{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:22:49Z","timestamp":1790940169513,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.jaci.2007.06.034","type":"journal-article","created":{"date-parts":[[2007,7,31]],"date-time":"2007-07-31T07:27:18Z","timestamp":1185866838000},"page":"286-292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life"],"prefix":"10.1016","volume":"120","author":[{"given":"Christina","family":"Weber-Chrysochoou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Crisafulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Almqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warwick J.","family":"Britton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy B.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2007.06.034_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2007.06.034_bib2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev.iy.12.040194.001303","article-title":"Lymphokine production by human T cells in disease states","volume":"12","author":"Romagnani","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2007.06.034_bib3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1067\/mai.2003.139","article-title":"Chemokines in asthma: cooperative interaction between chemokines and IL-13","volume":"111","author":"Zimmermann","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.06.034_bib4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.all.0000162309.97480.45","article-title":"Cytokines, allergy, and asthma","volume":"5","author":"Ngoc","year":"2005","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.06.034_bib5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0091-6749(92)90070-I","article-title":"Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis","volume":"90","author":"van Reijsen","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.06.034_bib6","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1016\/S0140-6736(00)03496-6","article-title":"Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response","volume":"356","author":"Leckie","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2007.06.034_bib7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1164\/rccm.200208-789OC","article-title":"Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway","volume":"167","author":"Flood-Page","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2007.06.034_bib8","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1046\/j.1365-2222.1999.00654.x","article-title":"Regulation of T-helper cell responses to inhalant allergen during early childhood","volume":"29","author":"Macaubas","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.06.034_bib9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0140-6736(98)05104-6","article-title":"Development of allergen-specific T-cell memory in atopic and normal children","volume":"353","author":"Prescott","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2007.06.034_bib10","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(94)91641-1","article-title":"Reduced interferon-gamma secretion in neonates and subsequent atopy","volume":"344","author":"Tang","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2007.06.034_bib11","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1046\/j.1365-2222.2002.01391.x","article-title":"Increased Th1 and Th2 allergen-induced cytokine responses in children with atopic disease","volume":"32","author":"Smart","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.06.034_bib12","doi-asserted-by":"crossref","first-page":"F68","DOI":"10.1136\/adc.2006.106492","article-title":"Antenatal risk factors, cytokines and the development of atopic disease in early childhood","volume":"92","author":"Chung","year":"2007","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jaci.2007.06.034_bib13","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1445-5994.1994.tb02171.x","article-title":"Asthma severity and morbidity in a population sample of Sydney schoolchildren, part II: importance of house dust mite allergens","volume":"24","author":"Peat","year":"1994","journal-title":"Aust N Z J Med"},{"key":"10.1016\/j.jaci.2007.06.034_bib14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0197-2456(01)00112-X","article-title":"The childhood asthma prevention study (CAPS): design and research protocol of a randomized trial for the primary prevention of asthma","volume":"22","author":"Mihrshahi","year":"2001","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.jaci.2007.06.034_bib15","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1067\/mai.2003.36","article-title":"Eighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the Childhood Asthma Prevention Study (CAPS)","volume":"111","author":"Mihrshahi","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.06.034_bib16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jaci.2004.06.057","article-title":"Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study","volume":"114","author":"Peat","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.06.034_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jaci.2006.04.004","article-title":"Prevention of asthma during the first 5 years of life: a randomized controlled trial","volume":"118","author":"Marks","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.06.034_bib18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1046\/j.1365-2222.2002.01292.x","article-title":"Cord blood mononuclear cell cytokine responses in relation to maternal house dust mite allergen exposure","volume":"32","author":"Marks","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.06.034_bib19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/001316447303300309","article-title":"The equivalence of weighted kappa and the intraclass correlation coefficient as measures of reliability","volume":"33","author":"Fleiss","year":"1973","journal-title":"Educ Psych Meas"},{"key":"10.1016\/j.jaci.2007.06.034_bib20","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1002\/sim.4780111406","article-title":"An overview of methods for the analysis of longitudinal data","volume":"11","author":"Zeger","year":"1992","journal-title":"Stat Med"},{"key":"10.1016\/j.jaci.2007.06.034_bib21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0895-4356(03)00028-3","article-title":"Application of negative binomial modeling for discrete outcomes: a case study in aging research","volume":"56","author":"Byers","year":"2003","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.jaci.2007.06.034_bib22","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1136\/bmj.2.5659.723","article-title":"Clinical significance of skin reactions to mite extracts in children with asthma","volume":"2","author":"Morrison-Smith","year":"1969","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2007.06.034_bib23","doi-asserted-by":"crossref","unstructured":"Witt C, Stuckey MS, Woolcock A, Dawkins R. Positive allergy prick tests associated with bronchial histamine responsiveness in an unselected population. J Allergy Clin Immunol 1986;77:698-702.","DOI":"10.1016\/0091-6749(86)90413-6"},{"key":"10.1016\/j.jaci.2007.06.034_bib24","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1046\/j.1365-2222.1999.00631.x","article-title":"On early sensitization to allergens and development of respiratory symptoms","volume":"29","author":"Sherrill","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.06.034_bib25","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1136\/thorax.57.2.104","article-title":"Risk factors for onset and remission of atopy, wheeze and airway hyperresponsiveness","volume":"57","author":"Xuan","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2007.06.034_bib26","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1067\/mai.2001.118786","article-title":"The pattern of atopic sensitization is associated with the development of asthma in childhood","volume":"108","author":"Illi","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.06.034_bib27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life","volume":"332","author":"Martinez","year":"1995","journal-title":"N Engl J\u00a0Med"},{"key":"10.1016\/j.jaci.2007.06.034_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0091-6749(87)80022-2","article-title":"Comparison by electroblotting of IgE-binding components in extracts of house dust mite bodies and spent mite culture","volume":"79","author":"Tovey","year":"1987","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2007.06.034_bib29","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1365-2222.1993.tb00338.x","article-title":"Mite allergens groups I-VII: a catalogue of enzymes","volume":"23","author":"Thomas","year":"1993","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.06.034_bib30","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/j.1365-2222.1997.tb01170.x","article-title":"TH2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early childhood","volume":"27","author":"Yabuhara","year":"1997","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.06.034_bib31","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1046\/j.1365-2222.2001.01176.x","article-title":"Selective development of a strong Th2 cytokine profile in high-risk children who develop atopy: risk factors and regulatory role of IFN-gamma, IL-4 and IL-10","volume":"31","author":"van der Velden","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.06.034_bib32","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1046\/j.1365-2222.2002.01532.x","article-title":"Polyclonal and allergen-induced cytokine responses in children with elevated immunoglobulin E but no atopic disease","volume":"32","author":"Smart","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2007.06.034_bib33","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0140-6736(05)17704-6","article-title":"An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children","volume":"365","author":"Heaton","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2007.06.034_bib34","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.4049\/jimmunol.160.7.3555","article-title":"IgE versus IgG4 production can be differentially regulated by IL-10","volume":"160","author":"Jeannin","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2007.06.034_bib35","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2007.06.034_bib36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nri1589","article-title":"Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma","volume":"5","author":"Hawrylowicz","year":"2005","journal-title":"Nat Rev Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907012547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674907012547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:07:54Z","timestamp":1758776874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674907012547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0091674907012547"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2007.06.034","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2007.06.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}