central regulatory role for eosinophils and the eotaxin\/CCR3 axis in chronic experimental allergic airway inflammation","volume":"103","author":"Fulkerson","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2007.06.024_bib11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1365-2249.1990.tb03305.x","article-title":"The effects of recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 on the secretory capacity of human blood eosinophils","volume":"80","author":"Tai","year":"1990","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2007.06.024_bib12","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1084\/jem.174.3.745","article-title":"Granulocyte\/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils","volume":"174","author":"Kita","year":"1991","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2007.06.024_bib13","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.4049\/jimmunol.163.10.5228","article-title":"Primary peripheral blood eosinophils rapidly degrade transfected granulocyte-macrophage colony-stimulating factor mRNA","volume":"163","author":"Esnault","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.06.024_bib14","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.4049\/jimmunol.169.11.6452","article-title":"Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge","volume":"169","author":"Liu","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.06.024_bib15","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","article-title":"Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes","volume":"66","author":"Liu","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2007.06.024_bib16","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/ni1266","article-title":"The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils","volume":"6","author":"Shen","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2007.06.024_bib17","doi-asserted-by":"crossref","first-page":"6999","DOI":"10.4049\/jimmunol.177.10.6999","article-title":"The peptidyl-prolyl isomerase Pin1 regulates granulocyte-macrophage colony-stimulating factor mRNA stability in T lymphocytes","volume":"177","author":"Esnault","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.06.024_bib18","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/380544a0","article-title":"A human peptidyl-prolyl isomerase essential for regulation of mitosis","volume":"380","author":"Lu","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2007.06.024_bib19","doi-asserted-by":"crossref","first-page":"e226","DOI":"10.1371\/journal.pone.0000226","article-title":"Pin1 modulates the type 1 immune response","volume":"2","author":"Esnault","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jaci.2007.06.024_bib20","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jaci.2004.07.015","article-title":"Systemic and pulmonary effects of fluticasone administered through a metered-dose inhaler in rats","volume":"114","author":"Sorkness","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.06.024_bib21","doi-asserted-by":"crossref","first-page":"L85","DOI":"10.1152\/ajplung.00234.2006","article-title":"Altered allergen-induced eosinophil trafficking and physiological dysfunction in airways with preexisting virus-induced injury","volume":"292","author":"Sorkness","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2007.06.024_bib22","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1165\/ajrcmb.24.1.4125","article-title":"Reduced interferon-gamma secretion by natural killer cells from rats susceptible to postviral chronic airway dysfunction","volume":"24","author":"Mikus","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2007.06.024_bib23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-1759(91)90315-7","article-title":"An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils","volume":"145","author":"Hansel","year":"1991","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jaci.2007.06.024_bib24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/jcb.240340306","article-title":"Phosphorylation and dephosphorylation of soluble proteins in human eosinophils","volume":"34","author":"Ramesh","year":"1987","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jaci.2007.06.024_bib25","doi-asserted-by":"crossref","first-page":"5953","DOI":"10.1021\/bi973162p","article-title":"Selective inactivation of parvulin-like peptidyl-prolyl cis\/trans isomerases by juglone","volume":"37","author":"Hennig","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.jaci.2007.06.024_bib26","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature01832","article-title":"Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration","volume":"424","author":"Liou","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2007.06.024_bib27","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.jaci.2003.08.015","article-title":"Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF","volume":"112","author":"Martinez-Moczygemba","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.06.024_bib28","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S1097-2765(03)00490-8","article-title":"Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65\/RelA","volume":"12","author":"Ryo","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.jaci.2007.06.024_bib29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0014-5793(01)02411-5","article-title":"Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cis-trans isomerase Pin1","volume":"496","author":"Liu","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jaci.2007.06.024_bib30","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1182\/blood.V79.12.3101.bloodjournal79123101","article-title":"Interleukin-5, eosinophils, and disease","volume":"79","author":"Sanderson","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2007.06.024_bib31","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0140-6736(04)15592-X","article-title":"Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease","volume":"363","author":"Ling","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2007.06.024_bib32","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.neuron.2006.01.034","article-title":"Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery","volume":"49","author":"Becker","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.jaci.2007.06.024_bib33","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1080\/00498250500356621","article-title":"Metabolism and disposition of juglone in male F344 rats","volume":"35","author":"Chen","year":"2005","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jaci.2007.06.024_bib34","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/nar\/29.3.767","article-title":"Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription","volume":"29","author":"Chao","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2007.06.024_bib35","doi-asserted-by":"crossref","first-page":"7523","DOI":"10.1158\/1078-0432.CCR-05-0457","article-title":"Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer","volume":"11","author":"Ryo","year":"2005","journal-title":"Clin Cancer Res"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907012444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907012444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:10:00Z","timestamp":1758777000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674907012444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0091674907012444"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2007.06.024","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A critical role for Pin1 in allergic pulmonary eosinophilia in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2007.06.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}